Discovery of 2-(4-Methylfuran-2(5 H)-ylidene)malononitrile and thieno[3,2-b ]thiophene-2-carboxylic acid derivatives as G protein-coupled receptor 35 (GPR35) agonists

Journal of Medicinal Chemistry

Volumn 54, Issue 20, 2011, Pages 7385-7396

  Deng, Huayun ^a   Hu, Haibei ^a   He, Mingqian ^a   Hu, Jieyu ^a   Niu, Weijun ^a   Ferrie, Ann M ^a   Fang, Ye ^a  

^a Corning Inc ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (3,4 DIBROMOTHIOPHEN 2 YL)ETHANONE; 2 (3 CYANO 4 METHYL 1 OXASPIRO[4.5]DEC 3 EN 2 YLIDENE)MALONONITRILE; 2 (3 CYANO 4,5,5 TRIMETHYLFURAN 2(5H) YLIDENE)MALONONITRILE; 2 (4 METHYLFURAN 2(5H) YLIDENE)MALONONITRILE DERIVATIVE; 2 (4' CYANO 3' METHYL 5'H SPIRO [FLUORENE 9,2' FURAN] 5' YLIDENE)MALONONITRILE; 2 [3 CYANO 4 METHYL 5 PHENYL 5 (TRIFLUOROMETHYL)FURAN 2(5H) YLIDENE]MALONONITRILE; 2 [3 CYANO 4,5 DIMETHYL 5 (2,3,4 TRICHLOROPHENYL)FURAN 2(5H) YLIDENE]MALONONITRILE; 2 [3 CYANO 4,5 DIMETHYL 5 (PERFLUOROPHENYL)FURAN 2(5H) YLIDENE)MALONONITRILE]; 2 [3 CYANO 5 (2,4 DIFLUOROPHENYL) 4,5 DIMETHYLFURAN 2(5H) YLIDENE]MALONONITRILE; 2 [3 CYANO 5 (3,4 DICHLOROPHENYL) 4,5 DIMETHYLFURAN 2(5H) YLIDENE]MALONONITRILE; 2 [5 (4 BUTYLPHENYL) 3 CYANO 4,5 DIMETHYLFURAN 2(5H) YLIDENE]MALONONITRILE; 3 HEXYLTHIENO[3,2 B]THIOPHENE 2 CARBOXYLIC ACID; 5 METHYLDITHIENO[3,2 B:2',3' D]THIOPHENE 2 CARBOXYLIC ACID; 6 BROMO 3 METHYLTHIENO[3,2 B]THIOPHENE 2 CARBOXYLIC ACID; 6 BROMO 3 OCTYLTHIENO[3,2 B]THIOPHENE 2 CARBOXYLIC ACID; 6 BROMO 3 PENTADECYLTHIENO[3,2 B]THIOPHENE 2 CARBOXYLIC ACID; 6 BROMO 3 TRIDECYLTHIENO[3,2 B]THIOPHENE 2 CARBOXYLIC ACID; 6 BROMO 3 UNDECYLTHIENO[3,2 B]THIOPHENE 2 CARBOXYLIC ACID; 6 HEXYLTHIENO[3,2 B]THIOPHENE 2 CARBOXYLIC ACID; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; ETHYL 6 BROMO 3 METHYLTHIENO[3,2 B]THIOPHENE 2 CARBOXYLIC ACID; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 35; G PROTEIN COUPLED RECEPTOR 35 AGONIST; THIENO[3,2 B]THIOPHENE 2 CARBOXYLIC ACID; THIENO[3,2 B]THIOPHENE 2 CARBOXYLIC ACID DERIVATIVE; UNCLASSIFIED DRUG; ZAPRINAST;

ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

ARRESTINS; CELL LINE; FURANS; GENES, REPORTER; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; NITRILES; PROTEIN TRANSPORT; RECEPTORS, G-PROTEIN-COUPLED; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 80054935789     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200999f     Document Type: Article

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