Transcription regulation by the adaptor protein Fe65 and the nucleosome assembly factor SET

EMBO Reports

Volumn 6, Issue 1, 2005, Pages 77-82

  Telese, Francesca ^a   Bruni, Paola ^a   Donizetti, Aldo ^a   Gianni, Davide ^a,b   D'Ambrosio, Chiara ^c   Scaloni, Andrea ^c   Zambrano, Nicola ^a   Rosenfeld, Michael G ^b   Russo, Tommaso ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c CNR   (Italy)

Author keywords

Alzheimer; APP; Chromatin immunoprecipitation; KAI1; Tip60

Indexed keywords

AMYLOID PRECURSOR PROTEIN; COMPLEMENTARY DNA; HISTONE ACETYLTRANSFERASE; NUCLEAR PROTEIN; PROTEIN FE65; TRANSCRIPTION FACTOR GAL4; AMYLOID; CD82 ANTIGEN; KAI1 PROTEIN, HUMAN; LEUKOCYTE ANTIGEN; MEMBRANE PROTEIN; NONHISTONE PROTEIN; ONCOPROTEIN; SET PROTEIN, HUMAN; TEMPLATE ACTIVATING FACTOR I; TEMPLATE ACTIVATING FACTOR-I; TRANSCRIPTION FACTOR;

ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN INTERACTION; REPORTER GENE; RNA INTERFERENCE; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; AMINO ACID SEQUENCE; CELL LINE; CHEMISTRY; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOSOME; TRANSACTIVATION;

AMINO ACID SEQUENCE; AMYLOID; ANTIGENS, CD; CELL LINE; CHROMOSOMAL PROTEINS, NON-HISTONE; HUMANS; KANGAI-1 PROTEIN; MEMBRANE GLYCOPROTEINS; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; NUCLEOSOMES; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; PROTO-ONCOGENE PROTEINS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 21444436589     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/sj.embor.7400309     Document Type: Article

References (23)

1. Baek SH, Ohgi KA, Rose DW, Koo EH, Glass CK, Rosenfeld MG (2002) Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-κB and β-amyloid precursor protein. Cell 110: 55-67
2. Cao X, Sudhof TC (2001 ) A transcriptionally active complex of APP with Fe65 and histone acetyltransferase Tip60. Science 293: 115-120
3. Cao X, Sudhof TC (2004) Dissection of amyloid-β precursor protein-dependent transcriptional transactivation. J Biol Chem 279: 24601-24611
4. Ermekova KS, Zambrano N, Linn H, Minopoli G, Gertler F, Russo T, Sudol M (1997) The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled. J Biol Chem 272: 32869-32877
5. Fan Z, Beresford PJ, Oh DY, Zhang D, Lieberman J (2003) Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor. Cell 112: 659-672
6. Fiore F, Zambrano N, Minopoli G, Donini V, Duilio A, Russo T (1995) The regions of the Fe65 protein homologous to the phosphotyrosine interaction/phosphotyrosine binding domain of She bind the intracellular domain of the Alzheimer's amyloid precursor protein. J Biol Chem 270: 30853-30856
7. Gao Y, Pimplikar SW (2001) The γ-secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus. Proc Natl Acad Sci USA 98: 14979-14984
8. Gianni D et al (2003) Platelet-derived growth factor induces the β-γ-secretase-mediated cleavage of Alzheimer's amyloid precursor protein through a Src-Rac-dependent pathway. J Biol Chem 278: 9290-9297
9. Haass C (2004) Take five-BACE and the γ-secretase quartet conduct Alzheimer's amyloid β-peptide generation. EMBO J 23: 483-488
10. Kimberly WT, Zheng JB, Guenette SY, Selkoe DJ (2001) The intracellular domain of the β-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner. J Biol Chem 276: 40288-40292
11. Marambaud P, Wen PH, Dutt A, Shioi J, Takashima A, Siman R, Robakis NK (2003) A CBP binding transcriptional repressor produced by the PS1/-cleavage of N-cadherin is inhibited by PS1 FAD mutations. Cell 114: 635-645
12. Minopoli G, de Candia P, Bonetti A, Faraonio R, Zambrano N, Russo T (2001) The β-amyloid precursor protein functions as a cytosolic anchoring site that prevents Fe65 nuclear translocation. J Biol Chem 276: 6545-6550
13. Muresan Z, Muresan V (2004) A phosphorylated, carboxy-terminal fragment of β-amyloid precursor protein localizes to the splicing factor compartment. Hum Mol Genet 13: 475-488
14. Sabo SL, Ikin AF, Buxbaum JD, Greengard P (2001) The Alzheimer amyloid precursor protein (APP) and FE65, an APP-binding protein, regulate cell movement. J Cell Biol 153: 1403-1414
15. Schweisguth F (2004) Notch signaling activity. Curr Biol 14: 129-138
16. Seo SB, McNamara P, Heo S, Turner A, Lane WS, Chakravarti D (2001) Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein. Cell 104: 119-130
17. Shang Y, Brown M (2002) Molecular determinants for the tissue specificity of SERMs. Science 295: 2465-2468
18. Shikama N et al (2000) Functional interaction between nucleosome assembly proteins and p300/CREB-binding protein family coactivators. Mol Cell Biol 20: 8933-8943
19. Skerra A, Schmidt TGM (2000) Use of the Strep-tag and streptavidin for recombinant protein purification and detection. Methods Enzymol 326: 271-304
20. Sudol M, Hunter T (2000) NeW wrinkles for an old domain. Cell 103: 1001-1004
21. Von Lindern M, van Baal S, Wiegant J, Raap A, Hagemeijer A, Grosveld G (1992) Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3′ half to different genes: characterization of the set gene. Mol Cell Biol 12: 3346-3355
22. Von Rotz RC, Kohli BM, Bosset J, Meier M, Suzuki T, Nitsch RM, Konietzko U (2004) The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor. J Cell Sci 117: 4435-4448
23. Wen C, Levitan D, Li X, Greenwald I (2000) Spr-2, a suppressor of the egg-laying defect caused by loss of Sel-12 presenilin in Caenorhabditis elegans, is a member of the SET protein subfamily. Proc Natl Acad Sci USA 97: 14524-14529