Aberrant expression of chemokine receptor CCR4 in human gastric cancer contributes to tumor-induced immunosuppression

Cancer Science

Volumn 102, Issue 7, 2011, Pages 1264-1271

  Yang, Yong Mei ^a   Feng, A Lei ^a   Zhou, Cheng Jun ^b   Liang, Xiao Hong ^c   Mao, Hai Ting ^a   Deng, Bi Ping ^a   Yan, Shi ^a   Sun, Jin Tang ^a   Du, Lu Tao ^a   Liu, Jia ^a   Wang, Qing Jie ^a   Neckenig, Markus R ^d   Yang, Qi Feng ^a   Qu, Xun ^a  

^a SHANDONG UNIVERSITY   (China)

^b SHANDONG UNIVERSITY   (China)

^c SHANDONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^d UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR4; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; CANCER CELL CULTURE; COCULTURE; CYTOKINE PRODUCTION; DOWN REGULATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE DEFICIENCY; MALE; NATURAL KILLER CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOMACH CARCINOMA; TUMOR IMMUNITY; UPREGULATION;

ADULT; AGED; FEMALE; GRANZYMES; HUMANS; IMMUNE TOLERANCE; INTERLEUKIN-10; MALE; MIDDLE AGED; NF-KAPPA B; RECEPTORS, CCR4; STOMACH NEOPLASMS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79959193759     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2011.01934.x     Document Type: Article

References (40)

1. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010; 127(12): 2893-917.
2. D'Elios MM, Del Prete G, Amedei A. New frontiers in cell-based immunotherapy of cancer. Expert Opin Ther Pat 2009; 19: 623-41.
3. Maehara Y, Tomisaki S, Oda S et al. Lymph node metastasis and relation to tumor growth potential and local immune response in advanced gastric cancer. Int J Cancer 1997; 74: 224-8.
4. Fukuda K, Tsujitani S, Maeta Y, Yamaguchi K, Ikeguchi M, Kaibara N. The expression of RCAS1 and tumor infiltrating lymphocytes in patients with T3 gastric carcinoma. Gastric Cancer 2002; 5: 220-7.
5. Chochi K, Ichikura T, Kinoshita M et al. Helicobacter pylori augments growth of gastric cancers via the lipopolysaccharide-toll-like receptor 4 pathway whereas its lipopolysaccharide attenuates antitumor activities of human mononuclear cells. Clin Cancer Res 2008; 14: 2909-17.
6. Coussens LM, Werb Z. Inflammation and cancer. Nature 2002; 420: 860-7.
7. Murphy PM, Baggiolini M, Charo IF et al. International union of pharmacology. XXII. Nomenclature for chemokine receptors. Pharmacol Rev 2000; 52: 145-76.
8. Iwasa S, Yanagawa T, Fan J, Katoh R. Expression of CXCR4 and its ligand SDF-1 in intestinal-type gastric cancer is associated with lymph node and liver metastasis. Anticancer Res 2009; 29: 4751-8.
9. Arigami T, Natsugoe S, Uenosono Y et al. CCR7 and CXCR4 expression predicts lymph node status including micrometastasis in gastric cancer. Int J Oncol 2009; 35: 19-24.
10. Mashino K, Sadanaga N, Yamaguchi H et al. Expression of chemokine receptor CCR7 is associated with lymph node metastasis of gastric carcinoma. Cancer Res 2002; 62: 2937-41.
11. Lee JH, Cho YS, Lee JY et al. The chemokine receptor CCR4 is expressed and associated with a poor prognosis in patients with gastric cancer. Ann Surg 2009; 249: 933-41.
12. Bonecchi R, Bianchi G, Bordignon PP et al. Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. J Exp Med 1998; 187: 129-34.
13. Imai T, Nagira M, Takagi S et al. Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine. Int Immunol 1999; 11: 81-8.
14. Iellem A, Mariani M, Lang R et al. Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells. J Exp Med 2001; 194: 847-53.
15. Enarsson K, Lundgren A, Kindlund B et al. Function and recruitment of mucosal regulatory T cells in human chronic Helicobacter pylori infection and gastric adenocarcinoma. Clin Immunol 2006; 121: 358-68.
16. Ness TL, Ewing JL, Hogaboam CM, Kunkel SL. CCR4 is a key modulator of innate immune responses. J Immunol 2006; 177: 7531-9.
17. Ishida T, Inagaki H, Utsunomiya A et al. CXC chemokine receptor 3 and CC chemokine receptor 4 expression in T-cell and NK-cell lymphomas with special reference to clinicopathological significance for peripheral T-cell lymphoma, unspecified. Clin Cancer Res 2004; 10: 5494-500.
18. Yano H, Ishida T, Inagaki A et al. Regulatory T-cell function of adult T-cell leukemia/lymphoma cells. Int J Cancer 2007; 120: 2052-7.
19. Olkhanud PB, Baatar D, Bodogai M et al. Breast cancer lung metastasis requires expression of chemokine receptor CCR4 and regulatory T cells. Cancer Res 2009; 69: 5996-6004.
20. Nakamura ES, Koizumi K, Kobayashi M et al. RANKL-induced CCL22/macrophage-derived chemokine produced from osteoclasts potentially promotes the bone metastasis of lung cancer expressing its receptor CCR4. Clin Exp Metastasis 2006; 23: 9-18.
21. Ishida T, Ishii T, Inagaki A et al. Specific recruitment of CC chemokine receptor 4-positive regulatory T cells in Hodgkin lymphoma fosters immune privilege. Cancer Res 2006; 66: 5716-22.
22. Remmele W, Schicketanz K-H. Immunohistochemical determination of estrogen and progesterone receptor content in human breast cancer. Computer-assisted image analysis (QIC score) vs. subjective grading (IRS). Pathol Res Pract 1993; 8: 227-45.
23. Chan VW, Kothakota S, Rohan MC et al. Secondary lymphoid-tissue chemokine (SLC) is chemotactic for mature dendritic cells. Blood 1999; 93: 3610-16.
24. Wang Y, Zhang Y, Han W et al. Two C-terminal peptides of human CKLF1 interact with the chemokine receptor CCR4. Int J Biochem Cell Biol 2008; 40: 909-19.
25. Takamiya M, Fujita S, Saigusa K et al. Simultaneous detection of cytokines in human dermal wounds with a multiplex bead-based immunoassay for wound age estimation. Int J Legal Med 2008; 122: 143-8.
26. Cózar JM, Canton J, Tallada M et al. Analysis of NK cells and chemokine receptors in tumor infiltrating CD4 T lymphocytes in human renal carcinomas. Cancer Immunol Immunother 2005; 54: 858-66.
27. Ohtani H, Jin Z, Takegawa S et al. Abundant expression of CXCL9 (MIG) by stromal cells that include dendritic cells and accumulation of CXCR3+ T cells in lymphocyte-rich gastric carcinoma. J Pathol 2009; 217: 21-31.
28. Li Q, Yu YY, Zhu ZG et al. Effect of NF-kappaB constitutive activation on proliferation and apoptosis of gastric cancer cell lines. Eur Surg Res 2005; 37: 105-10.
29. Zhao C, Lu X, Bu X, Zhang N, Wang W. Involvement of tumor necrosis factor-alpha in the upregulation of CXCR4 expression in gastric cancer induced by Helicobacter pylori. BMC Cancer 2010; 10: 419.
30. Mocellin S, Rossi CR, Pilati P, Nitti D. Tumor necrosis factor, cancer and anticancer therapy. Cytokine Growth Factor Rev 2005; 16: 35-53.
31. Karin M. Nuclear factor-kappaB in cancer development and progression. Nature 2006; 441: 431-6.
32. Okamura H, Tsutsi H, Komatsu T et al. Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature 1995; 378: 88-91.
33. Howard M, O'Garra A, Ishida H, de Waal Malefyt R, de Viris J. Biological properties of interleukin 10. J Clin Immunol 1992; 12: 239-47.
34. Urosevic M, Dummer R. HLA-G and IL-10 expression in human cancer-different stories with the same message. Semin Cancer Biol 2003; 13: 337-42.
35. Johansson-Lindbom B, Ingvarsson S, Borrebaeck CA. Germinal centers regulate human Th2 development. J Immunol 2003; 171: 1657-66.
36. Watanabe H, Enjoji M, Imai T. Gastric carcinoma with lymphoid stroma. Its morphologic characteristics and prognostic correlations. Cancer 1976; 38: 232-43.
37. Mizukami Y, Kono K, Kawaguchi Y et al. CCL17 and CCL22 chemokines within tumor microenvironment are related to accumulation of Foxp3+ regulatory T cells in gastric cancer. Int J Cancer 2008; 122: 2286-93.
38. Smyth MJ, Hayakawa Y, Takeda K, Yagita H. New aspects of natural-killer-cell surveillance and therapy of cancer. Nat Rev Cancer 2002; 2: 850-61.
39. Shi L, Kam CM, Powers JC et al. Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions. J Exp Med 1992; 176: 1521-9.
40. Nakajima H, Park HL, Henkart PA. Synergistic roles of granzymes A and B in mediating target cell death by rat basophilic leukemia mast cell tumors also expressing cytolysin/perforin. J Exp Med 1995; 181: 1037-46.