메뉴 건너뛰기




Volumn 5, Issue MAR, 2014, Pages

Autoimmunity as a double agent in tumor killing and cancer promotion

Author keywords

Antitumor; Autoimmunity; Cytokine; Inflammation; Tumorigenesis

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 23; INTERLEUKIN 4; PSEUDOMONAS EXOTOXIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

EID: 84897946330     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2014.00116     Document Type: Review
Times cited : (43)

References (150)
  • 1
    • 84867209754 scopus 로고    scopus 로고
    • Autoimmunity-mediated antitumor immunity: tumor as an immunoprivileged self
    • doi:10.1002/eji.201242590
    • Miska J, Bas E, Devarajan P, Chen Z. Autoimmunity-mediated antitumor immunity: tumor as an immunoprivileged self. Eur J Immunol (2012) 42:2584-2596. doi:10.1002/eji.201242590
    • (2012) Eur J Immunol , vol.42 , pp. 2584-2596
    • Miska, J.1    Bas, E.2    Devarajan, P.3    Chen, Z.4
  • 2
    • 84886945424 scopus 로고    scopus 로고
    • The immunological identity of tumor: self implications
    • doi:10.4161/onci.23794
    • Miska J, Devarajan P, Chen Z. The immunological identity of tumor: self implications. Oncoimmunology (2013) 2:e23794. doi:10.4161/onci.23794
    • (2013) Oncoimmunology , vol.2
    • Miska, J.1    Devarajan, P.2    Chen, Z.3
  • 3
    • 0035901090 scopus 로고    scopus 로고
    • Inflammation and cancer: back to Virchow?
    • doi:10.1016/S0140-6736(00)04046-0
    • Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow? Lancet (2001) 357:539-45. doi:10.1016/S0140-6736(00)04046-0
    • (2001) Lancet , vol.357 , pp. 539-545
    • Balkwill, F.1    Mantovani, A.2
  • 4
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • doi:10.1016/j.cell.2011.02.013
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell (2011) 144:646-74. doi:10.1016/j.cell.2011.02.013
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 5
    • 33846465547 scopus 로고    scopus 로고
    • Immunostimulatory monoclonal antibodies for cancer therapy
    • doi:10.1038/nrc2051
    • Melero I, Hervas-Stubbs S, Glennie M, Pardoll DM, Chen L. Immunostimulatory monoclonal antibodies for cancer therapy. Nat Rev Cancer (2007) 7:95-106. doi:10.1038/nrc2051
    • (2007) Nat Rev Cancer , vol.7 , pp. 95-106
    • Melero, I.1    Hervas-Stubbs, S.2    Glennie, M.3    Pardoll, D.M.4    Chen, L.5
  • 6
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • doi:10.1056/NEJMoa1003466
    • Hodi FS, O'Day SJ, McDermott DF, Weber RW, Sosman JA, Haanen JB, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med (2010) 363:711-23. doi:10.1056/NEJMoa1003466
    • (2010) N Engl J Med , vol.363 , pp. 711-723
    • Hodi, F.S.1    O'Day, S.J.2    McDermott, D.F.3    Weber, R.W.4    Sosman, J.A.5    Haanen, J.B.6
  • 7
  • 8
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • doi:10.1056/NEJMoa1200694
    • Brahmer JR, Tykodi SS, Chow LQ, Hwu WJ, Topalian SL, Hwu P, et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med (2012) 366:2455-65. doi:10.1056/NEJMoa1200694
    • (2012) N Engl J Med , vol.366 , pp. 2455-2465
    • Brahmer, J.R.1    Tykodi, S.S.2    Chow, L.Q.3    Hwu, W.J.4    Topalian, S.L.5    Hwu, P.6
  • 9
    • 77953337676 scopus 로고    scopus 로고
    • Inhibiting the inhibitors: evaluating agents targeting cancer immunosuppression
    • doi:10.1517/14712598.2010.482207
    • Whiteside TL. Inhibiting the inhibitors: evaluating agents targeting cancer immunosuppression. Expert Opin Biol Ther (2010) 10:1019-35. doi:10.1517/14712598.2010.482207
    • (2010) Expert Opin Biol Ther , vol.10 , pp. 1019-1035
    • Whiteside, T.L.1
  • 10
    • 0842266786 scopus 로고    scopus 로고
    • Interferon-gamma: an overview of signals, mechanisms and functions
    • doi:10.1189/jlb.0603252
    • Schroder K, Hertzog PJ, Ravasi T, Hume DA. Interferon-gamma: an overview of signals, mechanisms and functions. J Leukoc Biol (2004) 75:163-89. doi:10.1189/jlb.0603252
    • (2004) J Leukoc Biol , vol.75 , pp. 163-189
    • Schroder, K.1    Hertzog, P.J.2    Ravasi, T.3    Hume, D.A.4
  • 11
    • 0036005884 scopus 로고    scopus 로고
    • The roles of IFN gamma in protection against tumor development and cancer immunoediting
    • doi:10.1016/S1359-6101(01)00038-7
    • Ikeda H, Old LJ, Schreiber RD. The roles of IFN gamma in protection against tumor development and cancer immunoediting. Cytokine Growth Factor Rev (2002) 13:95-109. doi:10.1016/S1359-6101(01)00038-7
    • (2002) Cytokine Growth Factor Rev , vol.13 , pp. 95-109
    • Ikeda, H.1    Old, L.J.2    Schreiber, R.D.3
  • 12
    • 56849100624 scopus 로고    scopus 로고
    • IFN inducibility of major histocompatibility antigens in tumors
    • doi:10.1016/S0065-230X(08)00407-7
    • Seliger B, Ruiz-Cabello F, Garrido F. IFN inducibility of major histocompatibility antigens in tumors. Adv Cancer Res (2008) 101:249-76. doi:10.1016/S0065-230X(08)00407-7
    • (2008) Adv Cancer Res , vol.101 , pp. 249-276
    • Seliger, B.1    Ruiz-Cabello, F.2    Garrido, F.3
  • 13
    • 52049111828 scopus 로고    scopus 로고
    • How interferon-gamma keeps autoimmune diseases in check
    • doi:10.1016/j.it.2008.07.002
    • Kelchtermans H, Billiau A, Matthys P. How interferon-gamma keeps autoimmune diseases in check. Trends Immunol (2008) 29:479-86. doi:10.1016/j.it.2008.07.002
    • (2008) Trends Immunol , vol.29 , pp. 479-486
    • Kelchtermans, H.1    Billiau, A.2    Matthys, P.3
  • 14
    • 34147130293 scopus 로고    scopus 로고
    • Yin and yang interplay of IFN-gamma in inflammation and autoimmune disease
    • doi:10.1172/JCI31860
    • Zhang J. Yin and yang interplay of IFN-gamma in inflammation and autoimmune disease. J Clin Invest (2007) 117:871-3. doi:10.1172/JCI31860
    • (2007) J Clin Invest , vol.117 , pp. 871-873
    • Zhang, J.1
  • 15
    • 68949114416 scopus 로고    scopus 로고
    • T-bet knockout prevents Helicobacter felis-induced gastric cancer
    • doi:10.4049/jimmunol.0900511
    • Stoicov C, Fan X, Liu JH, Bowen G, Whary M, Kurt-Jones E, et al. T-bet knockout prevents Helicobacter felis-induced gastric cancer. J Immunol (2009) 183:642-9. doi:10.4049/jimmunol.0900511
    • (2009) J Immunol , vol.183 , pp. 642-649
    • Stoicov, C.1    Fan, X.2    Liu, J.H.3    Bowen, G.4    Whary, M.5    Kurt-Jones, E.6
  • 16
    • 84869195346 scopus 로고    scopus 로고
    • Transgenic expression of interferon-gamma in mouse stomach leads to inflammation, metaplasia, and dysplasia
    • doi:10.1016/j.ajpath.2012.08.017
    • Syu LJ, El-Zaatari M, Eaton KA, Liu Z, Tetarbe M, Keeley TM, et al. Transgenic expression of interferon-gamma in mouse stomach leads to inflammation, metaplasia, and dysplasia. Am J Pathol (2012) 181:2114-25. doi:10.1016/j.ajpath.2012.08.017
    • (2012) Am J Pathol , vol.181 , pp. 2114-2125
    • Syu, L.J.1    El-Zaatari, M.2    Eaton, K.A.3    Liu, Z.4    Tetarbe, M.5    Keeley, T.M.6
  • 17
    • 78650983452 scopus 로고    scopus 로고
    • Interferon gamma limits the effectiveness of melanoma peptide vaccines
    • doi:10.1182/blood-2010-08-298117
    • Cho HI, Lee YR, Celis E. Interferon gamma limits the effectiveness of melanoma peptide vaccines. Blood (2011) 117:135-44. doi:10.1182/blood-2010-08-298117
    • (2011) Blood , vol.117 , pp. 135-144
    • Cho, H.I.1    Lee, Y.R.2    Celis, E.3
  • 18
    • 0036855636 scopus 로고    scopus 로고
    • IFN-gamma protects short-term ovarian carcinoma cell lines from CTL lysis via a CD94/NKG2A-dependent mechanism
    • doi:10.1172/JCI200215564
    • Malmberg KJ, Levitsky V, Norell H, de Matos CT, Carlsten M, Schedvins K, et al. IFN-gamma protects short-term ovarian carcinoma cell lines from CTL lysis via a CD94/NKG2A-dependent mechanism. J Clin Invest (2002) 110:1515-23. doi:10.1172/JCI200215564
    • (2002) J Clin Invest , vol.110 , pp. 1515-1523
    • Malmberg, K.J.1    Levitsky, V.2    Norell, H.3    de Matos, C.T.4    Carlsten, M.5    Schedvins, K.6
  • 20
    • 33645782015 scopus 로고    scopus 로고
    • TNF-alpha in cancer treatment: molecular insights, antitumor effects, and clinical utility
    • doi:10.1634/theoncologist.11-4-397
    • van Horssen R, Ten Hagen TL, Eggermont AM. TNF-alpha in cancer treatment: molecular insights, antitumor effects, and clinical utility. Oncologist (2006) 11:397-408. doi:10.1634/theoncologist.11-4-397
    • (2006) Oncologist , vol.11 , pp. 397-408
    • van Horssen, R.1    Ten Hagen, T.L.2    Eggermont, A.M.3
  • 21
    • 79952996039 scopus 로고    scopus 로고
    • Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stage
    • doi:10.1136/ard.2010.140145
    • Grivennikov SI, Karin M. Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stage. Ann Rheum Dis (2011) 70(Suppl 1):i104-8. doi:10.1136/ard.2010.140145
    • (2011) Ann Rheum Dis , vol.70 , Issue.SUPPL. 1
    • Grivennikov, S.I.1    Karin, M.2
  • 22
    • 84876796439 scopus 로고    scopus 로고
    • Inflammation, autophagy, and obesity: common features in the pathogenesis of pancreatitis and pancreatic cancer
    • doi:10.1053/j.gastro.2013.02.007
    • Gukovsky I, Li N, Todoric J, Gukovskaya A, Karin M. Inflammation, autophagy, and obesity: common features in the pathogenesis of pancreatitis and pancreatic cancer. Gastroenterology (2013) 144:1199.e-209.e. doi:10.1053/j.gastro.2013.02.007
    • (2013) Gastroenterology , vol.144 , Issue.1199
    • Gukovsky, I.1    Li, N.2    Todoric, J.3    Gukovskaya, A.4    Karin, M.5
  • 23
    • 74549167737 scopus 로고    scopus 로고
    • Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression
    • doi:10.1016/j.cell.2009.12.052
    • Park EJ, Lee JH, Yu GY, He G, Ali SR, Holzer RG, et al. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell (2010) 140:197-208. doi:10.1016/j.cell.2009.12.052
    • (2010) Cell , vol.140 , pp. 197-208
    • Park, E.J.1    Lee, J.H.2    Yu, G.Y.3    He, G.4    Ali, S.R.5    Holzer, R.G.6
  • 24
    • 67349162130 scopus 로고    scopus 로고
    • Tumour necrosis factor and cancer
    • doi:10.1038/nrc2628
    • Balkwill F. Tumour necrosis factor and cancer. Nat Rev Cancer (2009) 9:361-71. doi:10.1038/nrc2628
    • (2009) Nat Rev Cancer , vol.9 , pp. 361-371
    • Balkwill, F.1
  • 25
    • 76949084622 scopus 로고    scopus 로고
    • TNF-alpha/NF-kappaB/Snail pathway in cancer cell migration and invasion
    • doi:10.1038/sj.bjc.6605530
    • Wu Y, Zhou BP. TNF-alpha/NF-kappaB/Snail pathway in cancer cell migration and invasion. Br J Cancer (2010) 102:639-44. doi:10.1038/sj.bjc.6605530
    • (2010) Br J Cancer , vol.102 , pp. 639-644
    • Wu, Y.1    Zhou, B.P.2
  • 26
    • 84874760851 scopus 로고    scopus 로고
    • Inflammation-mediated genetic and epigenetic alterations drive cancer development in the neighboring epithelium upon stromal abrogation of TGF-beta signaling
    • doi:10.1371/journal.pgen.1003251
    • Achyut BR, Bader DA, Robles AI, Wangsa D, Harris CC, Ried T, et al. Inflammation-mediated genetic and epigenetic alterations drive cancer development in the neighboring epithelium upon stromal abrogation of TGF-beta signaling. PLoS Genet (2013) 9:e1003251. doi:10.1371/journal.pgen.1003251
    • (2013) PLoS Genet , vol.9
    • Achyut, B.R.1    Bader, D.A.2    Robles, A.I.3    Wangsa, D.4    Harris, C.C.5    Ried, T.6
  • 27
    • 73349111306 scopus 로고    scopus 로고
    • The tale of transforming growth factor-beta (TGFbeta) signaling: a soigne enigma
    • doi:10.1002/iub.239
    • Chaudhury A, Howe PH. The tale of transforming growth factor-beta (TGFbeta) signaling: a soigne enigma. IUBMB Life (2009) 61:929-39. doi:10.1002/iub.239
    • (2009) IUBMB Life , vol.61 , pp. 929-939
    • Chaudhury, A.1    Howe, P.H.2
  • 28
    • 20644472421 scopus 로고    scopus 로고
    • Transforming growth factor-beta controls T helper type 1 cell development through regulation of natural killer cell interferon-gamma
    • doi:10.1038/ni1197
    • Laouar Y, Sutterwala FS, Gorelik L, Flavell RA. Transforming growth factor-beta controls T helper type 1 cell development through regulation of natural killer cell interferon-gamma. Nat Immunol (2005) 6:600-7. doi:10.1038/ni1197
    • (2005) Nat Immunol , vol.6 , pp. 600-607
    • Laouar, Y.1    Sutterwala, F.S.2    Gorelik, L.3    Flavell, R.A.4
  • 29
    • 35348940144 scopus 로고    scopus 로고
    • Pathobiology of transforming growth factor beta in cancer, fibrosis and immunologic disease, and therapeutic considerations
    • doi:10.1038/labinvest.3700669
    • Prud'homme GJ. Pathobiology of transforming growth factor beta in cancer, fibrosis and immunologic disease, and therapeutic considerations. Lab Invest (2007) 87:1077-91. doi:10.1038/labinvest.3700669
    • (2007) Lab Invest , vol.87 , pp. 1077-1091
    • Prud'homme, G.J.1
  • 30
    • 84867290406 scopus 로고    scopus 로고
    • Dendritic cell-specific disruption of TGF-beta receptor II leads to altered regulatory T cell phenotype and spontaneous multiorgan autoimmunity
    • doi:10.4049/jimmunol.1201029
    • Ramalingam R, Larmonier CB, Thurston RD, Midura-Kiela MT, Zheng SG, Ghishan FK, et al. Dendritic cell-specific disruption of TGF-beta receptor II leads to altered regulatory T cell phenotype and spontaneous multiorgan autoimmunity. J Immunol (2012) 189:3878-93. doi:10.4049/jimmunol.1201029
    • (2012) J Immunol , vol.189 , pp. 3878-3893
    • Ramalingam, R.1    Larmonier, C.B.2    Thurston, R.D.3    Midura-Kiela, M.T.4    Zheng, S.G.5    Ghishan, F.K.6
  • 31
    • 84875492465 scopus 로고    scopus 로고
    • Tumor associated macrophages and neutrophils in tumor progression
    • doi:10.1002/jcp.24260
    • Galdiero MR, Garlanda C, Jaillon S, Marone G, Mantovani A. Tumor associated macrophages and neutrophils in tumor progression. J Cell Physiol (2013) 228:1404-12. doi:10.1002/jcp.24260
    • (2013) J Cell Physiol , vol.228 , pp. 1404-1412
    • Galdiero, M.R.1    Garlanda, C.2    Jaillon, S.3    Marone, G.4    Mantovani, A.5
  • 32
    • 65549158084 scopus 로고    scopus 로고
    • Tumor-derived TGF-beta mediates conversion of CD4+Foxp3+ regulatory T cells in a murine model of pancreas cancer
    • doi:10.1097/CJI.0b013e318189f13c
    • Moo-Young TA, Larson JW, Belt BA, Tan MC, Hawkins WG, Eberlein TJ, et al. Tumor-derived TGF-beta mediates conversion of CD4+Foxp3+ regulatory T cells in a murine model of pancreas cancer. J Immunother (2009) 32:12-21. doi:10.1097/CJI.0b013e318189f13c
    • (2009) J Immunother , vol.32 , pp. 12-21
    • Moo-Young, T.A.1    Larson, J.W.2    Belt, B.A.3    Tan, M.C.4    Hawkins, W.G.5    Eberlein, T.J.6
  • 33
    • 84866018690 scopus 로고    scopus 로고
    • TGF-beta-miR-34a-CCL22 signaling-induced Treg cell recruitment promotes venous metastases of HBV-positive hepatocellular carcinoma
    • doi:10.1016/j.ccr.2012.07.023
    • Yang P, Li QJ, Feng Y, Zhang Y, Markowitz GJ, Ning S, et al. TGF-beta-miR-34a-CCL22 signaling-induced Treg cell recruitment promotes venous metastases of HBV-positive hepatocellular carcinoma. Cancer Cell (2012) 22:291-303. doi:10.1016/j.ccr.2012.07.023
    • (2012) Cancer Cell , vol.22 , pp. 291-303
    • Yang, P.1    Li, Q.J.2    Feng, Y.3    Zhang, Y.4    Markowitz, G.J.5    Ning, S.6
  • 34
    • 77954557286 scopus 로고    scopus 로고
    • TGFbeta and cancer metastasis: an inflammation link
    • doi:10.1007/s10555-010-9226-3
    • Yang L. TGFbeta and cancer metastasis: an inflammation link. Cancer Metastasis Rev (2010) 29:263-71. doi:10.1007/s10555-010-9226-3
    • (2010) Cancer Metastasis Rev , vol.29 , pp. 263-271
    • Yang, L.1
  • 35
    • 47549090432 scopus 로고    scopus 로고
    • TGFbeta in cancer
    • doi:10.1016/j.cell.2008.07.001
    • Massague J. TGFbeta in cancer. Cell (2008) 134:215-30. doi:10.1016/j.cell.2008.07.001
    • (2008) Cell , vol.134 , pp. 215-230
    • Massague, J.1
  • 36
    • 84875610850 scopus 로고    scopus 로고
    • Recent advances in understanding the molecular mechanisms of the development and function of Th17 cells
    • doi:10.1111/gtc.12039
    • Kurebayashi Y, Nagai S, Ikejiri A, Koyasu S. Recent advances in understanding the molecular mechanisms of the development and function of Th17 cells. Genes Cells (2013) 18:247-65. doi:10.1111/gtc.12039
    • (2013) Genes Cells , vol.18 , pp. 247-265
    • Kurebayashi, Y.1    Nagai, S.2    Ikejiri, A.3    Koyasu, S.4
  • 37
    • 77950196277 scopus 로고    scopus 로고
    • T(H)17 cells in tumour immunity and immunotherapy
    • doi:10.1038/nri2742
    • Zou W, Restifo NP. T(H)17 cells in tumour immunity and immunotherapy. Nat Rev Immunol (2010) 10:248-56. doi:10.1038/nri2742
    • (2010) Nat Rev Immunol , vol.10 , pp. 248-256
    • Zou, W.1    Restifo, N.P.2
  • 38
    • 34250164929 scopus 로고    scopus 로고
    • Systemic administration of IL-23 induces potent antitumor immunity primarily mediated through Th1-type response in association with the endogenously expressed IL-12
    • Kaiga T, Sato M, Kaneda H, Iwakura Y, Takayama T, Tahara H. Systemic administration of IL-23 induces potent antitumor immunity primarily mediated through Th1-type response in association with the endogenously expressed IL-12. J Immunol (2007) 178:7571-80.
    • (2007) J Immunol , vol.178 , pp. 7571-7580
    • Kaiga, T.1    Sato, M.2    Kaneda, H.3    Iwakura, Y.4    Takayama, T.5    Tahara, H.6
  • 39
    • 67651094058 scopus 로고    scopus 로고
    • Endogenous IL-17 contributes to reduced tumor growth and metastasis
    • doi:10.1182/blood-2008-09-177360
    • Kryczek I, Wei S, Szeliga W, Vatan L, Zou W. Endogenous IL-17 contributes to reduced tumor growth and metastasis. Blood (2009) 114:357-9. doi:10.1182/blood-2008-09-177360
    • (2009) Blood , vol.114 , pp. 357-359
    • Kryczek, I.1    Wei, S.2    Szeliga, W.3    Vatan, L.4    Zou, W.5
  • 40
    • 70449530422 scopus 로고    scopus 로고
    • T helper 17 cells promote cytotoxic T cell activation in tumor immunity
    • doi:10.1016/j.immuni.2009.09.014
    • Martin-Orozco N, Muranski P, Chung Y, Yang XO, Yamazaki T, Lu S, et al. T helper 17 cells promote cytotoxic T cell activation in tumor immunity. Immunity (2009) 31:787-98. doi:10.1016/j.immuni.2009.09.014
    • (2009) Immunity , vol.31 , pp. 787-798
    • Martin-Orozco, N.1    Muranski, P.2    Chung, Y.3    Yang, X.O.4    Yamazaki, T.5    Lu, S.6
  • 41
    • 84876070070 scopus 로고    scopus 로고
    • T helper type 17 cells contribute to anti-tumour immunity and promote the recruitment of T helper type 1 cells to the tumour
    • doi:10.1111/imm.12055
    • Nuñez S, Saez JJ, Fernandez D, Flores-Santibanez F, Alvarez K, Tejon G, et al. T helper type 17 cells contribute to anti-tumour immunity and promote the recruitment of T helper type 1 cells to the tumour. Immunology (2013) 139:61-71. doi:10.1111/imm.12055
    • (2013) Immunology , vol.139 , pp. 61-71
    • Nuñez, S.1    Saez, J.J.2    Fernandez, D.3    Flores-Santibanez, F.4    Alvarez, K.5    Tejon, G.6
  • 42
    • 84879552667 scopus 로고    scopus 로고
    • Ex vivo analysis of pancreatic cancer-infiltrating T lymphocytes reveals that ENO-specific Tregs accumulate in tumor tissue and inhibit Th1/Th17 effector cell functions
    • doi:10.1007/s00262-013-1429-3
    • Amedei A, Niccolai E, Benagiano M, Della Bella C, Cianchi F, Bechi P, et al. Ex vivo analysis of pancreatic cancer-infiltrating T lymphocytes reveals that ENO-specific Tregs accumulate in tumor tissue and inhibit Th1/Th17 effector cell functions. Cancer Immunol Immunother (2013) 62:1249-60. doi:10.1007/s00262-013-1429-3
    • (2013) Cancer Immunol Immunother , vol.62 , pp. 1249-1260
    • Amedei, A.1    Niccolai, E.2    Benagiano, M.3    Della Bella, C.4    Cianchi, F.5    Bechi, P.6
  • 43
    • 84862822148 scopus 로고    scopus 로고
    • Pivotal roles of the interleukin-23/T helper 17 cell axis in hepatitis B
    • doi:10.1111/j.1478-3231.2012.02764.x
    • Huang Z, van Velkinburgh JC, Ni B, Wu Y. Pivotal roles of the interleukin-23/T helper 17 cell axis in hepatitis B. Liver Int (2012) 32:894-901. doi:10.1111/j.1478-3231.2012.02764.x
    • (2012) Liver Int , vol.32 , pp. 894-901
    • Huang, Z.1    van Velkinburgh, J.C.2    Ni, B.3    Wu, Y.4
  • 44
    • 77950182472 scopus 로고    scopus 로고
    • Circulating Th17 cells frequency is associated with the disease progression in HBV infected patients
    • doi:10.1111/j.1440-1746.2009.06154.x
    • Wu W, Li J, Chen F, Zhu H, Peng G, Chen Z. Circulating Th17 cells frequency is associated with the disease progression in HBV infected patients. J Gastroenterol Hepatol (2010) 25:750-7. doi:10.1111/j.1440-1746.2009.06154.x
    • (2010) J Gastroenterol Hepatol , vol.25 , pp. 750-757
    • Wu, W.1    Li, J.2    Chen, F.3    Zhu, H.4    Peng, G.5    Chen, Z.6
  • 45
    • 79955757122 scopus 로고    scopus 로고
    • Interferon-gamma negatively regulates Th17-mediated immunopathology during mouse hepatitis virus infection
    • doi:10.1007/s00109-010-0711-5
    • Yang W, Ding X, Deng J, Lu Y, Matsuda Z, Thiel A, et al. Interferon-gamma negatively regulates Th17-mediated immunopathology during mouse hepatitis virus infection. J Mol Med (Berl) (2011) 89:399-409. doi:10.1007/s00109-010-0711-5
    • (2011) J Mol Med (Berl) , vol.89 , pp. 399-409
    • Yang, W.1    Ding, X.2    Deng, J.3    Lu, Y.4    Matsuda, Z.5    Thiel, A.6
  • 46
    • 77956264119 scopus 로고    scopus 로고
    • Involvement of Th17 and Th1 effector responses in patients with Hepatitis B
    • doi:10.1007/s10875-010-9416-3
    • Ye Y, Xie X, Yu J, Zhou L, Xie H, Jiang G, et al. Involvement of Th17 and Th1 effector responses in patients with Hepatitis B. J Clin Immunol (2010) 30:546-55. doi:10.1007/s10875-010-9416-3
    • (2010) J Clin Immunol , vol.30 , pp. 546-555
    • Ye, Y.1    Xie, X.2    Yu, J.3    Zhou, L.4    Xie, H.5    Jiang, G.6
  • 47
    • 77951936316 scopus 로고    scopus 로고
    • IL-17 promotes tumor development through the induction of tumor promoting microenvironments at tumor sites and myeloid-derived suppressor cells
    • doi:10.4049/jimmunol.0902574
    • He D, Li H, Yusuf N, Elmets CA, Li J, Mountz JD, et al. IL-17 promotes tumor development through the induction of tumor promoting microenvironments at tumor sites and myeloid-derived suppressor cells. J Immunol (2010) 184:2281-8. doi:10.4049/jimmunol.0902574
    • (2010) J Immunol , vol.184 , pp. 2281-2288
    • He, D.1    Li, H.2    Yusuf, N.3    Elmets, C.A.4    Li, J.5    Mountz, J.D.6
  • 48
    • 84878047707 scopus 로고    scopus 로고
    • Increased Th17 cells in the tumor microenvironment is mediated by IL-23 via tumor-secreted prostaglandin E2
    • doi:10.4049/jimmunol.1203141
    • Qian X, Gu L, Ning H, Zhang Y, Hsueh EC, Fu M, et al. Increased Th17 cells in the tumor microenvironment is mediated by IL-23 via tumor-secreted prostaglandin E2. J Immunol (2013) 190:5894-902. doi:10.4049/jimmunol.1203141
    • (2013) J Immunol , vol.190 , pp. 5894-5902
    • Qian, X.1    Gu, L.2    Ning, H.3    Zhang, Y.4    Hsueh, E.C.5    Fu, M.6
  • 49
    • 84871094734 scopus 로고    scopus 로고
    • IL-23 is pro-proliferative, epigenetically regulated and modulated by chemotherapy in non-small cell lung cancer
    • doi:10.1016/j.lungcan.2012.10.003
    • Baird AM, Leonard J, Naicker KM, Kilmartin L, O'Byrne KJ, Gray SG. IL-23 is pro-proliferative, epigenetically regulated and modulated by chemotherapy in non-small cell lung cancer. Lung Cancer (2013) 79:83-90. doi:10.1016/j.lungcan.2012.10.003
    • (2013) Lung Cancer , vol.79 , pp. 83-90
    • Baird, A.M.1    Leonard, J.2    Naicker, K.M.3    Kilmartin, L.4    O'Byrne, K.J.5    Gray, S.G.6
  • 50
    • 77951618566 scopus 로고    scopus 로고
    • IL-23 promotes growth and proliferation in human squamous cell carcinoma of the oral cavity
    • doi:10.3892/ijo_00000620
    • Fukuda M, Ehara M, Suzuki S, Ohmori Y, Sakashita H. IL-23 promotes growth and proliferation in human squamous cell carcinoma of the oral cavity. Int J Oncol (2010) 36:1355-65. doi:10.3892/ijo_00000620
    • (2010) Int J Oncol , vol.36 , pp. 1355-1365
    • Fukuda, M.1    Ehara, M.2    Suzuki, S.3    Ohmori, Y.4    Sakashita, H.5
  • 51
    • 84874773199 scopus 로고    scopus 로고
    • Interleukin 23 regulates proliferation of lung cancer cells in a concentration-dependent way in association with the interleukin-23 receptor
    • doi:10.1093/carcin/bgs384
    • Li J, Zhang L, Zhang J, Wei Y, Li K, Huang L, et al. Interleukin 23 regulates proliferation of lung cancer cells in a concentration-dependent way in association with the interleukin-23 receptor. Carcinogenesis (2013) 34:658-66. doi:10.1093/carcin/bgs384
    • (2013) Carcinogenesis , vol.34 , pp. 658-666
    • Li, J.1    Zhang, L.2    Zhang, J.3    Wei, Y.4    Li, K.5    Huang, L.6
  • 52
    • 79952724783 scopus 로고    scopus 로고
    • Intratumor T helper type 2 cell infiltrate correlates with cancer-associated fibroblast thymic stromal lymphopoietin production and reduced survival in pancreatic cancer
    • doi:10.1084/jem.20101876
    • De Monte L, Reni M, Tassi E, Clavenna D, Papa I, Recalde H, et al. Intratumor T helper type 2 cell infiltrate correlates with cancer-associated fibroblast thymic stromal lymphopoietin production and reduced survival in pancreatic cancer. J Exp Med (2011) 208:469-78. doi:10.1084/jem.20101876
    • (2011) J Exp Med , vol.208 , pp. 469-478
    • De Monte, L.1    Reni, M.2    Tassi, E.3    Clavenna, D.4    Papa, I.5    Recalde, H.6
  • 53
    • 34249000341 scopus 로고    scopus 로고
    • Breast cancer instructs dendritic cells to prime interleukin 13-secreting CD4+ T cells that facilitate tumor development
    • doi:10.1084/jem.20061120
    • Aspord C, Pedroza-Gonzalez A, Gallegos M, Tindle S, Burton EC, Su D, et al. Breast cancer instructs dendritic cells to prime interleukin 13-secreting CD4+ T cells that facilitate tumor development. J Exp Med (2007) 204:1037-47. doi:10.1084/jem.20061120
    • (2007) J Exp Med , vol.204 , pp. 1037-1047
    • Aspord, C.1    Pedroza-Gonzalez, A.2    Gallegos, M.3    Tindle, S.4    Burton, E.C.5    Su, D.6
  • 54
    • 84871219267 scopus 로고    scopus 로고
    • Cytokine stimulation of epithelial cancer cells: the similar and divergent functions of IL-4 and IL-13
    • doi:10.1158/0008-5472.CAN-12-3544
    • Hallett MA, Venmar KT, Fingleton B. Cytokine stimulation of epithelial cancer cells: the similar and divergent functions of IL-4 and IL-13. Cancer Res (2012) 72:6338-43. doi:10.1158/0008-5472.CAN-12-3544
    • (2012) Cancer Res , vol.72 , pp. 6338-6343
    • Hallett, M.A.1    Venmar, K.T.2    Fingleton, B.3
  • 55
    • 77953943322 scopus 로고    scopus 로고
    • Epithelial interleukin-4 receptor expression promotes colon tumor growth
    • doi:10.1093/carcin/bgq044
    • Koller FL, Hwang DG, Dozier EA, Fingleton B. Epithelial interleukin-4 receptor expression promotes colon tumor growth. Carcinogenesis (2010) 31:1010-7. doi:10.1093/carcin/bgq044
    • (2010) Carcinogenesis , vol.31 , pp. 1010-1017
    • Koller, F.L.1    Hwang, D.G.2    Dozier, E.A.3    Fingleton, B.4
  • 56
    • 34848866647 scopus 로고    scopus 로고
    • Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4
    • doi:10.1016/j.stem.2007.08.001
    • Todaro M, Alea MP, Di Stefano AB, Cammareri P, Vermeulen L, Iovino F, et al. Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4. Cell Stem Cell (2007) 1:389-402. doi:10.1016/j.stem.2007.08.001
    • (2007) Cell Stem Cell , vol.1 , pp. 389-402
    • Todaro, M.1    Alea, M.P.2    Di Stefano, A.B.3    Cammareri, P.4    Vermeulen, L.5    Iovino, F.6
  • 57
    • 84861894074 scopus 로고    scopus 로고
    • High expression of IL-13 receptor alpha2 in colorectal cancer is associated with invasion, liver metastasis, and poor prognosis
    • doi:10.1158/0008-5472.CAN-11-4090
    • Barderas R, Bartolome RA, Fernandez-Acenero MJ, Torres S, Casal JI. High expression of IL-13 receptor alpha2 in colorectal cancer is associated with invasion, liver metastasis, and poor prognosis. Cancer Res (2012) 72:2780-90. doi:10.1158/0008-5472.CAN-11-4090
    • (2012) Cancer Res , vol.72 , pp. 2780-2790
    • Barderas, R.1    Bartolome, R.A.2    Fernandez-Acenero, M.J.3    Torres, S.4    Casal, J.I.5
  • 58
    • 72249115096 scopus 로고    scopus 로고
    • A novel role of interleukin-13 receptor alpha2 in pancreatic cancer invasion and metastasis
    • doi:10.1158/0008-5472.CAN-09-2100
    • Fujisawa T, Joshi B, Nakajima A, Puri RK. A novel role of interleukin-13 receptor alpha2 in pancreatic cancer invasion and metastasis. Cancer Res (2009) 69:8678-85. doi:10.1158/0008-5472.CAN-09-2100
    • (2009) Cancer Res , vol.69 , pp. 8678-8685
    • Fujisawa, T.1    Joshi, B.2    Nakajima, A.3    Puri, R.K.4
  • 59
    • 84861602528 scopus 로고    scopus 로고
    • IL-13 regulates cancer invasion and metastasis through IL-13Ralpha2 via ERK/AP-1 pathway in mouse model of human ovarian cancer
    • doi:10.1002/ijc.26366
    • Fujisawa T, Joshi BH, Puri RK. IL-13 regulates cancer invasion and metastasis through IL-13Ralpha2 via ERK/AP-1 pathway in mouse model of human ovarian cancer. Int J Cancer (2012) 131:344-56. doi:10.1002/ijc.26366
    • (2012) Int J Cancer , vol.131 , pp. 344-356
    • Fujisawa, T.1    Joshi, B.H.2    Puri, R.K.3
  • 61
    • 61349100687 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells as regulators of the immune system
    • doi:10.1038/nri2506
    • Gabrilovich DI, Nagaraj S. Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol (2009) 9:162-74. doi:10.1038/nri2506
    • (2009) Nat Rev Immunol , vol.9 , pp. 162-174
    • Gabrilovich, D.I.1    Nagaraj, S.2
  • 62
    • 77950950894 scopus 로고    scopus 로고
    • Macrophage diversity enhances tumor progression and metastasis
    • doi:10.1016/j.cell.2010.03.014
    • Qian BZ, Pollard JW. Macrophage diversity enhances tumor progression and metastasis. Cell (2010) 141:39-51. doi:10.1016/j.cell.2010.03.014
    • (2010) Cell , vol.141 , pp. 39-51
    • Qian, B.Z.1    Pollard, J.W.2
  • 63
    • 77949379050 scopus 로고    scopus 로고
    • B-cell-derived lymphotoxin promotes castration-resistant prostate cancer
    • doi:10.1038/nature08782
    • Ammirante M, Luo JL, Grivennikov S, Nedospasov S, Karin M. B-cell-derived lymphotoxin promotes castration-resistant prostate cancer. Nature (2010) 464:302-5. doi:10.1038/nature08782
    • (2010) Nature , vol.464 , pp. 302-305
    • Ammirante, M.1    Luo, J.L.2    Grivennikov, S.3    Nedospasov, S.4    Karin, M.5
  • 64
    • 84872530748 scopus 로고    scopus 로고
    • Tissue damage-associated "danger signals" influence T-cell responses that promote the progression of preneoplasia to cancer
    • doi:10.1158/0008-5472.CAN-12-2704
    • He Y, Zha J, Wang Y, Liu W, Yang X, Yu P. Tissue damage-associated "danger signals" influence T-cell responses that promote the progression of preneoplasia to cancer. Cancer Res (2013) 73:629-39. doi:10.1158/0008-5472.CAN-12-2704
    • (2013) Cancer Res , vol.73 , pp. 629-639
    • He, Y.1    Zha, J.2    Wang, Y.3    Liu, W.4    Yang, X.5    Yu, P.6
  • 65
    • 67650495415 scopus 로고    scopus 로고
    • IL-17 can promote tumor growth through an IL-6-Stat3 signaling pathway
    • doi:10.1084/jem.20090207
    • Wang L, Yi T, Kortylewski M, Pardoll DM, Zeng D, Yu H. IL-17 can promote tumor growth through an IL-6-Stat3 signaling pathway. J Exp Med (2009) 206:1457-64. doi:10.1084/jem.20090207
    • (2009) J Exp Med , vol.206 , pp. 1457-1464
    • Wang, L.1    Yi, T.2    Kortylewski, M.3    Pardoll, D.M.4    Zeng, D.5    Yu, H.6
  • 66
    • 84891493325 scopus 로고    scopus 로고
    • Autoimmune effector memory T cells: the bad and the good
    • doi:10.1007/s12026-013-8448-1
    • Devarajan P, Chen Z. Autoimmune effector memory T cells: the bad and the good. Immunol Res (2013) 57:12-22. doi:10.1007/s12026-013-8448-1
    • (2013) Immunol Res , vol.57 , pp. 12-22
    • Devarajan, P.1    Chen, Z.2
  • 67
    • 84862976472 scopus 로고    scopus 로고
    • A decade of imaging cellular motility and interaction dynamics in the immune system
    • doi:10.1126/science.1221063
    • Germain RN, Robey EA, Cahalan MD. A decade of imaging cellular motility and interaction dynamics in the immune system. Science (2012) 336:1676-81. doi:10.1126/science.1221063
    • (2012) Science , vol.336 , pp. 1676-1681
    • Germain, R.N.1    Robey, E.A.2    Cahalan, M.D.3
  • 68
    • 84896860062 scopus 로고    scopus 로고
    • Real-time immune cell interactions in target tissue during autoimmune-induced damage and graft tolerance
    • doi:10.1084/jem.20130785
    • Miska J, Abdulreda MH, Devarajan P, Lui JB, Suzuki J, Pileggi A, et al. Real-time immune cell interactions in target tissue during autoimmune-induced damage and graft tolerance. J Exp Med (2014) 211:441-56. doi:10.1084/jem.20130785
    • (2014) J Exp Med , vol.211 , pp. 441-456
    • Miska, J.1    Abdulreda, M.H.2    Devarajan, P.3    Lui, J.B.4    Suzuki, J.5    Pileggi, A.6
  • 69
    • 77953732636 scopus 로고    scopus 로고
    • Immune tolerance induction by integrating innate and adaptive immune regulators
    • doi:10.3727/096368909X480314
    • Suzuki J, Ricordi C, Chen Z. Immune tolerance induction by integrating innate and adaptive immune regulators. Cell Transplant (2010) 19:253-68. doi:10.3727/096368909X480314
    • (2010) Cell Transplant , vol.19 , pp. 253-268
    • Suzuki, J.1    Ricordi, C.2    Chen, Z.3
  • 70
    • 38649133581 scopus 로고    scopus 로고
    • Prognostic significance of CD3+ tumor-infiltrating lymphocytes in ovarian carcinoma
    • doi:10.1016/j.ygyno.2007.10.016
    • Tomsova M, Melichar B, Sedlakova I, Steiner I. Prognostic significance of CD3+ tumor-infiltrating lymphocytes in ovarian carcinoma. Gynecol Oncol (2008) 108:415-20. doi:10.1016/j.ygyno.2007.10.016
    • (2008) Gynecol Oncol , vol.108 , pp. 415-420
    • Tomsova, M.1    Melichar, B.2    Sedlakova, I.3    Steiner, I.4
  • 71
    • 84874615958 scopus 로고    scopus 로고
    • Prognostic impact of expression of Bcl-2 and Bax genes in circulating immune cells derived from patients with head and neck carcinoma
    • doi:10.1593/neo.121528
    • Tano T, Okamoto M, Kan S, Nakashiro K, Shimodaira S, Koido S, et al. Prognostic impact of expression of Bcl-2 and Bax genes in circulating immune cells derived from patients with head and neck carcinoma. Neoplasia (2013) 15:305-14. doi:10.1593/neo.121528
    • (2013) Neoplasia , vol.15 , pp. 305-314
    • Tano, T.1    Okamoto, M.2    Kan, S.3    Nakashiro, K.4    Shimodaira, S.5    Koido, S.6
  • 72
    • 84877004454 scopus 로고    scopus 로고
    • Cytokine patterns in patients with cancer: a systematic review
    • doi:10.1016/S1470-2045(12)70582-X
    • Lippitz BE. Cytokine patterns in patients with cancer: a systematic review. Lancet Oncol (2013) 14:e218-28. doi:10.1016/S1470-2045(12)70582-X
    • (2013) Lancet Oncol , vol.14
    • Lippitz, B.E.1
  • 74
    • 2042495412 scopus 로고    scopus 로고
    • Characterization of CD8+ cytotoxic T lymphocyte/tumor cell interactions reflecting recognition of an endogenously expressed murine wild-type p53 determinant
    • doi:10.1007/s002620000156
    • Hilburger Ryan M, Abrams SI. Characterization of CD8+ cytotoxic T lymphocyte/tumor cell interactions reflecting recognition of an endogenously expressed murine wild-type p53 determinant. Cancer Immunol Immunother (2001) 49:603-12. doi:10.1007/s002620000156
    • (2001) Cancer Immunol Immunother , vol.49 , pp. 603-612
    • Hilburger Ryan, M.1    Abrams, S.I.2
  • 75
    • 0027190467 scopus 로고
    • An evaluation of the potential to use tumor-associated antigens as targets for antitumor T cell therapy using transgenic mice expressing a retroviral tumor antigen in normal lymphoid tissues
    • doi:10.1084/jem.177.6.1681
    • Hu J, Kindsvogel W, Busby S, Bailey MC, Shi YY, Greenberg PD. An evaluation of the potential to use tumor-associated antigens as targets for antitumor T cell therapy using transgenic mice expressing a retroviral tumor antigen in normal lymphoid tissues. J Exp Med (1993) 177:1681-90. doi:10.1084/jem.177.6.1681
    • (1993) J Exp Med , vol.177 , pp. 1681-1690
    • Hu, J.1    Kindsvogel, W.2    Busby, S.3    Bailey, M.C.4    Shi, Y.Y.5    Greenberg, P.D.6
  • 76
    • 0031963994 scopus 로고    scopus 로고
    • Activation of low avidity CTL specific for a self epitope results in tumor rejection but not autoimmunity
    • Morgan DJ, Kreuwel HT, Fleck S, Levitsky HI, Pardoll DM, Sherman LA. Activation of low avidity CTL specific for a self epitope results in tumor rejection but not autoimmunity. J Immunol (1998) 160:643-51.
    • (1998) J Immunol , vol.160 , pp. 643-651
    • Morgan, D.J.1    Kreuwel, H.T.2    Fleck, S.3    Levitsky, H.I.4    Pardoll, D.M.5    Sherman, L.A.6
  • 77
    • 56749180605 scopus 로고    scopus 로고
    • Immunotherapy of autoimmunity and cancer: the penalty for success
    • doi:10.1038/nri2438
    • Caspi RR. Immunotherapy of autoimmunity and cancer: the penalty for success. Nat Rev Immunol (2008) 8:970-6. doi:10.1038/nri2438
    • (2008) Nat Rev Immunol , vol.8 , pp. 970-976
    • Caspi, R.R.1
  • 78
    • 24944459890 scopus 로고    scopus 로고
    • Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4
    • doi:10.1200/JCO.2005.06.205
    • Attia P, Phan GQ, Maker AV, Robinson MR, Quezado MM, Yang JC, et al. Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4. J Clin Oncol (2005) 23:6043-53. doi:10.1200/JCO.2005.06.205
    • (2005) J Clin Oncol , vol.23 , pp. 6043-6053
    • Attia, P.1    Phan, G.Q.2    Maker, A.V.3    Robinson, M.R.4    Quezado, M.M.5    Yang, J.C.6
  • 79
    • 77955359494 scopus 로고    scopus 로고
    • Therapeutic cancer vaccines in combination with conventional therapy
    • doi:10.1155/2010/237623
    • Andersen MH, Junker N, Ellebaek E, Svane IM, Thor Straten P. Therapeutic cancer vaccines in combination with conventional therapy. J Biomed Biotechnol (2010) 2010:237623. doi:10.1155/2010/237623
    • (2010) J Biomed Biotechnol , vol.2010 , pp. 237623
    • Andersen, M.H.1    Junker, N.2    Ellebaek, E.3    Svane, I.M.4    Thor Straten, P.5
  • 80
    • 80053469514 scopus 로고    scopus 로고
    • The two faces of interferon-gamma in cancer
    • doi:10.1158/1078-0432.CCR-11-0482
    • Zaidi MR, Merlino G. The two faces of interferon-gamma in cancer. Clin Cancer Res (2011) 17:6118-24. doi:10.1158/1078-0432.CCR-11-0482
    • (2011) Clin Cancer Res , vol.17 , pp. 6118-6124
    • Zaidi, M.R.1    Merlino, G.2
  • 81
    • 34447333719 scopus 로고    scopus 로고
    • Development of IFN-gamma resistance is associated with attenuation of SOCS genes induction and constitutive expression of SOCS 3 in melanoma cells
    • doi:10.1038/sj.bjc.6603849
    • Fojtova M, Boudny V, Kovarik A, Lauerova L, Adamkova L, Souckova K, et al. Development of IFN-gamma resistance is associated with attenuation of SOCS genes induction and constitutive expression of SOCS 3 in melanoma cells. Br J Cancer (2007) 97:231-7. doi:10.1038/sj.bjc.6603849
    • (2007) Br J Cancer , vol.97 , pp. 231-237
    • Fojtova, M.1    Boudny, V.2    Kovarik, A.3    Lauerova, L.4    Adamkova, L.5    Souckova, K.6
  • 82
    • 73849120349 scopus 로고    scopus 로고
    • Clinical use of interferon-gamma
    • doi:10.1111/j.1749-6632.2009.05069.x
    • Miller CH, Maher SG, Young HA. Clinical use of interferon-gamma. Ann N Y Acad Sci (2009) 1182:69-79. doi:10.1111/j.1749-6632.2009.05069.x
    • (2009) Ann N Y Acad Sci , vol.1182 , pp. 69-79
    • Miller, C.H.1    Maher, S.G.2    Young, H.A.3
  • 83
    • 77954954369 scopus 로고    scopus 로고
    • Cancer and inflammation: promise for biologic therapy
    • doi:10.1097/CJI.0b013e3181d32e74
    • Demaria S, Pikarsky E, Karin M, Coussens LM, Chen YC, El-Omar EM, et al. Cancer and inflammation: promise for biologic therapy. J Immunother (2010) 33:335-51. doi:10.1097/CJI.0b013e3181d32e74
    • (2010) J Immunother , vol.33 , pp. 335-351
    • Demaria, S.1    Pikarsky, E.2    Karin, M.3    Coussens, L.M.4    Chen, Y.C.5    El-Omar, E.M.6
  • 84
    • 20344376407 scopus 로고    scopus 로고
    • Mechanisms of disease: Inflammation and the origins of cancer
    • doi:10.1038/ncponc0081 quiz 91 p following 113
    • Moss SF, Blaser MJ. Mechanisms of disease: Inflammation and the origins of cancer. Nat Clin Pract Oncol (2005) 2:90-7. doi:10.1038/ncponc0081 quiz 91 p following 113
    • (2005) Nat Clin Pract Oncol , vol.2 , pp. 90-97
    • Moss, S.F.1    Blaser, M.J.2
  • 85
    • 0037300753 scopus 로고    scopus 로고
    • Anti-interferon-gamma antibodies in the treatment of autoimmune diseases
    • Skurkovich B, Skurkovich S. Anti-interferon-gamma antibodies in the treatment of autoimmune diseases. Curr Opin Mol Ther (2003) 5:52-7.
    • (2003) Curr Opin Mol Ther , vol.5 , pp. 52-57
    • Skurkovich, B.1    Skurkovich, S.2
  • 86
    • 84888128597 scopus 로고    scopus 로고
    • Anticytokine therapy, particularly anti-IFN-gamma, in Th1-mediated autoimmune diseases
    • doi:10.1586/1744666X.1.1.11
    • Skurkovich S, Skurkovich B, Kelly J. Anticytokine therapy, particularly anti-IFN-gamma, in Th1-mediated autoimmune diseases. Expert Rev Clin Immunol (2005) 1:11-25. doi:10.1586/1744666X.1.1.11
    • (2005) Expert Rev Clin Immunol , vol.1 , pp. 11-25
    • Skurkovich, S.1    Skurkovich, B.2    Kelly, J.3
  • 87
    • 33845981808 scopus 로고    scopus 로고
    • Inflammation, atrophy, and gastric cancer
    • doi:10.1172/JCI30111
    • Fox JG, Wang TC. Inflammation, atrophy, and gastric cancer. J Clin Invest (2007) 117:60-9. doi:10.1172/JCI30111
    • (2007) J Clin Invest , vol.117 , pp. 60-69
    • Fox, J.G.1    Wang, T.C.2
  • 88
    • 43049113155 scopus 로고    scopus 로고
    • What lurks beneath: IL-11, via Stat3, promotes inflammation-associated gastric tumorigenesis
    • doi:10.1172/JCI35344
    • Merchant JL. What lurks beneath: IL-11, via Stat3, promotes inflammation-associated gastric tumorigenesis. J Clin Invest (2008) 118:1628-31. doi:10.1172/JCI35344
    • (2008) J Clin Invest , vol.118 , pp. 1628-1631
    • Merchant, J.L.1
  • 89
    • 77952903266 scopus 로고    scopus 로고
    • Helicobacter pylori: gastric cancer and beyond
    • doi:10.1038/nrc2857
    • Polk DB, Peek RM Jr. Helicobacter pylori: gastric cancer and beyond. Nat Rev Cancer (2010) 10:403-14. doi:10.1038/nrc2857
    • (2010) Nat Rev Cancer , vol.10 , pp. 403-414
    • Polk, D.B.1    Peek Jr., R.M.2
  • 90
    • 0031566688 scopus 로고    scopus 로고
    • Pernicious anemia
    • doi:10.1056/NEJM199711133372007
    • Toh BH, van Driel IR, Gleeson PA. Pernicious anemia. N Engl J Med (1997) 337:1441-8. doi:10.1056/NEJM199711133372007
    • (1997) N Engl J Med , vol.337 , pp. 1441-1448
    • Toh, B.H.1    van Driel, I.R.2    Gleeson, P.A.3
  • 91
    • 0037622073 scopus 로고    scopus 로고
    • Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms
    • doi:10.1016/S0016-5085(03)00157-4
    • El-Omar EM, Rabkin CS, Gammon MD, Vaughan TL, Risch HA, Schoenberg JB, et al. Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms. Gastroenterology (2003) 124:1193-201. doi:10.1016/S0016-5085(03)00157-4
    • (2003) Gastroenterology , vol.124 , pp. 1193-1201
    • El-Omar, E.M.1    Rabkin, C.S.2    Gammon, M.D.3    Vaughan, T.L.4    Risch, H.A.5    Schoenberg, J.B.6
  • 92
    • 9144249648 scopus 로고    scopus 로고
    • Gastric cancer development in mice lacking the SHP2 binding site on the IL-6 family co-receptor gp130
    • doi:10.1053/j.gastro.2003.10.066
    • Judd LM, Alderman BM, Howlett M, Shulkes A, Dow C, Moverley J, et al. Gastric cancer development in mice lacking the SHP2 binding site on the IL-6 family co-receptor gp130. Gastroenterology (2004) 126:196-207. doi:10.1053/j.gastro.2003.10.066
    • (2004) Gastroenterology , vol.126 , pp. 196-207
    • Judd, L.M.1    Alderman, B.M.2    Howlett, M.3    Shulkes, A.4    Dow, C.5    Moverley, J.6
  • 93
    • 54549089856 scopus 로고    scopus 로고
    • Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice
    • doi:10.1016/j.ccr.2008.10.011
    • Tu S, Bhagat G, Cui G, Takaishi S, Kurt-Jones EA, Rickman B, et al. Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice. Cancer Cell (2008) 14:408-19. doi:10.1016/j.ccr.2008.10.011
    • (2008) Cancer Cell , vol.14 , pp. 408-419
    • Tu, S.1    Bhagat, G.2    Cui, G.3    Takaishi, S.4    Kurt-Jones, E.A.5    Rickman, B.6
  • 94
    • 77949906174 scopus 로고    scopus 로고
    • Current understanding of SPEM and its standing in the preneoplastic process
    • doi:10.1007/s10120-009-0527-6
    • Weis VG, Goldenring JR. Current understanding of SPEM and its standing in the preneoplastic process. Gastric Cancer (2009) 12:189-97. doi:10.1007/s10120-009-0527-6
    • (2009) Gastric Cancer , vol.12 , pp. 189-197
    • Weis, V.G.1    Goldenring, J.R.2
  • 95
    • 0034677646 scopus 로고    scopus 로고
    • A novel transcription factor, T-bet, directs Th1 lineage commitment
    • doi:10.1016/S0092-8674(00)80702-3
    • Szabo SJ, Kim ST, Costa GL, Zhang X, Fathman CG, Glimcher LH. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell (2000) 100:655-69. doi:10.1016/S0092-8674(00)80702-3
    • (2000) Cell , vol.100 , pp. 655-669
    • Szabo, S.J.1    Kim, S.T.2    Costa, G.L.3    Zhang, X.4    Fathman, C.G.5    Glimcher, L.H.6
  • 96
    • 34548729257 scopus 로고    scopus 로고
    • IFN-gamma acts directly on activated CD4+ T cells during mycobacterial infection to promote apoptosis by inducing components of the intracellular apoptosis machinery and by inducing extracellular proapoptotic signals
    • Li X, McKinstry KK, Swain SL, Dalton DK. IFN-gamma acts directly on activated CD4+ T cells during mycobacterial infection to promote apoptosis by inducing components of the intracellular apoptosis machinery and by inducing extracellular proapoptotic signals. J Immunol (2007) 179:939-49.
    • (2007) J Immunol , vol.179 , pp. 939-949
    • Li, X.1    McKinstry, K.K.2    Swain, S.L.3    Dalton, D.K.4
  • 97
    • 37549061827 scopus 로고    scopus 로고
    • Creating immune privilege: active local suppression that benefits friends, but protects foes
    • doi:10.1038/nri2233
    • Mellor AL, Munn DH. Creating immune privilege: active local suppression that benefits friends, but protects foes. Nat Rev Immunol (2008) 8:74-80. doi:10.1038/nri2233
    • (2008) Nat Rev Immunol , vol.8 , pp. 74-80
    • Mellor, A.L.1    Munn, D.H.2
  • 98
    • 79958830077 scopus 로고    scopus 로고
    • IFN-gamma inhibits gastric carcinogenesis by inducing epithelial cell autophagy and T-cell apoptosis
    • doi:10.1158/0008-5472.CAN-10-4009
    • Tu SP, Quante M, Bhagat G, Takaishi S, Cui G, Yang XD, et al. IFN-gamma inhibits gastric carcinogenesis by inducing epithelial cell autophagy and T-cell apoptosis. Cancer Res (2011) 71:4247-59. doi:10.1158/0008-5472.CAN-10-4009
    • (2011) Cancer Res , vol.71 , pp. 4247-4259
    • Tu, S.P.1    Quante, M.2    Bhagat, G.3    Takaishi, S.4    Cui, G.5    Yang, X.D.6
  • 99
    • 69949106925 scopus 로고    scopus 로고
    • The double-edged sword of autophagy modulation in cancer
    • doi:10.1158/1078-0432.CCR-07-5023
    • White E, DiPaola RS. The double-edged sword of autophagy modulation in cancer. Clin Cancer Res (2009) 15:5308-16. doi:10.1158/1078-0432.CCR-07-5023
    • (2009) Clin Cancer Res , vol.15 , pp. 5308-5316
    • White, E.1    DiPaola, R.S.2
  • 100
    • 38549102077 scopus 로고    scopus 로고
    • TNF-mediated inflammatory disease
    • doi:10.1002/path.2287
    • Bradley JR. TNF-mediated inflammatory disease. J Pathol (2008) 214:149-60. doi:10.1002/path.2287
    • (2008) J Pathol , vol.214 , pp. 149-160
    • Bradley, J.R.1
  • 103
    • 0034754259 scopus 로고    scopus 로고
    • Fever and cancer in perspective
    • Hobohm U. Fever and cancer in perspective. Cancer Immunol Immunother (2001) 50:391-6.
    • (2001) Cancer Immunol Immunother , vol.50 , pp. 391-396
    • Hobohm, U.1
  • 104
    • 44749088915 scopus 로고    scopus 로고
    • Physiological functions of tumor necrosis factor and the consequences of its pathologic overexpression or blockade: mouse models
    • doi:10.1016/j.cytogfr.2008.04.010
    • Kruglov AA, Kuchmiy A, Grivennikov SI, Tumanov AV, Kuprash DV, Nedospasov SA. Physiological functions of tumor necrosis factor and the consequences of its pathologic overexpression or blockade: mouse models. Cytokine Growth Factor Rev (2008) 19:231-44. doi:10.1016/j.cytogfr.2008.04.010
    • (2008) Cytokine Growth Factor Rev , vol.19 , pp. 231-244
    • Kruglov, A.A.1    Kuchmiy, A.2    Grivennikov, S.I.3    Tumanov, A.V.4    Kuprash, D.V.5    Nedospasov, S.A.6
  • 105
    • 0032983865 scopus 로고    scopus 로고
    • Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis
    • doi:10.1038/10552
    • Moore RJ, Owens DM, Stamp G, Arnott C, Burke F, East N, et al. Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis. Nat Med (1999) 5:828-31. doi:10.1038/10552
    • (1999) Nat Med , vol.5 , pp. 828-831
    • Moore, R.J.1    Owens, D.M.2    Stamp, G.3    Arnott, C.4    Burke, F.5    East, N.6
  • 106
    • 84884670639 scopus 로고    scopus 로고
    • Tumor promoters: from chemicals to inflammatory proteins
    • doi:10.1007/s00432-013-1455-8
    • Fujiki H, Sueoka E, Suganuma M. Tumor promoters: from chemicals to inflammatory proteins. J Cancer Res Clin Oncol (2013) 139:1603-14. doi:10.1007/s00432-013-1455-8
    • (2013) J Cancer Res Clin Oncol , vol.139 , pp. 1603-1614
    • Fujiki, H.1    Sueoka, E.2    Suganuma, M.3
  • 107
    • 84874642641 scopus 로고    scopus 로고
    • The inflammatory microenvironment in hepatocellular carcinoma: a pivotal role for tumor-associated macrophages
    • doi:10.1155/2013/187204
    • Capece D, Fischietti M, Verzella D, Gaggiano A, Cicciarelli G, Tessitore A, et al. The inflammatory microenvironment in hepatocellular carcinoma: a pivotal role for tumor-associated macrophages. Biomed Res Int (2013) 2013:187204. doi:10.1155/2013/187204
    • (2013) Biomed Res Int , vol.2013 , pp. 187204
    • Capece, D.1    Fischietti, M.2    Verzella, D.3    Gaggiano, A.4    Cicciarelli, G.5    Tessitore, A.6
  • 108
    • 34948850204 scopus 로고    scopus 로고
    • Oxidative stress signalling: a potential mediator of tumour necrosis factor alpha-induced genomic instability in primary vascular endothelial cells
    • doi:10.1259/bjr/15316848
    • Natarajan M, Gibbons CF, Mohan S, Moore S, Kadhim MA. Oxidative stress signalling: a potential mediator of tumour necrosis factor alpha-induced genomic instability in primary vascular endothelial cells. Br J Radiol (2007) 80(1):S13-22. doi:10.1259/bjr/15316848
    • (2007) Br J Radiol , vol.80 , Issue.1
    • Natarajan, M.1    Gibbons, C.F.2    Mohan, S.3    Moore, S.4    Kadhim, M.A.5
  • 109
    • 0033872036 scopus 로고    scopus 로고
    • Disruption of redox homeostasis in tumor necrosis factor-induced apoptosis in a murine hepatocyte cell line
    • doi:10.1016/S0002-9440(10)64533-6
    • Pierce RH, Campbell JS, Stephenson AB, Franklin CC, Chaisson M, Poot M, et al. Disruption of redox homeostasis in tumor necrosis factor-induced apoptosis in a murine hepatocyte cell line. Am J Pathol (2000) 157:221-36. doi:10.1016/S0002-9440(10)64533-6
    • (2000) Am J Pathol , vol.157 , pp. 221-236
    • Pierce, R.H.1    Campbell, J.S.2    Stephenson, A.B.3    Franklin, C.C.4    Chaisson, M.5    Poot, M.6
  • 110
    • 0037453028 scopus 로고    scopus 로고
    • Oxidative stress mediates tumor necrosis factor-alpha-induced mitochondrial DNA damage and dysfunction in cardiac myocytes
    • doi:10.1161/01.CIR.0000055318.09997.1F
    • Suematsu N, Tsutsui H, Wen J, Kang D, Ikeuchi M, Ide T, et al. Oxidative stress mediates tumor necrosis factor-alpha-induced mitochondrial DNA damage and dysfunction in cardiac myocytes. Circulation (2003) 107:1418-23. doi:10.1161/01.CIR.0000055318.09997.1F
    • (2003) Circulation , vol.107 , pp. 1418-1423
    • Suematsu, N.1    Tsutsui, H.2    Wen, J.3    Kang, D.4    Ikeuchi, M.5    Ide, T.6
  • 112
    • 48449086316 scopus 로고    scopus 로고
    • TGF-beta: a master of all T cell trades
    • doi:10.1016/j.cell.2008.07.025
    • Li MO, Flavell RA. TGF-beta: a master of all T cell trades. Cell (2008) 134:392-404. doi:10.1016/j.cell.2008.07.025
    • (2008) Cell , vol.134 , pp. 392-404
    • Li, M.O.1    Flavell, R.A.2
  • 113
    • 0027531528 scopus 로고
    • Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death
    • doi:10.1073/pnas.90.2.770
    • Kulkarni AB, Huh CG, Becker D, Geiser A, Lyght M, Flanders KC, et al. Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci U S A (1993) 90:770-4. doi:10.1073/pnas.90.2.770
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 770-774
    • Kulkarni, A.B.1    Huh, C.G.2    Becker, D.3    Geiser, A.4    Lyght, M.5    Flanders, K.C.6
  • 114
    • 0037100520 scopus 로고    scopus 로고
    • Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable
    • doi:10.1182/blood.V100.2.560
    • Leveen P, Larsson J, Ehinger M, Cilio CM, Sundler M, Sjostrand LJ, et al. Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable. Blood (2002) 100:560-8. doi:10.1182/blood.V100.2.560
    • (2002) Blood , vol.100 , pp. 560-568
    • Leveen, P.1    Larsson, J.2    Ehinger, M.3    Cilio, C.M.4    Sundler, M.5    Sjostrand, L.J.6
  • 115
    • 84863496897 scopus 로고    scopus 로고
    • TGF-beta of lung cancer microenvironment upregulates B7H1 and GITRL expression in dendritic cells and is associated with regulatory T cell generation
    • doi:10.3892/or.2012.1822
    • Ni XY, Sui HX, Liu Y, Ke SZ, Wang YN, Gao FG. TGF-beta of lung cancer microenvironment upregulates B7H1 and GITRL expression in dendritic cells and is associated with regulatory T cell generation. Oncol Rep (2012) 28:615-21. doi:10.3892/or.2012.1822
    • (2012) Oncol Rep , vol.28 , pp. 615-621
    • Ni, X.Y.1    Sui, H.X.2    Liu, Y.3    Ke, S.Z.4    Wang, Y.N.5    Gao, F.G.6
  • 116
    • 36749121992 scopus 로고    scopus 로고
    • HER-2 overexpression differentially alters transforming growth factor-beta responses in luminal versus mesenchymal human breast cancer cells
    • doi:10.1186/bcr1343
    • Wilson CA, Cajulis EE, Green JL, Olsen TM, Chung YA, Damore MA, et al. HER-2 overexpression differentially alters transforming growth factor-beta responses in luminal versus mesenchymal human breast cancer cells. Breast Cancer Res (2005) 7:R1058-79. doi:10.1186/bcr1343
    • (2005) Breast Cancer Res , vol.7
    • Wilson, C.A.1    Cajulis, E.E.2    Green, J.L.3    Olsen, T.M.4    Chung, Y.A.5    Damore, M.A.6
  • 117
    • 0037444273 scopus 로고    scopus 로고
    • Loss of c-myc repression coincides with ovarian cancer resistance to transforming growth factor beta growth arrest independent of transforming growth factor beta/Smad signaling
    • Baldwin RL, Tran H, Karlan BY. Loss of c-myc repression coincides with ovarian cancer resistance to transforming growth factor beta growth arrest independent of transforming growth factor beta/Smad signaling. Cancer Res (2003) 63:1413-9.
    • (2003) Cancer Res , vol.63 , pp. 1413-1419
    • Baldwin, R.L.1    Tran, H.2    Karlan, B.Y.3
  • 118
    • 84866029510 scopus 로고    scopus 로고
    • Complexities of TGF-beta targeted cancer therapy
    • doi:10.7150/ijbs.4564
    • Connolly EC, Freimuth J, Akhurst RJ. Complexities of TGF-beta targeted cancer therapy. Int J Biol Sci (2012) 8:964-78. doi:10.7150/ijbs.4564
    • (2012) Int J Biol Sci , vol.8 , pp. 964-978
    • Connolly, E.C.1    Freimuth, J.2    Akhurst, R.J.3
  • 119
    • 79952771133 scopus 로고    scopus 로고
    • Outgrowth of drug-resistant carcinomas expressing markers of tumor aggression after long-term TbetaRI/II kinase inhibition with LY2109761
    • doi:10.1158/0008-5472.CAN-10-2941
    • Connolly EC, Saunier EF, Quigley D, Luu MT, De Sapio A, Hann B, et al. Outgrowth of drug-resistant carcinomas expressing markers of tumor aggression after long-term TbetaRI/II kinase inhibition with LY2109761. Cancer Res (2011) 71:2339-49. doi:10.1158/0008-5472.CAN-10-2941
    • (2011) Cancer Res , vol.71 , pp. 2339-2349
    • Connolly, E.C.1    Saunier, E.F.2    Quigley, D.3    Luu, M.T.4    De Sapio, A.5    Hann, B.6
  • 120
    • 58149231532 scopus 로고    scopus 로고
    • Differential roles of interleukin-17A and-17F in host defense against mucoepithelial bacterial infection and allergic responses
    • doi:10.1016/j.immuni.2008.11.009
    • Ishigame H, Kakuta S, Nagai T, Kadoki M, Nambu A, Komiyama Y, et al. Differential roles of interleukin-17A and-17F in host defense against mucoepithelial bacterial infection and allergic responses. Immunity (2009) 30:108-19. doi:10.1016/j.immuni.2008.11.009
    • (2009) Immunity , vol.30 , pp. 108-119
    • Ishigame, H.1    Kakuta, S.2    Nagai, T.3    Kadoki, M.4    Nambu, A.5    Komiyama, Y.6
  • 121
    • 84871317687 scopus 로고    scopus 로고
    • The role and regulation of human Th17 cells in tumor immunity
    • doi:10.1016/j.ajpath.2012.08.041
    • Ye J, Livergood RS, Peng G. The role and regulation of human Th17 cells in tumor immunity. Am J Pathol (2013) 182:10-20. doi:10.1016/j.ajpath.2012.08.041
    • (2013) Am J Pathol , vol.182 , pp. 10-20
    • Ye, J.1    Livergood, R.S.2    Peng, G.3
  • 122
    • 84876806691 scopus 로고    scopus 로고
    • Dynamic regulatory network controlling TH17 cell differentiation
    • doi:10.1038/nature11981
    • Yosef N, Shalek AK, Gaublomme JT, Jin H, Lee Y, Awasthi A, et al. Dynamic regulatory network controlling TH17 cell differentiation. Nature (2013) 496:461-8. doi:10.1038/nature11981
    • (2013) Nature , vol.496 , pp. 461-468
    • Yosef, N.1    Shalek, A.K.2    Gaublomme, J.T.3    Jin, H.4    Lee, Y.5    Awasthi, A.6
  • 123
    • 27544490377 scopus 로고    scopus 로고
    • Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • doi:10.1038/ni1254
    • Harrington LE, Hatton RD, Mangan PR, Turner H, Murphy TL, Murphy KM, et al. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol (2005) 6:1123-32. doi:10.1038/ni1254
    • (2005) Nat Immunol , vol.6 , pp. 1123-1132
    • Harrington, L.E.1    Hatton, R.D.2    Mangan, P.R.3    Turner, H.4    Murphy, T.L.5    Murphy, K.M.6
  • 124
    • 27544465354 scopus 로고    scopus 로고
    • A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
    • doi:10.1038/ni1261
    • Park H, Li Z, Yang XO, Chang SH, Nurieva R, Wang YH, et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol (2005) 6:1133-41. doi:10.1038/ni1261
    • (2005) Nat Immunol , vol.6 , pp. 1133-1141
    • Park, H.1    Li, Z.2    Yang, X.O.3    Chang, S.H.4    Nurieva, R.5    Wang, Y.H.6
  • 125
    • 34247464330 scopus 로고    scopus 로고
    • Swords into plowshares: IL-23 repurposes tumor immune surveillance
    • doi:10.1016/j.it.2007.03.006
    • Langowski JL, Kastelein RA, Oft M. Swords into plowshares: IL-23 repurposes tumor immune surveillance. Trends Immunol (2007) 28:207-12. doi:10.1016/j.it.2007.03.006
    • (2007) Trends Immunol , vol.28 , pp. 207-212
    • Langowski, J.L.1    Kastelein, R.A.2    Oft, M.3
  • 126
    • 30544436785 scopus 로고    scopus 로고
    • Understanding the IL-23-IL-17 immune pathway
    • doi:10.1016/j.it.2005.10.003
    • McKenzie BS, Kastelein RA, Cua DJ. Understanding the IL-23-IL-17 immune pathway. Trends Immunol (2006) 27:17-23. doi:10.1016/j.it.2005.10.003
    • (2006) Trends Immunol , vol.27 , pp. 17-23
    • McKenzie, B.S.1    Kastelein, R.A.2    Cua, D.J.3
  • 127
    • 70449715722 scopus 로고    scopus 로고
    • Protumor vs antitumor functions of IL-17
    • doi:10.4049/jimmunol.0901017
    • Murugaiyan G, Saha B. Protumor vs antitumor functions of IL-17. J Immunol (2009) 183:4169-75. doi:10.4049/jimmunol.0901017
    • (2009) J Immunol , vol.183 , pp. 4169-4175
    • Murugaiyan, G.1    Saha, B.2
  • 128
    • 0033638507 scopus 로고    scopus 로고
    • Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
    • doi:10.1016/S1074-7613(00)00070-4
    • Oppmann B, Lesley R, Blom B, Timans JC, Xu Y, Hunte B, et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity (2000) 13:715-25. doi:10.1016/S1074-7613(00)00070-4
    • (2000) Immunity , vol.13 , pp. 715-725
    • Oppmann, B.1    Lesley, R.2    Blom, B.3    Timans, J.C.4    Xu, Y.5    Hunte, B.6
  • 129
    • 79952754854 scopus 로고    scopus 로고
    • TGF-beta in Th17 cell development: the truth is out there
    • doi:10.1016/j.immuni.2011.03.009
    • Hatton RD. TGF-beta in Th17 cell development: the truth is out there. Immunity (2011) 34:288-90. doi:10.1016/j.immuni.2011.03.009
    • (2011) Immunity , vol.34 , pp. 288-290
    • Hatton, R.D.1
  • 130
    • 33746534417 scopus 로고    scopus 로고
    • IL-23 promotes tumour incidence and growth
    • doi:10.1038/nature04808
    • Langowski JL, Zhang X, Wu L, Mattson JD, Chen T, Smith K, et al. IL-23 promotes tumour incidence and growth. Nature (2006) 442:461-5. doi:10.1038/nature04808
    • (2006) Nature , vol.442 , pp. 461-465
    • Langowski, J.L.1    Zhang, X.2    Wu, L.3    Mattson, J.D.4    Chen, T.5    Smith, K.6
  • 131
    • 84857774124 scopus 로고    scopus 로고
    • The IL23/Th17 pathway as a therapeutic target in chronic inflammatory diseases
    • doi:10.2174/187152812800392805
    • Toussirot E. The IL23/Th17 pathway as a therapeutic target in chronic inflammatory diseases. Inflamm Allergy Drug Targets (2012) 11:159-68. doi:10.2174/187152812800392805
    • (2012) Inflamm Allergy Drug Targets , vol.11 , pp. 159-168
    • Toussirot, E.1
  • 132
    • 84875544506 scopus 로고    scopus 로고
    • Interleukin-4-and interleukin-13-mediated alternatively activated macrophages: roles in homeostasis and disease
    • doi:10.1146/annurev-immunol-032712-095906
    • Van Dyken SJ, Locksley RM. Interleukin-4-and interleukin-13-mediated alternatively activated macrophages: roles in homeostasis and disease. Annu Rev Immunol (2013) 31:317-43. doi:10.1146/annurev-immunol-032712-095906
    • (2013) Annu Rev Immunol , vol.31 , pp. 317-343
    • Van Dyken, S.J.1    Locksley, R.M.2
  • 133
    • 77953991456 scopus 로고    scopus 로고
    • Regulation of the T helper cell type 2 (Th2)/T regulatory cell (Treg) balance by IL-4 and STAT6
    • doi:10.1189/jlb.1209772
    • Chapoval S, Dasgupta P, Dorsey NJ, Keegan AD. Regulation of the T helper cell type 2 (Th2)/T regulatory cell (Treg) balance by IL-4 and STAT6. J Leukoc Biol (2010) 87:1011-8. doi:10.1189/jlb.1209772
    • (2010) J Leukoc Biol , vol.87 , pp. 1011-1018
    • Chapoval, S.1    Dasgupta, P.2    Dorsey, N.J.3    Keegan, A.D.4
  • 134
    • 84868030361 scopus 로고    scopus 로고
    • Tumor-associated macrophages: function, phenotype, and link to prognosis in human lung cancer
    • Quatromoni JG, Eruslanov E. Tumor-associated macrophages: function, phenotype, and link to prognosis in human lung cancer. Am J Transl Res (2012) 4:376-89.
    • (2012) Am J Transl Res , vol.4 , pp. 376-389
    • Quatromoni, J.G.1    Eruslanov, E.2
  • 135
    • 38649137731 scopus 로고    scopus 로고
    • Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system
    • doi:10.1016/j.cell.2007.12.030
    • LaPorte SL, Juo ZS, Vaclavikova J, Colf LA, Qi X, Heller NM, et al. Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system. Cell (2008) 132:259-72. doi:10.1016/j.cell.2007.12.030
    • (2008) Cell , vol.132 , pp. 259-272
    • LaPorte, S.L.1    Juo, Z.S.2    Vaclavikova, J.3    Colf, L.A.4    Qi, X.5    Heller, N.M.6
  • 136
    • 77649198441 scopus 로고    scopus 로고
    • Investigational therapeutics targeting the IL-4/IL-13/STAT-6 pathway for the treatment of asthma
    • doi:10.1183/09059180.00007609
    • Oh CK, Geba GP, Molfino N. Investigational therapeutics targeting the IL-4/IL-13/STAT-6 pathway for the treatment of asthma. Eur Respir Rev (2010) 19:46-54. doi:10.1183/09059180.00007609
    • (2010) Eur Respir Rev , vol.19 , pp. 46-54
    • Oh, C.K.1    Geba, G.P.2    Molfino, N.3
  • 137
    • 55349135863 scopus 로고    scopus 로고
    • Endogenous interleukin-4 promotes tumor development by increasing tumor cell resistance to apoptosis
    • doi:10.1158/0008-5472.CAN-08-0449
    • Li Z, Jiang J, Wang Z, Zhang J, Xiao M, Wang C, et al. Endogenous interleukin-4 promotes tumor development by increasing tumor cell resistance to apoptosis. Cancer Res (2008) 68:8687-94. doi:10.1158/0008-5472.CAN-08-0449
    • (2008) Cancer Res , vol.68 , pp. 8687-8694
    • Li, Z.1    Jiang, J.2    Wang, Z.3    Zhang, J.4    Xiao, M.5    Wang, C.6
  • 138
    • 84879736910 scopus 로고    scopus 로고
    • Lineage tracing reveals multipotent stem cells maintain human adenomas and the pattern of clonal expansion in tumor evolution
    • doi:10.1073/pnas.1220353110
    • Humphries A, Cereser B, Gay LJ, Miller DS, Das B, Gutteridge A, et al. Lineage tracing reveals multipotent stem cells maintain human adenomas and the pattern of clonal expansion in tumor evolution. Proc Natl Acad Sci U S A (2013) 110:E2490-9. doi:10.1073/pnas.1220353110
    • (2013) Proc Natl Acad Sci U S A , vol.110
    • Humphries, A.1    Cereser, B.2    Gay, L.J.3    Miller, D.S.4    Das, B.5    Gutteridge, A.6
  • 139
    • 84864854371 scopus 로고    scopus 로고
    • Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas
    • doi:10.1126/science.1224676
    • Schepers AG, Snippert HJ, Stange DE, van den Born M, van Es JH, van de Wetering M, et al. Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas. Science (2012) 337:730-5. doi:10.1126/science.1224676
    • (2012) Science , vol.337 , pp. 730-735
    • Schepers, A.G.1    Snippert, H.J.2    Stange, D.E.3    van den Born, M.4    van Es, J.H.5    van de Wetering, M.6
  • 140
    • 40549084643 scopus 로고    scopus 로고
    • IL-4-mediated drug resistance in colon cancer stem cells
    • doi:10.4161/cc.7.3.5389
    • Todaro M, Perez Alea M, Scopelliti A, Medema JP, Stassi G. IL-4-mediated drug resistance in colon cancer stem cells. Cell Cycle (2008) 7:309-13. doi:10.4161/cc.7.3.5389
    • (2008) Cell Cycle , vol.7 , pp. 309-313
    • Todaro, M.1    Perez Alea, M.2    Scopelliti, A.3    Medema, J.P.4    Stassi, G.5
  • 141
    • 0037393323 scopus 로고    scopus 로고
    • IL-13 receptors and signaling pathways: an evolving web
    • doi:10.1067/mai.2003.1333 quiz 691
    • Hershey GK. IL-13 receptors and signaling pathways: an evolving web. J Allergy Clin Immunol (2003) 111:677-90. doi:10.1067/mai.2003.1333 quiz 691
    • (2003) J Allergy Clin Immunol , vol.111 , pp. 677-690
    • Hershey, G.K.1
  • 142
    • 74549138477 scopus 로고    scopus 로고
    • Interleukin 13 mediates signal transduction through interleukin 13 receptor alpha2 in pancreatic ductal adenocarcinoma: role of IL-13 pseudomonas exotoxin in pancreatic cancer therapy
    • doi:10.1158/1078-0432.CCR-09-2015
    • Shimamura T, Fujisawa T, Husain SR, Joshi B, Puri RK. Interleukin 13 mediates signal transduction through interleukin 13 receptor alpha2 in pancreatic ductal adenocarcinoma: role of IL-13 pseudomonas exotoxin in pancreatic cancer therapy. Clin Cancer Res (2010) 16:577-86. doi:10.1158/1078-0432.CCR-09-2015
    • (2010) Clin Cancer Res , vol.16 , pp. 577-586
    • Shimamura, T.1    Fujisawa, T.2    Husain, S.R.3    Joshi, B.4    Puri, R.K.5
  • 143
    • 84873980242 scopus 로고    scopus 로고
    • Targeting of interleukin-13 receptor alpha2 for treatment of head and neck squamous cell carcinoma induced by conditional deletion of TGF-beta and PTEN signaling
    • doi:10.1186/1479-5876-11-45
    • Hall B, Nakashima H, Sun ZJ, Sato Y, Bian Y, Husain SR, et al. Targeting of interleukin-13 receptor alpha2 for treatment of head and neck squamous cell carcinoma induced by conditional deletion of TGF-beta and PTEN signaling. J Transl Med (2013) 11:45. doi:10.1186/1479-5876-11-45
    • (2013) J Transl Med , vol.11 , pp. 45
    • Hall, B.1    Nakashima, H.2    Sun, Z.J.3    Sato, Y.4    Bian, Y.5    Husain, S.R.6
  • 144
    • 33747204065 scopus 로고    scopus 로고
    • The IL-4 and IL-13 pseudomonas exotoxins: new hope for brain tumor therapy
    • doi:10.3171/foc.2006.20.4.6
    • Shimamura T, Husain SR, Puri RK. The IL-4 and IL-13 pseudomonas exotoxins: new hope for brain tumor therapy. Neurosurg Focus (2006) 20:E11. doi:10.3171/foc.2006.20.4.6
    • (2006) Neurosurg Focus , vol.20
    • Shimamura, T.1    Husain, S.R.2    Puri, R.K.3
  • 145
    • 45549090167 scopus 로고    scopus 로고
    • Cintredekin besudotox in treatment of malignant glioma
    • doi:10.1517/14712598.8.6.805
    • Mut M, Sherman JH, Shaffrey ME, Schiff D. Cintredekin besudotox in treatment of malignant glioma. Expert Opin Biol Ther (2008) 8:805-12. doi:10.1517/14712598.8.6.805
    • (2008) Expert Opin Biol Ther , vol.8 , pp. 805-812
    • Mut, M.1    Sherman, J.H.2    Shaffrey, M.E.3    Schiff, D.4
  • 146
    • 84866147745 scopus 로고    scopus 로고
    • Current trends in targeted therapies for glioblastoma multiforme
    • doi:10.1155/2012/878425
    • Ohka F, Natsume A, Wakabayashi T. Current trends in targeted therapies for glioblastoma multiforme. Neurol Res Int (2012) 2012:878425. doi:10.1155/2012/878425
    • (2012) Neurol Res Int , pp. 878425
    • Ohka, F.1    Natsume, A.2    Wakabayashi, T.3
  • 147
    • 84874218779 scopus 로고    scopus 로고
    • From biomarkers to a clue of biology: a computation-aided perspective of immune gene expression profiles in human type 1 diabetes
    • doi:10.3389/fimmu.2012.00320
    • Han D, Cai X, Wen J, Kenyon NS, Chen Z. From biomarkers to a clue of biology: a computation-aided perspective of immune gene expression profiles in human type 1 diabetes. Front Immunol (2012) 3:320. doi:10.3389/fimmu.2012.00320
    • (2012) Front Immunol , vol.3 , pp. 320
    • Han, D.1    Cai, X.2    Wen, J.3    Kenyon, N.S.4    Chen, Z.5
  • 148
    • 77954560509 scopus 로고    scopus 로고
    • Combination of intensive chemotherapy and anticancer vaccines in the treatment of human malignancies: the hematological experience
    • doi:10.1155/2010/692097
    • Liseth K, Ersvaer E, Hervig T, Bruserud O. Combination of intensive chemotherapy and anticancer vaccines in the treatment of human malignancies: the hematological experience. J Biomed Biotechnol (2010) 2010:692097. doi:10.1155/2010/692097
    • (2010) J Biomed Biotechnol , vol.2010 , pp. 692097
    • Liseth, K.1    Ersvaer, E.2    Hervig, T.3    Bruserud, O.4
  • 149
    • 45549092607 scopus 로고    scopus 로고
    • Cancer immunology
    • doi:10.1056/NEJMra072739
    • Finn OJ. Cancer immunology. N Engl J Med (2008) 358:2704-15. doi:10.1056/NEJMra072739
    • (2008) N Engl J Med , vol.358 , pp. 2704-2715
    • Finn, O.J.1
  • 150
    • 84874192617 scopus 로고    scopus 로고
    • T-helper-1-cell cytokines drive cancer into senescence
    • doi:10.1038/nature11824
    • Braumüller H, Wieder T, Brenner E, Assmann S, Hahn M, Alkhaled M, et al. T-helper-1-cell cytokines drive cancer into senescence. Nature (2013) 494:361-5. doi:10.1038/nature11824
    • (2013) Nature , vol.494 , pp. 361-365
    • Braumüller, H.1    Wieder, T.2    Brenner, E.3    Assmann, S.4    Hahn, M.5    Alkhaled, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.