Interweaving the cell cycle machinery with cell differentiation

Cell Cycle

Volumn 6, Issue 23, 2007, Pages 2932-2938

  Miller, Jeffrey P ^a   Yeh, Nancy ^b   Vidal, Anxo ^b,c   Koff, Andrew ^a,b  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Cdk inhibitors; Cell cycle; Chondrocyte; Differentiation; Oligodendrocyte; Pocket proteins

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR;

CARCINOGENESIS; CARTILAGE CELL; CELL CYCLE ARREST; CELL CYCLE REGULATION; CELL DIFFERENTIATION; CELL PROLIFERATION; HUMAN; NONHUMAN; OLIGODENDROGLIA; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

MUS;

EID: 37549000146     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.6.23.5042     Document Type: Review

References (86)

1. Blagosklonny MV, Pardee AB. The restriction point of the cell cycle. Cell Cycle 2002; 1:103-10.
2. 1 events and regulation of cell proliferation. Science 1989; 246:603-8.
3. Sherr CJ, Roberts JM. Living with or without cyclins and cyclin-dependent kinases. Genes Dev 2004; 18:2699-711.
4. Trimarchi JM, Lees JA. Sibling rivalry in the E2F family. Nat Rev Mol Cell Biol 2002; 3:11-20.
5. 1-phase progression. Genes Dev 1999; 13:1501-12.
6. Cobrinik D. Pocket proteins and cell cycle control. Oncogene 2005; 24:2796-809.
7. Ericson KK, Krull D, Slomiany P, Grossel MJ. Expression of cyclin-dependent kinase 6, but not cyclin-dependent kinase 4, alters morphology of cultured mouse astrocytes. Mol Cancer Res 2003; 1:654-64.
8. Grossel MJ, Hinds PW. Beyond the cell cycle: A new role for Cdk6 in differentiation. J Cell Biochem 2006; 97:485-93.
9. Grossel MJ, Hinds PW. From cell cycle to differentiation: An expanding role for cdk6. Cell Cycle 2006; 5:266-70.
10. Ye X, Zhu C, Harper JW. A premature-termination mutation in the Mus musculus cyclin-dependent kinase 3 gene. Proc Natl Acad Sci USA 2001; 98:1682-6.
11. 1 cyclin-dependent kinases. Genes Dev 1995; 9:1149-63.
12. Du W, Pogoriler J. Retinoblastoma family genes. Oncogene 2006; 25:5190-200.
13. Attwooll C, Lazzerini Denchi E, Helin K. The E2F family: Specific functions and overlapping interests. EMBO J 2004; 23:4709-16.
14. Lee EY, Cam H, Ziebold U, Rayman JB, Lees JA, Dynlacht BD. E2F4 loss suppresses tumorigenesis in Rb mutant mice. Cancer Cell 2002; 2:463-72.
15. Cobrinik D, Lee MH, Hannon G, Mulligan G, Bronson RT, Dyson N, Harlow E, Beach D, Weinberg RA, Jacks T. Shared role of the pRB-related p130 and p107 proteins in limb development. Genes Dev 1996; 10:1633-44.
16. Hurford Jr RK, Cobrinik D, Lee MH, Dyson N. pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes. Genes Dev 1997; 11:1447-63.
17. Hansen JB, Kristiansen K. Pocket proteins control white versus brown fat cell differentiation. Cell Cycle 2006; 5:341-2.
18. Sun H, Chang Y, Schweers B, Dyer MA, Zhang X, Hayward SW, Goodrich DW. An E2F binding-deficient Rb1 protein partially rescues developmental defects associated with Rb1 nullizygosity. Mol Cell Biol 2006; 26:1527-37.
19. Uziel T, Zindy F, Sherr CJ, Roussel MF. The CDK inhibitor p18Ink4c is a tumor suppressor in medulloblastoma. Cell Cycle 2006; 5:363-5.
20. Paternot S, Arsenijevic T, Coulonval K, Bockstaele L, Dumont JE, Roger PP. Distinct specificities of pRb phosphorylation by CDK4 activated by cyclin D1 or cyclin D3: Differential involvement in the distinct mitogenic modes of thyroid epithelial cells. Cell Cycle 2006; 5:61-70.
21. Blain SW, Montalvo E, Massague J. Differential interaction of the cyclin-dependent kinase (Cdk) inhibitor p27Kip1 with cyclin A-Cdk2 and cyclin D2-Cdk4. J Biol Chem 1997; 272:25863-72.
22. Soos TJ, Kiyokawa H, Yan JS, Rubin MS, Giordano A, DeBlasio A, Bottega S, Wong B, Mendelsohn J, Koff A. Formation of p27-CDK complexes during the human mitotic cell cycle. Cell Growth Differ 1996; 7:135-46.
23. Chu I, Sun J, Arnaout A, Kahn H, Hanna W, Narod S, Sun P, Tan CK, Hengst L, Slingerland J. p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2. Cell 2007; 128:281-94.
24. Grimmler M, Wang Y, Mund T, Cilensek Z, Keidel EM, Waddell MB, Jakel H, Kullmann M, Kriwacki RW, Hengst L. Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases. Cell 2007; 128:269-80.
25. Vidal A, Zacharoulis S, Guo W, Shaffer D, Giancotti F, Bramley AH, de la Hoz C, Jensen KK, Kato D, MacDonald DD, Knowles J, Yeh N, Frohman LA, Rafii S, Lyden D, Koff A. p130Rb2 and p27kip1 cooperate to control mobilization of angiogenic progenitors from the bone marrow. Proc Natl Acad Sci USA 2005; 102:6890-5.
26. Edwards PA. The use of transplanted mammary gland to study cancer signalling pathways. Adv Exp Med Biol 2000; 480:163-7.
27. Doles JD, Vezina CM, Lipinski RJ, Peterson RE, Bushman W. Growth, morphogenesis, and differentiation during mouse prostate development in situ, in renal grafts, and in vitro. Prostate 2005; 65:390-9.
28. Chien WM, Rabin S, Macias E, Miliani de Marval PL, Garrison K, Orthel J, Rodriguez-Puebla M, Fero ML. Genetic mosaics reveal both cell-autonomous and cell-non-autonomous function of murine p27Kip1. Proc Natl Acad Sci USA 2006; 103:4122-7.
29. Vidal A, Carneiro C, Zalvide JB. Of mice without pockets: Mouse models to study the function of Rb family proteins. Front Biosci 2007; 12:4483-96.
30. Vidal A, Koff A. Cell-cycle inhibitors: Three families united by a common cause. Gene 2000; 247:1-15.
31. Ciemerych MA, Sicinski P. Cell cycle in mouse development. Oncogene 2005; 24:2877-98.
32. DeGregori J. The genetics of the E2F family of transcription factors: Shared functions and unique roles. Biochim Biophys Acta 2002; 1602:131-50.
33. Durand B, Raff M. A cell-intrinsic timer that operates during oligodendrocyte development. Bioessays 2000; 22:64-71.
34. Nicolay DJ, Doucette JR, Nazarali AJ. Transcriptional control of oligodendrogenesis. Glia 2007; 55:1287-99.
35. Casaccia-Bonnefil P, Tikoo R, Kiyokawa H, Friedrich Jr V, Chao MV, Koff A. Oligodendrocyte precursor differentiation is perturbed in the absence of the cyclin-dependent kinase inhibitor p27Kip1. Genes Dev 1997; 11:2335-46.
36. Durand B, Gao FB, Raff M. Accumulation of the cyclin-dependent kinase inhibitor p27/ Kip1 and the timing of oligodendrocyte differentiation. EMBO J 1997; 16:306-17.
37. Casaccia-Bonnefil P, Liu A. Relationship between cell cycle molecules and onset of oligodendrocyte differentiation. J Neurosci Res 2003; 72:1-11.
38. Nguyen L, Borgs L, Vandenbosch R, Mangin JM, Beukelaers P, Moonen G, Gallo V, Malgrange B, Belachew S. The Yin and Yang of cell cycle progression and differentiation in the oligodendroglial lineage. Ment Retard Dev Disabil Res Rev 2006; 12:85-96.
39. Casaccia-Bonnefil P, Hardy RJ, Teng KK, Levine JM, Koff A, Chao MV. Loss of p27Kip1 function results in increased proliferative capacity of oligodendrocyte progenitors but unaltered timing of differentiation. Development 1999; 126:4027-37.
40. Zezula J, Casaccia-Bonnefil P, Ezhevsky SA, Osterhout DJ, Levine JM, Dowdy SF, Chao MV, Koff A. p21cip1 is required for the differentiation of oligodendrocytes independently of cell cycle withdrawal. EMBO Rep 2001; 2:27-34.
41. Vernon AE, Devine C, Philpott A. The cdk inhibitor p27Xic1 is required for differentiation of primary neurones in Xenopus. Development 2003; 130:85-92.
42. 1/S phase cyclin-dependent kinase overexpression perturbs early development and delays tissue-specific differentiation in Xenopus. Development 2004; 131:2577-86.
43. Vernon AE, Philpott A. A single cdk inhibitor, p27Xic1, functions beyond cell cycle regulation to promote muscle differentiation in Xenopus. Development 2003; 130:71-83.
44. Ohnuma S, Philpott A, Wang K, Holt CE, Harris WA. p27Xic1, a Cdk inhibitor, promotes the determination of glial cells in Xenopus retina. Cell 1999; 99:499-510.
45. Wei Q, Eviatar-Ribak T, Miskimins WK, Miskimins R. Galectin-4 is involved in p27-mediated activation of the myelin basic protein promoter. J Neurochem 2007; 101:1214-23.
46. Dugas JC, Ibrahim A, Barres BA. A crucial role for p57(Kip2) in the intracellular timer that controls oligodendrocyte differentiation. J Neurosci 2007; 27:6185-96.
47. Cheng M, Sexl V, Sherr CJ, Roussel MF. Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1). Proc Natl Acad Sci USA 1998; 95:1091-6.
48. 1. Cancer Res 1999; 59:2577-80.
49. Kiefer JC. Back to basics: Sox genes. Dev Dyn 2007; 236:2356-66.
50. Kronenberg HM. Developmental regulation of the growth plate. Nature 2003; 423:332-6.
51. Yan Y, Frisen J, Lee MH, Massague J, Barbacid M. Ablation of the CDK inhibitor p57Kip2 results in increased apoptosis and delayed differentiation during mouse development. Genes Dev 1997; 11:973-83.
52. Zhang P, Liegeois NJ, Wong C, Finegold M, Hou H, Thompson JC, Silverman A, Harper JW, DePinho RA, Elledge SJ. Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith-Wiedemann syndrome. Nature 1997; 387:151-8.
53. Yeh N, Miller JP, Gaur T, Capellini TD, Nikolich-Zugich J, de la Hoz C, Selleri L, Bromage TG, van Wijnen AJ, Stein GS, Lian JB, Vidal A, Koff A. Cooperation between p27 and p107 during endochondral ossification suggests a genetic pathway controlled by p27 and p130. Mol Cell Biol 2007; 27:5161-71.
54. Karsenty G, Wagner EF. Reaching a genetic and molecular understanding of skeletal development. Dev Cell 2002; 2:389-406.
55. MacLean HE, Guo J, Knight MC, Zhang P, Cobrinik D, Kronenberg HM. The cyclin-dependent kinase inhibitor p57(Kip2) mediates proliferative actions of PTHrP in chondrocytes. J Clin Invest 2004; 113:1334-43.
56. Laplantine E, Rossi F, Sahni M, Basilico C, Cobrinik D. FGF signaling targets the pRb-related p107 and p130 proteins to induce chondrocyte growth arrest. J Cell Biol 2002; 158:741-50.
57. Scheijen B, Bronk M, van der Meer T, Bernards R. Constitutive E2F1 overexpression delays endochondral bone formation by inhibiting chondrocyte differentiation. Mol Cell Biol 2003; 23:3656-68.
58. Dailey L, Laplantine E, Priore R, Basilico C. A network of transcriptional and signaling events is activated by FGF to induce chondrocyte growth arrest and differentiation. J Cell Biol 2003; 161:1053-66.
59. Lengner CJ, Lepper C, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Primary mouse embryonic fibroblasts: A model of mesenchymal cartilage formation. J Cell Physiol 2004; 200:327-33.
60. Lefebvre V, Smits P. Transcriptional control of chondrocyte fate and differentiation. Birth Defects Res C Embryo Today 2005; 75:200-12.
61. Thomas DM, Carty SA, Piscopo DM, Lee JS, Wang WF, Forrester WC, Hinds PW. The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation. Mol Cell 2001; 8:303-16.
62. Iavarone A, Garg P, Lasorella A, Hsu J, Israel MA. The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma protein. Genes Dev 1994; 8:1270-84.
63. Lasorella A, Iavarone A, Israel MA. Id2 specifically alters regulation of the cell cycle by tumor suppressor proteins. Mol Cell Biol 1996; 16:2570-8.
64. Dotto GP. p21(WAF1/Cip1): More than a break to the cell cycle? Biochim Biophys Acta 2000; 1471:M43-56.
65. Gartel AL, Tyner AL. The role of the cyclin-dependent kinase inhibitor p21 in apoptosis. Mol Cancer Ther 2002; 1:639-49.
66. Nguyen L, Besson A, Heng JI, Schuurmans C, Teboul L, Parras C, Philpott A, Roberts JM, Guillemot F. p27kip1 independently promotes neuronal differentiation and migration in the cerebral cortex. Genes Dev 2006; 20:1511-24.
67. Joaquin M, Watson RJ. The cell cycle-regulated B-Myb transcription factor overcomes cyclin-dependent kinase inhibitory activity of p57(KIP2) by interacting with its cyclin-binding domain. J Biol Chem 2003; 278:44255-64.
68. Bernards R. CDK-independent activities of D type cyclins. Biochim Biophys Acta 1999; 1424:M17-22.
69. Petre CE, Wetherill YB, Danielsen M, Knudsen KE. Cyclin D1: Mechanism and consequence of androgen receptor co-repressor activity. J Biol Chem 2002; 277:2207-15.
70. Petre-Draviam CE, Williams EB, Burd CJ, Gladden A, Moghadam H, Meller J, Diehl JA, Knudsen KE. A central domain of cyclin D1 mediates nuclear receptor corepressor activity. Oncogene 2005; 24:431-44.
71. Zwijsen RM, Wientjens E, Klompmaker R, van der Sman J, Bernards R, Michalides RJ. CDK-independent activation of estrogen receptor by cyclin D1. Cell 1997; 88:405-15.
72. Baker GL, Landis MW, Hinds PW. Multiple functions of D-type cyclins can antagonize pRb-mediated suppression of proliferation. Cell Cycle 2005; 4:330-8.
73. Shim J, Lee H, Park J, Kim H, Choi EJ. A non-enzymatic p21 protein inhibitor of stress-activated protein kinases. Nature 1996; 381:804-6.
74. Moeller SJ, Head ED, Sheaff RJ. p27Kip1 inhibition of GRB2-SOS formation can regulate Ras activation. Mol Cell Biol 2003; 23:3735-52.
75. Sugiyama Y, Tomoda K, Tanaka T, Arata Y, Yoneda-Kato N, Kato J. Direct binding of the signal-transducing adaptor Grb2 facilitates down-regulation of the cyclin-dependent kinase inhibitor p27Kip1. J Biol Chem 2001; 276:12084-90.
76. Besson A, Gurian-West M, Schmidt A, Hall A, Roberts JM. p27Kip1 modulates cell migration through the regulation of RhoA activation. Genes Dev 2004; 18:862-76.
77. Coqueret O. New roles for p21 and p27 cell-cycle inhibitors: A function for each cell compartment? Trends Cell Biol 2003; 13:65-70.
78. Denicourt C, Dowdy SF. Cip/Kip proteins: More than just CDKs inhibitors. Genes Dev 2004; 18:851-5.
79. Besson A, Assoian RK, Roberts JM. Regulation of the cytoskeleton: An oncogenic function for CDK inhibitors? Nat Rev Cancer 2004; 4:948-55.
80. Chibazakura T, McGrew SG, Cooper JA, Yoshikawa H, Roberts JM. Regulation of cyclin-dependent kinase activity during mitotic exit and maintenance of genome stability by p21, p27, and p107. Proc Natl Acad Sci USA 2004; 101:4465-70.
81. Coats S, Whyte P, Fero ML, Lacy S, Chung G, Randel E, Firpo E, Roberts JM. A new pathway for mitogen-dependent cdk2 regulation uncovered in p27(Kip1)-deficient cells. Curr Biol 1999; 9:163-73.
82. Hirai H, Sherr CJ. Interaction of D-type cyclins with a novel myb-like transcription factor, DMP1. Mol Cell Biol 1996; 16:6457-67.
83. Lazaro JB, Bailey PJ, Lassar AB. Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation. Genes Dev 2002; 16:1792-805.
84. Arnold MA, Kim Y, Czubryt MP, Phan D, McAnally J, Qi X, Shelton JM, Richardson JA, Bassel-Duby R, Olson EN. MEF2C transcription factor controls chondrocyte hypertrophy and bone development. Dev Cell 2007; 12:377-89.
85. Matsuura I, Denissova NG, Wang G, He D, Long J, Liu F. Cyclin-dependent kinases regulate the antiproliferative function of Smads. Nature 2004; 430:226-31.
86. Buttitta LA, Katzaroff AJ, Perez CL, de la Cruz A, Edgar BA. A double-assurance mechanism controls cell cycle exit upon terminal differentiation in Drosophila. Dev Cell 2007; 12:631-43.