The chemokine receptor CCR4 promotes tumor growth and lung metastasis in breast cancer

Breast Cancer Research and Treatment

Volumn 131, Issue 3, 2012, Pages 837-848

  Li, Ji Yu ^a   Ou, Zhou Luo ^a   Yu, San Jian ^a   Gu, Xiao Li ^a   Yang, Chen ^a   Chen, Ao Xiang ^a   Di, Gen Hong ^a   Shen, Zhen Zhou ^a   Shao, Zhi Ming ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Breast cancer; CCR4; Chemokine; Metastasis

Indexed keywords

CHEMOKINE RECEPTOR CCR4; MESSENGER RNA;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE METASTASIS; BREAST CANCER; CANCER CELL; CANCER RECURRENCE; CANCER SURVIVAL; CCR4 GENE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; GENE FUNCTION; GENE OVEREXPRESSION; GENE PRODUCT; GROWTH INHIBITION; HUMAN; HUMAN CELL; LUNG METASTASIS; LYMPH NODE METASTASIS; MOUSE; NONHUMAN; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS; RNA INTERFERENCE; SURVIVAL RATE; TUMOR GROWTH;

ANIMALS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CHEMOKINE CCL17; CHEMOKINE CCL22; DISEASE PROGRESSION; FEMALE; GENE EXPRESSION; GENETIC VECTORS; HUMANS; LENTIVIRUS; LUNG NEOPLASMS; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM METASTASIS; PROGNOSIS; RECEPTORS, CCR4; RNA INTERFERENCE; SURVIVAL ANALYSIS; TRANSDUCTION, GENETIC; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84856229131     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-011-1502-6     Document Type: Article

References (30)

1. A Jemal R Siegel J Xu E Ward 2010 Cancer statistics, 2010 CA Cancer J Clin 60 5 277 300 20610543 10.3322/caac.20073
2. F Balkwill 2003 Chemokine biology in cancer Semin Immunol 15 1 49 55 12495640 10.1016/S1044-5323(02)00127-6 1:CAS:528:DC%2BD38XpsFyhtrk%3D
3. S Ali G Lazennec 2007 Chemokines: novel targets for breast cancer metastasis Cancer Metastasis Rev 26 3-4 401 420 17717637 10.1007/s10555-007- 9073-z 1:CAS:528:DC%2BD2sXht1yktLbJ
4. M Baggiolini 1998 Chemokines and leukocyte traffic Nature 392 6676 565 568 9560152 10.1038/33340 1:CAS:528:DyaK1cXis1Smurk%3D
5. A Muller B Homey H Soto N Ge D Catron ME Buchanan T McClanahan E Murphy W Yuan SN Wagner JL Barrera A Mohar E Verastegui A Zlotnik 2001 Involvement of chemokine receptors in breast cancer metastasis Nature 410 6824 50 56 11242036 10.1038/35065016 1:CAS:528:DC%2BD3MXhvVSgu74%3D
6. S Manes E Mira R Colomer S Montero LM Real C Gomez-Mouton S Jimenez-Baranda A Garzon RA Lacalle K Harshman A Ruiz AC Martinez 2003 CCR5 expression influences the progression of human breast cancer in a p53-dependent manner J Exp Med 198 9 1381 1389 14597737 10.1084/jem.20030580 1:CAS:528:DC%2BD3sXovVKiurk%3D
7. Z Miao KE Luker BC Summers R Berahovich MS Bhojani A Rehemtulla CG Kleer JJ Essner A Nasevicius GD Luker MC Howard TJ Schall 2007 CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature Proc Natl Acad Sci USA 104 40 15735 15740 17898181 10.1073/pnas.0610444104 1:CAS:528:DC%2BD2sXhtFGns7%2FJ
8. LY Feng ZL Ou FY Wu ZZ Shen ZM Shao 2009 Involvement of a novel chemokine decoy receptor CCX-CKR in breast cancer growth, metastasis and patient survival Clin Cancer Res 15 9 2962 2970 19383822 10.1158/1078-0432.CCR-08-2495 1:CAS:528:DC%2BD1MXltFOrt7Y%3D
9. J Wang ZL Ou YF Hou JM Luo ZZ Shen J Ding ZM Shao 2006 Enhanced expression of Duffy antigen receptor for chemokines by breast cancer cells attenuates growth and metastasis potential Oncogene 25 54 7201 7211 16785997 10.1038/sj.onc.1209703 1:CAS:528:DC%2BD28Xht1SrtbrF
10. FY Wu ZL Ou LY Feng JM Luo LP Wang ZZ Shen ZM Shao 2008 Chemokine decoy receptor d6 plays a negative role in human breast cancer Mol Cancer Res 6 8 1276 1288 18708360 10.1158/1541-7786.MCR-07-2108 1:CAS:528:DC%2BD1cXpvVarurc%3D
11. XH Zeng ZL Ou KD Yu LY Feng WJ Yin J Li ZZ Shen ZM Shao 2011 Coexpression of atypical chemokine binders (ACBs) in breast cancer predicts better outcomes Breast Cancer Res Treat 125 3 715 727 20369284 10.1007/s10549-010-0875-2 1:CAS:528:DC%2BC3MXhtVelsL8%3D
12. T Imai M Nagira S Takagi M Kakizaki M Nishimura J Wang PW Gray K Matsushima O Yoshie 1999 Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine Int Immunol 11 1 81 88 10050676 10.1093/intimm/11.1.81 1:CAS:528:DyaK1MXhtVWgurY%3D
13. P Ghia G Strola L Granziero M Geuna G Guida F Sallusto N Ruffing L Montagna P Piccoli M Chilosi F Caligaris-Cappio 2002 Chronic lymphocytic leukemia B cells are endowed with the capacity to attract CD4+, CD40L+T cells by producing CCL22 Eur J Immunol 32 5 1403 1413 11981828 10.1002/1521-4141(200205) 32:5<1403::AID-IMMU1403>3.0.CO;2-Y 1:CAS:528:DC%2BD38XjvFKjsLs%3D
14. T Ishida R Ueda 2006 CCR4 as a novel molecular target for immunotherapy of cancer Cancer Sci 97 11 1139 1146 16952304 10.1111/j.1349-7006.2006.00307.x 1:CAS:528:DC%2BD28XhtFemtbjJ
15. O Yoshie R Fujisawa T Nakayama H Harasawa H Tago D Izawa K Hieshima Y Tatsumi K Matsushima H Hasegawa A Kanamaru S Kamihira Y Yamada 2002 Frequent expression of CCR4 in adult T-cell leukemia and human T-cell leukemia virus type 1-transformed T cells Blood 99 5 1505 1511 11861261 10.1182/blood.V99.5.1505 1:CAS:528:DC%2BD38XhvFyqt7s%3D
16. K Yamamoto A Utsunomiya K Tobinai K Tsukasaki N Uike K Uozumi K Yamaguchi Y Yamada S Hanada K Tamura S Nakamura H Inagaki K Ohshima H Kiyoi T Ishida K Matsushima S Akinaga M Ogura M Tomonaga R Ueda 2010 Phase I study of KW-0761, a defucosylated humanized anti-CCR4 antibody, in relapsed patients with adult T-cell leukemia-lymphoma and peripheral T-cell lymphoma J Clin Oncol 28 9 1591 1598 20177026 10.1200/JCO.2009.25.3575 1:CAS:528:DC%2BC3cXltFGht7w%3D
17. JH Lee YS Cho JY Lee MC Kook JW Park BH Nam JM Bae 2009 The chemokine receptor CCR4 is expressed and associated with a poor prognosis in patients with gastric cancer Ann Surg 249 6 933 941 19474687 10.1097/SLA.0b013e3181a77ccc
18. PB Olkhanud D Baatar M Bodogai F Hakim R Gress RL Anderson J Deng M Xu S Briest A Biragyn 2009 Breast cancer lung metastasis requires expression of chemokine receptor CCR4 and regulatory T cells Cancer Res 69 14 5996 6004 19567680 10.1158/0008-5472.CAN-08-4619 1:CAS:528:DC%2BD1MXosV2mt78%3D
19. DQ Li L Wang F Fei YF Hou JM Luo R Zeng J Wu JS Lu GH Di ZL Ou QC Xia ZZ Shen ZM Shao 2006 Identification of breast cancer metastasis-associated proteins in an isogenic tumor metastasis model using two-dimensional gel electrophoresis and liquid chromatography-ion trap-mass spectrometry Proteomics 6 11 3352 3368 16637015 10.1002/pmic.200500617 1:CAS:528:DC%2BD28Xmt1artL0%3D
20. JE Burdette JS Jeruss SJ Kurley EJ Lee TK Woodruff 2005 Activin A mediates growth inhibition and cell cycle arrest through Smads in human breast cancer cells Cancer Res 65 17 7968 7975 16140969 1:CAS:528:DC%2BD2MXpslahs7w%3D
21. GD Luker CM Pica AS Kumar DF Covey D Piwnica-Worms 2000 Effects of cholesterol and enantiomeric cholesterol on P-glycoprotein localization and function in low-density membrane domains Biochemistry 39 26 7651 7661 10869171 10.1021/bi9928593 1:CAS:528:DC%2BD3cXjslGmu7g%3D
22. R Benelli G Lorusso A Albini DM Noonan 2006 Cytokines and chemokines as regulators of angiogenesis in health and disease Curr Pharm Des 12 24 3101 3115 16918437 10.2174/138161206777947461 1:CAS:528:DC%2BD28Xotlalt7o%3D
23. P Romagnani L Lasagni F Annunziato M Serio S Romagnani 2004 CXC chemokines: the regulatory link between inflammation and angiogenesis Trends Immunol 25 4 201 209 15039047 10.1016/j.it.2004.02.006 1:CAS:528: DC%2BD2cXisVarsrk%3D
24. K Kawakami M Kawakami PJ Snoy SR Husain RK Puri 2001 In vivo overexpression of IL-13 receptor alpha2 chain inhibits tumorigenicity of human breast and pancreatic tumors in immunodeficient mice J Exp Med 194 12 1743 1754 11748276 10.1084/jem.194.12.1743 1:CAS:528:DC%2BD38Xpt1Wr
25. J Folkman 2002 Role of angiogenesis in tumor growth and metastasis Semin Oncol 29 6 Suppl 16 15 18 12516034 1:CAS:528:DC%2BD3sXlvFSqtg%3D%3D
26. A Zlotnik O Yoshie 2000 Chemokines: a new classification system and their role in immunity Immunity 12 2 121 127 10714678 10.1016/S1074-7613(00)80165-X 1:CAS:528:DC%2BD3cXhslKqsL8%3D
27. IC Lo JM Shih MJ Jiang 2005 Reactive oxygen species and ERK 1/2 mediate monocyte chemotactic protein-1-stimulated smooth muscle cell migration J Biomed Sci 12 2 377 388 15917991 10.1007/s11373-005-1703-2 1:CAS:528: DC%2BD2MXhtlajur%2FE
28. I Barao AM Hanash W Hallett LA Welniak K Sun D Redelman BR Blazar RB Levy WJ Murphy 2006 Suppression of natural killer cell-mediated bone marrow cell rejection by CD4+ CD25+ regulatory T cells Proc Natl Acad Sci USA 103 14 5460 5465 16567639 10.1073/pnas.0509249103 1:CAS:528:DC%2BD28Xjslejsro%3D
29. YM Li Y Pan Y Wei X Cheng BP Zhou M Tan X Zhou W Xia GN Hortobagyi D Yu MC Hung 2004 Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis Cancer Cell 6 5 459 469 15542430 10.1016/j.ccr.2004.09.027 1:CAS:528:DC%2BD2cXhtVGlurvF
30. MJ Piccart-Gebhart M Procter B Leyland-Jones A Goldhirsch M Untch I Smith L Gianni J Baselga R Bell C Jackisch D Cameron M Dowsett CH Barrios G Steger CS Huang M Andersson M Inbar M Lichinitser I Lang U Nitz H Iwata C Thomssen C Lohrisch TM Suter J Ruschoff T Suto V Greatorex C Ward C Straehle E McFadden MS Dolci RD Gelber 2005 Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer N Engl J Med 353 16 1659 1672 16236737 10.1056/NEJMoa052306 1:CAS:528:DC%2BD2MXhtFansr3L