Development of a sweetness sensor for aspartame, a positively charged high-potency sweetener

Sensors (Switzerland)

Volumn 14, Issue 4, 2014, Pages 7359-7373

  Yasuura, Masato ^a   Tahara, Yusuke ^a   Ikezaki, Hidekazu ^b   Toko, Kiyoshi ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b Intelligent Sensor Technology   (Japan)

Author keywords

Aspartame; High potency sweetener; Lipid polymer membrane; Sweetness sensor; Taste sensor

Indexed keywords

ELECTRIC CHARGE; FOOD ADDITIVES; MEMBRANES; PEPTIDES; SOLVENTS; SUGAR SUBSTITUTES;

ASPARTAME; HIGH-POTENCY SWEETENERS; LIPID/POLYMER MEMBRANES; SWEETNESS SENSORS; TASTE SENSOR;

SENSORS;

EID: 84899155713     PISSN: 14248220     EISSN: None     Source Type: Journal    
DOI: 10.3390/s140407359     Document Type: Article

References (37)

1. Chandrashekar, J.; Hoon, M.A.; Ryba, N.J.P.; Zuker, C.S. The receptors and cells for mammalian taste. Nature 2006, 444, 288-294.
2. Kovacic, P.; Somanathan, R. Mechanism of taste; electrochemistry, receptors and signal transduction. J. Electrost. 2012, 70, 7-14.
3. Zhao, G.Q.; Zhang, Y.; Hoon, M.A.; Chandrashekar, J.; Erlenbach, I.; Ryba, N.J. P.; Zuker, C.S. The receptors for mammalian sweet and umami taste. Cell 2003, 115, 255-266.
4. Xu, H.; Staszewski, L.; Tang, H.; Adler, E.; Zoller, M.; Li, X. Different functional roles of T1R subunits in the heteromeric taste receptors. Proc. Natl. Acad. Sci. USA 2004, 101, 14258-14263.
5. Jiang, P.; Ji, Q.; Liu, Z.; Snyder, L.A.; Benard, L.M.J.; Margolskee, R.F.; Max, M. The cysteine-rich region of T1R3 determines responses to intensely sweet proteins. J. Biol. Chem. 2004, 279, 45068-45075.
6. Jiang, P.; Cui, M.; Ji, Q.; Liu, Z.; Benard, L.; Margolskee, R.F.; Osman, R.; Max, M. Molecular mechanisms of sweet receptor function. Chem. Senses 2005, 30, i17-i18.
7. Servant, G.; Tachdjian, C.; Tang, X.Q.; Werner, S.; Zhang, F.; Li, X.; Kamdar, P.; Petrovic, G.; Ditschun, T.; Java, A., et al. Positive allosteric modulators of the human sweet taste receptor enhance sweet taste. Proc. Natl. Acad. Sci. USA 2010, 107, 4746-4751.
8. Shallenberger, R.S.; Acree, T.E. Molecular theory of sweet taste. Nature 1967, 216, 480-482.
9. Acree, T.E.; Shallenberger, R.S.; Ebeling, S. Thirty years of the AH-B theory. Dev. Food Sci. 1998, 40, 1-13.
10. Eggers, S.C.; Acree, T.E.; Shallenberger, R.S. Sweetness chemoreception theory and sweetness transduction. Food Chem. 2000, 68, 45-49.
11. Hayes, J.E. Transdisciplinary perspectives on sweetness. Chemosens. Percept. 2008, 1, 48-57.
12. Cardello, H.M.A.B.; DaSilva, M.A.P.A.; DaMasio, M.H. Measurement of the relative sweetness of stevia extract, aspartame and cyclamate/saccharin blend as compared to sucrose at different concentrations. Plant Foods Hum. Nutr. 1999, 54, 119-130.
13. Farkas, A.; Hid, J. The black agonist-receptor model of high potency sweeteners, and its implication to sweetness taste and sweetener design. J. Food Sci. 2011, 76, S465-S468.
14. Guadagni, D.G.; Maier, V.P.; Turnbaugh, J.H. Some factors affecting sensory thresholds and relative bitterness of limonin and naringin. J. Sci. Food Agric. 1974, 25, 1199-1205.
15. Moraes, P.C.B.T.; Bolini, H.M.A. Different sweeteners in beverages prepared with instant and roasted ground coffee: ideal and equivalent sweetness. J. Sens. Stud. 2010, 25, 215-225.
16. Anand, V.; Kataria, M.; Kukkar, V.; Saharan, V.; Choudhury, P.K. The latest trends in the taste assessment of pharmaceuticals. Drug Discov. Today 2007, 12, 257-265.
17. Lvova, L.; Martinelli, E.; Dini, F.; Bergamini, A.; Paolesse, R.; Natale, C.D.; D'Amico, A. Clinical analysis of human urine by means of potentiometric electronic tongue. Talanta 2009, 77, 1097-1104.
18. Lorenz, J.K.; Reo, J.P.; Hendl, O.; Worthington, J.H.; Petrossian, V.D. Evaluation of a taste sensor instrument (electronic tongue) for use in formulation development. Int. J. Pharm. 2009, 367, 65-72.
19. Riul, A., Jr.; Dantas, C.A.R.; Miyazaki, C.M.; Oliveira, O.N., Jr. Recent advances in electronic tongues. Analyst 2010, 135, 2481-2495.
20. Woertz, K.; Tissen, C.; Kleinebudde, P.; Breitkreutz, J. Taste sensing system (electronic tongues) for pharmaceutical applications. Int. J. Pharm. 2011, 417, 256-271.
21. Winquist, F.; Olsson, J.; Eriksson, M. Multicomponent analysis of drinking water by a voltammetric electronic tongue. Anal. Chim. Acta 2011, 683, 192-197.
22. Kirsanov, D.; Mednova, O.; Vietoris, V.; Kilmartin, P.A.; Legin, A. Towards reliable estimation of an -electronic tongue{norm of matrix} predictive ability from PLS regression models in wine analysis. Talanta 2012, 90, 109-116.
23. Rudnitskaya, A.; Kirsanov, D.; Blinova, Y.; Legin, E.; Seleznev, B.; Clapham, D.; Ives, R.S.; Saunders, K.A.; Legin, A. Assessment of bitter taste of pharmaceuticals with multisensory system employing 3 way PLS regression. Anal. Chim. Acta 2013, 770, 45-52.
24. Habara, M.; Toko, K. Biomimetic membrane for taste sensing. In Bottom-up Nanofabrication; Ariga, K., Nalwa, H.S., Eds.; American Scientific Publishers: Valencia, CA, USA, 2009; Volume 6, pp. 91-109.
25. Kobayashi, Y.; Habara, M.; Ikezaki, H.; Chen, R.; Naito, Y.; Toko, K. Advanced taste sensors based on artificial lipids with global selectivity to basic taste qualities and high correlation to sensory scores. Sensors 2010, 10, 3411-3443.
26. Fukagawa, T.; Tahara, Y.; Yasuura, M.; Habara, M.; Ikezaki, H.; Toko, K. Relationship between taste sensor response and amount of quinine adsorbed on lipid/polymer membrane. J. Innov. Electron. Commun. 2012, 2, 1-6.
27. Tahara, Y.; Toko, K. Electronic tongues-A review. IEEE Sens. J. 2013, 13, 3001-3011.
28. Akitomi, H.; Tahara, Y.; Yasuura, M.; Kobayashi, Y.; Ikezaki, H.; Toko, K. Quantification of tastes of amino acids using taste sensors. Sens. Actuators B 2013, 179, 276-281.
29. Ito, M.; Wada, K.; Yoshida, M.; Hazekawa, M.; Abe, K.; Chen, R.; Habara, M.; Ikezaki, H.; Uchida, T. Quantitative evaluation of bitterness of H1-receptor antagonists and masking effect of acesulfame potassium, an artificial sweetener, using a taste sensor. Sens. Mater. 2013, 25, 17-30.
30. Ishiwaki, T. Application of taste sensor to blending of coffee. In Biochemical Sensors: Mimicking Gustatory and Olfactory Senses; Toko, K., Ed.; Pan Stanford Publishing: Singapore, Singapore, 2013; pp. 83-90.
31. Toyota, K.; Cui, H.; Abe, K.; Habara, M.; Toko, K.; Ikezaki, H. Study on sweetness sensor with lipid/polymer membranes: Sweet-responsive substances. Sens. Mater. 2011, 23, 465-474.
32. Toyota, K.; Cui, H.; Abe, K.; Habara, M.; Toko, K.; Ikezaki, H. Study on sweetness sensor with lipid/polymer membranes: Response to various sugars. Sens. Mater. 2011, 23, 475-482.
33. Kuhn, C.; Bufe, B.; Winnig, M.; Hofmann, T.; Frank, O.; Behrens, M.; Lewtschenko, T.; Slack, J.P.; Ward, C.D.; Meyerhof, W. Bitter taste receptors for saccharin and acesulfame, K. J. Neurosci. 2004, 24, 10260-10265.
34. Riera, C.E.; Vogel, H.; Simon, S.A.; le Coutre, J. Artificial sweeteners and salts producing a metallic taste sensation activate TRPV1 receptors. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2007, 293, R626-R634.
35. Schiffman, S.S. Rationale for further medical and health research on high-potency sweeteners. Chem. Senses 2012, 37, 671-679.
36. Ikezaki, H.; Taniguchi, A.; Toko, K. Quantification of taste of green tea with taste sensor. IEEJ Trans. Sens. Micromach. 1997, 117, 465-470.
37. Hara, D.; Fukagawa, T.; Tahara, Y.; Yasuura, M.; Toko, K. Examination of amount of astringent substances adsorbed onto lipid/polymer membrane used in taste sensor. Sens. Lett. 2014, (accepted).