Probing biochemical mechanisms of action of muscarinic m3 receptor antagonists with label-free whole cell assays

Analytical Chemistry

Volumn 84, Issue 19, 2012, Pages 8232-8239

  Deng, Huayun ^a   Wang, Chaoming ^a,b   Su, Ming ^b   Fang, Ye ^a  

^a Corning Inc ^*  (United States)

^b University of Central Florida   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING EQUILIBRIA; BINDING KINETICS; BIOCHEMICAL MECHANISMS; DRUG BINDING; IN-VIVO; LABEL FREE; RAPID RESPONSE; RECEPTOR ANTAGONISTS; RECEPTOR SIGNALING; RESIDENCE TIME; WHOLE CELL;

CELLS; KINETICS; SIGNALING;

CYTOLOGY;

ACETYLCHOLINE; MUSCARINIC M3 RECEPTOR; SCOPOLAMINE DERIVATIVE; TIOTROPIUM BROMIDE;

ARTICLE; CELL STRAIN HT29; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; GENETIC PROCEDURES; HUMAN; KINETICS; METABOLISM; MICROFLUIDIC ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; TUMOR CELL CULTURE;

ACETYLCHOLINE; BIOSENSING TECHNIQUES; HT29 CELLS; HUMANS; KINETICS; MICROFLUIDIC ANALYTICAL TECHNIQUES; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTOR, MUSCARINIC M3; SCOPOLAMINE DERIVATIVES; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84867050365     PISSN: 00032700     EISSN: 15206882     Source Type: Journal    
DOI: 10.1021/ac301495n     Document Type: Article

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