Notch signaling in chondrocytes modulates endochondral ossification and osteoarthritis development

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 5, 2013, Pages 1875-1880

  Hosaka, Yoko ^a   Saito, Taku ^a   Sugita, Shurei ^a   Hikata, Tomohiro ^b   Kobayashi, Hiroshi ^a   Fukai, Atsushi ^a   Taniguchi, Yuki ^a   Hirata, Makoto ^a   Akiyama, Haruhiko ^c   Chung, Ung Il ^a   Kawaguchi, Hiroshi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b KEIO UNIVERSITY   (Japan)

^c KYOTO UNIVERSITY   (Japan)

Author keywords

Cartilage degradation; Skeletal development

Indexed keywords

BINDING PROTEIN; COLLAGEN TYPE 2; IMMUNOGLOBULIN J RECOMBINATION SIGNAL SEQUENCE BINDING PROTEIN; JAGGED1; NOTCH1 RECEPTOR; NOTCH2 RECEPTOR; TAMOXIFEN; TRANSCRIPTION FACTOR HES 1; TRANSCRIPTION FACTOR SOX9;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTICULAR CARTILAGE; BONE GROWTH; CARTILAGE CELL; CELL DIFFERENTIATION; CELL NUCLEUS; DISEASE COURSE; ENCHONDRAL OSSIFICATION; HUMAN; KNEE; MALE; MOUSE; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CALCIUM-BINDING PROTEINS; CARTILAGE; CELL LINE; CELL LINE, TUMOR; CHONDROCYTES; COLLAGEN TYPE II; DIPEPTIDES; FLUORESCENT ANTIBODY TECHNIQUE; HELA CELLS; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOGLOBULIN J RECOMBINATION SIGNAL SEQUENCE-BINDING PROTEIN; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; KNEE JOINT; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; OSTEOARTHRITIS; OSTEOGENESIS; RECEPTOR, NOTCH1; RECEPTOR, NOTCH2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SOX9 TRANSCRIPTION FACTOR;

EID: 84873156916     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1207458110     Document Type: Article

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