메뉴 건너뛰기




Volumn 5 MAR, Issue , 2014, Pages

Label-free drug discovery

Author keywords

Cell phenotypic screen; Drug safety toxicity; Label free drug discovery; Lead selection; Molecular mechanism of action; Phenotypic screen; Polypharmacology; Target identification

Indexed keywords

4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; 4,4' (2,2 DICHLOROETHENE 1,1 DIYL)BIS(2,6 DINITROPHENOL); ADENOSINE A2A RECEPTOR AGONIST; ANTINEOPLASTIC AGENT; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; ERLOTINIB; GEFITINIB; METHACHOLINE; MUSCARINIC M3 RECEPTOR; NITROPHENOL; TYRPHOSTIN; UNCLASSIFIED DRUG;

EID: 84897936888     PISSN: None     EISSN: 16639812     Source Type: Journal    
DOI: 10.3389/fphar.2014.00052     Document Type: Review
Times cited : (69)

References (87)
  • 1
    • 84863116827 scopus 로고    scopus 로고
    • Dynamic monitoring of beating periodicity of stem cell-derived cardiomyocytes as a predictive tool for preclinical safety assessment
    • doi: 10.1111/j.1476-5381.2011.01623.x
    • Abassi, Y. A., Xi, B., Li, N., Ouyang, W., Seiler, A., Watzele, M., et al. (2012). Dynamic monitoring of beating periodicity of stem cell-derived cardiomyocytes as a predictive tool for preclinical safety assessment. Br. J. Pharmacol. 165, 1424-1441. doi: 10.1111/j.1476-5381.2011.01623.x.
    • (2012) Br. J. Pharmacol. , vol.165 , pp. 1424-1441
    • Abassi, Y.A.1    Xi, B.2    Li, N.3    Ouyang, W.4    Seiler, A.5    Watzele, M.6
  • 2
    • 67651112016 scopus 로고    scopus 로고
    • Kinetic cell-based morphological screening: prediction of mechanism of compound action and off-target effects
    • doi: 10.1016/j.chembiol.2009.05.011
    • Abassi, Y. A., Xi, B., Zhang, W., Ye, P., Kirstein, S. L., Gaylord, M. R., et al. (2009). Kinetic cell-based morphological screening: prediction of mechanism of compound action and off-target effects. Chem. Biol. 16, 712-723. doi: 10.1016/j.chembiol.2009.05.011.
    • (2009) Chem. Biol. , vol.16 , pp. 712-723
    • Abassi, Y.A.1    Xi, B.2    Zhang, W.3    Ye, P.4    Kirstein, S.L.5    Gaylord, M.R.6
  • 3
    • 79955601786 scopus 로고    scopus 로고
    • Trial watch: phase II failures: 2008-2010
    • doi: 10.1038/nrd3439
    • Arrowsmith, J. (2011). Trial watch: phase II failures: 2008-2010. Nat. Rev. Drug Discov. 10, 328-329. doi: 10.1038/nrd3439.
    • (2011) Nat. Rev. Drug Discov. , vol.10 , pp. 328-329
    • Arrowsmith, J.1
  • 4
    • 79955633316 scopus 로고    scopus 로고
    • Real-time label-free monitoring of adipose-derived stem cell differentiation with electric cell-substrate impedance sensing
    • doi: 10.1073/pnas.1018260108
    • Bagnaninchi, P. O., and Drummond, N. (2011). Real-time label-free monitoring of adipose-derived stem cell differentiation with electric cell-substrate impedance sensing. Proc. Natl. Acad. Sci. U.S.A. 108, 6462-6467. doi: 10.1073/pnas.1018260108.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 6462-6467
    • Bagnaninchi, P.O.1    Drummond, N.2
  • 5
    • 84859169877 scopus 로고    scopus 로고
    • The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
    • doi: 10.1038/nature11003
    • Barretina, J., Caponigro, G., Stransky, N., Venkatesan, K., Margolin, A. A., Kim, S., et al. (2012). The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature 483, 603-607. doi: 10.1038/nature11003.
    • (2012) Nature , vol.483 , pp. 603-607
    • Barretina, J.1    Caponigro, G.2    Stransky, N.3    Venkatesan, K.4    Margolin, A.A.5    Kim, S.6
  • 6
    • 70350524083 scopus 로고    scopus 로고
    • Resveratrol is not a direct activator of SIRT1 enzyme activity
    • doi: 10.1111/j.1747-0285.2009.00901.x
    • Beher, D., Wu, J., Cumine, S., Kim, K. W., Lu, S. C., Atangan, L., et al. (2009). Resveratrol is not a direct activator of SIRT1 enzyme activity. Chem. Biol. Drug Des. 74, 619-624. doi: 10.1111/j.1747-0285.2009.00901.x.
    • (2009) Chem. Biol. Drug Des. , vol.74 , pp. 619-624
    • Beher, D.1    Wu, J.2    Cumine, S.3    Kim, K.W.4    Lu, S.C.5    Atangan, L.6
  • 7
    • 40049100210 scopus 로고    scopus 로고
    • Analysis of pharmacology data and the prediction of adverse drug reactions and off-target effects from chemical structure
    • doi: 10.1002/cmdc.200700026
    • Bender, A., Scheiber, J., Glick, M., Davies, J. W., Azzaoui, K., Hamon, J., et al. (2007). Analysis of pharmacology data and the prediction of adverse drug reactions and off-target effects from chemical structure. Chem. Med. Chem. 2, 861-873. doi: 10.1002/cmdc.200700026.
    • (2007) Chem. Med. Chem. , vol.2 , pp. 861-873
    • Bender, A.1    Scheiber, J.2    Glick, M.3    Davies, J.W.4    Azzaoui, K.5    Hamon, J.6
  • 8
    • 84890966535 scopus 로고    scopus 로고
    • Dynamic ligand binding dictates partial agonism at a G protein-coupled receptor
    • doi: 10.1038/nchembio.1384
    • Bock, A., Chirinda, B., Krebs, F., Messerer, R., Bätz, J., Muth, M., et al. (2014). Dynamic ligand binding dictates partial agonism at a G protein-coupled receptor. Nat. Chem. Biol. 10, 18-20. doi: 10.1038/nchembio.1384.
    • (2014) Nat. Chem. Biol. , vol.10 , pp. 18-20
    • Bock, A.1    Chirinda, B.2    Krebs, F.3    Messerer, R.4    Bätz, J.5    Muth, M.6
  • 9
    • 47249146126 scopus 로고    scopus 로고
    • Drug target identification using side-effect similarity
    • doi: 10.1126/science.1158140
    • Campillos, M., Kuhn, M., Gavin, A.-C., Jensen, L. J., and Bork, P. (2008). Drug target identification using side-effect similarity. Science 321, 263-266. doi: 10.1126/science.1158140.
    • (2008) Science , vol.321 , pp. 263-266
    • Campillos, M.1    Kuhn, M.2    Gavin, A.-C.3    Jensen, L.J.4    Bork, P.5
  • 10
    • 80054868459 scopus 로고    scopus 로고
    • Ligand discovery from a dopamine D3 receptor homology model and crystal structure
    • doi: 10.1038/nchembio.662
    • Carlsson, J., Coleman, R. G., Setola, V., Irwin, J. J., Fan, H., Schlessinger, A., et al. (2011). Ligand discovery from a dopamine D3 receptor homology model and crystal structure. Nat. Chem. Biol. 7, 769-778. doi: 10.1038/nchembio.662.
    • (2011) Nat. Chem. Biol. , vol.7 , pp. 769-778
    • Carlsson, J.1    Coleman, R.G.2    Setola, V.3    Irwin, J.J.4    Fan, H.5    Schlessinger, A.6
  • 11
    • 84867017626 scopus 로고    scopus 로고
    • Discovery of nitrophenols as GPR35 agonists
    • doi: 10.1039/C2MD20210G
    • Deng, H., and Fang, Y. (2012a). Discovery of nitrophenols as GPR35 agonists. Med. Chem. Comm. 3, 1270-1274. doi: 10.1039/C2MD20210G.
    • (2012) Med. Chem. Comm. , vol.3 , pp. 1270-1274
    • Deng, H.1    Fang, Y.2
  • 12
    • 84863828527 scopus 로고    scopus 로고
    • Synthesis and agonistic activity at the GPR35 of 5,6-dihydroxyindole-2-carboxylic acid analogs
    • doi: 10.1021/ml300076u
    • Deng, H., and Fang, Y. (2012b). Synthesis and agonistic activity at the GPR35 of 5,6-dihydroxyindole-2-carboxylic acid analogs. ACS Med. Chem. Lett. 3, 550-554. doi: 10.1021/ml300076u.
    • (2012) ACS Med. Chem. Lett. , vol.3 , pp. 550-554
    • Deng, H.1    Fang, Y.2
  • 13
    • 79958142575 scopus 로고    scopus 로고
    • Tyrphostin analogs are GPR35 agonists
    • doi: 10.1016/j.febslet.2011.05.026
    • Deng, H., Hu, H., and Fang, Y. (2011a). Tyrphostin analogs are GPR35 agonists. FEBS Lett. 585, 1957-1962. doi: 10.1016/j.febslet.2011.05.026.
    • (2011) FEBS Lett. , vol.585 , pp. 1957-1962
    • Deng, H.1    Hu, H.2    Fang, Y.3
  • 14
    • 80054935789 scopus 로고    scopus 로고
    • Discovery of 2-(4-methylfuran-2(5H)-ylidene)malononitrile and thieno[3,2-b]thiophene-2-carboxylic acid derivatives as G protein-coupled receptor-35 (GPR35) agonists
    • doi: 10.1021/jm200999f
    • Deng, H., Hu, H., He, M., Hu, J., Niu, W., Ferrie, A. M., et al. (2011b). Discovery of 2-(4-methylfuran-2(5H)-ylidene)malononitrile and thieno[3,2-b]thiophene-2-carboxylic acid derivatives as G protein-coupled receptor-35 (GPR35) agonists. J. Med. Chem. 54, 7385-7396. doi: 10.1021/jm200999f.
    • (2011) J. Med. Chem. , vol.54 , pp. 7385-7396
    • Deng, H.1    Hu, H.2    He, M.3    Hu, J.4    Niu, W.5    Ferrie, A.M.6
  • 15
    • 84860115550 scopus 로고    scopus 로고
    • Multiple tyrosine metabolites are GPR35 agonists
    • doi: 10.1038/srep00373
    • Deng, H., Hu, H., and Fang, Y. (2012a). Multiple tyrosine metabolites are GPR35 agonists. Sci. Rep. 2, 373. doi: 10.1038/srep00373.
    • (2012) Sci. Rep. , vol.2 , pp. 373
    • Deng, H.1    Hu, H.2    Fang, Y.3
  • 16
    • 84867050365 scopus 로고    scopus 로고
    • Probing biochemical mechanisms of action of muscarinic M3 receptor antagonists with label-free whole-cell assays
    • doi: 10.1021/ac301495n
    • Deng, H., Wang, C., Su, M., and Fang, Y. (2012b). Probing biochemical mechanisms of action of muscarinic M3 receptor antagonists with label-free whole-cell assays. Anal. Chem. 84, 8232-8239. doi: 10.1021/ac301495n.
    • (2012) Anal. Chem. , vol.84 , pp. 8232-8239
    • Deng, H.1    Wang, C.2    Su, M.3    Fang, Y.4
  • 17
    • 84883344244 scopus 로고    scopus 로고
    • Label-free cell phenotypic efficacy of agonists at endogenous muscarinic M3 receptor correlates with their residence time
    • doi: 10.1016/j.vascn.2013.07.005
    • Deng, H., Sun, H., and Fang, Y. (2013a). Label-free cell phenotypic efficacy of agonists at endogenous muscarinic M3 receptor correlates with their residence time. J. Pharmacol. Toxicol. Methods 68, 323-333. doi: 10.1016/j.vascn.2013.07.005.
    • (2013) J. Pharmacol. Toxicol. Methods , vol.68 , pp. 323-333
    • Deng, H.1    Sun, H.2    Fang, Y.3
  • 18
    • 84881426930 scopus 로고    scopus 로고
    • Label-free cell phenotypic assessment of the molecular mechanism of action of epidermal growth factor receptor inhibitors
    • doi: 10.1039/C3RA40426A
    • Deng, H., Wang, C., and Fang, Y. (2013b). Label-free cell phenotypic assessment of the molecular mechanism of action of epidermal growth factor receptor inhibitors. RSC Adv. 3, 10370-10378. doi: 10.1039/C3RA40426A.
    • (2013) RSC Adv. , vol.3 , pp. 10370-10378
    • Deng, H.1    Wang, C.2    Fang, Y.3
  • 19
    • 70349758970 scopus 로고    scopus 로고
    • A 100K well screen for a muscarinic receptor using the Epic label-free system-a reflection on the benefits of the label-free approach to screening seven-transmembrane receptors
    • doi: 10.1080/10799890903079844
    • Dodgson, K., Gedge, L., Murray, D. C., and Coldwell, M. (2009). A 100K well screen for a muscarinic receptor using the Epic label-free system-a reflection on the benefits of the label-free approach to screening seven-transmembrane receptors. J. Recept. Signal. Transduct. 29, 163-172. doi: 10.1080/10799890903079844.
    • (2009) J. Recept. Signal. Transduct. , vol.29 , pp. 163-172
    • Dodgson, K.1    Gedge, L.2    Murray, D.C.3    Coldwell, M.4
  • 20
    • 84875457503 scopus 로고    scopus 로고
    • The why and how of phenotypic small-molecule screens
    • doi: 10.1038/nchembio.1206
    • Eggert, U. S. (2013). The why and how of phenotypic small-molecule screens. Nat. Chem. Biol. 9, 206-209. doi: 10.1038/nchembio.1206.
    • (2013) Nat. Chem. Biol. , vol.9 , pp. 206-209
    • Eggert, U.S.1
  • 21
    • 79953793127 scopus 로고    scopus 로고
    • Primary cells and stem cells in drug discovery: emerging tools for high-throughput screening
    • doi: 10.1089/adt.2010.0305
    • Eglen, R., and Reisine, T. (2011). Primary cells and stem cells in drug discovery: emerging tools for high-throughput screening. Assay Drug Dev. Technol. 9, 108-124. doi: 10.1089/adt.2010.0305.
    • (2011) Assay Drug Dev. Technol. , vol.9 , pp. 108-124
    • Eglen, R.1    Reisine, T.2
  • 22
    • 33845877164 scopus 로고    scopus 로고
    • Label-free cell-based assays with optical biosensors in drug discovery
    • doi: 10.1089/adt.2006.4.583
    • Fang, Y. (2006). Label-free cell-based assays with optical biosensors in drug discovery. Assay Drug Dev. Technol. 4, 583-595. doi: 10.1089/adt.2006.4.583.
    • (2006) Assay Drug Dev. Technol. , vol.4 , pp. 583-595
    • Fang, Y.1
  • 23
    • 78649343774 scopus 로고    scopus 로고
    • Label-free receptor assays
    • doi: 10.1016/j.ddtec.2010.05.001
    • Fang, Y. (2010). Label-free receptor assays. Drug Discov. Today Technol. 7:e5-e11. doi: 10.1016/j.ddtec.2010.05.001.
    • (2010) Drug Discov. Today Technol. , vol.7
    • Fang, Y.1
  • 24
    • 83455169708 scopus 로고    scopus 로고
    • The development of label-free cellular assays for drug discovery
    • doi: 10.1517/17460441.2012.642360
    • Fang, Y. (2011a). The development of label-free cellular assays for drug discovery. Expert Opin. Drug Discov. 6, 1285-1298. doi: 10.1517/17460441.2012.642360.
    • (2011) Expert Opin. Drug Discov. , vol.6 , pp. 1285-1298
    • Fang, Y.1
  • 25
    • 83455262545 scopus 로고    scopus 로고
    • Label-free biosensors for cell biology
    • doi: 10.4061/2011/460850
    • Fang, Y. (2011b). Label-free biosensors for cell biology. Int. J. Electrochem. 2011:e460850. doi: 10.4061/2011/460850.
    • (2011) Int. J. Electrochem. , vol.2011
    • Fang, Y.1
  • 26
    • 84866875777 scopus 로고    scopus 로고
    • Ligand-receptor interaction platforms and their applications for drug discovery
    • doi: 10.1517/17460441.2012.715631
    • Fang, Y. (2012). Ligand-receptor interaction platforms and their applications for drug discovery. Expert Opin. Drug Discov. 7, 969-988. doi: 10.1517/17460441.2012.715631.
    • (2012) Expert Opin. Drug Discov. , vol.7 , pp. 969-988
    • Fang, Y.1
  • 27
    • 84875279578 scopus 로고    scopus 로고
    • Troubleshooting and deconvoluting label-free cell phenotypic assays in drug discovery
    • doi: 10.1016/j.vascn.2013.01.004
    • Fang, Y. (2013). Troubleshooting and deconvoluting label-free cell phenotypic assays in drug discovery. J. Pharmacol. Toxicol. Methods 67, 69-81. doi: 10.1016/j.vascn.2013.01.004.
    • (2013) J. Pharmacol. Toxicol. Methods , vol.67 , pp. 69-81
    • Fang, Y.1
  • 28
    • 39649108870 scopus 로고    scopus 로고
    • Label-free optical biosensor for ligand-directed functional selectivity acting on β2-adrenoceptor in living cells
    • doi: 10.1016/j.febslet.2008.01.021
    • Fang, Y., and Ferrie, A. M. (2008). Label-free optical biosensor for ligand-directed functional selectivity acting on β2-adrenoceptor in living cells. FEBS Lett. 582, 558-564. doi: 10.1016/j.febslet.2008.01.021.
    • (2008) FEBS Lett. , vol.582 , pp. 558-564
    • Fang, Y.1    Ferrie, A.M.2
  • 29
    • 33748469378 scopus 로고    scopus 로고
    • Resonant waveguide grating biosensor for living cell sensing
    • doi: 10.1529/biophysj.105.077818
    • Fang, Y., Ferrie, A. M., Fontaine, N. H., Mauro, J., and Balakrishnan, J. (2006). Resonant waveguide grating biosensor for living cell sensing. Biophys. J. 91, 1925-1940. doi: 10.1529/biophysj.105.077818.
    • (2006) Biophys. J. , vol.91 , pp. 1925-1940
    • Fang, Y.1    Ferrie, A.M.2    Fontaine, N.H.3    Mauro, J.4    Balakrishnan, J.5
  • 30
    • 24644496122 scopus 로고    scopus 로고
    • Characteristics of dynamic mass redistribution of EGF receptor signaling in living cells measured with label free optical biosensors
    • doi: 10.1021/ac050887n
    • Fang, Y., Ferrie, A. M., Fontaine, N. H., and Yuen, P. K. (2005). Characteristics of dynamic mass redistribution of EGF receptor signaling in living cells measured with label free optical biosensors. Anal. Chem. 77, 5720-5725. doi: 10.1021/ac050887n.
    • (2005) Anal. Chem. , vol.77 , pp. 5720-5725
    • Fang, Y.1    Ferrie, A.M.2    Fontaine, N.H.3    Yuen, P.K.4
  • 31
    • 67650070045 scopus 로고    scopus 로고
    • Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds
    • doi: 10.1038/nrd2876
    • Feng, Y., Mitchison, T. J., Bender, A., Young, D. W., and Tallarico, J. A. (2009). Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds. Nat. Rev. Drug Discov. 8, 567-578. doi: 10.1038/nrd2876.
    • (2009) Nat. Rev. Drug Discov. , vol.8 , pp. 567-578
    • Feng, Y.1    Mitchison, T.J.2    Bender, A.3    Young, D.W.4    Tallarico, J.A.5
  • 32
    • 84862115332 scopus 로고    scopus 로고
    • High resolution resonant waveguide grating imager for cell cluster analysis under physiological condition
    • doi: 10.1063/1.4723691
    • Ferrie, A. M., Deichmann, O. D., Wu, Q., and Fang, Y. (2012). High resolution resonant waveguide grating imager for cell cluster analysis under physiological condition. Appl. Phys. Lett. 100, 223701. doi: 10.1063/1.4723691.
    • (2012) Appl. Phys. Lett. , vol.100 , pp. 223701
    • Ferrie, A.M.1    Deichmann, O.D.2    Wu, Q.3    Fang, Y.4
  • 33
    • 80053899050 scopus 로고    scopus 로고
    • Label-free integrative pharmacology on-target of drugs at the β2-adrenergic receptor
    • doi: 10.1038/srep00033
    • Ferrie, A. M., Sun, H., and Fang, Y. (2011). Label-free integrative pharmacology on-target of drugs at the β2-adrenergic receptor. Sci. Rep. 1, 33. doi: 10.1038/srep00033.
    • (2011) Sci. Rep. , vol.1 , pp. 33
    • Ferrie, A.M.1    Sun, H.2    Fang, Y.3
  • 34
    • 84893117844 scopus 로고    scopus 로고
    • Divergent label-free cell phenotypic pharmacology of ligands at the overexpressed β2-adrenergic receptors
    • doi: 10.1038/srep03828
    • Ferrie, A. M., Sun, H., Zaytseva, N., and Fang, Y. (2014). Divergent label-free cell phenotypic pharmacology of ligands at the overexpressed β2-adrenergic receptors. Sci. Rep. 4, 3828. doi: 10.1038/srep03828.
    • (2014) Sci. Rep. , vol.4 , pp. 3828
    • Ferrie, A.M.1    Sun, H.2    Zaytseva, N.3    Fang, Y.4
  • 35
    • 84884681390 scopus 로고    scopus 로고
    • Label-free optical biosensor with microfluidics identifies an intracellular signalling wave mediated through the β2-adrerengic receptor
    • doi: 10.1039/c3ib40112j
    • Ferrie, A. M., Wang, C., Deng, H., and Fang, Y. (2013). Label-free optical biosensor with microfluidics identifies an intracellular signalling wave mediated through the β2-adrerengic receptor. Integr. Biol. 5, 1253-1261. doi: 10.1039/c3ib40112j.
    • (2013) Integr. Biol. , vol.5 , pp. 1253-1261
    • Ferrie, A.M.1    Wang, C.2    Deng, H.3    Fang, Y.4
  • 36
    • 78650667671 scopus 로고    scopus 로고
    • Resonant waveguide grating imager for live cell sensing
    • doi: 10.1063/1.3522894
    • Ferrie, A. M., Wu, Q., and Fang, Y. (2010). Resonant waveguide grating imager for live cell sensing. Appl. Phys. Lett. 97, 223704. doi: 10.1063/1.3522894.
    • (2010) Appl. Phys. Lett. , vol.97 , pp. 223704
    • Ferrie, A.M.1    Wu, Q.2    Fang, Y.3
  • 37
    • 80052307735 scopus 로고    scopus 로고
    • Kinetic cellular phenotypic profiling: prediction, identification, and analysis of bioactive natural products
    • doi: 10.1021/ac201670e
    • Fu, H., Fu, W., Sun, M., Shou, Q., Zhai, Y., Cheng, H., et al. (2011). Kinetic cellular phenotypic profiling: prediction, identification, and analysis of bioactive natural products. Anal. Chem. 83, 6518-6526. doi: 10.1021/ac201670e.
    • (2011) Anal. Chem. , vol.83 , pp. 6518-6526
    • Fu, H.1    Fu, W.2    Sun, M.3    Shou, Q.4    Zhai, Y.5    Cheng, H.6
  • 38
    • 84859187259 scopus 로고    scopus 로고
    • Systematic identification of genomic markers of drug sensitivity in cancer cells
    • doi: 10.1038/nature11005
    • Garnett, M. J., Edelman, E. J., Heidorn, S. J., Greenman, C. D., Dastur, A., and Lau, K. W. (2012). Systematic identification of genomic markers of drug sensitivity in cancer cells. Nature 483, 570-575. doi: 10.1038/nature11005.
    • (2012) Nature , vol.483 , pp. 570-575
    • Garnett, M.J.1    Edelman, E.J.2    Heidorn, S.J.3    Greenman, C.D.4    Dastur, A.5    Lau, K.W.6
  • 39
    • 84862192766 scopus 로고    scopus 로고
    • ChEMBL: a large-scale bioactivity database for drug discovery
    • doi: 10.1093/nar/gkr777
    • Gaulton, A., Bellis, L. J., Bento, A. P., Chambers, J., Davies, M., Hersey, A., et al. (2012). ChEMBL: a large-scale bioactivity database for drug discovery. Nucleic Acids Res. 40, D1100-D1107. doi: 10.1093/nar/gkr777.
    • (2012) Nucleic Acids Res. , vol.40
    • Gaulton, A.1    Bellis, L.J.2    Bento, A.P.3    Chambers, J.4    Davies, M.5    Hersey, A.6
  • 40
    • 79955631465 scopus 로고    scopus 로고
    • Agonist-directed desensitization of the β2-adrenergic receptor
    • doi: 10.1371/journal.pone.0019282
    • Goral, V., Jin, Y., Sun, H., Ferrie, A. M., Wu, Q., and Fang, Y. (2011). Agonist-directed desensitization of the β2-adrenergic receptor. PLoS ONE 6:e19282. doi: 10.1371/journal.pone.0019282.
    • (2011) PLoS ONE , vol.6
    • Goral, V.1    Jin, Y.2    Sun, H.3    Ferrie, A.M.4    Wu, Q.5    Fang, Y.6
  • 41
    • 84863228021 scopus 로고    scopus 로고
    • Functional efficacy of adenosine A2A receptor agonists is positively correlated to their receptor residence time
    • doi: 10.1111/j.1476-5381.2012.01897.x
    • Guo, D., Mulder-Krieger, T., Ijzerman, A. P., and Heitman, L. H. (2012). Functional efficacy of adenosine A2A receptor agonists is positively correlated to their receptor residence time. Br. J. Pharmacol. 166, 1846-1959. doi: 10.1111/j.1476-5381.2012.01897.x.
    • (2012) Br. J. Pharmacol. , vol.166 , pp. 1846-1959
    • Guo, D.1    Mulder-Krieger, T.2    Ijzerman, A.P.3    Heitman, L.H.4
  • 42
    • 17044373269 scopus 로고    scopus 로고
    • Finding the target after screening the phenotype
    • doi: 10.1016/S1359-6446(05)03415-X
    • Hart, C. P. (2005). Finding the target after screening the phenotype. Drug Discov. Today 10, 513-519. doi: 10.1016/S1359-6446(05)03415-X.
    • (2005) Drug Discov. Today , vol.10 , pp. 513-519
    • Hart, C.P.1
  • 43
    • 84886745200 scopus 로고    scopus 로고
    • Decoding signaling and function of the orphan G protein-coupled receptor GPR17 with a small-molecule agonist
    • doi: 10.1126/scisignal.2004350
    • Hennen, S., Wang, H., Peters, L., Merten, N., Simon, K., Spinrath, A., et al. (2013). Decoding signaling and function of the orphan G protein-coupled receptor GPR17 with a small-molecule agonist. Sci. Signal. 6, ra93. doi: 10.1126/scisignal.2004350.
    • (2013) Sci. Signal. , vol.6
    • Hennen, S.1    Wang, H.2    Peters, L.3    Merten, N.4    Simon, K.5    Spinrath, A.6
  • 44
    • 84863990917 scopus 로고    scopus 로고
    • Semantic integration of physiology phenotypes with an application to the Cellular Phenotype Ontology
    • doi: 10.1093/bioinformatics/bts250
    • Hoehndorf, R., Harris, M. A., Herre, H., Rustici, G., and Gkoutos, G. V. (2012). Semantic integration of physiology phenotypes with an application to the Cellular Phenotype Ontology. Bioinformatics 28, 1783-1789. doi: 10.1093/bioinformatics/bts250.
    • (2012) Bioinformatics , vol.28 , pp. 1783-1789
    • Hoehndorf, R.1    Harris, M.A.2    Herre, H.3    Rustici, G.4    Gkoutos, G.V.5
  • 45
    • 54249155522 scopus 로고    scopus 로고
    • Network pharmacology: the next paradigm in drug discovery
    • doi: 10.1038/nchembio.118
    • Hopkins, A. L. (2008). Network pharmacology: the next paradigm in drug discovery. Nat. Chem. Biol. 4, 682-690. doi: 10.1038/nchembio.118.
    • (2008) Nat. Chem. Biol. , vol.4 , pp. 682-690
    • Hopkins, A.L.1
  • 46
    • 84866881898 scopus 로고    scopus 로고
    • Label-free phenotypic profiling identified D-luciferin as a GPR35 agonist
    • doi: 10.1371/journal.pone.0034934
    • Hu, H., Deng, H., and Fang, Y. (2012). Label-free phenotypic profiling identified D-luciferin as a GPR35 agonist. PLoS ONE 7:e34934. doi: 10.1371/journal.pone.0034934.
    • (2012) PLoS ONE , vol.7
    • Hu, H.1    Deng, H.2    Fang, Y.3
  • 47
    • 13844312649 scopus 로고    scopus 로고
    • ZINC-a free database of commercially available compounds for virtual screening
    • doi: 10.1021/ci049714
    • Irwin, J. J., and Shoichet, B. K. (2005). ZINC-a free database of commercially available compounds for virtual screening. J. Chem. Inf. Model. 45, 177-182. doi: 10.1021/ci049714.
    • (2005) J. Chem. Inf. Model. , vol.45 , pp. 177-182
    • Irwin, J.J.1    Shoichet, B.K.2
  • 48
    • 33947596504 scopus 로고    scopus 로고
    • Why is cancer drug discovery so difficult?
    • doi: 10.1038/nrd2155
    • Kamb, A., Wee, S., and Lengauer, C. (2007). Why is cancer drug discovery so difficult? Nat. Rev. Drug Discov. 6, 115-120. doi: 10.1038/nrd2155.
    • (2007) Nat. Rev. Drug Discov. , vol.6 , pp. 115-120
    • Kamb, A.1    Wee, S.2    Lengauer, C.3
  • 50
    • 70449634957 scopus 로고    scopus 로고
    • Predicting new molecular targets for known drugs
    • doi: 10.1038/nature08506
    • Keiser, M. J., Setola, V., Irwin, J. J., Laggner, C., Abbas, A. I., Hufeisen, S. J., et al. (2009). Predicting new molecular targets for known drugs. Nature 462, 175-181. doi: 10.1038/nature08506.
    • (2009) Nature , vol.462 , pp. 175-181
    • Keiser, M.J.1    Setola, V.2    Irwin, J.J.3    Laggner, C.4    Abbas, A.I.5    Hufeisen, S.J.6
  • 51
    • 68249113457 scopus 로고    scopus 로고
    • Cellular assays as portals to seven-transmembrane receptor-based drug discovery
    • doi: 10.1038/nrd2838
    • Kenakin, T. (2009). Cellular assays as portals to seven-transmembrane receptor-based drug discovery. Nat. Rev. Drug Discov. 8, 617-626. doi: 10.1038/nrd2838.
    • (2009) Nat. Rev. Drug Discov. , vol.8 , pp. 617-626
    • Kenakin, T.1
  • 52
    • 84872048999 scopus 로고    scopus 로고
    • The potential for selective pharmacological therapies through biased receptor signaling
    • doi: 10.1186/2050-6511-13-3
    • Kenakin, T. (2012). The potential for selective pharmacological therapies through biased receptor signaling. BMC Pharmacol. Toxicol. 13:3. doi: 10.1186/2050-6511-13-3.
    • (2012) BMC Pharmacol. Toxicol. , vol.13 , pp. 3
    • Kenakin, T.1
  • 54
    • 33644524741 scopus 로고    scopus 로고
    • Cell signaling dynamics in time and space
    • doi: 10.1038/nrm1838
    • Kholodenko, B. N. (2006). Cell signaling dynamics in time and space. Nat. Rev. Mol. Cell Biol. 7, 165-176. doi: 10.1038/nrm1838.
    • (2006) Nat. Rev. Mol. Cell Biol. , vol.7 , pp. 165-176
    • Kholodenko, B.N.1
  • 55
    • 78651287426 scopus 로고    scopus 로고
    • DrugBank 3.0: a comprehensive resource for 'omics' research on drugs
    • doi: 10.1093/nar/gkq1126
    • Knox, C., Law, V., Jewison, T., Liu, P., Ly, S., Frolkis, A., et al. (2011). DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 39, D1035-D1041. doi: 10.1093/nar/gkq1126.
    • (2011) Nucleic Acids Res. , vol.39
    • Knox, C.1    Law, V.2    Jewison, T.3    Liu, P.4    Ly, S.5    Frolkis, A.6
  • 56
    • 81055140589 scopus 로고    scopus 로고
    • From in silico target prediction to multi-target drug design: current databases, methods and applications
    • doi: 10.1016/j.jprot.2011.05.011
    • Koutsoukas, A., Simms, B., Kirchmair, J., Bond, P. J., Whitmore, A. V., Zimmer, S., et al. (2011). From in silico target prediction to multi-target drug design: current databases, methods and applications. J. Proteomics 74, 2554-2574. doi: 10.1016/j.jprot.2011.05.011.
    • (2011) J. Proteomics , vol.74 , pp. 2554-2574
    • Koutsoukas, A.1    Simms, B.2    Kirchmair, J.3    Bond, P.J.4    Whitmore, A.V.5    Zimmer, S.6
  • 57
    • 84861490509 scopus 로고    scopus 로고
    • Modern phenotypic drug discovery is a viable, neoclassic pharma strategy
    • doi: 10.1021/jm201649s
    • Lee, J. A., Uhlik, M. T., Moxham, C. M., Tomandl, D., and Sall, D. J. (2012). Modern phenotypic drug discovery is a viable, neoclassic pharma strategy. J. Med. Chem. 55, 4527-4538. doi: 10.1021/jm201649s.
    • (2012) J. Med. Chem. , vol.55 , pp. 4527-4538
    • Lee, J.A.1    Uhlik, M.T.2    Moxham, C.M.3    Tomandl, D.4    Sall, D.J.5
  • 58
    • 33746347333 scopus 로고    scopus 로고
    • Tyrphostins and other tyrosine kinase inhibitors
    • doi: 10.1146/annurev.biochem.75.103004.142657
    • Levitzki, A., and Mishani, E. (2006). Tyrphostins and other tyrosine kinase inhibitors. Annu. Rev. Biochem. 75, 93-109. doi: 10.1146/annurev.biochem.75.103004.142657.
    • (2006) Annu. Rev. Biochem. , vol.75 , pp. 93-109
    • Levitzki, A.1    Mishani, E.2
  • 59
    • 84875607396 scopus 로고    scopus 로고
    • Cell biology: receptor signals come in waves
    • doi: 10.1038/nature12086
    • Lohse, M. J., and Calebiro, D. (2013). Cell biology: receptor signals come in waves. Nature 495, 457-458. doi: 10.1038/nature12086.
    • (2013) Nature , vol.495 , pp. 457-458
    • Lohse, M.J.1    Calebiro, D.2
  • 60
    • 84862510972 scopus 로고    scopus 로고
    • Large-scale prediction and testing of drug activity on side-effect targets
    • doi: 10.1038/nature11159
    • Lounkine, E., Keiser, M. J., Whitebread, S., Mikhailov, S., Hamon, J., Jenkins, J. L., et al. (2012). Large-scale prediction and testing of drug activity on side-effect targets. Nature 486, 361-367. doi: 10.1038/nature11159.
    • (2012) Nature , vol.486 , pp. 361-367
    • Lounkine, E.1    Keiser, M.J.2    Whitebread, S.3    Mikhailov, S.4    Hamon, J.5    Jenkins, J.L.6
  • 61
    • 35248895259 scopus 로고    scopus 로고
    • Impedance-based cellular assay technologies: recent advances, future promise
    • doi: 10.1016/j.coph.2007.08.004
    • McGuinness, R. (2007). Impedance-based cellular assay technologies: recent advances, future promise. Curr. Opin. Pharmacol. 7, 535-540. doi: 10.1016/j.coph.2007.08.004.
    • (2007) Curr. Opin. Pharmacol. , vol.7 , pp. 535-540
    • McGuinness, R.1
  • 62
    • 84879825146 scopus 로고    scopus 로고
    • Label-free integrative pharmacology ontarget of opioid ligands at the opioid receptor family
    • doi: 10.1186/2050-6511-14-17
    • Morse, M., Sun, H., Tran, E., Levenson, R., and Fang, Y. (2013). Label-free integrative pharmacology ontarget of opioid ligands at the opioid receptor family. BMC Pharmacol. Toxicol. 14:17. doi: 10.1186/2050-6511-14-17.
    • (2013) BMC Pharmacol. Toxicol. , vol.14 , pp. 17
    • Morse, M.1    Sun, H.2    Tran, E.3    Levenson, R.4    Fang, Y.5
  • 63
    • 80053928946 scopus 로고    scopus 로고
    • Ligand-directed functional selectivity at the mu opioid receptor revealed by label-free on-target pharmacology
    • doi: 10.1371/journal.pone.0025643
    • Morse, M., Tran, E., Levension, R. L., and Fang, Y. (2011). Ligand-directed functional selectivity at the mu opioid receptor revealed by label-free on-target pharmacology. PLoS ONE 6:e25643. doi: 10.1371/journal.pone.0025643.
    • (2011) PLoS ONE , vol.6
    • Morse, M.1    Tran, E.2    Levension, R.L.3    Fang, Y.4
  • 64
    • 77950246109 scopus 로고    scopus 로고
    • SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1
    • doi: 10.1074/jbc.M109.088682
    • Pacholec, M., Bleasdale, J. E., Chrunyk, B., Cunningham, D., Flynn, D., Garofalo, R. S., et al. (2010). SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1. J. Biol. Chem. 285, 8340-8351. doi: 10.1074/jbc.M109.088682.
    • (2010) J. Biol. Chem. , vol.285 , pp. 8340-8351
    • Pacholec, M.1    Bleasdale, J.E.2    Chrunyk, B.3    Cunningham, D.4    Flynn, D.5    Garofalo, R.S.6
  • 65
    • 84866395402 scopus 로고    scopus 로고
    • Dynamic mass redistribution assay decodes differentiation of a neural progenitor stem cell
    • doi: 10.1177/1087057112455059
    • Pai, S., Verrier, F., Sun, H., Hu, H., Ferrie, A. M., Eshraghi, A., et al. (2012). Dynamic mass redistribution assay decodes differentiation of a neural progenitor stem cell. J. Biomol. Screen. 17, 1180-1191. doi: 10.1177/1087057112455059.
    • (2012) J. Biomol. Screen. , vol.17 , pp. 1180-1191
    • Pai, S.1    Verrier, F.2    Sun, H.3    Hu, H.4    Ferrie, A.M.5    Eshraghi, A.6
  • 66
    • 79957889347 scopus 로고    scopus 로고
    • The productivity crisis in pharmaceutical R&D
    • doi: 10.1038/nrd3405
    • Pammolli, F., Magazzini, L., and Riccaboni, M. (2011). The productivity crisis in pharmaceutical R&D. Nat. Rev. Drug Discov. 10, 428-438. doi: 10.1038/nrd3405.
    • (2011) Nat. Rev. Drug Discov. , vol.10 , pp. 428-438
    • Pammolli, F.1    Magazzini, L.2    Riccaboni, M.3
  • 68
    • 79961007572 scopus 로고    scopus 로고
    • Trends in the exploitation of novel drug targets
    • doi: 10.1038/nrd3478
    • Rask-Andersen, M., Almén, M. S., and Schiöth, H. B. (2011). Trends in the exploitation of novel drug targets. Nat. Rev. Drug Discov. 10, 579-590. doi: 10.1038/nrd3478.
    • (2011) Nat. Rev. Drug Discov. , vol.10 , pp. 579-590
    • Rask-Andersen, M.1    Almén, M.S.2    Schiöth, H.B.3
  • 69
    • 4644271084 scopus 로고    scopus 로고
    • Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia
    • doi: 10.1038/nrd1346
    • Roth, B. L., Sheffler, D. J., and Kroeze, W. K. (2004). Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia. Nat. Rev. Drug Discov. 3, 353-359. doi: 10.1038/nrd1346.
    • (2004) Nat. Rev. Drug Discov. , vol.3 , pp. 353-359
    • Roth, B.L.1    Sheffler, D.J.2    Kroeze, W.K.3
  • 70
    • 84857743319 scopus 로고    scopus 로고
    • Diagnosing the decline in pharamaceutical R&D efficiency
    • doi: 10.1038/nrd3681
    • Scannell, J. W. (2012). Diagnosing the decline in pharamaceutical R&D efficiency. Nat. Rev. Drug Discov. 11, 191-200. doi: 10.1038/nrd3681.
    • (2012) Nat. Rev. Drug Discov. , vol.11 , pp. 191-200
    • Scannell, J.W.1
  • 71
    • 84875458314 scopus 로고    scopus 로고
    • Target identification and mechanism of action in chemical biology and drug discovery
    • doi: 10.1038/nchembio.1199
    • Schenone, M., Danèík, V., Wagner, B. K., and Clemons, P. A. (2013). Target identification and mechanism of action in chemical biology and drug discovery. Nat. Chem. Biol. 9, 232-240. doi: 10.1038/nchembio.1199.
    • (2013) Nat. Chem. Biol. , vol.9 , pp. 232-240
    • Schenone, M.1    Danèík, V.2    Wagner, B.K.3    Clemons, P.A.4
  • 72
    • 0030795295 scopus 로고    scopus 로고
    • Reliable determination of binding affinity and kinetics using surface plasmon resonance biosensors
    • doi: 10.1016/S0958-1669(97)80074-2
    • Schuck, P. (1997). Reliable determination of binding affinity and kinetics using surface plasmon resonance biosensors. Curr. Opin. Biotechnol. 8, 498-502. doi: 10.1016/S0958-1669(97)80074-2.
    • (1997) Curr. Opin. Biotechnol. , vol.8 , pp. 498-502
    • Schuck, P.1
  • 73
    • 38549121773 scopus 로고    scopus 로고
    • ChemBank: a small-molecule screening and cheminformatics resource database
    • doi: 10.1093/nar/gkm843
    • Seiler, K. P., George, G. A., Happ, M. P., Bodycombe, N. E., Carrinski, H. A., Norton, S., et al. (2008). ChemBank: a small-molecule screening and cheminformatics resource database. Nucleic Acids Res. 36, D351-D359. doi: 10.1093/nar/gkm843.
    • (2008) Nucleic Acids Res. , vol.36
    • Seiler, K.P.1    George, G.A.2    Happ, M.P.3    Bodycombe, N.E.4    Carrinski, H.A.5    Norton, S.6
  • 74
    • 33749011163 scopus 로고    scopus 로고
    • The NCI60 human tumour cell line anticancer drug screen
    • doi: 10.1038/nrc1951
    • Shoemaker, R. H. (2006). The NCI60 human tumour cell line anticancer drug screen. Nat. Rev. Cancer 6, 813-823. doi: 10.1038/nrc1951.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 813-823
    • Shoemaker, R.H.1
  • 75
    • 84860513814 scopus 로고    scopus 로고
    • Structure-based drug screening for G-protein-coupled receptors
    • doi: 10.1016/j.tips.2012.03.007
    • Shoichet, B. K., and Kobilka, B. K. (2012). Structure-based drug screening for G-protein-coupled receptors. Trends Pharmacol. Sci. 33, 268-272. doi: 10.1016/j.tips.2012.03.007.
    • (2012) Trends Pharmacol. Sci. , vol.33 , pp. 268-272
    • Shoichet, B.K.1    Kobilka, B.K.2
  • 76
    • 84871918476 scopus 로고    scopus 로고
    • The GPCR Network: a large-scale collaboration to determine human GPCR structure and function
    • doi: 10.1038/nrd3859
    • Stevens, R. C., Cherezov, V., Katritch, V., Abagyan, R., Kuhn, P., Rosen, H., et al. (2012). The GPCR Network: a large-scale collaboration to determine human GPCR structure and function. Nat. Rev. Drug Discov. 12, 25-34. doi: 10.1038/nrd3859.
    • (2012) Nat. Rev. Drug Discov. , vol.12 , pp. 25-34
    • Stevens, R.C.1    Cherezov, V.2    Katritch, V.3    Abagyan, R.4    Kuhn, P.5    Rosen, H.6
  • 77
    • 79959929769 scopus 로고    scopus 로고
    • How were new medicines discovered?
    • doi: 10.1038/nrd3480
    • Swinney, D. C., and Anthony, J. (2011). How were new medicines discovered? Nat. Rev. Drug Discov. 10, 507-519. doi: 10.1038/nrd3480.
    • (2011) Nat. Rev. Drug Discov. , vol.10 , pp. 507-519
    • Swinney, D.C.1    Anthony, J.2
  • 78
    • 58149391231 scopus 로고    scopus 로고
    • Duplexed label-free G protein-coupled receptor assays for high throughput screening
    • doi: 10.1177/1087057108326141
    • Tran, E., and Fang, Y. (2008). Duplexed label-free G protein-coupled receptor assays for high throughput screening. J. Biomol. Screen. 13, 975-985. doi: 10.1177/1087057108326141.
    • (2008) J. Biomol. Screen. , vol.13 , pp. 975-985
    • Tran, E.1    Fang, Y.2
  • 79
    • 33845876624 scopus 로고    scopus 로고
    • Cellular dielectric spectroscopy: a label-free comprehensive platform for functional evaluation of endogenous receptors
    • doi: 10.1089/adt.2006.4.609
    • Verdonk, E., Johnson, K., McGuinness, R., Leung, G., Chen, Y.-W., Tang, H. R., et al. (2006). Cellular dielectric spectroscopy: a label-free comprehensive platform for functional evaluation of endogenous receptors. Assays Drug Dev. Technol. 4, 609-619. doi: 10.1089/adt.2006.4.609.
    • (2006) Assays Drug Dev. Technol. , vol.4 , pp. 609-619
    • Verdonk, E.1    Johnson, K.2    McGuinness, R.3    Leung, G.4    Chen, Y.-W.5    Tang, H.R.6
  • 80
    • 81355148507 scopus 로고    scopus 로고
    • GPCRs regulate the assembly of a multienzyme complex for purine biosynthesis
    • doi: 10.1038/nchembio.690
    • Verrier, F., An, S., Ferrie, A. M., Sun, H., Kyoung, M., Deng, H., et al. (2011). GPCRs regulate the assembly of a multienzyme complex for purine biosynthesis. Nat. Chem. Biol. 7, 909-915. doi: 10.1038/nchembio.690.
    • (2011) Nat. Chem. Biol. , vol.7 , pp. 909-915
    • Verrier, F.1    An, S.2    Ferrie, A.M.3    Sun, H.4    Kyoung, M.5    Deng, H.6
  • 81
    • 67849104638 scopus 로고    scopus 로고
    • PubChem: a public information system for analyzing bioactivities of small molecules
    • doi: 10.1093/nar/gkp456
    • Wang, Y., Xiao, J., Suzek, T. O., Zhang, J., Wang, J., and Bryant, S. H. (2009). PubChem: a public information system for analyzing bioactivities of small molecules. Nucleic Acids Res. 37, W623-W633. doi: 10.1093/nar/gkp456.
    • (2009) Nucleic Acids Res. , vol.37
    • Wang, Y.1    Xiao, J.2    Suzek, T.O.3    Zhang, J.4    Wang, J.5    Bryant, S.H.6
  • 82
  • 83
    • 4644289587 scopus 로고    scopus 로고
    • Multitarget drugs: the end of the "one-target-one-disease" philosophy?
    • doi: 10.1016/S1359-6446(04)03213-1
    • Wermuth, C. G. (2004). Multitarget drugs: the end of the "one-target-one-disease" philosophy? Drug Discov. Today 9, 826-827. doi: 10.1016/S1359-6446(04)03213-1.
    • (2004) Drug Discov. Today , vol.9 , pp. 826-827
    • Wermuth, C.G.1
  • 84
    • 35748961114 scopus 로고    scopus 로고
    • Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges
    • doi: 10.1038/nrd2423
    • Wilke, R. A., Lin, D. W., Roden, D. M., Watkins, P. B., Flockhart, D., Zineh, I., et al. (2007). Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges. Nat. Rev. Drug Discov. 6, 906-916. doi: 10.1038/nrd2423.
    • (2007) Nat. Rev. Drug Discov. , vol.6 , pp. 906-916
    • Wilke, R.A.1    Lin, D.W.2    Roden, D.M.3    Watkins, P.B.4    Flockhart, D.5    Zineh, I.6
  • 86
    • 37249026328 scopus 로고    scopus 로고
    • Integrating high-content screening and ligand-target prediction to identify mechanism of action
    • doi: 10.1038/nchembio.2007.53
    • Young, D. W., Bender, A., Hoyt, J., McWhinnie, E., Chirn, G. W., Tao, C. Y., et al. (2008). Integrating high-content screening and ligand-target prediction to identify mechanism of action. Nat. Chem. Biol. 4, 59-68. doi: 10.1038/nchembio.2007.53.
    • (2008) Nat. Chem. Biol. , vol.4 , pp. 59-68
    • Young, D.W.1    Bender, A.2    Hoyt, J.3    McWhinnie, E.4    Chirn, G.W.5    Tao, C.Y.6
  • 87
    • 84874630073 scopus 로고    scopus 로고
    • Target identification for small bioactive molecules: finding the needle in the haystack
    • doi: 10.1002/anie.201208749
    • Ziegler, S., Pries, V., Hedberg, C., and Waldmann, H. (2013). Target identification for small bioactive molecules: finding the needle in the haystack. Angew. Chem. Int. Ed. Engl. 52, 2744-2792. doi: 10.1002/anie.201208749.
    • (2013) Angew. Chem. Int. Ed. Engl. , vol.52 , pp. 2744-2792
    • Ziegler, S.1    Pries, V.2    Hedberg, C.3    Waldmann, H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.