3,3′-Diindolylmethane inhibits migration and invasion of human cancer cells through combined suppression of ERK and AKT pathways

Oncology Reports

Volumn 25, Issue 2, 2011, Pages 194-197

  Rajoria, Shilpi ^a   Suriano, Robert ^a   Wilson, Yushan Lisa ^b   Schantz, Stimson P ^b   Moscatello, Augustine ^b   Geliebter, Jan ^a   Tiwari, Raj K ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b NEW YORK EYE AND EAR INFIRMARY   (United States)

Author keywords

3,3 diindolylmethane; Invasion; Migration

Indexed keywords

3,3' DIINDOLYLYLMETHANE; CYCLIN D1; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; METHANE; MITOGEN ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CANCER INVASION; CELL ADHESION; CELL CYCLE G1 PHASE; CELL MIGRATION; CELL PROLIFERATION; DIET SUPPLEMENTATION; DRUG INHIBITION; IN VITRO STUDY; METASTASIS; PHENOTYPE; PRIORITY JOURNAL; VEGETABLE; WESTERN BLOTTING;

EID: 78651371344     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2010.1076     Document Type: Article

References (32)

1. American Cancer Society. Colorectal Cancer Facts & Figures 2008-2010. American Cancer Society, Atlanta, 2008.
2. Johnson IT: New approaches to role of diet in prevention of cancers of the alimentary tract. Mutat Res 551: 9-28, 2004.
3. Sarkar FH and Li Y: Harnessing the fruits of nature for the development of multi-targeted cancer therapeutics. Cancer Treat Rev 35: 597-607, 2009.
4. Bode AM and Dong Z: Cancer prevention research - then and now. Nat Rev Cancer 9: 508-516, 2009.
5. Ashok BT, Chen YG, Liu X, Garikapaty VP, Seplowitz R, Tschorn J, Roy K, Mittelman A and Tiwari RK: Multiple molecular targets of indole-3-carbinol, a chemopreventive anti-estrogen in breast cancer. Eur J Cancer Prev 2: S86-S93, 2002. (Pubitemid 35265867)
6. Garikapaty VP, Ashok BT, Chen YG, Mittelman A, Iatropoulos M and Tiwari RK: Anti-carcinogenic and anti-metastatic properties of indole-3-carbinol in prostate cancer. Oncol Rep 13: 89-93, 2005.
7. Tiwari RK, Guo L, Bradlow HL, Telang NT and Osborne MP: Selective responsiveness of human breast cancer cells to Indole-3-carbinol, a chemopreventive agent. J Natl Cancer Inst 86: 126-131, 1994. (Pubitemid 24983592)
8. Leibelt DA, Hedstrom OR, Fischer KA, Pereira CB and Williams DE: Evaluation of chronic dietary exposure to indole-3-carbinol and absorption-enhanced 3,3′-diindolylmethane in sprague-dawley rats. Toxicol Sci 74: 10-21, 2003.
9. Li Y, Wang Z, Kong D, Murthy S, Dou QP, Sheng S, Reddy GP and Sarkar FH: Regulation of FOXO3a/β-catenin/GSK-3β signaling by 3,3′-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in prostate cancer cells. J Biol Chem 282: 21542-21550, 2007. (Pubitemid 47099972)
10. Rahman KM, Ali S, Aboukameel A, Sarkar SH, Wang Z, Philip PA, Sakr WA and Raz A: Inactivation of NF-κB by 3,3′-diindolylmethane contributes to increased apoptosis induced by chemotherapeutic agent in breast cancer cells. Mol Cancer Ther 6: 2757-2765, 2007.
11. Xue L, Firestone GL and Bjeldanes LF: DIM stimulates IFNgamma gene expression in human breast cancer cells via the specific activation of JNK and p38 pathways. Oncogene 24: 2343-2353, 2005.
12. Kong D, Li Y, Wang Z, Banerjee S and Sarkar FH: Inhibition of angiogenesis and invasion by 3,3′-diindolylmethane is mediated by the nuclear factor-κB downstream target genes MMP-9 and uPA that regulated bioavailability of vascular endothelial growth factor in prostate cancer. Cancer Res 67: 3310-3319, 2007.
13. Ahmad A, Kong D, Sarkar SH, Wang Z, Banerjee S and Sarkar FH: Inactivation of uPA and its receptor uPAR by 3,3′-diindolylmethane (DIM) leads to the inhibition of prostate cancer cell growth and migration. J Cell Biochem 107: 516-527, 2009.
14. Ahmad A, Kong D, Wang Z, Sarkar SH, Banerjee S and Sarkar FH: Down-regulation of uPA and uPAR by 3,3′-diindolylmethane contributes to the inhibition of cell growth and migration of breast cancer cells. J Cell Biochem 108: 916-925, 2009.
15. Hsu EL, Chen N, Westbrook A, Wang F, Zhang R, Taylor RT and Hankinson O: CXCR4 and CXCL12 down-regulation: a novel mechanism for the chemoprotection of 3,3′-diindolylmethane for breast and ovarian cancers. Cancer Lett 265: 113-123, 2008.
16. Hsu EL, Chen N, Westbrook A, Wang F, Zhang R, Taylor RT and Hankinson O: Modulation of CXCR4, CXCL12, and tumor cell invasion potential in vitro by phytochemicals. J Oncol 2009: 491985, 2009.
17. Schweppe RE, Klopper JP, Korch C, Pugazhenthi U, Benezra M, Knauf JA, Fagin JA, Marlow L, Copland JA, Smallridge RC and Haugen BR: Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification. J Clin Endocrinol Metab 93: 4331-4341, 2008.
18. Rajoria S, Suriano R, Shanmugam A, Wilson YL, Schantz SP, Geliebter J and Tiwari RK: Metastatic phenotype is regulated by estrogen in thyroid cells. Thyroid 20: 33-41, 2010.
19. Hanahan D and Weinberg RA: The hallmarks of cancer. Cell 100: 57-70, 2000.
20. Gupta GP and Massagué J: Cancer metastasis: building a framework. Cell 127: 679-695, 2006.
21. Liang CC, Park AY and Guan JL: In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro. Nat Protoc 2: 329-333, 2007.
22. Cheng GZ, Zhang W and Wang LH: Regulation of cancer cell survival, migration, and invasion by Twist: AKT2 comes to interplay. Cancer Res 68: 957-960, 2008. (Pubitemid 351272210)
23. Hennessy BT, Smith DL, Ram PT, Lu Y and Mills GB: Exploiting the PI3K/AKT pathway for cancer drug discovery. Nat Rev Drug Discov 4: 988-100, 2005.
24. Yuan TL and Cantley LC: PI3K pathway alterations in cancer: variations on a theme. Oncogene 27: 5497-5510, 2008.
25. Palmqvist R, Stenling R, Oberg A and Landberg G: Expression of cyclin D1 and retinoblastoma protein in colorectal cancer. Eur J Cancer 34: 1575-1581, 1998. (Pubitemid 28446340)
26. Arber N, Hibshoosh H, Moss SF, Sutter T, Zhang Y, Begg M, Wang S, Weinstein IB and Holt PR: Increased expression of cyclin D1 is an early event in multistage colorectal carcinogenesis. Gastroenterology 110: 669-674, 1996. (Pubitemid 26071834)
27. La Vecchia C: Mediterranean diet and cancer. Public Health Nutr 7: 965-968, 2004.
28. Heber D: Vegetables, fruits and phytoestrogens in the prevention of diseases. J Postgrad Med 50: 145-149, 2004.
29. Cooke D, Steward WP, Gescher AJ and Marczylo T: Anthocyans from fruits and vegetables: does bright colour signal cancer chemopreventive activity? Eur J Cancer 41: 1931-1940, 2005.
30. Surh YJ: Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 3: 768-780, 2003.
31. Dihlmann S, Kloor M, Fallsehr C and von Knebel Doeberitz M: Regulation of AKT1 expression by beta-catenin/Tcf/Lef signaling in colorectal cancer cells. Carcinogenesis 26: 1503-1512, 2005. (Pubitemid 41236043)
32. Sawai H, Yasuda A, Ochi N, Ma J, Matsuo Y, Wakasugi T, Takahashi H, Funahashi H, Sato M and Takeyama H: Loss of PTEN expression is associated with colorectal cancer liver metastasis and poor patient survival. BMC Gastroenterol 8: 56, 2008.