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Volumn 114, Issue 4, 2014, Pages 2390-2431

Catalytic C-C bond-forming multi-component cascade or domino reactions: Pushing the boundaries of complexity in asymmetric organocatalysis

Author keywords

[No Author keywords available]

Indexed keywords

ASYMMETRIC ORGANOCATALYSIS; CHLORINATED SOLVENT; HETEROCYCLIC COMPOUND; MEDICINAL CHEMISTRY; MOLECULAR ARCHITECTURE; STEREOGENIC CARBONS; SUSTAINABLE STRATEGIES; SYNTHETIC EFFICIENCY;

EID: 84897671012     PISSN: 00092665     EISSN: 15206890     Source Type: Journal    
DOI: 10.1021/cr400215u     Document Type: Review
Times cited : (1004)

References (304)
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    • More recently, Hong et al. reported that, when 2-hydroxynitrostyrenes were used in reaction with glutaraldehyde, a domino Michael/acetalization/Henry reaction occurred, to furnish, after subsequent oxidation, tetrahydro-6 H -benzo[ c ]chromenones in good yields (76-81%) and excellent selectivities (80:20-88:12 dr and >99% ee). See: Hong, B.-C.; Kotame, P.; Lia, J.-H. Org. Biomol. Chem. 2011, 9, 382
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    • For an example of a Brønsted-acid-catalyzed quadruple cascade (two new C-C and two new C-N bonds), leading to an indoloquinolizidine derivative with 49% ee, see: Rueping, M.; Volla, C. M. R. RSC Adv. 2011, 1, 79
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