메뉴 건너뛰기




Volumn 23, Issue 3, 2014, Pages 204-210

The emerging role of the inflammasome in kidney diseases

Author keywords

glomerulonephritis; NLRP3; proteinuria; tubulointerstitial inflammation

Indexed keywords

CRYOPYRIN; INFLAMMASOME; ANTIINFLAMMATORY AGENT; AUTACOID; CARRIER PROTEIN; NLRP3 PROTEIN, HUMAN;

EID: 84898547262     PISSN: 10624821     EISSN: 14736543     Source Type: Journal    
DOI: 10.1097/01.mnh.0000444814.49755.90     Document Type: Review
Times cited : (85)

References (48)
  • 1
    • 0036671894 scopus 로고    scopus 로고
    • The inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
    • Martinon F, Burns K, Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell 2002; 10:417-426.
    • (2002) Mol Cell , vol.10 , pp. 417-426
    • Martinon, F.1    Burns, K.2    Tschopp, J.3
  • 2
    • 84882621088 scopus 로고    scopus 로고
    • Involvement of endoplasmic reticulum stress in albuminuria induced inflammasome activation in renal proximal tubular cells
    • Fang L, Xie D, Wu X, et al. Involvement of endoplasmic reticulum stress in albuminuria induced inflammasome activation in renal proximal tubular cells. PLoS One 2013; 8:e72344.
    • (2013) PLoS One , vol.8
    • Fang, L.1    Xie, D.2    Wu, X.3
  • 3
    • 84866512376 scopus 로고    scopus 로고
    • Cell volume regulation modulates NLRP3 inflammasome activation
    • Compan V, Baroja-Mazo A, López-Castejón G, et al. Cell volume regulation modulates NLRP3 inflammasome activation. Immunity 2012; 37:487-500.
    • (2012) Immunity , vol.37 , pp. 487-500
    • Compan, V.1    Baroja-Mazo, A.2    López-Castejón, G.3
  • 4
    • 84876237736 scopus 로고    scopus 로고
    • The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation
    • Subramanian N, Natarajan K, Clatworthy MR, et al. The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation. Cell 2013; 153:348-361.
    • (2013) Cell , vol.153 , pp. 348-361
    • Subramanian, N.1    Natarajan, K.2    Clatworthy, M.R.3
  • 5
    • 84884332722 scopus 로고    scopus 로고
    • Mechanisms of NOD-like receptor-associated inflammasome activation
    • Wen H, Miao EA, Ting JP-Y. Mechanisms of NOD-like receptor-associated inflammasome activation. Immunity 2013; 39:432-441.
    • (2013) Immunity , vol.39 , pp. 432-441
    • Wen, H.1    Miao, E.A.2    Ting, J.P.-Y.3
  • 7
    • 84869504451 scopus 로고    scopus 로고
    • Inflammasomes and their roles in health and disease
    • Lamkanfi M, Dixit VM. Inflammasomes and their roles in health and disease. Annu Rev Cell Dev Biol 2012; 28:137-161.
    • (2012) Annu Rev Cell Dev Biol , vol.28 , pp. 137-161
    • Lamkanfi, M.1    Dixit, V.M.2
  • 9
    • 79957773993 scopus 로고    scopus 로고
    • The inflammasomes in kidney disease
    • Anders H-J, Muruve DA. The inflammasomes in kidney disease. J Am Soc Nephrol 2011; 22:1007-1018.
    • (2011) J Am Soc Nephrol , vol.22 , pp. 1007-1018
    • Anders, H.-J.1    Muruve, D.A.2
  • 10
    • 84892754061 scopus 로고    scopus 로고
    • Canonical and noncanonical effects of the NLRP3 inflammasome in kidney inflammation and fibrosis
    • Lorenz G, Darisipudi MN, Anders H-J. Canonical and noncanonical effects of the NLRP3 inflammasome in kidney inflammation and fibrosis. Nephrol Dial Transplant 2014; 29:41-48.
    • (2014) Nephrol Dial Transplant , vol.29 , pp. 41-48
    • Lorenz, G.1    Darisipudi, M.N.2    Anders, H.-J.3
  • 11
    • 78650659200 scopus 로고    scopus 로고
    • An inflammasome-independent role for epithelial-expressed Nlrp3 in renal ischemia-reperfusion injury
    • Shigeoka AA, Mueller JL, Kambo A, et al. An inflammasome-independent role for epithelial-expressed Nlrp3 in renal ischemia-reperfusion injury. J Immunol 2010; 185:6277-6285.
    • (2010) J Immunol , vol.185 , pp. 6277-6285
    • Shigeoka, A.A.1    Mueller, J.L.2    Kambo, A.3
  • 12
    • 84879591473 scopus 로고    scopus 로고
    • Pathogenic and protective role of macrophages in kidney disease
    • Cao Q, Wang Y, Harris DCH. Pathogenic and protective role of macrophages in kidney disease. Am J Physiol Renal Physiol 2013; 305:F3-F11.
    • (2013) Am J Physiol Renal Physiol , vol.305
    • Cao, Q.1    Wang, Y.2    Harris, D.C.H.3
  • 14
    • 77957887259 scopus 로고    scopus 로고
    • The NLRP3 inflammasome promotes renal inflammation and contributes to CKD
    • Vilaysane A, Chun J, Seamone ME, et al. The NLRP3 inflammasome promotes renal inflammation and contributes to CKD. J Am Soc Nephrol 2010; 21:1732-1744.
    • (2010) J Am Soc Nephrol , vol.21 , pp. 1732-1744
    • Vilaysane, A.1    Chun, J.2    Seamone, M.E.3
  • 15
    • 83355168710 scopus 로고    scopus 로고
    • Pivotal role of Toll-like receptors 2 and 4, its adaptor molecule MyD88, and inflammasome complex in experimental tubule-interstitial nephritis
    • Correa-Costa M, Braga TT, Semedo P, et al. Pivotal role of Toll-like receptors 2 and 4, its adaptor molecule MyD88, and inflammasome complex in experimental tubule-interstitial nephritis. PLoS One 2011; 6:e29004.
    • (2011) PLoS One , vol.6
    • Correa-Costa, M.1    Braga, T.T.2    Semedo, P.3
  • 16
    • 84874930374 scopus 로고    scopus 로고
    • ATP-P2X4 signaling mediates NLRP3 inflammasome activation: A novel pathway of diabetic nephropathy
    • Chen K, Zhang J, Zhang W, et al. ATP-P2X4 signaling mediates NLRP3 inflammasome activation: a novel pathway of diabetic nephropathy. Int J Biochem Cell Biol 2013; 45:932-943.
    • (2013) Int J Biochem Cell Biol , vol.45 , pp. 932-943
    • Chen, K.1    Zhang, J.2    Zhang, W.3
  • 17
    • 84873827527 scopus 로고    scopus 로고
    • Calcium oxalate crystals induce renal inflammation by NLRP3-mediated IL-1b secretion
    • Mulay SR, Kulkarni OP, Rupanagudi KV, et al. Calcium oxalate crystals induce renal inflammation by NLRP3-mediated IL-1b secretion. J Clin Invest 2013; 123:236-246.
    • (2013) J Clin Invest , vol.123 , pp. 236-246
    • Mulay, S.R.1    Kulkarni, O.P.2    Rupanagudi, K.V.3
  • 18
    • 84888332141 scopus 로고    scopus 로고
    • NALP3-mediated inflammation is a principal cause of progressive renal failure in oxalate nephropathy
    • Knauf F, Asplin JR, Granja I, et al. NALP3-mediated inflammation is a principal cause of progressive renal failure in oxalate nephropathy. Kidney Int 2013; 84:895-901.
    • (2013) Kidney Int , vol.84 , pp. 895-901
    • Knauf, F.1    Asplin, J.R.2    Granja, I.3
  • 19
    • 84868618082 scopus 로고    scopus 로고
    • Uromodulin triggers IL-1bdependent innate immunity via the NLRP3 inflammasome
    • Darisipudi MN, Thomasova D, Mulay SR, et al. Uromodulin triggers IL-1bdependent innate immunity via the NLRP3 inflammasome. J Am Soc Nephrol 2012; 23:1783-1789.
    • (2012) J Am Soc Nephrol , vol.23 , pp. 1783-1789
    • Darisipudi, M.N.1    Thomasova, D.2    Mulay, S.R.3
  • 20
    • 84255178199 scopus 로고    scopus 로고
    • Cellular inhibitors of apoptosis proteins cIAP1 and cIAP2 are required for efficient caspase-1 activation by the inflammasome
    • LabbéK, McIntire CR, Doiron K, et al. Cellular inhibitors of apoptosis proteins cIAP1 and cIAP2 are required for efficient caspase-1 activation by the inflammasome. Immunity 2011; 35:897-907.
    • (2011) Immunity , vol.35 , pp. 897-907
    • Labbék1    McIntire, C.R.2    Doiron, K.3
  • 21
    • 84857404572 scopus 로고    scopus 로고
    • Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation
    • Vince JE, Wong WW-L, Gentle I, et al. Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation. Immunity 2012; 36:215-227.
    • (2012) Immunity , vol.36 , pp. 215-227
    • Vince, J.E.1    Ww-L, W.2    Gentle, I.3
  • 22
    • 84882431324 scopus 로고    scopus 로고
    • NLRP3 inflammasome knockout mice are protected against ischemic but not cisplatin-induced acute kidney injury
    • Kim H-J, Lee DW, Ravichandran K, et al. NLRP3 inflammasome knockout mice are protected against ischemic but not cisplatin-induced acute kidney injury. J Pharmacol Exp Ther 2013; 346:465-472.
    • (2013) J Pharmacol Exp Ther , vol.346 , pp. 465-472
    • Kim, H.-J.1    Lee, D.W.2    Ravichandran, K.3
  • 23
    • 15244341319 scopus 로고    scopus 로고
    • The pathophysiology of acute renal failure
    • Lameire N. The pathophysiology of acute renal failure. Crit Care Clin 2005; 21:197-210.
    • (2005) Crit Care Clin , vol.21 , pp. 197-210
    • Lameire, N.1
  • 24
    • 80055053463 scopus 로고    scopus 로고
    • Anti-GBM glomerulonephritis involves IL-1 but is independent of NLRP3/ASC inflammasome-mediated activation of caspase-1
    • Lichtnekert J, Kulkarni OP, Mulay SR, et al. Anti-GBM glomerulonephritis involves IL-1 but is independent of NLRP3/ASC inflammasome-mediated activation of caspase-1. PLoS One 2011; 6:e26778.
    • (2011) PLoS One , vol.6
    • Lichtnekert, J.1    Kulkarni, O.P.2    Mulay, S.R.3
  • 25
    • 84871961792 scopus 로고    scopus 로고
    • P2X7 receptor-mediated Nlrp3- inflammasome activation is a genetic determinant of macrophagedependent crescentic glomerulonephritis
    • Deplano S, Cook HT, Russell R, et al. P2X7 receptor-mediated Nlrp3- inflammasome activation is a genetic determinant of macrophagedependent crescentic glomerulonephritis. J Leukoc Biol 2013; 93:127-134.
    • (2013) J Leukoc Biol , vol.93 , pp. 127-134
    • Deplano, S.1    Cook, H.T.2    Russell, R.3
  • 26
    • 84889048300 scopus 로고    scopus 로고
    • P2X7 blockade attenuates murine lupus nephritis by inhibiting activation of the NLRP3/ASC/Caspase 1 pathway
    • Zhao J, Wang H, Dai C, et al. P2X7 blockade attenuates murine lupus nephritis by inhibiting activation of the NLRP3/ASC/Caspase 1 pathway. Arthritis Rheum 2013; 65:3176-3185.
    • (2013) Arthritis Rheum , vol.65 , pp. 3176-3185
    • Zhao, J.1    Wang, H.2    Dai, C.3
  • 27
    • 84879486085 scopus 로고    scopus 로고
    • Bay11-7082 attenuates murine lupus nephritis via inhibiting NLRP3 inflammasome and NF-kB activation
    • Zhao J, Zhang H, Huang Y, et al. Bay11-7082 attenuates murine lupus nephritis via inhibiting NLRP3 inflammasome and NF-kB activation. Int Immunopharmacol 2013; 17:116-122.
    • (2013) Int Immunopharmacol , vol.17 , pp. 116-122
    • Zhao, J.1    Zhang, H.2    Huang, Y.3
  • 28
    • 84885464688 scopus 로고    scopus 로고
    • A novel antagonist of Toll-like receptors 7, 8 and 9 suppresses lupus disease-associated parameters in NZBW/F1 mice
    • Zhu F-G, Jiang W, Bhagat L, et al. A novel antagonist of Toll-like receptors 7, 8 and 9 suppresses lupus disease-associated parameters in NZBW/F1 mice. Autoimmunity 2013; 46:419-428.
    • (2013) Autoimmunity , vol.46 , pp. 419-428
    • Zhu, F.-G.1    Jiang, W.2    Bhagat, L.3
  • 29
    • 79959926939 scopus 로고    scopus 로고
    • Epigallocatechin-3-gallate prevents lupus nephritis development in mice via enhancing the Nrf2 antioxidant pathway and inhibiting NLRP3 inflammasome activation
    • Tsai P-Y, Ka S-M, Chang J-M, et al. Epigallocatechin-3-gallate prevents lupus nephritis development in mice via enhancing the Nrf2 antioxidant pathway and inhibiting NLRP3 inflammasome activation. Free Radic Biol Med 2011; 51:744-754.
    • (2011) Free Radic Biol Med , vol.51 , pp. 744-754
    • Tsai, P.-Y.1    Ka, S.-M.2    Chang, J.-M.3
  • 30
    • 84877870521 scopus 로고    scopus 로고
    • Antroquinonol mitigates an accelerated and progressive IgA nephropathy model in mice by activating the Nrf2 pathway and inhibiting T cells and NLRP3 inflammasome
    • Yang S-M, Ka S-M, Hua K-F, et al. Antroquinonol mitigates an accelerated and progressive IgA nephropathy model in mice by activating the Nrf2 pathway and inhibiting T cells and NLRP3 inflammasome. Free Radic Biol Med 2013; 61C:285-297.
    • (2013) Free Radic Biol Med , vol.61 C , pp. 285-297
    • Yang, S.-M.1    Ka, S.-M.2    Hua, K.-F.3
  • 31
    • 84886605380 scopus 로고    scopus 로고
    • Osthole mitigates progressive IgA nephropathy by inhibiting reactive oxygen species generation and NF-kB/ NLRP3 pathway
    • Hua K-F, Yang S-M, Kao T-Y, et al. Osthole mitigates progressive IgA nephropathy by inhibiting reactive oxygen species generation and NF-kB/ NLRP3 pathway. PLoS One 2013; 8:e77794.
    • (2013) PLoS One , vol.8
    • Hua, K.-F.1    Yang, S.-M.2    Kao, T.-Y.3
  • 32
    • 84865820621 scopus 로고    scopus 로고
    • Activation of Nod-like receptor protein 3 inflammasomes turns on podocyte injury and glomerular sclerosis in hyperhomocysteinemia
    • Zhang C, Boini KM, Xia M, et al. Activation of Nod-like receptor protein 3 inflammasomes turns on podocyte injury and glomerular sclerosis in hyperhomocysteinemia. Hypertension 2012; 60:154-162.
    • (2012) Hypertension , vol.60 , pp. 154-162
    • Zhang, C.1    Boini, K.M.2    Xia, M.3
  • 33
    • 84875730240 scopus 로고    scopus 로고
    • NADPH oxidase-mediated triggering of inflammasome activation in mouse podocytes and glomeruli during hyperhomocysteinemia
    • Abais JM, Zhang C, Xia M, et al. NADPH oxidase-mediated triggering of inflammasome activation in mouse podocytes and glomeruli during hyperhomocysteinemia. Antioxid Redox Signal 2013; 18:1537-1548.
    • (2013) Antioxid Redox Signal , vol.18 , pp. 1537-1548
    • Abais, J.M.1    Zhang, C.2    Xia, M.3
  • 34
    • 84888607647 scopus 로고    scopus 로고
    • Contribution of endogenously produced reactive oxygen species to the activation of podocyte NLRP3 inflammasomes in hyperhomocysteinemia
    • Abais JM, Xia M, Li G, et al. Contribution of endogenously produced reactive oxygen species to the activation of podocyte NLRP3 inflammasomes in hyperhomocysteinemia. Free Radic Biol Med 2014; 67:211-220.
    • (2014) Free Radic Biol Med , vol.67 , pp. 211-220
    • Abais, J.M.1    Xia, M.2    Li, G.3
  • 35
    • 84885422386 scopus 로고    scopus 로고
    • The purinergic 2X7 receptor participates in renal inflammation and injury induced by high-fat diet: Possible role of NLRP3 inflammasome activation
    • Solini A, Menini S, Rossi C, et al. The purinergic 2X7 receptor participates in renal inflammation and injury induced by high-fat diet: possible role of NLRP3 inflammasome activation. J Pathol 2013; 231:342-353.
    • (2013) J Pathol , vol.231 , pp. 342-353
    • Solini, A.1    Menini, S.2    Rossi, C.3
  • 36
    • 84878702257 scopus 로고    scopus 로고
    • Podocytes are nonhematopoietic professional antigen-presenting cells
    • Goldwich A, Burkard M, Olke M, et al. Podocytes are nonhematopoietic professional antigen-presenting cells. J Am Soc Nephrol 2013; 24:906-916.
    • (2013) J Am Soc Nephrol , vol.24 , pp. 906-916
    • Goldwich, A.1    Burkard, M.2    Olke, M.3
  • 37
    • 68949206247 scopus 로고    scopus 로고
    • The Oxford classification of IgA nephropathy: Pathology definitions, correlations, and reproducibility
    • Working Group of the International IgA Nephropathy Network the Renal Pathology Society
    • Working Group of the International IgA Nephropathy Network the Renal Pathology Society. Roberts ISD, Cook HT, Troyanov S, et al. The Oxford classification of IgA nephropathy: pathology definitions, correlations, and reproducibility. Kidney Int 2009; 76:546-556.
    • (2009) Kidney Int , vol.76 , pp. 546-556
    • Isd, R.1    Cook, H.T.2    Troyanov, S.3
  • 38
    • 79958781145 scopus 로고    scopus 로고
    • Predicting outcomes of lupus nephritis with tubulointerstitial inflammation and scarring
    • Hsieh C, Chang A, Brandt D, et al. Predicting outcomes of lupus nephritis with tubulointerstitial inflammation and scarring. Arthritis Care Res 2011; 63:865-874.
    • (2011) Arthritis Care Res , vol.63 , pp. 865-874
    • Hsieh, C.1    Chang, A.2    Brandt, D.3
  • 39
    • 0029883141 scopus 로고    scopus 로고
    • Risk of developing end-stage renal disease in a cohort of mass screening
    • Iseki K, Iseki C, Ikemiya Y, Fukiyama K. Risk of developing end-stage renal disease in a cohort of mass screening. Kidney Int 1996; 49:800-805.
    • (1996) Kidney Int , vol.49 , pp. 800-805
    • Iseki, K.1    Iseki, C.2    Ikemiya, Y.3    Fukiyama, K.4
  • 40
    • 34047212211 scopus 로고    scopus 로고
    • Mitochondria are the major targets in albumin-induced apoptosis in proximal tubule cells
    • Erkan E, Devarajan P, Schwartz GJ. Mitochondria are the major targets in albumin-induced apoptosis in proximal tubule cells. J Am Soc Nephrol 2007; 18:1199-1208.
    • (2007) J Am Soc Nephrol , vol.18 , pp. 1199-1208
    • Erkan, E.1    Devarajan, P.2    Schwartz, G.J.3
  • 41
    • 84875730197 scopus 로고    scopus 로고
    • Selective estrogen receptor modulation attenuates proteinuria-induced renal tubular damage by modulating mitochondrial oxidative status
    • Nishi Y, Satoh M, Nagasu H, et al. Selective estrogen receptor modulation attenuates proteinuria-induced renal tubular damage by modulating mitochondrial oxidative status. Kidney Int 2013; 83:662-673.
    • (2013) Kidney Int , vol.83 , pp. 662-673
    • Nishi, Y.1    Satoh, M.2    Nagasu, H.3
  • 42
    • 41449083289 scopus 로고    scopus 로고
    • Gender and human chronic renal disease
    • Silbiger S, Neugarten J. Gender and human chronic renal disease. Gend Med 2008; 5 (Suppl. A):S3-S10.
    • (2008) Gend Med , vol.5 , Issue.SUPPL. A
    • Silbiger, S.1    Neugarten, J.2
  • 43
    • 84873820932 scopus 로고    scopus 로고
    • Endocytosis of albumin by podocytes elicits an inflammatory response and induces apoptotic cell death
    • Okamura K, Dummer P, Kopp J, et al. Endocytosis of albumin by podocytes elicits an inflammatory response and induces apoptotic cell death. PLoS One 2013; 8:e54817.
    • (2013) PLoS One , vol.8
    • Okamura, K.1    Dummer, P.2    Kopp, J.3
  • 44
    • 84872737232 scopus 로고    scopus 로고
    • Inflammasome-independentNLRP3 augments TGF-b signaling in kidney epithelium
    • Wang W,Wang X, Chun J, et al. Inflammasome-independentNLRP3 augments TGF-b signaling in kidney epithelium. J Immunol 2013; 190:1239-1249.
    • (2013) J Immunol , vol.190 , pp. 1239-1249
    • Wang Wwang, X.1    Chun, J.2
  • 45
    • 84864128173 scopus 로고    scopus 로고
    • How does TGF-b mediate tubulointerstitial fibrosis?
    • Gewin L, Zent R. How does TGF-b mediate tubulointerstitial fibrosis? Semin Nephrol 2012; 32:228-235.
    • (2012) Semin Nephrol , vol.32 , pp. 228-235
    • Gewin, L.1    Zent, R.2
  • 46
    • 0034836835 scopus 로고    scopus 로고
    • Apoptosis in podocytes induced by TGF-beta and Smad7
    • Schiffer M, Bitzer M, Roberts IS, et al. Apoptosis in podocytes induced by TGF-beta and Smad7. J Clin Invest 2001; 108:807-816.
    • (2001) J Clin Invest , vol.108 , pp. 807-816
    • Schiffer, M.1    Bitzer, M.2    Roberts, I.S.3
  • 47
    • 29144490392 scopus 로고    scopus 로고
    • Podocyte depletion causes glomerulosclerosis: Diphtheria toxin-induced podocyte depletion in rats expressing human diphtheria toxin receptor transgene
    • Wharram BL, Goyal M, Wiggins JE, et al. Podocyte depletion causes glomerulosclerosis: diphtheria toxin-induced podocyte depletion in rats expressing human diphtheria toxin receptor transgene. J Am Soc Nephrol 2005; 16:2941-2952.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 2941-2952
    • Wharram, B.L.1    Goyal, M.2    Wiggins, J.E.3
  • 48
    • 12344256754 scopus 로고    scopus 로고
    • Pathways to nephron loss starting from glomerular diseases - Insights from animal models
    • Kriz W, LeHir M. Pathways to nephron loss starting from glomerular diseases - insights from animal models. Kidney Int 2005; 67:404-419.
    • (2005) Kidney Int , vol.67 , pp. 404-419
    • Kriz, W.1    Lehir, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.