Rationale for further medical and health research on high-potency sweeteners

Chemical Senses

Volumn 37, Issue 8, 2012, Pages 671-679

  Schiffman, Susan S ^a  

^a NONE   (United States)

Author keywords

Artificial sweeteners; High potency sweeteners; Pharmacokinetics

Indexed keywords

ACESULFAME; ALDEHYDE; CYTOCHROME P450 2D1; CYTOCHROME P450 3A4; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; GLUCOSE TRANSPORTER 2; GLYCOPROTEIN P; GLYCOPROTEIN P INHIBITOR; INSULIN; METHOTREXATE; NEOTAME; ORGANIC ANION TRANSPORTER; PROTEIN TAS1R1; PROTEIN TAS1R2; PROTEIN TAS1R3; RECEPTOR PROTEIN; SACCHARIN SODIUM; SODIUM GLUCOSE COTRANSPORTER 1; STEVIOL; SUCRALOSE; SWEETENING AGENT; UNCLASSIFIED DRUG;

APPETITE; BIOACCUMULATION; BODY WEIGHT; ELECTROENCEPHALOGRAM; FOOD DRUG INTERACTION; GASTROINTESTINAL ABSORPTION; HUMAN; INSULIN RELEASE; MEDICAL RESEARCH; NERVE CELL PLASTICITY; NONHUMAN; NOTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN SECRETION; RECEPTOR UPREGULATION; TASTE BUD; TOXICITY TESTING; URINARY EXCRETION;

ABSORPTION; ANIMALS; APPETITE; BIOMEDICAL RESEARCH; BODY WEIGHT; BRAIN; DRUG INTERACTIONS; FOOD SAFETY; GASTROINTESTINAL TRACT; HOT TEMPERATURE; HUMANS; KIDNEY; SWEETENING AGENTS;

EID: 84866369224     PISSN: 0379864X     EISSN: 14643553     Source Type: Journal    
DOI: 10.1093/chemse/bjs053     Document Type: Note

References (86)

1. Abou-Donia MB, El-Masry EM, Abdel-Rahman AA, McLendon RE, Schiffman SS. 2008. Splenda alters gut microflora and increases intestinal P-glycoprotein and cytochrome P-450 in male rats. J Toxicol Environ Health A. 71:1415-1429.
2. American Dietetic Association. 2004. Position of the American Dietetic Association: use of nutritive and nonnutritive sweeteners. J Am Diet Assoc. 104:255-275.
3. Attia EA, Shehata HA, Askar A. 1993. An alternative formula for the sweetening of reduced-calorie cakes. Food Chem. 48:169-172.
4. Bannach G, Almeida RR, Lacerda LG, Schnitzler E, Ionashiro M. 2009. Thermal stability and thermal decomposition of sucralose. Eclet Quím. 34:21-26.
5. Barndt RL, Jackson G. 1990. Stability of sucralose in baked goods. Food Technol. 44(1):62-66.
6. Brown RJ, Walter M, Rother KI. 2009. Ingestion of diet soda before a glucose load augments glucagon-like peptide-1 secretion. Diabetes Care. 32:2184-2186.
7. Burdge GC, Hanson MA, Slater-Jefferies JL, Lillycrop KA. 2007. Epigenetic regulation of transcription: a mechanism for inducing variations in phenotype (fetal programming) by differences in nutrition during early life? Br J Nutr. 97:1036-1046.
8. Calorie Control Council. 2010. Consumer use of low-calorie, sugar-free foods & beverages. Atlanta, GA: Calorie Control Council National Consumer Survey, 2010. Available from: http://www.caloriecontrol.org/ press-room/trends-and-statistics.
9. Centers for Disease Control (CDC). 2011. Crude and age-adjusted percentage of civilian, noninstitutionalized population with diagnosed diabetes, United States, 1980-2010. Atlanta (GA): Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Division of Diabetes Translation Available from: www.cdc.gov/diabetes/statistics/prev/national/figage. htm.
10. Corkey BE. 2012. Banting lecture 2011: hyperinsulinemia: cause or consequence? Diabetes. 61:4-13.
11. Cranmer MF. 1980. Saccharin. Scherr GH, editor. Park Forest South (IL): Pathotox Publishers, Inc.
12. Cummings JH, Macfarlane GT. 1991. The control and consequences of bacterial fermentation in the human colon. J Appl Bacteriol. 70:443-459.
13. Custodio JM, Wu CY, Benet LZ. 2008. Predicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption. Adv Drug Deliv Rev. 60:717-733.
14. de Carvalho LC, Segato MP, Nunes RS, Novak C, Cavalheiro ETG. 2009. Thermoanalytical studies of some sweeteners. J Therm Anal Calorim. 97:359-365.
15. European Union (EU). 2004. Directive 2003/115/EC of the European Parliament and of the Council of 22 December 2003 amending Directive 94/35/EC on sweeteners for use in foodstuffs. Off J Eur Union. 47(L24):65-71. Available from: http://eur-lex.europa.eu/JOHtml.do? uri=OJ:L:2004:024:SOM:en:HTML.
16. Fayle SE, Gerrard JA. 2002. The Maillard reaction. Cambridge (UK): The Royal Society of Chemistry.
17. Feil R, Fraga MF. 2012. Epigenetics and the environment: emerging patterns and implications. Nat Rev Genet. 13:97-109.
18. Goldsmith LA. 2000. Acute and subchronic toxicity of sucralose. Food Chem Toxicol. 38(Suppl 2):S53-S69.
19. Grotz VL, Henry RR, McGill JB, Prince MJ, Shamoon H, Trout JR, Pi-Sunyer FX. 2003. Lack of effect of sucralose on glucose homeostasis in subjects with type 2 diabetes. J Am Diet Assoc. 103:1607-1612.
20. Guarner F, Malagelada JR. 2003. Gut flora in health and disease. Lancet. 361(9356):512-519.
21. Hutchinson SA. 1996. The effect of pH, temperature and reactants on the thermal and non-thermal degradation of the high-intensity sweeteners: alitame and sucralose. [PhD dissertation]. New Brunswick (NJ): Rutgers University.
22. Hutchinson SA, Ho GS, Ho CT. 1999. Stability and degradation of the high-intensity sweeteners: aspartame, alitame, and sucralose. Food Rev Int. 15(2):249-261.
23. International Transporter Consortium, Giacomini KM, Huang SM, Tweedie DJ, Benet LZ, Brouwer KL, Chu X, Dahlin A, Evers R, Fischer V, et al. 2010. Membrane transporters in drug development. Nat Rev Drug Discov. 9:215-236.
24. Jang HJ, Kokrashvili Z, Theodorakis MJ, Carlson OD, Kim BJ, Zhou J, Kim HH, Xu X, Chan SL, Juhaszova M, et al. 2007. Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1. Proc Natl Acad Sci U S A. 104:15069-15074.
25. Krewski D, Acosta D Jr, Andersen M, Anderson H, Bailar JC 3rd, Boekelheide K, Brent R, Charnley G, Cheung VG, Green S Jr, et al. 2010. Toxicity testing in the 21st century: a vision and a strategy. J Toxicol Environ Health B Crit Rev. 13:51-138.
26. Labare MP, Alexander M. 1994. Microbial cometabolism of sucralose, a chlorinated disaccharide, in environmental samples. Appl Microbiol Biotechnol. 42:173-178.
27. Leatherhead Food Research. 2011. The global food additives market. 5th ed. Leatherhead (UK): Leatherhead Food Research.
28. Linke HA. 1977. Growth inhibition of glucose-grown cariogenic and other streptococci by saccharin in vitro. Z Naturforsch C. 32(9-10): 839-843.
29. Linke HA, Doyle GA. 1985. Effect of saccharin on growth and acid production of glucose-grown pathogenic and oral bacteria. Microbios. 42(169-170):163-173.
30. Mace OJ, Affleck J, Patel N, Kellett GL. 2007. Sweet taste receptors in rat small intestine stimulate glucose absorption through apical GLUT2. J Physiol. 582(Pt 1):379-392.
31. MacKenzie T, Brooks B, O'Connor G. 2006. Beverage intake, diabetes, and glucose control of adults in America. Ann Epidemiol. 16: 688-691.
32. Mann SW, Yuschak MM, Amyes SJ, Aughton P, Finn JP. 2000. A combined chronic toxicity/carcinogenicity study of sucralose in Sprague-Dawley rats. Food Chem Toxicol. 38(Suppl 2):S71-S89.
33. Margolskee RF, Dyer J, Kokrashvili Z, Salmon KSH, Ilegems E, Daly K, Maillet EL, Ninomiya Y, Mosinger B, Shirazi-Beechey SP. 2007. T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1. Proc Natl Acad Sci USA. 104: 15075-15080.
34. Mattes RD, Popkin BM. 2009. Nonnutritive sweetener consumption in humans: effects on appetite and food intake and their putative mechanisms. Am J Clin Nutr. 89:1-14.
35. Mauron J. 1981. The Maillard reaction in food; a critical review from the nutritional standpoint. Prog Food Nutr Sci. 5:5-35.
36. McKay JA, Mathers JC. 2011. Diet induced epigenetic changes and their implications for health. Acta Physiol (Oxf). 202:103-118.
37. Meinl W, Sczesny S, Brigelius-Flohé R, Blaut M, Glatt H. 2009. Impact of gut microbiota on intestinal and hepatic levels of phase 2 xenobiotic-metabolizing enzymes in the rat. Drug Metab Dispos. 37:1179-1186.
38. Merck Index. 2006. Merck index. Whitehouse Station (NJ): Merck & Co.
39. Nabors LO, editor. 2012. Alternative sweeteners. 4th ed. Boca Raton (FL): CRC Press.
40. Nakagawa Y, Nagasawa M, Yamada S, Hara A, Mogami H, Nikolaev VO, Lohse MJ, Shigemura N, Ninomiya Y, Kojima I. 2009. Sweet taste receptor expressed in pancreatic b-cells activates the calcium and cyclic AMP signaling systems and stimulates insulin secretion. PLoS One. 4(4):e5106.
41. Ness C. 2004. Splenda 101: carb counters have embraced it. Millions are buying it. But what does it taste like? And how does it behave in the kitchen? San Francisco Chronicle, 15 September 2004. Available from: http://www.sfgate.com/cgi-bin/article.cgi?f=/c/a/2004/09/15/FDGA58M7L21.DTL.
42. Nicholson JK, Holmes E, Wilson ID. 2005. Gut microorganisms, mammalian metabolism and personalized health care. Nat Rev Microbiol. 3:431-438.
43. Nunes APM, Ferreira-Machado SC, Nunes RM, Dantas FJS, De Mattos JCP, Caldeira-de-Araújo A. 2007. Analysis of genotoxic potentiality of stevioside by comet assay. Food Chem Toxicol. 45:662-666.
44. Nursten HE. 2005. The Maillard reaction. Chemistry, biochemistry and implications. Cambridge (UK): The Royal Society of Chemistry.
45. O'Brien PJ, Siraki AG, Shangari N. 2005. Aldehyde sources, metabolism, molecular toxicity mechanisms, and possible effects on human health. Crit Rev Toxicol. 35:609-662.
46. Oldacay M, Erdem G. 2000. The effect of sodium saccharin on the growth of Escherichia coli, Proteus, Pseudomonas aeruginosa, Staphylococcus epidermidis, Staphylococcus aureus and Enterococcus faecalis. Türk Mikrobiyol Cem Derg. 30:35-37.
47. Ouwehand AC, Vaughan EE. 2006. Gastrointestinal microbiology. New York: Taylor and Francis Group.
48. Pfeffer M, Ziesenitz SC, Siebert G. 1985. Acesulfame K, cyclamate and saccharin inhibit the anaerobic fermentation of glucose by intestinal bacteria. Z Ernahrungswiss. 24:231-235.
49. Pfuhler S, Fellows M, van Benthem J, Corvi R, Curren R, Dearfield K, Fowler P, Frötschl R, Elhajouji A, Le Hégarat L, et al. 2011. In vitro genotoxicity test approaches with better predictivity: summary of an IWGT workshop. Mutat Res. 723:101-107.
50. Prakash S, Rodes L, Coussa-Charley M, Tomaro-Duchesneau C. 2011. Gut microbiota: next frontier in understanding human health and development of biotherapeutics. Biologics. 5:71-86.
51. Purlis E. 2010. Browning development in bakery products-a review. J Food Eng. 99:239-249.
52. Rahn A, Yaylayan VA. 2010. Thermal degradation of sucralose and its potential in generating chloropropanols in the presence of glycerol. Food Chem. 118:56-61.
53. Redlinger PA, Setser CS. 1987. Sensory quality of selected sweeteners: unbaked and baked flour doughs. J Food Sci. 52:1391-1393.
54. Ren X, Zhou L, Terwilliger R, Newton SS, de Araujo IE. 2009. Sweet taste signaling functions as a hypothalamic glucose sensor. Front Integr Neurosci. 3(12):1-15.
55. Renwick AG. 1985. The disposition of saccharin in animals and man-a review. Food Chem Toxicol. 23:429-435.
56. Roberts A, Renwick AG, Sims J, Snodin DJ. 2000. Sucralose metabolism and pharmacokinetics in man. Food Chem Toxicol. 38(Suppl 2): S31-S41.
57. Rudenga KJ, Small DM. 2011. Amygdala response to sucrose consumption is inversely related to artificial sweetener use. Appetite. 58:504-507.
58. Sasaki YF, Kawaguchi S, Kamaya A, Ohshita M, Kabasawa K, Iwama K, Taniguchi K, Tsuda S. 2002. The comet assay with 8 mouse organs: results with 39 currently used food additives. Mutat Res. 519: 103-119.
59. Schiffman SS, Booth BJ, Carr BT, Losee ML, Sattely-Miller EA, Graham BG. 1995. Investigation of synergism in binary mixtures of sweeteners. Brain Res Bull. 38:105-120.
60. Schiffman SS, Sattely-Miller EA, Graham BG, Booth BJ, Gibes KM. 2000. Synergism among ternary mixtures of fourteen sweeteners. Chem Senses. 25:131-140.
61. Schiffman SS, Sattely-Miller EA, Graham BG, Zervakis J, Butchko HH, Stargel WW. 2003. Effect of repeated presentation on sweetness intensity of binary and ternary mixtures of sweeteners. Chem Senses. 28:219-229.
62. Schuetz EG, Beck WT, Schuetz JD. 1996. Modulators and substrates of Pglycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells. Mol Pharmacol. 49:311-318.
63. Servant G, Tachdjian C, Li X, Karanewsky DS. 2011. The sweet taste of true synergy: positive allosteric modulation of the human sweet taste receptor. Trends Pharmacol Sci. 32:631-636.
64. Servant G, Tachdjian C, Tang XQ, Werner S, Zhang F, Li X, Kamdar P, Petrovic G, Ditschun T, Java A, et al. 2010. Positive allosteric modulators of the human sweet taste receptor enhance sweet taste. Proc Natl Acad Sci USA. 107:4746-4751.
65. Shugarts S, Benet LZ. 2009. The role of transporters in the pharmacokinetics of orally administered drugs. Pharm Res. 26:2039-2054.
66. Sigma-Aldrich. 2012. Steviol hydrate. Available from: http://www.sigmaaldrich. com/catalog/product/sigma/h8664?lang=en®ion=US.
67. Sims J, Roberts A, Daniel JW, Renwick AG. 2000. The metabolic fate of sucralose in rats. Food Chem Toxicol. 38(Suppl 2):S115-S121.
68. Smith DA, editor. 2010. Metabolism, pharmacokinetics and toxicity of functional groups: impact of chemical building blocks on ADMET (RSC Drug Discovery). Cambridge (UK): The Royal Society of Chemistry.
69. Smith DA, Allerton C, Kalgutkar A, van de Waterbeemd H, Walker DK. 2012. Pharmacokinetics and metabolism in drug design. Weinheim (Germany): Wiley-VCH Verlag & Co.
70. Speit G, Vasquez M, Hartmann A. 2009. The comet assay as an indicator test for germ cell genotoxicity. Mutat Res. 681:3-12.
71. Srimaroeng C, Jutabha P, Pritchard JB, Endou H, Chatsudthipong V. 2005. Interactions of stevioside and steviol with renal organic anion transporters in S2 cells and mouse renal cortical slices. Pharm Res. 22:858-866.
72. Stouder C, Paoloni-Giacobino A. 2010. Transgenerational effects of the endocrine disruptor vinclozolin on the methylation pattern of imprinted genes in the mouse sperm. Reproduction 139:373-379.
73. Swithers SE, Martin AA, Davidson TL. 2010. High-intensity sweeteners and energy balance. Physiol Behav. 100:55-62.
74. Szakács G, Váradi A, Ozvegy-Laczka C, Sarkadi B. 2008. The role of ABC transporters in drug absorption, distribution, metabolism, excretion and toxicity (ADME-Tox). Drug Discov Today. 13:379-393.
75. United States Food and Drug Administration (US FDA). 1998. Food additives permitted for direct addition to food for human consumption; sucralose. 21CFR Part 172 [Docket No. 87F-0086]. Fed Regist. 63(64): 16417-16433. Available from: http://www.fda.gov/ohrms/dockets/98fr/ 040398a.pdf.
76. United States Food and Drug Administration (US FDA). 2008. Guidance for industry. Safety testing of drug metabolites. Rockville (MD): U.S. Department of Health and Human Services, Food and Drug Administration's Center for Drug Evaluation and Research (CDER).
77. United States Food and Drug Administration (US FDA). 2011. Drug development and drug interactions: table of substrates, inhibitors and inducers. Table 11. Major human transporters (9/16/2011). Available from: http://www.fda.gov/Drugs/DevelopmentApprovalProcess/ DevelopmentResources/DrugInteractionsLabeling/ucm093664.htm. Accessed March 23, 2012.
78. Uwai Y, Saito H, Inui K. 2000. Interaction between methotrexate and nonsteroidal anti-inflammatory drugs in organic anion transporter. Eur J Pharmacol. 409:31-36.
79. Volz M, Christ O, Eckert HG, Herok J, Kellner H-M, Rupp W. 1991. Kinetics and biotransformation of acesulfame-K. In: Mayer DG, Kemper FH, editors. Acesulfame-K. New York: Marcel Dekker. p. 7-26.
80. Vucetic Z, Kimmel J, Totoki K, Hollenbeck E, Reyes TM. 2010. Maternal highfat diet alters methylation and gene expression of dopamine and opioidrelated genes. Endocrinology. 151:4756-4764.
81. Wolf PA, Bridges JR, Wicklund R. 2010. Application of agonist-receptor modeling to the sweetness synergy between high fructose corn syrup and sucralose, and between high-potency sweeteners. J Food Sci. 75:S95-S102.
82. World Health Organization (WHO). 2003. Adherence to long-term therapies: evidence for action. Geneva (Switzerland): World Health Organisation. ISBN: 92-4-154599-2. Available from: http://www.who.int/chp/knowledge/publications/adherence_full_report.pdf.
83. World Health Organization (WHO). 2004. Neotame. In: Safety evaluation of certain food additives and contaminants. WHO food additives series: 52. Prepared by the sixty-first meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA). Geneva (Switzerland): World Health Organization. Available from: http://www.inchem.org/ documents/jecfa/jecmono/v52je08.htm#abs/.
84. Yang Q. 2010. Gain weight by "going diet?"Artificial sweeteners and the neurobiology of sugar cravings: neuroscience 2010. Yale J Biol Med. 83:101-108.
85. Zama AM, Uzumcu M. 2010. Epigenetic effects of endocrine-disrupting chemicals on female reproduction: an ovarian perspective. Front Neuroendocrinol. 31:420-439.
86. Zhang F, Klebansky B, Fine RM, Liu H, Xu H, Servant G, Zoller M, Tachdjian C, Li X. 2010. Molecular mechanism of the sweet taste enhancers. Proc Natl Acad Sci USA. 107:4752-4757.