-
1
-
-
14844302670
-
Latent transforming growth factor-beta (TGF-beta) binding proteins: orchestrators of TGF-beta availability
-
Rifkin D.B. Latent transforming growth factor-beta (TGF-beta) binding proteins: orchestrators of TGF-beta availability. J Biol Chem 2005, 280:7409-7412.
-
(2005)
J Biol Chem
, vol.280
, pp. 7409-7412
-
-
Rifkin, D.B.1
-
2
-
-
43049146157
-
The role of proteases in transforming growth factor-beta activation
-
Jenkins G. The role of proteases in transforming growth factor-beta activation. Int J Biochem Cell Biol 2008, 40:1068-1078.
-
(2008)
Int J Biochem Cell Biol
, vol.40
, pp. 1068-1078
-
-
Jenkins, G.1
-
3
-
-
0026496172
-
TGF beta signals through a heteromeric protein kinase receptor complex
-
Wrana J.L., Attisano L., Carcamo J., Zentella A., Doody J., Laiho M., et al. TGF beta signals through a heteromeric protein kinase receptor complex. Cell 1992, 71:1003-1014.
-
(1992)
Cell
, vol.71
, pp. 1003-1014
-
-
Wrana, J.L.1
Attisano, L.2
Carcamo, J.3
Zentella, A.4
Doody, J.5
Laiho, M.6
-
4
-
-
0027930903
-
Formation of hetero-oligomeric complexes of type I and type II receptors for transforming growth factor-beta
-
Yamashita H., ten Dijke P., Franzen P., Miyazono K., Heldin C.H. Formation of hetero-oligomeric complexes of type I and type II receptors for transforming growth factor-beta. J Biol Chem 1994, 269:20172-20178.
-
(1994)
J Biol Chem
, vol.269
, pp. 20172-20178
-
-
Yamashita, H.1
ten Dijke, P.2
Franzen, P.3
Miyazono, K.4
Heldin, C.H.5
-
5
-
-
34247539528
-
A tale of two proteins: differential roles and regulation of Smad2 and Smad3 in TGF-beta signaling
-
Brown K.A., Pietenpol J.A., Moses H.L. A tale of two proteins: differential roles and regulation of Smad2 and Smad3 in TGF-beta signaling. J Cell Biochem 2007, 101:9-33.
-
(2007)
J Cell Biochem
, vol.101
, pp. 9-33
-
-
Brown, K.A.1
Pietenpol, J.A.2
Moses, H.L.3
-
6
-
-
58149213801
-
Non-Smad pathways in TGF-beta signaling
-
Zhang Y.E. Non-Smad pathways in TGF-beta signaling. Cell Res 2009, 19:128-139.
-
(2009)
Cell Res
, vol.19
, pp. 128-139
-
-
Zhang, Y.E.1
-
7
-
-
77957252460
-
Tubular overexpression of transforming growth factor-beta1 induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cells
-
Koesters R., Kaissling B., Lehir M., Picard N., Theilig F., Gebhardt R., et al. Tubular overexpression of transforming growth factor-beta1 induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cells. Am J Pathol 2010, 177:632-643.
-
(2010)
Am J Pathol
, vol.177
, pp. 632-643
-
-
Koesters, R.1
Kaissling, B.2
Lehir, M.3
Picard, N.4
Theilig, F.5
Gebhardt, R.6
-
8
-
-
0033667371
-
Antibody to transforming growth factor-beta ameliorates tubular apoptosis in unilateral ureteral obstruction
-
Miyajima A., Chen J., Lawrence C., Ledbetter S., Soslow R.A., Stern J., et al. Antibody to transforming growth factor-beta ameliorates tubular apoptosis in unilateral ureteral obstruction. Kidney Int 2000, 58:2301-2313.
-
(2000)
Kidney Int
, vol.58
, pp. 2301-2313
-
-
Miyajima, A.1
Chen, J.2
Lawrence, C.3
Ledbetter, S.4
Soslow, R.A.5
Stern, J.6
-
9
-
-
0027212686
-
Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts
-
Desmouliere A., Geinoz A., Gabbiani F., Gabbiani G. Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J Cell Biol 1993, 122:103-111.
-
(1993)
J Cell Biol
, vol.122
, pp. 103-111
-
-
Desmouliere, A.1
Geinoz, A.2
Gabbiani, F.3
Gabbiani, G.4
-
10
-
-
0023654923
-
Regulation of fibronectin and type I collagen mRNA levels by transforming growth factor-beta
-
Ignotz R.A., Endo T., Massague J. Regulation of fibronectin and type I collagen mRNA levels by transforming growth factor-beta. J Biol Chem 1987, 262:6443-6446.
-
(1987)
J Biol Chem
, vol.262
, pp. 6443-6446
-
-
Ignotz, R.A.1
Endo, T.2
Massague, J.3
-
11
-
-
0022471924
-
Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro
-
Roberts A.B., Sporn M.B., Assoian R.K., Smith J.M., Roche N.S., Wakefield L.M., et al. Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci U S A 1986, 83:4167-4171.
-
(1986)
Proc Natl Acad Sci U S A
, vol.83
, pp. 4167-4171
-
-
Roberts, A.B.1
Sporn, M.B.2
Assoian, R.K.3
Smith, J.M.4
Roche, N.S.5
Wakefield, L.M.6
-
12
-
-
2442724379
-
Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor
-
Edwards D.R., Murphy G., Reynolds J.J., Whitham S.E., Docherty A.J., Angel P., et al. Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor. EMBO J 1987, 6:1899-1904.
-
(1987)
EMBO J
, vol.6
, pp. 1899-1904
-
-
Edwards, D.R.1
Murphy, G.2
Reynolds, J.J.3
Whitham, S.E.4
Docherty, A.J.5
Angel, P.6
-
13
-
-
0028244447
-
Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues
-
Leco K.J., Khokha R., Pavloff N., Hawkes S.P., Edwards D.R. Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues. J Biol Chem 1994, 269:9352-9360.
-
(1994)
J Biol Chem
, vol.269
, pp. 9352-9360
-
-
Leco, K.J.1
Khokha, R.2
Pavloff, N.3
Hawkes, S.P.4
Edwards, D.R.5
-
14
-
-
0026041888
-
TGF beta elicits opposite responses in clonal subpopulations of NRK-49F cells
-
Tang N., Cunningham K., Enger M.D. TGF beta elicits opposite responses in clonal subpopulations of NRK-49F cells. Exp Cell Res 1991, 196:13-19.
-
(1991)
Exp Cell Res
, vol.196
, pp. 13-19
-
-
Tang, N.1
Cunningham, K.2
Enger, M.D.3
-
15
-
-
0026531659
-
Biosynthetic and proliferative characteristics of tubulointerstitial fibroblasts probed with paracrine cytokines
-
Alvarez R.J., Sun M.J., Haverty T.P., Iozzo R.V., Myers J.C., Neilson E.G. Biosynthetic and proliferative characteristics of tubulointerstitial fibroblasts probed with paracrine cytokines. Kidney Int 1992, 41:14-23.
-
(1992)
Kidney Int
, vol.41
, pp. 14-23
-
-
Alvarez, R.J.1
Sun, M.J.2
Haverty, T.P.3
Iozzo, R.V.4
Myers, J.C.5
Neilson, E.G.6
-
16
-
-
42249109021
-
Synergistic effect between EGF and TGF-beta1 in inducing oncogenic properties of intestinal epithelial cells
-
Uttamsingh S., Bao X., Nguyen K.T., Bhanot M., Gong J., Chan J.L., et al. Synergistic effect between EGF and TGF-beta1 in inducing oncogenic properties of intestinal epithelial cells. Oncogene 2008, 27:2626-2634.
-
(2008)
Oncogene
, vol.27
, pp. 2626-2634
-
-
Uttamsingh, S.1
Bao, X.2
Nguyen, K.T.3
Bhanot, M.4
Gong, J.5
Chan, J.L.6
-
17
-
-
11244292291
-
Imatinib mesylate blocks a non-Smad TGF-beta pathway and reduces renal fibrogenesis in vivo
-
Wang S., Wilkes M.C., Leof E.B., Hirschberg R. Imatinib mesylate blocks a non-Smad TGF-beta pathway and reduces renal fibrogenesis in vivo. FASEB J 2005, 19:1-11.
-
(2005)
FASEB J
, vol.19
, pp. 1-11
-
-
Wang, S.1
Wilkes, M.C.2
Leof, E.B.3
Hirschberg, R.4
-
18
-
-
1642535424
-
The phosphatidylinositol 3-kinase/Akt pathway enhances Smad3-stimulated mesangial cell collagen I expression in response to transforming growth factor-beta1
-
Runyan C.E., Schnaper H.W., Poncelet A.C. The phosphatidylinositol 3-kinase/Akt pathway enhances Smad3-stimulated mesangial cell collagen I expression in response to transforming growth factor-beta1. J Biol Chem 2004, 279:2632-2639.
-
(2004)
J Biol Chem
, vol.279
, pp. 2632-2639
-
-
Runyan, C.E.1
Schnaper, H.W.2
Poncelet, A.C.3
-
19
-
-
0041883785
-
Smad3 and PKCdelta mediate TGF-beta1-induced collagen I expression in human mesangial cells
-
Runyan C.E., Schnaper H.W., Poncelet A.C. Smad3 and PKCdelta mediate TGF-beta1-induced collagen I expression in human mesangial cells. Am J Physiol Renal Physiol 2003, 285:F413-F422.
-
(2003)
Am J Physiol Renal Physiol
, vol.285
-
-
Runyan, C.E.1
Schnaper, H.W.2
Poncelet, A.C.3
-
20
-
-
0032589970
-
TGF-beta1 activates MAP kinase in human mesangial cells: a possible role in collagen expression
-
Hayashida T., Poncelet A.C., Hubchak S.C., Schnaper H.W. TGF-beta1 activates MAP kinase in human mesangial cells: a possible role in collagen expression. Kidney Int 1999, 56:1710-1720.
-
(1999)
Kidney Int
, vol.56
, pp. 1710-1720
-
-
Hayashida, T.1
Poncelet, A.C.2
Hubchak, S.C.3
Schnaper, H.W.4
-
21
-
-
0029978253
-
Increased transforming growth factor-beta 1 expression in regenerating rat renal tubules following ischemic injury
-
Basile D.P., Rovak J.M., Martin D.R., Hammerman M.R. Increased transforming growth factor-beta 1 expression in regenerating rat renal tubules following ischemic injury. Am J Physiol 1996, 270:F500-F509.
-
(1996)
Am J Physiol
, vol.270
-
-
Basile, D.P.1
Rovak, J.M.2
Martin, D.R.3
Hammerman, M.R.4
-
22
-
-
0032540207
-
Transforming growth factor-beta receptor types I and II are expressed in renal tubules and are increased after chronic unilateral ureteral obstruction
-
Sutaria P.M., Ohebshalom M., McCaffrey T.A., Vaughan E.D., Felsen D. Transforming growth factor-beta receptor types I and II are expressed in renal tubules and are increased after chronic unilateral ureteral obstruction. Life Sci 1998, 62:1965-1972.
-
(1998)
Life Sci
, vol.62
, pp. 1965-1972
-
-
Sutaria, P.M.1
Ohebshalom, M.2
McCaffrey, T.A.3
Vaughan, E.D.4
Felsen, D.5
-
23
-
-
0036899231
-
Transforming growth factor-beta(1) in the kidney and urine of patients with glomerular disease and proteinuria
-
Goumenos D.S., Tsakas S., El Nahas A.M., Alexandri S., Oldroyd S., Kalliakmani P., et al. Transforming growth factor-beta(1) in the kidney and urine of patients with glomerular disease and proteinuria. Nephrol Dial Transplant 2002, 17:2145-2152.
-
(2002)
Nephrol Dial Transplant
, vol.17
, pp. 2145-2152
-
-
Goumenos, D.S.1
Tsakas, S.2
El Nahas, A.M.3
Alexandri, S.4
Oldroyd, S.5
Kalliakmani, P.6
-
24
-
-
77954621422
-
Trichostatin a prevents TGF-beta1-induced apoptosis by inhibiting ERK activation in human renal tubular epithelial cells
-
Yoshikawa M., Hishikawa K., Idei M., Fujita T. Trichostatin a prevents TGF-beta1-induced apoptosis by inhibiting ERK activation in human renal tubular epithelial cells. Eur J Pharmacol 2010, 642:28-36.
-
(2010)
Eur J Pharmacol
, vol.642
, pp. 28-36
-
-
Yoshikawa, M.1
Hishikawa, K.2
Idei, M.3
Fujita, T.4
-
25
-
-
3543109115
-
Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis
-
Lee C.G., Cho S.J., Kang M.J., Chapoval S.P., Lee P.J., Noble P.W., et al. Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis. J Exp Med 2004, 200:377-389.
-
(2004)
J Exp Med
, vol.200
, pp. 377-389
-
-
Lee, C.G.1
Cho, S.J.2
Kang, M.J.3
Chapoval, S.P.4
Lee, P.J.5
Noble, P.W.6
-
26
-
-
0032519925
-
Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF
-
Fadok V.A., Bratton D.L., Konowal A., Freed P.W., Westcott J.Y., Henson P.M. Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. J Clin Invest 1998, 101:890-898.
-
(1998)
J Clin Invest
, vol.101
, pp. 890-898
-
-
Fadok, V.A.1
Bratton, D.L.2
Konowal, A.3
Freed, P.W.4
Westcott, J.Y.5
Henson, P.M.6
-
27
-
-
0036786834
-
TGF-beta signaling in renal disease
-
Bottinger E.P., Bitzer M. TGF-beta signaling in renal disease. J Am Soc Nephrol 2002, 13:2600-2610.
-
(2002)
J Am Soc Nephrol
, vol.13
, pp. 2600-2610
-
-
Bottinger, E.P.1
Bitzer, M.2
-
28
-
-
0141720342
-
Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis
-
Li Y., Yang J., Dai C., Wu C., Liu Y. Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis. J Clin Invest 2003, 112:503-516.
-
(2003)
J Clin Invest
, vol.112
, pp. 503-516
-
-
Li, Y.1
Yang, J.2
Dai, C.3
Wu, C.4
Liu, Y.5
-
29
-
-
9644274187
-
Integrity of cell-cell contacts is a critical regulator of TGF-beta 1-induced epithelial-to-myofibroblast transition: role for beta-catenin
-
Masszi A., Fan L., Rosivall L., McCulloch C.A., Rotstein O.D., Mucsi I., et al. Integrity of cell-cell contacts is a critical regulator of TGF-beta 1-induced epithelial-to-myofibroblast transition: role for beta-catenin. Am J Pathol 2004, 165:1955-1967.
-
(2004)
Am J Pathol
, vol.165
, pp. 1955-1967
-
-
Masszi, A.1
Fan, L.2
Rosivall, L.3
McCulloch, C.A.4
Rotstein, O.D.5
Mucsi, I.6
-
30
-
-
0037405501
-
Central role for Rho in TGF-beta1-induced alpha-smooth muscle actin expression during epithelial-mesenchymal transition
-
Masszi A., Di Ciano C., Sirokmany G., Arthur W.T., Rotstein O.D., Wang J., et al. Central role for Rho in TGF-beta1-induced alpha-smooth muscle actin expression during epithelial-mesenchymal transition. Am J Physiol Renal Physiol 2003, 284:F911-F924.
-
(2003)
Am J Physiol Renal Physiol
, vol.284
-
-
Masszi, A.1
Di Ciano, C.2
Sirokmany, G.3
Arthur, W.T.4
Rotstein, O.D.5
Wang, J.6
-
31
-
-
0034785496
-
Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis
-
Yang J., Liu Y. Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis. Am J Pathol 2001, 159:1465-1475.
-
(2001)
Am J Pathol
, vol.159
, pp. 1465-1475
-
-
Yang, J.1
Liu, Y.2
-
32
-
-
0036233040
-
Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation
-
Strutz F., Zeisberg M., Ziyadeh F.N., Yang C.Q., Kalluri R., Muller G.A., et al. Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation. Kidney Int 2002, 61:1714-1728.
-
(2002)
Kidney Int
, vol.61
, pp. 1714-1728
-
-
Strutz, F.1
Zeisberg, M.2
Ziyadeh, F.N.3
Yang, C.Q.4
Kalluri, R.5
Muller, G.A.6
-
33
-
-
0346727324
-
Targeted disruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction
-
Sato M., Muragaki Y., Saika S., Roberts A.B., Ooshima A. Targeted disruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction. J Clin Invest 2003, 112:1486-1494.
-
(2003)
J Clin Invest
, vol.112
, pp. 1486-1494
-
-
Sato, M.1
Muragaki, Y.2
Saika, S.3
Roberts, A.B.4
Ooshima, A.5
-
34
-
-
77955602944
-
Resolved: EMT produces fibroblasts in the kidney
-
Zeisberg M., Duffield J.S. Resolved: EMT produces fibroblasts in the kidney. J Am Soc Nephrol 2010, 21:1247-1253.
-
(2010)
J Am Soc Nephrol
, vol.21
, pp. 1247-1253
-
-
Zeisberg, M.1
Duffield, J.S.2
-
35
-
-
79551521517
-
Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?
-
Kriz W., Kaissling B., Le Hir M. Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?. J Clin Invest 2011, 121:468-474.
-
(2011)
J Clin Invest
, vol.121
, pp. 468-474
-
-
Kriz, W.1
Kaissling, B.2
Le Hir, M.3
-
36
-
-
0024278715
-
Transforming growth factor beta 1 positively regulates its own expression in normal and transformed cells
-
Van Obberghen-Schilling E., Roche N.S., Flanders K.C., Sporn M.B., Roberts A.B. Transforming growth factor beta 1 positively regulates its own expression in normal and transformed cells. J Biol Chem 1988, 263:7741-7746.
-
(1988)
J Biol Chem
, vol.263
, pp. 7741-7746
-
-
Van Obberghen-Schilling, E.1
Roche, N.S.2
Flanders, K.C.3
Sporn, M.B.4
Roberts, A.B.5
-
37
-
-
34147106793
-
ERK, p38, and Smad signaling pathways differentially regulate transforming growth factor-beta1 autoinduction in proximal tubular epithelial cells
-
Zhang M., Fraser D., Phillips A. ERK, p38, and Smad signaling pathways differentially regulate transforming growth factor-beta1 autoinduction in proximal tubular epithelial cells. Am J Pathol 2006, 169:1282-1293.
-
(2006)
Am J Pathol
, vol.169
, pp. 1282-1293
-
-
Zhang, M.1
Fraser, D.2
Phillips, A.3
-
38
-
-
32844468585
-
Plasminogen activator inhibitor-1 gene deficiency attenuates TGF-beta1-induced kidney disease
-
Krag S., Danielsen C.C., Carmeliet P., Nyengaard J., Wogensen L. Plasminogen activator inhibitor-1 gene deficiency attenuates TGF-beta1-induced kidney disease. Kidney Int 2005, 68:2651-2666.
-
(2005)
Kidney Int
, vol.68
, pp. 2651-2666
-
-
Krag, S.1
Danielsen, C.C.2
Carmeliet, P.3
Nyengaard, J.4
Wogensen, L.5
-
39
-
-
0034912450
-
PAI-1 deficiency attenuates the fibrogenic response to ureteral obstruction
-
Oda T., Jung Y.O., Kim H.S., Cai X., Lopez-Guisa J.M., Ikeda Y., et al. PAI-1 deficiency attenuates the fibrogenic response to ureteral obstruction. Kidney Int 2001, 60:587-596.
-
(2001)
Kidney Int
, vol.60
, pp. 587-596
-
-
Oda, T.1
Jung, Y.O.2
Kim, H.S.3
Cai, X.4
Lopez-Guisa, J.M.5
Ikeda, Y.6
-
40
-
-
40149103283
-
Transforming growth factor-beta1-antisense modulates the expression of hepatocyte growth factor/scatter factor in keloid fibroblast cell culture
-
Naim R., Naumann A., Barnes J., Sauter A., Hormann K., Merkel D., et al. Transforming growth factor-beta1-antisense modulates the expression of hepatocyte growth factor/scatter factor in keloid fibroblast cell culture. Aesthetic Plast Surg 2008, 32:346-352.
-
(2008)
Aesthetic Plast Surg
, vol.32
, pp. 346-352
-
-
Naim, R.1
Naumann, A.2
Barnes, J.3
Sauter, A.4
Hormann, K.5
Merkel, D.6
-
41
-
-
78650864449
-
TGF-beta inhibits muscle differentiation by blocking autocrine signaling pathways initiated by IGF-II
-
Gardner S., Alzhanov D., Knollman P., Kuninger D., Rotwein P. TGF-beta inhibits muscle differentiation by blocking autocrine signaling pathways initiated by IGF-II. Mol Endocrinol 2011, 25:128-137.
-
(2011)
Mol Endocrinol
, vol.25
, pp. 128-137
-
-
Gardner, S.1
Alzhanov, D.2
Knollman, P.3
Kuninger, D.4
Rotwein, P.5
-
42
-
-
33947265169
-
Absence of integrin-mediated TGFbeta1 activation in vivo recapitulates the phenotype of TGFbeta1-null mice
-
Yang Z., Mu Z., Dabovic B., Jurukovski V., Yu D., Sung J., et al. Absence of integrin-mediated TGFbeta1 activation in vivo recapitulates the phenotype of TGFbeta1-null mice. J Cell Biol 2007, 176:787-793.
-
(2007)
J Cell Biol
, vol.176
, pp. 787-793
-
-
Yang, Z.1
Mu, Z.2
Dabovic, B.3
Jurukovski, V.4
Yu, D.5
Sung, J.6
-
43
-
-
0141537244
-
Transforming growth factor-beta-dependent and -independent pathways of induction of tubulointerstitial fibrosis in beta6(-/-) mice
-
Ma L.J., Yang H., Gaspert A., Carlesso G., Barty M.M., Davidson J.M., et al. Transforming growth factor-beta-dependent and -independent pathways of induction of tubulointerstitial fibrosis in beta6(-/-) mice. Am J Pathol 2003, 163:1261-1273.
-
(2003)
Am J Pathol
, vol.163
, pp. 1261-1273
-
-
Ma, L.J.1
Yang, H.2
Gaspert, A.3
Carlesso, G.4
Barty, M.M.5
Davidson, J.M.6
-
44
-
-
33745183811
-
Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury
-
Jenkins R.G., Su X., Su G., Scotton C.J., Camerer E., Laurent G.J., et al. Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury. J Clin Invest 2006, 116:1606-1614.
-
(2006)
J Clin Invest
, vol.116
, pp. 1606-1614
-
-
Jenkins, R.G.1
Su, X.2
Su, G.3
Scotton, C.J.4
Camerer, E.5
Laurent, G.J.6
-
45
-
-
0033524949
-
The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis
-
Munger J.S., Huang X., Kawakatsu H., Griffiths M.J., Dalton S.L., Wu J., et al. The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis. Cell 1999, 96:319-328.
-
(1999)
Cell
, vol.96
, pp. 319-328
-
-
Munger, J.S.1
Huang, X.2
Kawakatsu, H.3
Griffiths, M.J.4
Dalton, S.L.5
Wu, J.6
-
46
-
-
2942653435
-
Integrin alphaVbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1
-
Annes J.P., Chen Y., Munger J.S., Rifkin D.B. Integrin alphaVbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1. J Cell Biol 2004, 165:723-734.
-
(2004)
J Cell Biol
, vol.165
, pp. 723-734
-
-
Annes, J.P.1
Chen, Y.2
Munger, J.S.3
Rifkin, D.B.4
-
48
-
-
0034796171
-
Mechanical strains induced by tubular flow affect the phenotype of proximal tubular cells
-
Essig M., Terzi F., Burtin M., Friedlander G. Mechanical strains induced by tubular flow affect the phenotype of proximal tubular cells. Am J Physiol Renal Physiol 2001, 281:F751-F762.
-
(2001)
Am J Physiol Renal Physiol
, vol.281
-
-
Essig, M.1
Terzi, F.2
Burtin, M.3
Friedlander, G.4
-
49
-
-
0031977655
-
Dietary salt modulates renal production of transforming growth factor-beta in rats
-
Ying W.Z., Sanders P.W. Dietary salt modulates renal production of transforming growth factor-beta in rats. Am J Physiol 1998, 274:F635-F641.
-
(1998)
Am J Physiol
, vol.274
-
-
Ying, W.Z.1
Sanders, P.W.2
-
50
-
-
73849089954
-
Intratubular hydrodynamic forces influence tubulointerstitial fibrosis in the kidney
-
Rohatgi R., Flores D. Intratubular hydrodynamic forces influence tubulointerstitial fibrosis in the kidney. Curr Opin Nephrol Hypertens 2010, 19:65-71.
-
(2010)
Curr Opin Nephrol Hypertens
, vol.19
, pp. 65-71
-
-
Rohatgi, R.1
Flores, D.2
-
51
-
-
77955602214
-
TGF-beta receptor deletion in the renal collecting system exacerbates fibrosis
-
Gewin L., Bulus N., Mernaugh G., Moeckel G., Harris R.C., Moses H.L., et al. TGF-beta receptor deletion in the renal collecting system exacerbates fibrosis. J Am Soc Nephrol 2010, 21:1334-1343.
-
(2010)
J Am Soc Nephrol
, vol.21
, pp. 1334-1343
-
-
Gewin, L.1
Bulus, N.2
Mernaugh, G.3
Moeckel, G.4
Harris, R.C.5
Moses, H.L.6
-
52
-
-
0037435009
-
Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema
-
Morris D.G., Huang X., Kaminski N., Wang Y., Shapiro S.D., Dolganov G., et al. Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema. Nature 2003, 422:169-173.
-
(2003)
Nature
, vol.422
, pp. 169-173
-
-
Morris, D.G.1
Huang, X.2
Kaminski, N.3
Wang, Y.4
Shapiro, S.D.5
Dolganov, G.6
-
53
-
-
0342460497
-
Expression of a dominant-negative mutant TGF-beta type II receptor in transgenic mice reveals essential roles for TGF-beta in regulation of growth and differentiation in the exocrine pancreas
-
Bottinger E.P., Jakubczak J.L., Roberts I.S., Mumy M., Hemmati P., Bagnall K., et al. Expression of a dominant-negative mutant TGF-beta type II receptor in transgenic mice reveals essential roles for TGF-beta in regulation of growth and differentiation in the exocrine pancreas. EMBO J 1997, 16:2621-2633.
-
(1997)
EMBO J
, vol.16
, pp. 2621-2633
-
-
Bottinger, E.P.1
Jakubczak, J.L.2
Roberts, I.S.3
Mumy, M.4
Hemmati, P.5
Bagnall, K.6
-
54
-
-
34249091068
-
Inflammatory cells in renal injury and repair
-
Ferenbach D., Kluth D.C., Hughes J. Inflammatory cells in renal injury and repair. Semin Nephrol 2007, 27:250-259.
-
(2007)
Semin Nephrol
, vol.27
, pp. 250-259
-
-
Ferenbach, D.1
Kluth, D.C.2
Hughes, J.3
-
55
-
-
26944492287
-
Macrophages and progressive tubulointerstitial disease
-
Sean Eardley K., Cockwell P. Macrophages and progressive tubulointerstitial disease. Kidney Int 2005, 68:437-455.
-
(2005)
Kidney Int
, vol.68
, pp. 437-455
-
-
Sean Eardley, K.1
Cockwell, P.2
-
56
-
-
16844377774
-
Interleukin-6 regulation of transforming growth factor (TGF)-beta receptor compartmentalization and turnover enhances TGF-beta1 signaling
-
Zhang X.L., Topley N., Ito T., Phillips A. Interleukin-6 regulation of transforming growth factor (TGF)-beta receptor compartmentalization and turnover enhances TGF-beta1 signaling. J Biol Chem 2005, 280:12239-12245.
-
(2005)
J Biol Chem
, vol.280
, pp. 12239-12245
-
-
Zhang, X.L.1
Topley, N.2
Ito, T.3
Phillips, A.4
-
57
-
-
0026799402
-
Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease
-
Shull M.M., Ormsby I., Kier A.B., Pawlowski S., Diebold R.J., Yin M., et al. Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature 1992, 359:693-699.
-
(1992)
Nature
, vol.359
, pp. 693-699
-
-
Shull, M.M.1
Ormsby, I.2
Kier, A.B.3
Pawlowski, S.4
Diebold, R.J.5
Yin, M.6
-
58
-
-
0031944290
-
Regulation of immune responses by TGF-beta
-
Letterio J.J., Roberts A.B. Regulation of immune responses by TGF-beta. Annu Rev Immunol 1998, 16:137-161.
-
(1998)
Annu Rev Immunol
, vol.16
, pp. 137-161
-
-
Letterio, J.J.1
Roberts, A.B.2
-
59
-
-
0030584697
-
Transforming growth factor-beta 1 is the predominant paracrine inhibitor of macrophage cytokine synthesis produced by glomerular mesangial cells
-
Kitamura M., Suto T., Yokoo T., Shimizu F., Fine L.G. Transforming growth factor-beta 1 is the predominant paracrine inhibitor of macrophage cytokine synthesis produced by glomerular mesangial cells. J Immunol 1996, 156:2964-2971.
-
(1996)
J Immunol
, vol.156
, pp. 2964-2971
-
-
Kitamura, M.1
Suto, T.2
Yokoo, T.3
Shimizu, F.4
Fine, L.G.5
-
60
-
-
0028953810
-
Transforming growth factor beta and cell cycle regulation
-
Alexandrow M.G., Moses H.L. Transforming growth factor beta and cell cycle regulation. Cancer Res 1995, 55:1452-1457.
-
(1995)
Cancer Res
, vol.55
, pp. 1452-1457
-
-
Alexandrow, M.G.1
Moses, H.L.2
-
61
-
-
33645577150
-
TGF-beta1 induces IL-8 and MCP-1 through a connective tissue growth factor-independent pathway
-
Qi W., Chen X., Polhill T.S., Sumual S., Twigg S., Gilbert R.E., et al. TGF-beta1 induces IL-8 and MCP-1 through a connective tissue growth factor-independent pathway. Am J Physiol Renal Physiol 2006, 290:F703-F709.
-
(2006)
Am J Physiol Renal Physiol
, vol.290
-
-
Qi, W.1
Chen, X.2
Polhill, T.S.3
Sumual, S.4
Twigg, S.5
Gilbert, R.E.6
-
62
-
-
0029823534
-
Significance of postglomerular capillaries in the pathogenesis of chronic renal failure
-
Bohle A., Mackensen-Haen S., Wehrmann M. Significance of postglomerular capillaries in the pathogenesis of chronic renal failure. Kidney Blood Press Res 1996, 19:191-195.
-
(1996)
Kidney Blood Press Res
, vol.19
, pp. 191-195
-
-
Bohle, A.1
Mackensen-Haen, S.2
Wehrmann, M.3
-
63
-
-
57049135813
-
Stable expression of HIF-1alpha in tubular epithelial cells promotes interstitial fibrosis
-
Kimura K., Iwano M., Higgins D.F., Yamaguchi Y., Nakatani K., Harada K., et al. Stable expression of HIF-1alpha in tubular epithelial cells promotes interstitial fibrosis. Am J Physiol Renal Physiol 2008, 295:F1023-F1029.
-
(2008)
Am J Physiol Renal Physiol
, vol.295
-
-
Kimura, K.1
Iwano, M.2
Higgins, D.F.3
Yamaguchi, Y.4
Nakatani, K.5
Harada, K.6
-
64
-
-
68049097209
-
Vascular consequences of dietary salt intake
-
Sanders P.W. Vascular consequences of dietary salt intake. Am J Physiol Renal Physiol 2009, 297:F237-F243.
-
(2009)
Am J Physiol Renal Physiol
, vol.297
-
-
Sanders, P.W.1
-
65
-
-
33847227976
-
High-expression of transforming growth factor beta1 and phosphorylation of extracellular signal-regulated protein kinase in vascular smooth muscle cells from aorta and renal arterioles of spontaneous hypertension rats
-
Jing L., Zhang J.Z., Zhao L., Wang Y.L., Guo F.Y. High-expression of transforming growth factor beta1 and phosphorylation of extracellular signal-regulated protein kinase in vascular smooth muscle cells from aorta and renal arterioles of spontaneous hypertension rats. Clin Exp Hypertens 2007, 29:107-117.
-
(2007)
Clin Exp Hypertens
, vol.29
, pp. 107-117
-
-
Jing, L.1
Zhang, J.Z.2
Zhao, L.3
Wang, Y.L.4
Guo, F.Y.5
-
66
-
-
33645458871
-
CD44 disruption prevents degeneration of the capillary network in obstructive nephropathy via reduction of TGF-beta1-induced apoptosis
-
Rouschop K.M., Claessen N., Pals S.T., Weening J.J., Florquin S. CD44 disruption prevents degeneration of the capillary network in obstructive nephropathy via reduction of TGF-beta1-induced apoptosis. J Am Soc Nephrol 2006, 17:746-753.
-
(2006)
J Am Soc Nephrol
, vol.17
, pp. 746-753
-
-
Rouschop, K.M.1
Claessen, N.2
Pals, S.T.3
Weening, J.J.4
Florquin, S.5
-
67
-
-
55249103431
-
Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition
-
Zeisberg E.M., Potenta S.E., Sugimoto H., Zeisberg M., Kalluri R. Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition. J Am Soc Nephrol 2008, 19:2282-2287.
-
(2008)
J Am Soc Nephrol
, vol.19
, pp. 2282-2287
-
-
Zeisberg, E.M.1
Potenta, S.E.2
Sugimoto, H.3
Zeisberg, M.4
Kalluri, R.5
-
68
-
-
0025313526
-
Transforming growth factor-beta 1 modulates basic fibroblast growth factor-induced proteolytic and angiogenic properties of endothelial cells in vitro
-
Pepper M.S., Belin D., Montesano R., Orci L., Vassalli J.D. Transforming growth factor-beta 1 modulates basic fibroblast growth factor-induced proteolytic and angiogenic properties of endothelial cells in vitro. J Cell Biol 1990, 111:743-755.
-
(1990)
J Cell Biol
, vol.111
, pp. 743-755
-
-
Pepper, M.S.1
Belin, D.2
Montesano, R.3
Orci, L.4
Vassalli, J.D.5
-
69
-
-
3242757526
-
TGF-beta induces proangiogenic and antiangiogenic factors via parallel but distinct Smad pathways
-
Nakagawa T., Li J.H., Garcia G., Mu W., Piek E., Bottinger E.P., et al. TGF-beta induces proangiogenic and antiangiogenic factors via parallel but distinct Smad pathways. Kidney Int 2004, 66:605-613.
-
(2004)
Kidney Int
, vol.66
, pp. 605-613
-
-
Nakagawa, T.1
Li, J.H.2
Garcia, G.3
Mu, W.4
Piek, E.5
Bottinger, E.P.6
-
70
-
-
0035124069
-
Impaired angiogenesis in the aging kidney: vascular endothelial growth factor and thrombospondin-1 in renal disease
-
Kang D.H., Anderson S., Kim Y.G., Mazzalli M., Suga S., Jefferson J.A., et al. Impaired angiogenesis in the aging kidney: vascular endothelial growth factor and thrombospondin-1 in renal disease. Am J Kidney Dis 2001, 37:601-611.
-
(2001)
Am J Kidney Dis
, vol.37
, pp. 601-611
-
-
Kang, D.H.1
Anderson, S.2
Kim, Y.G.3
Mazzalli, M.4
Suga, S.5
Jefferson, J.A.6
-
71
-
-
0034917262
-
Impaired angiogenesis in the remnant kidney model: II. Vascular endothelial growth factor administration reduces renal fibrosis and stabilizes renal function
-
Kang D.H., Hughes J., Mazzali M., Schreiner G.F., Johnson R.J. Impaired angiogenesis in the remnant kidney model: II. Vascular endothelial growth factor administration reduces renal fibrosis and stabilizes renal function. J Am Soc Nephrol 2001, 12:1448-1457.
-
(2001)
J Am Soc Nephrol
, vol.12
, pp. 1448-1457
-
-
Kang, D.H.1
Hughes, J.2
Mazzali, M.3
Schreiner, G.F.4
Johnson, R.J.5
-
72
-
-
14044257274
-
Transforming growth factor-beta in acute renal failure: receptor expression, effects on proliferation, cellularity, and vascularization after recovery from injury
-
Spurgeon K.R., Donohoe D.L., Basile D.P. Transforming growth factor-beta in acute renal failure: receptor expression, effects on proliferation, cellularity, and vascularization after recovery from injury. Am J Physiol Renal Physiol 2005, 288:F568-F577.
-
(2005)
Am J Physiol Renal Physiol
, vol.288
-
-
Spurgeon, K.R.1
Donohoe, D.L.2
Basile, D.P.3
-
73
-
-
40749089639
-
Dual roles of immunoregulatory cytokine TGF-beta in the pathogenesis of autoimmunity-mediated organ damage
-
Saxena V., Lienesch D.W., Zhou M., Bommireddy R., Azhar M., Doetschman T., et al. Dual roles of immunoregulatory cytokine TGF-beta in the pathogenesis of autoimmunity-mediated organ damage. J Immunol 2008, 180:1903-1912.
-
(2008)
J Immunol
, vol.180
, pp. 1903-1912
-
-
Saxena, V.1
Lienesch, D.W.2
Zhou, M.3
Bommireddy, R.4
Azhar, M.5
Doetschman, T.6
-
74
-
-
77952998952
-
IL-10/TGF-beta-modified macrophages induce regulatory T cells and protect against adriamycin nephrosis
-
Cao Q., Wang Y., Zheng D., Sun Y., Lee V.W., Zheng G., et al. IL-10/TGF-beta-modified macrophages induce regulatory T cells and protect against adriamycin nephrosis. J Am Soc Nephrol 2010, 21:933-942.
-
(2010)
J Am Soc Nephrol
, vol.21
, pp. 933-942
-
-
Cao, Q.1
Wang, Y.2
Zheng, D.3
Sun, Y.4
Lee, V.W.5
Zheng, G.6
-
75
-
-
15944368868
-
Blockade of NFkappaB activation and renal inflammation by ultrasound-mediated gene transfer of Smad7 in rat remnant kidney
-
Ng Y.Y., Hou C.C., Wang W., Huang X.R., Lan H.Y. Blockade of NFkappaB activation and renal inflammation by ultrasound-mediated gene transfer of Smad7 in rat remnant kidney. Kidney Int Suppl 2005, 94:S83-S91.
-
(2005)
Kidney Int Suppl
, vol.94
-
-
Ng, Y.Y.1
Hou, C.C.2
Wang, W.3
Huang, X.R.4
Lan, H.Y.5
-
76
-
-
79551599216
-
The protective role of Smad7 in diabetic kidney disease: mechanism and therapeutic potential
-
Chen H.Y., Huang X.R., Wang W., Li J.H., Heuchel R.L., Chung A.C., et al. The protective role of Smad7 in diabetic kidney disease: mechanism and therapeutic potential. Diabetes 2011, 60:590-601.
-
(2011)
Diabetes
, vol.60
, pp. 590-601
-
-
Chen, H.Y.1
Huang, X.R.2
Wang, W.3
Li, J.H.4
Heuchel, R.L.5
Chung, A.C.6
-
77
-
-
23944486004
-
Signaling mechanism of TGF-beta1 in prevention of renal inflammation: role of Smad7
-
Wang W., Huang X.R., Li A.G., Liu F., Li J.H., Truong L.D., et al. Signaling mechanism of TGF-beta1 in prevention of renal inflammation: role of Smad7. J Am Soc Nephrol 2005, 16:1371-1383.
-
(2005)
J Am Soc Nephrol
, vol.16
, pp. 1371-1383
-
-
Wang, W.1
Huang, X.R.2
Li, A.G.3
Liu, F.4
Li, J.H.5
Truong, L.D.6
-
79
-
-
84872427169
-
Disruption of Smad4 impairs TGF-beta/Smad3 and Smad7 transcriptional regulation during renal inflammation and fibrosis in vivo and in vitro
-
Meng X., Huang X.R., Xiao J., Chung A.C., Qin W., Chen H.Y., et al. Disruption of Smad4 impairs TGF-beta/Smad3 and Smad7 transcriptional regulation during renal inflammation and fibrosis in vivo and in vitro. Kidney Int 2011.
-
(2011)
Kidney Int
-
-
Meng, X.1
Huang, X.R.2
Xiao, J.3
Chung, A.C.4
Qin, W.5
Chen, H.Y.6
-
80
-
-
51649106180
-
Cell-specific delivery of a transforming growth factor-beta type I receptor kinase inhibitor to proximal tubular cells for the treatment of renal fibrosis
-
Prakash J., de Borst M.H., van Loenen-Weemaes A.M., Lacombe M., Opdam F., van Goor H., et al. Cell-specific delivery of a transforming growth factor-beta type I receptor kinase inhibitor to proximal tubular cells for the treatment of renal fibrosis. Pharm Res 2008, 10:2427-2439.
-
(2008)
Pharm Res
, vol.10
, pp. 2427-2439
-
-
Prakash, J.1
de Borst, M.H.2
van Loenen-Weemaes, A.M.3
Lacombe, M.4
Opdam, F.5
van Goor, H.6
-
81
-
-
0037100520
-
Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable
-
Leveen P., Larsson J., Ehinger M., Cilio C.M., Sundler M., Sjostrand L.J., et al. Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable. Blood 2002, 100:560-568.
-
(2002)
Blood
, vol.100
, pp. 560-568
-
-
Leveen, P.1
Larsson, J.2
Ehinger, M.3
Cilio, C.M.4
Sundler, M.5
Sjostrand, L.J.6
|