-
1
-
-
41349099104
-
Cancer statistics, 2008
-
Jemal, A. et al. (2008) Cancer statistics, 2008. CA. Cancer J. Clin., 58, 71-96.
-
(2008)
CA. Cancer J. Clin.
, vol.58
, pp. 71-96
-
-
Jemal, A.1
-
2
-
-
70349878484
-
Expression of IL-32 in human lung cancer is related to the histotype and metastatic phenotype
-
Sorrentino, C. et al. (2009) Expression of IL-32 in human lung cancer is related to the histotype and metastatic phenotype. Am. J. Respir. Crit. Care Med., 180, 769-779.
-
(2009)
Am. J. Respir. Crit. Care Med.
, vol.180
, pp. 769-779
-
-
Sorrentino, C.1
-
3
-
-
0032253453
-
Involvement of interleukin-6 in the elevation of plasma fibrinogen levels in lung cancer patients
-
Yamaguchi, T. et al. (1998) Involvement of interleukin-6 in the elevation of plasma fibrinogen levels in lung cancer patients. Jpn. J. Clin. Oncol., 28, 740-744.
-
(1998)
Jpn. J. Clin. Oncol.
, vol.28
, pp. 740-744
-
-
Yamaguchi, T.1
-
4
-
-
74949121459
-
Expression of interleukin-1 receptor-associated kinase-1 in non-small cell lung carcinoma and preneoplastic lesions
-
Behrens, C. et al. (2010) Expression of interleukin-1 receptor-associated kinase-1 in non-small cell lung carcinoma and preneoplastic lesions. Clin. Cancer Res., 16, 34-44.
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 34-44
-
-
Behrens, C.1
-
5
-
-
80555134794
-
The protective role of TLR6 in a mouse model of asthma is mediated by IL-23 and IL-17A
-
Moreira, A.P. et al. (2011) The protective role of TLR6 in a mouse model of asthma is mediated by IL-23 and IL-17A. J. Clin. Invest., 121, 4420-4432.
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 4420-4432
-
-
Moreira, A.P.1
-
6
-
-
0033638507
-
Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
-
Oppmann, B. et al. (2000) Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity, 13, 715-725.
-
(2000)
Immunity
, vol.13
, pp. 715-725
-
-
Oppmann, B.1
-
7
-
-
0027239503
-
Antitumor and antimetastatic activity of interleukin 12 against murine tumors
-
Brunda, M.J. et al. (1993) Antitumor and antimetastatic activity of interleukin 12 against murine tumors. J. Exp. Med., 178, 1223-1230.
-
(1993)
J. Exp. Med.
, vol.178
, pp. 1223-1230
-
-
Brunda, M.J.1
-
8
-
-
0027963161
-
Recombinant IL-12 administration induces tumor regression in association with IFN-gamma production
-
Nastala, C.L. et al. (1994) Recombinant IL-12 administration induces tumor regression in association with IFN-gamma production. J. Immunol., 153, 1697-1706.
-
(1994)
J. Immunol.
, vol.153
, pp. 1697-1706
-
-
Nastala, C.L.1
-
9
-
-
0037434789
-
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
-
Cua, D.J. et al. (2003) Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature, 421, 744-748.
-
(2003)
Nature
, vol.421
, pp. 744-748
-
-
Cua, D.J.1
-
10
-
-
0346962972
-
Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation
-
Murphy, C.A. et al. (2003) Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J. Exp. Med., 198, 1951-1957.
-
(2003)
J. Exp. Med.
, vol.198
, pp. 1951-1957
-
-
Murphy, C.A.1
-
11
-
-
0347357773
-
IL-23 produced by CNS-resident cells controls T cell encephalitogenicity during the effector phase of experimental autoimmune encephalomyelitis
-
Becher, B. et al. (2003) IL-23 produced by CNS-resident cells controls T cell encephalitogenicity during the effector phase of experimental autoimmune encephalomyelitis. J. Clin. Invest., 112, 1186-1191.
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 1186-1191
-
-
Becher, B.1
-
12
-
-
33745685864
-
Interleukin-23 and interleukin-27 exert quite different antitumor and vaccine effects on poorly immunogenic melanoma
-
Oniki, S. et al. (2006) Interleukin-23 and interleukin-27 exert quite different antitumor and vaccine effects on poorly immunogenic melanoma. Cancer Res., 66, 6395-6404.
-
(2006)
Cancer Res
, vol.66
, pp. 6395-6404
-
-
Oniki, S.1
-
13
-
-
0037769934
-
Antitumor and antimetastatic activity of IL-23
-
Lo, C.H. et al. (2003) Antitumor and antimetastatic activity of IL-23. J. Immunol., 171, 600-607.
-
(2003)
J. Immunol.
, vol.171
, pp. 600-607
-
-
Lo, C.H.1
-
14
-
-
0038795484
-
Induction of systemic immunity by expression of interleukin-23 in murine colon carcinoma cells
-
Wang, Y.Q. et al. (2003) Induction of systemic immunity by expression of interleukin-23 in murine colon carcinoma cells. Int. J. Cancer, 105, 820-824.
-
(2003)
Int. J. Cancer
, vol.105
, pp. 820-824
-
-
Wang, Y.Q.1
-
15
-
-
33746534417
-
IL-23 promotes tumour incidence and growth
-
Langowski, J.L. et al. (2006) IL-23 promotes tumour incidence and growth. Nature, 442, 461-465.
-
(2006)
Nature
, vol.442
, pp. 461-465
-
-
Langowski, J.L.1
-
16
-
-
31144441631
-
In vitro and in situ expression of IL-23 by keratinocytes in healthy skin and psoriasis lesions: enhanced expression in psoriatic skin
-
Piskin, G. et al. (2006) In vitro and in situ expression of IL-23 by keratinocytes in healthy skin and psoriasis lesions: enhanced expression in psoriatic skin. J. Immunol., 176, 1908-1915.
-
(2006)
J. Immunol.
, vol.176
, pp. 1908-1915
-
-
Piskin, G.1
-
17
-
-
83655201522
-
IL-23/IL-23R: potential mediator of intestinal tumor progression from adenomatous polyps to colorectal carcinoma
-
Lan, F. et al. (2010) IL-23/IL-23R: potential mediator of intestinal tumor progression from adenomatous polyps to colorectal carcinoma. Int. J. Colorectal Dis., 26, 1511-1518.
-
(2010)
Int. J. Colorectal Dis.
, vol.26
, pp. 1511-1518
-
-
Lan, F.1
-
18
-
-
78149428394
-
Interleukin-23 acts as antitumor agent on childhood B-acute lymphoblastic leukemia cells
-
Cocco, C. et al. (2010) Interleukin-23 acts as antitumor agent on childhood B-acute lymphoblastic leukemia cells. Blood, 116, 3887-3898.
-
(2010)
Blood
, vol.116
, pp. 3887-3898
-
-
Cocco, C.1
-
19
-
-
77951618566
-
IL-23 promotes growth and proliferation in human squamous cell carcinoma of the oral cavity
-
Fukuda, M. et al. (2010) IL-23 promotes growth and proliferation in human squamous cell carcinoma of the oral cavity. Int. J. Oncol., 36, 1355-1365.
-
(2010)
Int. J. Oncol.
, vol.36
, pp. 1355-1365
-
-
Fukuda, M.1
-
20
-
-
0031915998
-
Prognostic and predictive factors in breast cancer by immunohistochemical analysis
-
Allred, D.C. et al. (1998) Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod. Pathol., 11, 155-168.
-
(1998)
Mod. Pathol.
, vol.11
, pp. 155-168
-
-
Allred, D.C.1
-
21
-
-
0036604306
-
A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit
-
Parham, C. et al. (2002) A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R. J. Immunol., 168, 5699-5708.
-
(2002)
IL-23R. J. Immunol.
, vol.168
, pp. 5699-5708
-
-
Parham, C.1
-
22
-
-
0030445948
-
A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits
-
Presky, D.H. et al. (1996) A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits. Proc. Natl. Acad. Sci. U.S.A., 93, 14002-14007.
-
(1996)
Proc. Natl. Acad. Sci. U.S.A.
, vol.93
, pp. 14002-14007
-
-
Presky, D.H.1
-
23
-
-
77958126831
-
Microtubule-targeted chemotherapeutic agents inhibit signal transducer and activator of transcription 3 (STAT3) signaling
-
Walker, S.R. et al. (2010) Microtubule-targeted chemotherapeutic agents inhibit signal transducer and activator of transcription 3 (STAT3) signaling. Mol. Pharmacol., 78, 903-908.
-
(2010)
Mol. Pharmacol.
, vol.78
, pp. 903-908
-
-
Walker, S.R.1
-
24
-
-
77955520465
-
A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells
-
Lin, L. et al. (2010) A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells. Mol Cancer, 16, 9-217.
-
(2010)
Mol Cancer
, vol.16
, pp. 9-217
-
-
Lin, L.1
-
25
-
-
33646397611
-
IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6
-
Yen, D. et al. (2006) IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J. Clin. Invest., 116, 1310-1316.
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 1310-1316
-
-
Yen, D.1
-
26
-
-
0037115541
-
Cancer immunotherapy with interleukin 12 and granulocyte - macrophage colony-stimulating factor-encapsulated microspheres coinduction of innate and adaptive antitumor immunity and cure of disseminated disease
-
Hill, H.C. et al. (2002) Cancer immunotherapy with interleukin 12 and granulocyte - macrophage colony-stimulating factor-encapsulated microspheres coinduction of innate and adaptive antitumor immunity and cure of disseminated disease. Cancer Res., 62, 7254-7263.
-
(2002)
Cancer Res
, vol.62
, pp. 7254-7263
-
-
Hill, H.C.1
-
27
-
-
77952402724
-
IL-23 suppresses innate immune response independently of IL-17A during carcinogenesis and metastasis
-
Teng, M.W. et al. (2010) IL-23 suppresses innate immune response independently of IL-17A during carcinogenesis and metastasis. Proc. Natl. Acad. Sci. U.S.A., 107, 8328-8333.
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 8328-8333
-
-
Teng, M.W.1
-
28
-
-
79952746350
-
Anti-IL-23 monoclonal antibody synergizes in combination with targeted therapies or IL-2 to suppress tumor growth and metastases
-
Teng, M.W. et al. (2011) Anti-IL-23 monoclonal antibody synergizes in combination with targeted therapies or IL-2 to suppress tumor growth and metastases. Cancer Res., 71, 2077-2086.
-
(2011)
Cancer Res
, vol.71
, pp. 2077-2086
-
-
Teng, M.W.1
-
29
-
-
0345358584
-
The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses
-
Trinchieri, G. et al. (2003) The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses. Immunity, 19, 641-644.
-
(2003)
Immunity
, vol.19
, pp. 641-644
-
-
Trinchieri, G.1
-
30
-
-
0036469065
-
Signal transduction and the control of gene expression
-
Brivanlou, A.H. et al. (2002) Signal transduction and the control of gene expression. Science, 295, 813-818.
-
(2002)
Science
, vol.295
, pp. 813-818
-
-
Brivanlou, A.H.1
-
31
-
-
69749101475
-
The IL-12 family of cytokines in infection, inflammation and autoimmune disorders
-
Gee, K. et al. (2009) The IL-12 family of cytokines in infection, inflammation and autoimmune disorders. Inflamm. Allergy Drug Targets, 8, 40-52.
-
(2009)
Inflamm. Allergy Drug Targets
, vol.8
, pp. 40-52
-
-
Gee, K.1
-
32
-
-
79953134246
-
Genomic views of STAT function in CD4+ T helper cell differentiation
-
O'Shea, J.J. et al. (2011) Genomic views of STAT function in CD4+ T helper cell differentiation. Nat. Rev. Immunol., 11, 239-250.
-
(2011)
Nat. Rev. Immunol.
, vol.11
, pp. 239-250
-
-
O'Shea, J.J.1
-
33
-
-
0034657336
-
The role of STATs in transcriptional control and their impact on cellular function
-
Bromberg, J. et al. (2000) The role of STATs in transcriptional control and their impact on cellular function. Oncogene, 19, 2468-2473.
-
(2000)
Oncogene
, vol.19
, pp. 2468-2473
-
-
Bromberg, J.1
-
34
-
-
80052168964
-
Ki-67 labeling index is associated with recurrence after segmentectomy under video-assisted thoracoscopic surgery in stage I non-small cell lung cancer
-
Yamashita, S. et al. (2011) Ki-67 labeling index is associated with recurrence after segmentectomy under video-assisted thoracoscopic surgery in stage I non-small cell lung cancer. Ann. Thorac. Cardiovasc. Surg., 17, 341-346.
-
(2011)
Ann. Thorac. Cardiovasc. Surg.
, vol.17
, pp. 341-346
-
-
Yamashita, S.1
-
35
-
-
23844516688
-
The role of p-STAT3 (ser727) revealed by its association with Ki-67 in cervical intraepithelial neoplasia
-
Yang, S.F. et al. (2005) The role of p-STAT3 (ser727) revealed by its association with Ki-67 in cervical intraepithelial neoplasia. Gynecol. Oncol., 98, 446-452.
-
(2005)
Gynecol. Oncol.
, vol.98
, pp. 446-452
-
-
Yang, S.F.1
-
36
-
-
84863174774
-
VEGF-mediated STAT3 activation inhibits retinal vascularization by down-regulating local erythropoietin expression
-
Wang, H. et al. (2012) VEGF-mediated STAT3 activation inhibits retinal vascularization by down-regulating local erythropoietin expression. Am. J. Pathol., 180, 1243-1253.
-
(2012)
Am. J. Pathol.
, vol.180
, pp. 1243-1253
-
-
Wang, H.1
-
37
-
-
79952175492
-
Blocking the IL-6-STAT3 signaling pathway: potential liver cancer therapy
-
Liu, Y. et al. (2011) Blocking the IL-6-STAT3 signaling pathway: potential liver cancer therapy. Future Oncol., 7, 161-164.
-
(2011)
Future Oncol
, vol.7
, pp. 161-164
-
-
Liu, Y.1
-
38
-
-
79551512841
-
Annexin A1 released from apoptotic cells acts through formyl peptide receptors to dampen inflammatory monocyte activation via JAK/STAT/SOCS signalling
-
Pupjalis, D. et al. (2011) Annexin A1 released from apoptotic cells acts through formyl peptide receptors to dampen inflammatory monocyte activation via JAK/STAT/SOCS signalling. EMBO Mol. Med., 3, 102-114.
-
(2011)
EMBO Mol. Med.
, vol.3
, pp. 102-114
-
-
Pupjalis, D.1
-
39
-
-
33744479688
-
Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells
-
Chen, Z. et al. (2006) Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells. Proc. Natl. Acad. Sci. U.S.A., 103, 8137-8142.
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, pp. 8137-8142
-
-
Chen, Z.1
-
40
-
-
0036005890
-
Interleukin-12 in anti-tumor immunity and immunotherapy
-
Colombo, M.P. et al. (2002) Interleukin-12 in anti-tumor immunity and immunotherapy. Cytokine Growth Factor Rev., 13, 155-168.
-
(2002)
Cytokine Growth Factor Rev
, vol.13
, pp. 155-168
-
-
Colombo, M.P.1
-
41
-
-
0034127567
-
Impaired tumorigenicity of human pancreatic cancer cells retrovirally transduced with interleukin-12 or interleukin-15 gene
-
Yoshida, Y. et al. (2000) Impaired tumorigenicity of human pancreatic cancer cells retrovirally transduced with interleukin-12 or interleukin-15 gene. Cancer Gene Ther., 7, 324-331.
-
(2000)
Cancer Gene Ther
, vol.7
, pp. 324-331
-
-
Yoshida, Y.1
-
42
-
-
0032479871
-
Interleukin 12-mediated prevention of spontaneous mammary adenocarcinomas in two lines of Her-2/neu transgenic mice
-
Boggio, K. et al. (1998) Interleukin 12-mediated prevention of spontaneous mammary adenocarcinomas in two lines of Her-2/neu transgenic mice. J. Exp. Med., 188, 589-596.
-
(1998)
J. Exp. Med.
, vol.188
, pp. 589-596
-
-
Boggio, K.1
-
43
-
-
0030766971
-
Effect of singledose interleukin-12 exposure on interleukin-12-associted toxicity and interferon-γ production
-
Leonard, L.P. et al. (1997) Effect of singledose interleukin-12 exposure on interleukin-12-associted toxicity and interferon-γ production. Blood, 90, 2541-2548.
-
(1997)
Blood
, vol.90
, pp. 2541-2548
-
-
Leonard, L.P.1
|