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Volumn 4, Issue , 2014, Pages

Pharmacological targeting of the β-amyloid precursor protein intracellular domain

Author keywords

[No Author keywords available]

Indexed keywords

1 (3',4' DICHLORO 2 FLUORO(1,1' BIPHENYL) 4 YL)CYCLOPROPANECARBOXYLIC ACID; 1-(3',4'-DICHLORO-2-FLUORO(1,1'-BIPHENYL)-4-YL)CYCLOPROPANECARBOXYLIC ACID; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); AMYLOID PRECURSOR PROTEIN; CD82 ANTIGEN; CD82 PROTEIN, HUMAN; CYCLOPROPANE DERIVATIVE; DRUG DERIVATIVE; FLURBIPROFEN; HISTONE; PEPTIDE FRAGMENT; SECRETASE;

EID: 84898459011     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep04618     Document Type: Article
Times cited : (20)

References (49)
  • 1
    • 17044439021 scopus 로고    scopus 로고
    • Alzheimer's disease: Abeta, tau and synaptic dysfunction
    • LaFerla, F. M. & Oddo, S. Alzheimer's disease: Abeta, tau and synaptic dysfunction. Trends Mol. Med. 11, 170-6 (2005).
    • (2005) Trends Mol. Med. , vol.11 , pp. 170-176
    • Laferla, F.M.1    Oddo, S.2
  • 2
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer's disease: Genes, proteins, and therapy
    • Selkoe, D. J. Alzheimer's disease: genes, proteins, and therapy. Physiol. Rev. 81, 741-66 (2001). (Pubitemid 32267077)
    • (2001) Physiological Reviews , vol.81 , Issue.2 , pp. 741-766
    • Selkoe, D.J.1
  • 3
    • 83555176204 scopus 로고    scopus 로고
    • Nuclear signalling by membrane protein intracellular domains: The AICD enigma
    • Beckett, C., Nalivaeva, N. N., Belyaev, N. D. & Turner, A. J. Nuclear signalling by membrane protein intracellular domains: the AICD enigma. Cell. Signal. 24, 402-9 (2012).
    • (2012) Cell. Signal. , vol.24 , pp. 402-409
    • Beckett, C.1    Nalivaeva, N.N.2    Belyaev, N.D.3    Turner, A.J.4
  • 4
    • 84872812991 scopus 로고    scopus 로고
    • Gamma-secretase-dependent proteolysis of transmembrane domain of amyloid precursor protein: Successive tri-and tetrapeptide release in amyloid beta-protein production
    • Takami, M. & Funamoto, S. gamma-Secretase-Dependent Proteolysis of Transmembrane Domain of Amyloid Precursor Protein: Successive Tri-and Tetrapeptide Release in Amyloid beta-Protein Production. Int. J. Alzheimers Dis. 2012, 591392 (2012).
    • (2012) Int. J. Alzheimers Dis. , vol.2012 , pp. 591392
    • Takami, M.1    Funamoto, S.2
  • 6
    • 79959636033 scopus 로고    scopus 로고
    • The many substrates of presenilin/gammasecretase
    • Haapasalo, A. & Kovacs, D. M. The many substrates of presenilin/gammasecretase. J. Alzheimers Dis. 25, 3-28 (2011).
    • (2011) J. Alzheimers Dis. , vol.25 , pp. 3-28
    • Haapasalo, A.1    Kovacs, D.M.2
  • 7
    • 78650669822 scopus 로고    scopus 로고
    • The transcriptionally active amyloid precursor protein (APP) intracellular domain is preferentially produced from the 695 isoform of APP in a beta-secretase-dependent pathway
    • Belyaev, N. D. et al. The transcriptionally active amyloid precursor protein (APP) intracellular domain is preferentially produced from the 695 isoform of APP in a beta-secretase-dependent pathway. J. Biol. Chem. 285, 41443-54 (2010).
    • (2010) J. Biol. Chem. , vol.285 , pp. 41443-41454
    • Belyaev, N.D.1
  • 8
    • 70350370474 scopus 로고    scopus 로고
    • Nuclear signaling by the APP intracellular domain occurs predominantly through the amyloidogenic processing pathway
    • Goodger, Z. V. et al. Nuclear signaling by the APP intracellular domain occurs predominantly through the amyloidogenic processing pathway. J. Cell Sci. 122, 3703-14 (2009).
    • (2009) J. Cell Sci. , vol.122 , pp. 3703-3714
    • Goodger, Z.V.1
  • 9
    • 70450235497 scopus 로고    scopus 로고
    • Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain
    • Ghosal, K. et al. Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain. Proc. Natl. Acad. Sci. U. S. A. 106, 18367-72 (2009).
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 18367-18372
    • Ghosal, K.1
  • 10
    • 84857720147 scopus 로고    scopus 로고
    • AICD nuclear signaling and its possible contribution toAlzheimer's disease
    • Konietzko, U. AICD nuclear signaling and its possible contribution toAlzheimer's disease. Curr. Alzheimer Res. 9, 200-16 (2012).
    • (2012) Curr. Alzheimer Res. , vol.9 , pp. 200-216
    • Konietzko, U.1
  • 12
    • 0035955693 scopus 로고    scopus 로고
    • The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner
    • Kimberly, W. T., Zheng, J. B., Guenette, S. Y. & Selkoe, D. J. The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner. J. Biol. Chem. 276, 40288-92 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 40288-40292
    • Kimberly, W.T.1    Zheng, J.B.2    Guenette, S.Y.3    Selkoe, D.J.4
  • 13
    • 0036677928 scopus 로고    scopus 로고
    • Direct visualization of the gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein: Association with Fe65 and translocation to the nucleus
    • Kinoshita, A.,Whelan, C. M., Smith, C. J., Berezovska, O. & Hyman, B. T. Direct visualization of the gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein: association with Fe65 and translocation to the nucleus. J. Neurochem. 82, 839-47 (2002).
    • (2002) J. Neurochem. , vol.82 , pp. 839-847
    • Kinoshita, A.1    Whelan, C.M.2    Smith, C.J.3    Berezovska, O.4    Hyman, B.T.5
  • 14
    • 5444275067 scopus 로고    scopus 로고
    • The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor
    • von Rotz, R. C. et al. The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor. J. Cell Sci. 117, 4435-48 (2004).
    • (2004) J. Cell Sci. , vol.117 , pp. 4435-4448
    • Von Rotz, R.C.1
  • 15
    • 0037067655 scopus 로고    scopus 로고
    • Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-κB and β-amyloid precursor protein
    • DOI 10.1016/S0092-8674(02)00809-7
    • Baek, S. H. et al. Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein. Cell 110, 55-67 (2002). (Pubitemid 34874606)
    • (2002) Cell , vol.110 , Issue.1 , pp. 55-67
    • Baek, S.H.1    Ohgi, K.A.2    Rose, D.W.3    Koo, E.H.4    Glass, C.K.5    Rosenfeld, M.G.6
  • 16
    • 0035816661 scopus 로고    scopus 로고
    • A transcriptivety active complex of APP with Fe65 and histone acetyltransferase Tip60
    • DOI 10.1126/science.1058783
    • Cao, X. & Sudhof, T. C. A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60. Science 293, 115-20 (2001). (Pubitemid 32625507)
    • (2001) Science , vol.293 , Issue.5527 , pp. 115-120
    • Cao, X.1    Sudhof, T.C.2
  • 17
    • 33845324145 scopus 로고    scopus 로고
    • C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3beta expression
    • Kim, H. S. et al. C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3beta expression. Faseb J. 17, 1951-3 (2003).
    • (2003) Faseb J. , vol.17 , pp. 1951-1953
    • Kim, H.S.1
  • 19
    • 27544442991 scopus 로고    scopus 로고
    • Activation of GSK-3 and phosphorylation of CRMP2 in transgenic mice expressing APP intracellular domain
    • DOI 10.1083/jcb.200505078
    • Ryan, K. A. & Pimplikar, S. W. Activation of GSK-3 and phosphorylation of CRMP2 in transgenicmice expressing APP intracellular domain. J. Cell Biol. 171, 327-35 (2005). (Pubitemid 41540024)
    • (2005) Journal of Cell Biology , vol.171 , Issue.2 , pp. 327-335
    • Ryan, K.A.1    Pimplikar, S.W.2
  • 21
    • 77955637621 scopus 로고    scopus 로고
    • APP intracellular domain impairs adult neurogenesis in transgenicmice by inducing neuroinflammation
    • Ghosal, K., Stathopoulos, A. & Pimplikar, S. W. APP intracellular domain impairs adult neurogenesis in transgenicmice by inducing neuroinflammation. PLoS One 5, e11866 (2010).
    • (2010) PLoS One , vol.5
    • Ghosal, K.1    Stathopoulos, A.2    Pimplikar, S.W.3
  • 23
    • 48349085043 scopus 로고    scopus 로고
    • The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-relevance for Alzheimer's disease
    • Muller, T., Meyer, H. E., Egensperger, R. & Marcus, K. The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-relevance for Alzheimer's disease. Prog. Neurobiol. 85, 393-406 (2008).
    • (2008) Prog. Neurobiol. , vol.85 , pp. 393-406
    • Muller, T.1    Meyer, H.E.2    Egensperger, R.3    Marcus, K.4
  • 24
    • 84655166492 scopus 로고    scopus 로고
    • The physiology of the beta-amyloid precursor protein intracellular domain AICD
    • Pardossi-Piquard, R. & Checler, F. The physiology of the beta-amyloid precursor protein intracellular domain AICD. J. Neurochem. 120 Suppl 1, 109-24 (2012).
    • (2012) J. Neurochem. , vol.120 , Issue.1 SUPPL. , pp. 109-124
    • Pardossi-Piquard, R.1    Checler, F.2
  • 25
    • 67650604641 scopus 로고    scopus 로고
    • CHF5074, a novel gamma-secretase modulator, attenuates brain beta-amyloid pathology and learning deficit in a mouse model of Alzheimer's disease
    • Imbimbo, B. P. et al. CHF5074, a novel gamma-secretase modulator, attenuates brain beta-amyloid pathology and learning deficit in a mouse model of Alzheimer's disease. Br. J. Pharmacol. 156, 982-93 (2009).
    • (2009) Br. J. Pharmacol. , vol.156 , pp. 982-993
    • Imbimbo, B.P.1
  • 26
    • 79960957636 scopus 로고    scopus 로고
    • The gamma-secretase modulator CHF5074 reduces the accumulation of native hyperphosphorylated tau in a transgenic mouse model of Alzheimer's disease
    • Lanzillotta, A. et al. The gamma-secretase modulator CHF5074 reduces the accumulation of native hyperphosphorylated tau in a transgenic mouse model of Alzheimer's disease. J. Mol. Neurosci. 45, 22-31 (2011).
    • (2011) J. Mol. Neurosci. , vol.45 , pp. 22-31
    • Lanzillotta, A.1
  • 27
    • 77954512014 scopus 로고    scopus 로고
    • CHF5074, a novel gamma-secretase modulator, restores hippocampal neurogenesis potential and reverses contextual memory deficit in a transgenic mouse model of Alzheimer's disease
    • Imbimbo, B. P. et al. CHF5074, a novel gamma-secretase modulator, restores hippocampal neurogenesis potential and reverses contextual memory deficit in a transgenic mouse model of Alzheimer's disease. J. Alzheimers Dis. 20, 159-73 (2010).
    • (2010) J. Alzheimers Dis. , vol.20 , pp. 159-173
    • Imbimbo, B.P.1
  • 28
    • 84875853369 scopus 로고    scopus 로고
    • Multi-target action of the novel anti-Alzheimer compound CHF5074: In vivo study of long term treatment in Tg2576 mice
    • Sivilia, S. et al. Multi-target action of the novel anti-Alzheimer compound CHF5074: in vivo study of long term treatment in Tg2576 mice. BMC Neurosci. 14, 44 (2013).
    • (2013) BMC Neurosci. , vol.14 , pp. 44
    • Sivilia, S.1
  • 29
    • 84888267995 scopus 로고    scopus 로고
    • CHF5074 Reduces Biomarkers of Neuroinflammation in Patients with Mild Cognitive Impairment: A 12-Week, Double-Blind, Placebo-Controlled Study
    • Ross, J. et al. CHF5074 Reduces Biomarkers of Neuroinflammation in Patients with Mild Cognitive Impairment: A 12-Week, Double-Blind, Placebo-Controlled Study. Curr. Alzheimer Res. 10, 742-53 (2013).
    • (2013) Curr. Alzheimer Res. , vol.10 , pp. 742-753
    • Ross, J.1
  • 31
    • 84883295915 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of CHF5074 after short-term administration in healthy subjects
    • Imbimbo, B. P. et al. Pharmacokinetics and Pharmacodynamics of CHF5074 After Short-term Administration in Healthy Subjects. Alzheimer Dis. Assoc. Disord. 27, 278-86 (2013).
    • (2013) Alzheimer Dis. Assoc. Disord. , vol.27 , pp. 278-286
    • Imbimbo, B.P.1
  • 32
    • 79959222583 scopus 로고    scopus 로고
    • The gamma-secretase modulator CHF5074 restores memory and hippocampal synaptic plasticity in plaque-free Tg2576 mice
    • Balducci, C. et al. The gamma-secretase modulator CHF5074 restores memory and hippocampal synaptic plasticity in plaque-free Tg2576 mice. J. Alzheimers Dis. 24, 799-816 (2011).
    • (2011) J. Alzheimers Dis. , vol.24 , pp. 799-816
    • Balducci, C.1
  • 33
    • 84874116487 scopus 로고    scopus 로고
    • CHF5074 restores visual memory ability and pre-synaptic cortical acetylcholine release in pre-plaque Tg2576 mice
    • Giuliani, A. et al. CHF5074 restores visual memory ability and pre-synaptic cortical acetylcholine release in pre-plaque Tg2576 mice. J. Neurochem. 124, 613-20 (2013).
    • (2013) J. Neurochem. , vol.124 , pp. 613-620
    • Giuliani, A.1
  • 35
    • 45149105232 scopus 로고    scopus 로고
    • Substrate-targeting gamma-secretase modulators
    • Kukar, T. L. et al. Substrate-targeting gamma-secretase modulators. Nature 453, 925-9 (2008).
    • (2008) Nature , vol.453 , pp. 925-929
    • Kukar, T.L.1
  • 37
    • 70350451482 scopus 로고    scopus 로고
    • Gamma-Secretase: Successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment
    • Takami, M. et al. gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment. J. Neurosci. 29, 13042-52 (2009).
    • (2009) J. Neurosci. , vol.29 , pp. 13042-13052
    • Takami, M.1
  • 38
    • 0037047434 scopus 로고    scopus 로고
    • The γ secretase-generated carboxyl-terminal domain of the amyloid precursor protein induces apoptosis via Tip60 in H4 cells
    • DOI 10.1074/jbc.M203372200
    • Kinoshita, A., Whelan, C. M., Berezovska, O. & Hyman, B. T. The gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein induces apoptosis via Tip60 in H4 cells. J Biol Chem 277, 28530-6 (2002). (Pubitemid 41079279)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.32 , pp. 28530-28536
    • Kinoshita, A.1    Whelan, C.M.2    Berezovska, O.3    Hyman, B.T.4
  • 39
    • 2642582435 scopus 로고    scopus 로고
    • Dissection of amyloid-β precursor protein-dependent transcriptional transactivation
    • DOI 10.1074/jbc.M402248200
    • Cao, X. & Sudhof, T. C. Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation. J. Biol. Chem. 279, 24601-11 (2004). (Pubitemid 38725327)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.23 , pp. 24601-24611
    • Cao, X.1    Sudhof, T.C.2
  • 40
    • 78649496201 scopus 로고    scopus 로고
    • Tyr(682) in the intracellular domain of APP regulates amyloidogenic APP processing in vivo
    • Barbagallo, A. P. et al. Tyr(682) in the intracellular domain of APP regulates amyloidogenic APP processing in vivo. PLoS One 5, e15503 (2010).
    • (2010) PLoS One , vol.5
    • Barbagallo, A.P.1
  • 41
    • 33947529531 scopus 로고    scopus 로고
    • RNA interference silencing of the adaptor molecules ShcC and Fe65 differentially affect amyloid precursor protein processing and Aβ generation
    • DOI 10.1074/jbc.M609293200
    • Xie, Z., Dong, Y.,Maeda, U., Xia, W. & Tanzi, R. E. RNA interference silencing of the adaptor molecules ShcC and Fe65 differentially affect amyloid precursor protein processing and Abeta generation. J. Biol. Chem. 282, 4318-25 (2007). (Pubitemid 47100999)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.7 , pp. 4318-4325
    • Xie, Z.1    Dong, Y.2    Maeda, U.3    Xia, W.4    Tanzi, R.E.5
  • 42
    • 33646480747 scopus 로고    scopus 로고
    • Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664
    • Galvan, V. et al. Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664. Proc. Natl. Acad. Sci. U. S. A. 103, 7130-5 (2006).
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 7130-7135
    • Galvan, V.1
  • 43
    • 79751470954 scopus 로고    scopus 로고
    • Secretase-independent and RhoGTPase/PAK/ERKdependent regulation of cytoskeleton dynamics in astrocytes by NSAIDs and derivatives
    • Lichtenstein, M. P. et al. Secretase-independent and RhoGTPase/PAK/ ERKdependent regulation of cytoskeleton dynamics in astrocytes by NSAIDs and derivatives. J. Alzheimers Dis. 22, 1135-55 (2010).
    • (2010) J. Alzheimers Dis. , vol.22 , pp. 1135-1155
    • Lichtenstein, M.P.1
  • 45
    • 34249951869 scopus 로고    scopus 로고
    • Involvement of beta-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity
    • Ma,H. et al. Involvement of beta-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity. Proc. Natl. Acad. Sci. U. S. A. 104, 8167-72 (2007).
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 8167-8172
    • Ma, H.1
  • 46
    • 58049089518 scopus 로고    scopus 로고
    • Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: Implications for Alzheimer disease
    • Belyaev, N. D., Nalivaeva, N. N., Makova, N. Z. & Turner, A. J. Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease. EMBO Rep. 10, 94-100 (2009).
    • (2009) EMBO Rep. , vol.10 , pp. 94-100
    • Belyaev, N.D.1    Nalivaeva, N.N.2    Makova, N.Z.3    Turner, A.J.4
  • 47
    • 84868307896 scopus 로고    scopus 로고
    • Detection of APP intracellular domain in brain tissue
    • Pimplikar, S. W. & Suryanarayana, A. Detection of APP intracellular domain in brain tissue. Methods Mol. Biol. 670, 85-91 (2011).
    • (2011) Methods Mol. Biol. , vol.670 , pp. 85-91
    • Pimplikar, S.W.1    Suryanarayana, A.2
  • 48
    • 64349084708 scopus 로고    scopus 로고
    • Purification, pharmacological modulation, and biochemical characterization of interactors of endogenous human gamma-secretase
    • Winkler, E. et al. Purification, pharmacological modulation, and biochemical characterization of interactors of endogenous human gamma-secretase. Biochemistry 48, 1183-97 (2009).
    • (2009) Biochemistry , vol.48 , pp. 1183-1197
    • Winkler, E.1
  • 49
    • 61349175777 scopus 로고    scopus 로고
    • Potent anti-HPV immune responses induced by tandem repeats of the HPV16 L2 (20-38) peptide displayed on bacterial thioredoxin
    • Rubio, I. et al. Potent anti-HPV immune responses induced by tandem repeats of the HPV16 L2 (20-38) peptide displayed on bacterial thioredoxin. Vaccine 27, 1949-56 (2009).
    • (2009) Vaccine , vol.27 , pp. 1949-1956
    • Rubio, I.1


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