Multi-target action of the novel anti-Alzheimer compound CHF5074: In vivo study of long term treatment in Tg2576 mice

BMC Neuroscience

Volumn 14, Issue , 2013, Pages

  Sivilia, Sandra ^a   Lorenzini, Luca ^a   Giuliani, Alessandro ^a   Gusciglio, Marco ^a,b   Fernandez, Mercedes ^a   Baldassarro, Vito Antonio ^a   Mangano, Chiara ^a   Ferraro, Luca ^b,c   Pietrini, Vladimiro ^d   Baroc, Maria Francesca ^d   Viscomi, Arturo R ^d,f   Ottonello, Simone ^d   Villetti, Gino ^e   Imbimbo, Bruno P ^e   Calzà, Laura ^a,b   Giardino, Luciana ^a,b  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b IRET Foundation   (Italy)

^c UNIVERSITY OF FERRARA   (Italy)

^d UNIVERSITY OF PARMA   (Italy)

^e Research and Development   (Italy)

^f GSK   (Italy)

Author keywords

Alzheimer's disease; Cell cycle events; CHF5074; Dendrite pathology; Tg2576 mice

Indexed keywords

1 [3',4' DICHLORO 2 FLUORO[1,1' BIPHENYL] 4 YL] CYCLOPROPANECARBOXYLIC ACID; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; CHF 5074; CYCLIN A; GAMMA SECRETASE INHIBITOR; N [N (3,5 DIFLUOROPHENACETYL) ALANYL] PHENYLGLYCINE TERT BUTYL ESTER; NEURON SPECIFIC NUCLEAR PROTEIN; NONSTEROID ANTIINFLAMMATORY AGENT; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; DENDRITIC SPINE; DRUG EFFECT; FEMALE; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MEMORY; MICROGLIA; MOUSE; NEUROPROTECTION; NONHUMAN; PROTEIN BLOOD LEVEL; WILD TYPE;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANALYSIS OF VARIANCE; ANIMALS; ANTIPSYCHOTIC AGENTS; BRAIN; CYCLIN A; CYCLOPROPANES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EXPLORATORY BEHAVIOR; FEMALE; FLURBIPROFEN; HUMANS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROGLIA; MUTATION; PEPTIDE FRAGMENTS; PHOSPHOPYRUVATE HYDRATASE; PLAQUE, AMYLOID; RECOGNITION (PSYCHOLOGY); SILVER STAINING;

EID: 84875853369     PISSN: None     EISSN: 14712202     Source Type: Journal    
DOI: 10.1186/1471-2202-14-44     Document Type: Article

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