The role(s) of cytokines/chemokines in urinary bladder inflammation and dysfunction

BioMed Research International

Volumn 2014, Issue , 2014, Pages

  Gonzalez, Eric J ^a   Arms, Lauren ^a   Vizzard, Margaret A ^a  

^a UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CXCR4; MONOCYTE CHEMOTACTIC PROTEIN 1; STROMAL CELL DERIVED FACTOR 1; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; CHEMOKINE; CHEMOKINE RECEPTOR; CYTOKINE; CYTOKINE RECEPTOR;

ANATOMY; BLADDER DYSFUNCTION; BLADDER FUNCTION; BLADDER MUCOSA; BLADDER PAIN SYNDROME; BLADDER SPHINCTER; CYSTALGIA; CYSTITIS; HUMAN; IMMUNE RESPONSE; INTERSTITIAL CYSTITIS; NOCICEPTION; NONHUMAN; PATHOPHYSIOLOGY; PERIPHERAL NERVOUS SYSTEM; REVIEW; SENSITIZATION; SYMPTOM; URETHRA; BLADDER; INFLAMMATION; METABOLISM; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION;

CHEMOKINES; CYTOKINES; HUMANS; INFLAMMATION; RECEPTORS, CHEMOKINE; RECEPTORS, CYTOKINE; SIGNAL TRANSDUCTION; URINARY BLADDER;

EID: 84897502601     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2014/120525     Document Type: Review

References (196)

1. Tank P. W., Grant's Dissector 2009 Philadelphia, Pa, USA Lippincott Williams & Wilkins
2. Lewis S. A., Everything you wanted to know about the bladder epithelium but were afraid to ask. American Journal of Physiology 2000 278 6 F867 F874 2-s2.0-0033939039 (Pubitemid 30441352)
3. Birder L. A., Andersson K. E., Urothelial signaling. Physiological Reviews 2013 93 2 653 680 10.1152/physrev.00030.2012
4. Wu X. R., Kong X. P., Pellicer A., Kreibich G., Sun T. T., Uroplakins in urothelial biology, function, and disease. Kidney International 2009 75 11 1153 1165 2-s2.0-67349126033 10.1038/ki.2009.73
5. Janssen D. A., van Wijk X. M., Jansen K. C., van Kuppevelt T. H., Heesakkers J. P., Schalken J. A., The distribution and function of chondroitin sulfate and other sulfated glycosaminoglycans in the human bladder and their contribution to the protective bladder barrier. Journal of Urology 2013 189 1 336 342 10.1016/j.juro.2012.09.022
6. Andersson K. E., McCloskey K. D., Lamina propria: the functional center of the bladder? Neurourology and Urodynamics 2014 33 1 9 16 10.1002/nau.22465
7. Andersson K. E., Arner A., Urinary bladder contraction and relaxation: physiology and pathophysiology. Physiological Reviews 2004 84 3 935 986 2-s2.0-3042637079 10.1152/physrev.00038.2003 (Pubitemid 38823771)
8. Krstic R. V., Human Microscopic Anatomy: An Atlas for Students in Medicine and Biology 2004 Berlin, Germany Springer
9. Yucel S., Baskin L. S., An anatomical description of the male and female urethral sphincter complex. Journal of Urology 2004 171 5 1890 1897 2-s2.0-4544323446 10.1097/01.ju.0000124106.16505.df (Pubitemid 38501034)
10. Fowler C. J., Griffiths D., de Groat W. C., The neural control of micturition. Nature Reviews Neuroscience 2008 9 6 453 466 2-s2.0-43949141253 10.1038/nrn2401 (Pubitemid 351704950)
11. Ashton-Miller J. A., DeLancey J. O. L., Functional anatomy of the female pelvic floor. Annals of the New York Academy of Sciences 2007 1101 266 296 2-s2.0-34250634834 10.1196/annals.1389.034 (Pubitemid 47092720)
12. de Groat W. C., Wickens C., Organization of the neural switching circuitry underlying reflex micturition. Acta Physiologica 2013 207 1 66 84 10.1111/apha.12014
13. Ochodnicky P., Uvelius B., Andersson K. E., Michel M. C., Autonomic nervous control of the urinary bladder. Acta Physiologica 2013 207 1 16 33
14. Beckel J. M., Holstege G., Neurophysiology of the lower urinary tract. Handbook of Experimental Pharmacology 2011 202 149 169 2-s2.0-79952212755 10.1007/978-3-642-16499-6-8
15. de Groat W. C., Yoshimura N., Mechanisms underlying the recovery of lower urinary tract function following spinal cord injury. Progress in Brain Research 2005 152 59 84 2-s2.0-25844492098 10.1016/S0079-6123(05)52005-3 (Pubitemid 41392856)
16. Griffiths D. J., The pontine micturition centres. Scandinavian Journal of Urology and Nephrology 2002 supplement 210 21 26 (Pubitemid 35373640)
17. Abrams P., Cardozo L., Fall M., Griffiths D., Rosier P., Ulmsten U., Van Kerrebroeck P., Victor A., Wein A., The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society. Urology 2002 21 2 167 178 (Pubitemid 34195211)
18. Coyne K. S., Sexton C. C., Thompson C. L., Milsom I., Irwin D., Kopp Z. S., Chapple C. R., Kaplan S., Tubaro A., Aiyer L. P., Wein A. J., The prevalence of lower urinary tract symptoms (LUTS) in the USA, the UK and Sweden: results from the epidemiology of LUTS (EpiLUTS) study. BJU International 2009 104 3 352 360 2-s2.0-68049126564 10.1111/j.1464-410X.2009.08427.x
19. Cameron A. P., Heidelbaugh J. J., Jimbo M., Diagnosis and office-based treatment of urinary incontinence in adults. Part one: diagnosis and testing. Therapeutic Advances in Urology 2013 5 4 181 187
20. Le B. V., Schaeffer A. J., Genitourinary pain syndromes, prostatitis, and lower urinary tract symptoms. Urologic Clinics of North America 2009 36 4 527 536 2-s2.0-70449722904 10.1016/j.ucl.2009.08.005
21. Hanno P. M., Wein A. J., Kavoussi L. R., Novick A. C., Partin A. W., Peters C. A., Bladder pain syndrome (interstitial cystitis) and related disorders. Campbell-Walsh Urology 2011 Philadelphia, Pa, USA Saunders Elsevier
22. Parsons J. K., Parsons C. L., The historical origins of interstitial cystitis. Journal of Urology 2004 171 1 20 22 2-s2.0-0346848840 10.1097/01.ju.0000099890.35040.8d (Pubitemid 37549080)
23. Skene A. J. C., Diseases of the Bladder and Urethra in Women 1887 New York, NY, USA Wm Wood
24. Hunner G. L., A rare type of bladder ulcer in women, report of cases. The Boston Medical and Surgical Journal 1915 172 18 660 664
25. Jones C. A., Nyberg L., Epidemiology of interstitial cystitis. Urology 1997 49 supplement 5 2 9 2-s2.0-0030952334 10.1016/S0090-4295(99)80327-6 (Pubitemid 27193947)
26. Hanno P. M., Staskin D. R., Krane R. J., Wein A. J., Interstitial Cystitis 1990 London, UK Springer
27. Hanno P. M., Burks D. A., Clemens J. Q., Dmochowski R. R., Erickson D., Fitzgerald M. P., Forrest J. B., Gordon B., Gray M., Mayer R. D., Newman D., Nyberg L. Jr., Payne C. K., Wesselmann U., Faraday M. M., AUA guideline for the diagnosis and treatment of interstitial cystitis/bladder pain syndrome. Journal of Urology 2011 185 6 2162 2170 2-s2.0-79955826536 10.1016/j.juro.2011.03.064
28. van de Merwe J. P., Nordling J., Bouchelouche P., Bouchelouche K., Cervigni M., Daha L. K., Elneil S., Fall M., Hohlbrugger G., Irwin P., Mortensen S., van Ophoven A., Osborne J. L., Peeker R., Richter B., Riedl C., Sairanen J., Tinzl M., Wyndaele J., Diagnostic criteria, classification, and nomenclature for painful bladder syndrome/interstitial Cystitis: an ESSIC proposal. European Urology 2008 53 1 60 67 2-s2.0-36448931592 10.1016/j.eururo.2007.09.019 (Pubitemid 350166740)
29. Sant G. R., Hanno P. M., Interstitial cystitis: current issues and controversies in diagnosis. Urology 2001 57 6, supplement 1 82 88 2-s2.0-0035382561 (Pubitemid 33733971)
30. Berry S. H., Elliott M. N., Suttorp M., Bogart L. M., Stoto M. A., Eggers P., Nyberg L., Clemens J. Q., Prevalence of symptoms of bladder pain syndrome/interstitial cystitis among adult females in the united states. Journal of Urology 2011 186 2 540 544 2-s2.0-79960200670 10.1016/j.juro.2011.03.132
31. Anger J. T., Zabihi N., Clemens J. Q., Payne C. K., Saigal C. S., Rodriguez L. V., Treatment choice, duration, and cost in patients with interstitial cystitis and painful bladder syndrome. International Urogynecology Journal and Pelvic Floor Dysfunction 2011 22 4 395 400 2-s2.0-79959777353 10.1007/s00192-010-1252-8
32. Sant G. R., Kempuraj D., Marchand J. E., Theoharides T. C., The mast cell in interstitial cystitis: role in pathophysiology and pathogenesis. Urology 2007 69 supplement 4 S34 S40 2-s2.0-34247273439 10.1016/j.urology.2006.08.1109 (Pubitemid 46616951)
33. Parsons C. L., Hurst R. E., Decreased urinary uronic acid levels in individuals with interstitial cystitis. Journal of Urology 1990 143 4 690 693 2-s2.0-0025276220 (Pubitemid 20112082)
34. Hurst R. E., Roy J. B., Min K. W., Veltri R. W., Marley G., Patton K., Shackelford D. L., Stein P., Parsons C. L., A deficit of chondroitin sulfate proteoglycans on the bladder uroepithelium in interstitial cystitis. Urology 1996 48 5 817 821 2-s2.0-0030298183 10.1016/S0090-4295(96)00322-6 (Pubitemid 26398711)
35. Parsons C. L., The role of a leaky epithelium and potassium in the generation of bladder symptoms in interstitial cystitis/overactive bladder, urethral syndrome, prostatitis and gynaecological chronic pelvic pain. BJU International 2011 107 3 370 375 2-s2.0-79251563470 10.1111/j.1464-410X.2010. 09843.x
36. Parsons C. L., Greene R. A., Chung M., Stanford E. J., Singh G., Abnormal urinary potassium metabolism in patients with interstitial cystitis. Journal of Urology 2005 173 4 1182 1185 2-s2.0-15044359254 10.1097/01.ju.0000148361.82074. 77 (Pubitemid 40380530)
37. Chelsky M. J., Rosen S. I., Knight L. C., Maurer A. H., Hanno P. M., Ruggieri M. R., Messing E. M., Bladder permeability in interstitial cystitis is similar to that of normal volunteers: direct measurement by transvesical absorption of 99mtechnetium-diethylenetriaminepentaacetic acid. Journal of Urology 1994 151 2 346 355 2-s2.0-0028098091
38. Grover S., Srivastava A., Lee R., Tewari A. K., Te A. E., Role of inflammation in bladder function and interstitial cystitis. Therapeutic Advances in Urology 2011 3 1 19 33 2-s2.0-79959272917 10.1177/1756287211398255
39. Erickson D. R., Belchis D. A., Dabbs D. J., Inflammatory cell types and clinical features of interstitial cystitis. Journal of Urology 1997 158 3 790 794 2-s2.0-0030755507 10.1016/S0022-5347(01)64317-9
40. Boucher W., El-Mansoury M., Pang X., Sant G. R., Theoharides T. C., Elevated mast cell tryptase in the urine of patients with interstitial cystitis. British Journal of Urology 1995 76 1 94 100 2-s2.0-0029010004
41. Enerback L., Fall M., Aldenborg F., Histamine and mucosal mast cells in interstitial cystitis. Agents and Actions 1989 27 1-2 113 116 2-s2.0-0024539387 (Pubitemid 19108512)
42. Kastrup J., Hald T., Larsen S., Nielsen V. G., Histamine content and mast cell count of detrusor muscle in patients with interstitial cystitis and other types of chronic cystitis. British Journal of Urology 1983 55 5 495 500 2-s2.0-0020591809 (Pubitemid 13008645)
43. Theoharides T. C., Sant G. R., El-Mansoury M., Letourneau R., Ucci A. A. Jr., Meares E. M. Jr., Activation of bladder mast cells in interstitial cystitis: a light and electron microscopic study. Journal of Urology 1995 153 3 629 636 2-s2.0-0028812320 10.1016/S0022-5347(01)67669-9
44. Vizzard M. A., Alterations in neuropeptide expression in lumbosacral bladder pathways following chronic cystitis. Journal of Chemical Neuroanatomy 2001 21 2 125 138 2-s2.0-0035062714 10.1016/S0891-0618(00)00115-0 (Pubitemid 32324236)
45. Yoshimura N., de Groat W. C., Increased excitability of afferent neurons innervating rat urinary bladder after chronic bladder inflammation. Journal of Neuroscience 1999 19 11 4644 4653 2-s2.0-0033152346 (Pubitemid 29241112)
46. Yu Y., de Groat W. C., Sensitization of pelvic afferent nerves in the in vitro rat urinary bladder-pelvic nerve preparation by purinergic agonists and cyclophosphamide pretreatment. American Journal of Physiology 2008 294 5 F1146 F1156 2-s2.0-45149107298 10.1152/ajprenal.00592.2007
47. Bjorling D. E., Wang Z., Bushman W., Models of inflammation of the lower urinary tract. Neurourology and Urodynamics 2011 30 5 673 682 2-s2.0-79959849591 10.1002/nau.21078
48. Fry C. H., Daneshgari F., Thor K., Drake M., Eccles R., Kanai A. J., Birder L. A., Animal models and their use in understanding lower urinary tract dysfunction. Neurourology and Urodynamics 2010 29 4 603 608 2-s2.0-77953552219 10.1002/nau.20903
49. Westropp J. L., Buffington C. A. T., In vivo models of interstitial cystitis. Journal of Urology 2002 167 2 694 702 2-s2.0-0036144863 (Pubitemid 34074569)
50. Lyngset A., The feline urological syndrome. Nordisk Veterinaermedicin 1972 24 11 577 585 2-s2.0-0015429955
51. Gao X., Buffington C. A. T., Au J. L.-S., Effect of interstitial cystitis on drug absorption from urinary bladder. Journal of Pharmacology and Experimental Therapeutics 1994 271 2 818 823 2-s2.0-0028034583 (Pubitemid 24377770)
52. Lavelle J. P., Meyers S. A., Ruiz W. G., Buffington C. A. T., Zeidel M. L., Apodaca G., Urothelial pathophysiological changes in feline interstitial cystitis: a human model. American Journal of Physiology 2000 278 4 F540 F553 2-s2.0-0034001571 (Pubitemid 30215231)
53. Birder L. A., Wolf-Johnston A. S., Chib M. K., Buffington C. A., Roppolo J. R., Hanna-Mitchell A. T., Beyond neurons: involvement of urothelial and glial cells in bladder function. Neurourology and Urodynamics 2010 29 1 88 96 2-s2.0-76049085259 10.1002/nau.20747
54. Robinson D., Cardozo L. D., The role of estrogens in female lower urinary tract dysfunction. Urology 2003 62 4, supplement 1 45 51 2-s2.0-0142139298 10.1016/S0090-4295(03)00676-9 (Pubitemid 41116582)
55. Rohrmann S., Nelson W. G., Rifai N., Kanarek N., Basaria S., Tsilidis K. K., Smit E., Giovannucci E., Platz E. A., Serum sex steroid hormones and lower urinary tract symptoms in third National Health and Nutrition Examination Survey (NHANES III). Urology 2007 69 4 708 713 2-s2.0-34147106611 10.1016/j.urology. 2007.01.011 (Pubitemid 46574931)
56. Yoshida A., Kageyama A., Fujino T., Nozawa Y., Yamada S., Loss of muscarinic and purinergic receptors in urinary bladder of rats with hydrochloric acid-induced cystitis. Urology 2010 76 4 1017 e7 2-s2.0-77957748870 10.1016/j.urology.2010.05.012
57. Osorio A. V., Simckes A. M., Hellerstein S., Hemorrhagic cystitis caused by acetic acid instillation. Journal of Urology 1996 155 2 685 2-s2.0-9044251979 10.1016/S0022-5347(01)66499-1 (Pubitemid 26023582)
58. Parsons C. L., Stauffer C. W., Schmidt J. D., Reversible inactivation of bladder surface glycosaminoglycan antibacterial activity by protamine sulfate. Infection and Immunity 1988 56 5 1341 1343 2-s2.0-0023903239
59. Soler R., Bruschini H., Freire M. P., Alves M. T., Srougi M., Ortiz V., Urine is necessary to provoke bladder inflammation in protamine sulfate induced urothelial injury. Journal of Urology 2008 180 4 1527 1531 2-s2.0-50949097916 10.1016/j.juro.2008.06.006
60. Stein P. C., Pham H., Ito T., Parsons C. L., Bladder injury model induced in rats by exposure to protamine sulfate followed by bacterial endotoxin. Journal of Urology 1996 155 3 1133 1138 2-s2.0-0030071849 10.1016/S0022-5347(01) 66406-1 (Pubitemid 26052730)
61. Powers J. F., Sladek N. E., Cytotoxic activity relative to 4-hydroxycyclophosphamide and phosphoramide mustard concentrations in the plasma of cyclophosphamide-treated rats. Cancer Research 1983 43 3 1101 1106 2-s2.0-0020663027 (Pubitemid 13160030)
62. Emadi A., Jones R. J., Brodsky R. A., Cyclophosphamide and cancer: golden anniversary. Nature Reviews Clinical Oncology 2009 6 11 638 647 2-s2.0-70350786392 10.1038/nrclinonc.2009.146
63. Batista C. K. L. P., Brito G. A. C., Souza M. L. P., Leitão B. T. A., Cunha F. Q., Ribeiro R. A., A model of hemorrhagic cystitis induced with acrolein in mice. Brazilian Journal of Medical and Biological Research 2006 39 11 1475 1481 2-s2.0-33847680551 10.1590/S0100-879X2006001100011 (Pubitemid 46357863)
64. Malley S. E., Vizzard M. A., Changes in urinary bladder cytokine mRNA and protein after cyclophosphamide-induced cystitis. Physiological Genomics 2002 2002 9 5 13 2-s2.0-0036360083 (Pubitemid 135707408)
65. Eichel L., Scheidweiler K., Kost J., Shojaie J., Schwarz E., Messing E., Wood R., Assessment of murine bladder permeability with fluorescein: validation with cyclophosphamide and protamine. Urology 2001 58 1 113 118 2-s2.0-0034930390 10.1016/S0090-4295(01)01007-X (Pubitemid 32633956)
66. Boucher M., Meen M., Codron J., Coudore F., Kemeny J., Eschalier A., Cyclophosphamide-induced in freely-moving conscious rats: behavioral approach to a new model of visceral pain. Journal of Urology 2000 164 1 203 208 2-s2.0-0034220389 (Pubitemid 30434301)
67. Stewart F. A., Mechanism of bladder damage and repair after treatment with radiation and cytostatic drugs. British Journal of Cancer 1986 53 supplement 7 280 291 2-s2.0-0022457987 (Pubitemid 16076189)
68. Driscoll A., Teichman J. M. H., How do patients with interstitial cystitis present? Journal of Urology 2001 166 6 2118 2120 2-s2.0-0035169935 (Pubitemid 33065233)
69. Petrone R. L., Agha A. H., Roy J. B., Hurst R. E., Urodynamic findings in patients with interstitial cystitis. Journal of Urology A 1995 153 4 290
70. Ho N., Koziol J. A., Parsons C. L., Sant G. R., Epidemiology of interstitial cystitis. Interstitial Cystitis 1997 Philadelphia, Pa, USA Lippincott-Raven 9 16
71. Johansson S. L., Ogawa K., Fall M., Sant G. R., The pathology of interstitial cystitis. Interstitial Cystitis 1997 Philadelphia, Pa, USA Lippincott-Raven 143 152
72. Sant G. R., Hanno P. M., Interstitial cystitis: current issues and controversies in diagnosis. Urology 2001 57 6 82 88 2-s2.0-0035382561 (Pubitemid 33733971)
73. Dinarello C. A., Proinflammatory and anti-inflammatory cytokines as mediators in the pathogenesis of septic shock. Chest 1997 112 supplement 6 321S 329S 2-s2.0-0031452476 (Pubitemid 28013408)
74. Dray A., Inflammatory mediators of pain. British Journal of Anaesthesia 1995 75 2 125 131 2-s2.0-0029081831
75. Lindsay R. M., Harmar A. J., Nerve growth factor regulates expression of neuropeptide genes in adult sensory neurons. Nature 1989 337 6205 362 364 2-s2.0-0024503489 (Pubitemid 19043498)
76. Baba H., Doubell T. P., Woolf C. J., Peripheral inflammation facilitates A β fiber-mediated synaptic input to the substantia gelatinosa of the adult rat spinal cord. Journal of Neuroscience 1999 19 2 859 867 2-s2.0-0033555793 (Pubitemid 29036036)
77. Woolf C. J., Doubell T. P., The pathophysiology of chronic pain-increased sensitivity to low threshold A β -fibre inputs. Current Opinion in Neurobiology 1994 4 4 525 534 2-s2.0-0028025568 10.1016/0959-4388(94)90053-1 (Pubitemid 24258912)
78. White F. A., Jung H., Miller R. J., Chemokines and the pathophysiology of neuropathic pain. Proceedings of the National Academy of Sciences of the United States of America 2007 104 51 20151 20158 2-s2.0-38049150644 10.1073/pnas.0709250104
79. Rutkowski M. D., DeLeo J. A., The role of cytokines in the initiation and maintenance of chronic pain. Drug News and Perspectives 2002 15 10 626 632 2-s2.0-0036972549 10.1358/dnp.2002.15.10.740239 (Pubitemid 36152050)
80. White F. A., Bhangoo S. K., Miller R. J., Chemokines: integrators of pain and inflammation. Nature Reviews Drug Discovery 2005 4 10 834 844 2-s2.0-27644510131 10.1038/nrd1852 (Pubitemid 41553964)
81. Cheng J., Ji R., Intracellular signaling in primary sensory neurons and persistent pain. Neurochemical Research 2008 33 10 1970 1978 2-s2.0-51749091756 10.1007/s11064-008-9711-z
82. Sun J. H., Yang B., Donnelly D. F., Ma C., LaMotte R. H., MCP-1 enhances excitability of nociceptive neurons in chronically compressed dorsal root ganglia. Journal of Neurophysiology 2006 96 5 2189 2199 2-s2.0-33751220188 10.1152/jn.00222.2006 (Pubitemid 44785875)
83. White F. A., Sun J., Waters S. M., Ma C., Ren D., Ripsch M., Steflik J., Cortright D. N., LaMotte R. H., Miller R. J., Excitatory monocyte chemoattractant protein-1 signaling is up-regulated in sensory neurons after chronic compression of the dorsal root ganglion. Proceedings of the National Academy of Sciences of the United States of America 2005 102 39 14092 14097 2-s2.0-25444490392 10.1073/pnas.0503496102 (Pubitemid 41377708)
84. Bhangoo S., Ren D., Miller R. J., Henry K. J., Lineswala J., Hamdouchi C., Li B., Monahan P. E., Chan D. M., Ripsch M. S., White F. A., Delayed functional expression of neuronal chemokine receptors following focal nerve demyelination in the rat: a mechanism for the development of chronic sensitization of peripheral nociceptors. Molecular Pain 2007 3 38 2-s2.0-39049085666 10.1186/1744-8069-3-38 (Pubitemid 351234176)
85. Bhangoo S. K., Ren D., Miller R. J., Chan D. M., Ripsch M. S., Weiss C., McGinnis C., White F. A., CXCR4 chemokine receptor signaling mediates pain hypersensitivity in association with antiretroviral toxic neuropathy. Brain, Behavior, and Immunity 2007 21 5 581 591 2-s2.0-34249737450 10.1016/j.bbi.2006. 12.003 (Pubitemid 46829778)
86. Oh S. B., Endoh T., Simen A. A., Ren D., Miller R. J., Regulation of calcium currents by chemokines and their receptors. Journal of Neuroimmunology 2002 123 1-2 66 75 2-s2.0-0036184216 10.1016/S0165-5728(01)00485-4 (Pubitemid 34195608)
87. Oh S. B., Tran P. B., Gillard S. E., Hurley R. W., Hammond D. L., Miller R. J., Chemokines and glycoprotein 120 produce pain hypersensitivity by directly exciting primary nociceptive neurons. Journal of Neuroscience 2001 21 14 5027 5035 2-s2.0-0035878073 (Pubitemid 32622928)
88. Dansereau M., Gosselin R., Pohl M., Pommierjt B., Mechighel P., Mauborgne A., Rostene J. W., Kitabgi P., Beaudet N., Sarret P., Melik-Parsadaniantzt S., Spinal CCL2 pronociceptive action is no longer effective in CCR2 receptor antagonist-treated rats. Journal of Neurochemistry 2008 106 2 757 769 2-s2.0-51649086477 10.1111/j.1471-4159.2008.05429.x
89. Jung H., Toth P. T., White F. A., Miller R. J., Monocyte chemoattractant protein-1 functions as a neuromodulator in dorsal root ganglia neurons. Journal of Neurochemistry 2008 104 1 254 263 2-s2.0-37249022426 10.1111/j.1471-4159. 2007.04969.x (Pubitemid 350265055)
90. Zhang N., Inan S., Cowan A., Sun R., Wang J. M., Rogers T. J., Caterina M., Oppenheim J. J., A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1. Proceedings of the National Academy of Sciences of the United States of America 2005 102 12 4536 4541 (Pubitemid 40397147)
91. Bhangoo S. K., Ripsch M. S., Buchanan D. J., Miller R. J., White F. A., Increased chemokine signaling in a model of HIV1-associated peripheral neuropathy. Molecular Pain 2009 5 48 2-s2.0-69749127051 10.1186/1744-8069-5-48
92. Tanaka T., Minami M., Nakagawa T., Satoh M., Enhanced production of monocyte chemoattractant protein-1 in the dorsal root ganglia in a rat model of neuropathic pain: possible involvement in the development of neuropathic pain. Neuroscience Research 2004 48 4 463 469 2-s2.0-1642404488 10.1016/j.neures.2004. 01.004 (Pubitemid 38369344)
93. Verge G. M., Milligan E. D., Maier S. F., Watkins L. R., Naeve G. S., Foster A. C., Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions. European Journal of Neuroscience 2004 20 5 1150 1160 2-s2.0-4544252839 10.1111/j.1460-9568.2004.03593.x (Pubitemid 39233569)
94. Jung H., Miller R. J., Activation of the nuclear factor of activated T-cells (NFAT) mediates upregulation of CCR2 chemokine receptors in dorsal root ganglion (DRG) neurons: a possible mechanism for activity-dependent transcription in DRG neurons in association with neuropathic pain. Molecular and Cellular Neuroscience 2008 37 1 170 177 2-s2.0-37449017192 10.1016/j.mcn.2007. 09.004
95. Kim M., Suh H., Brosnan C. F., Lee S. C., Regulation of RANTES/CCL5 expression in human astrocytes by interleukin-1 and interferon- β Journal of Neurochemistry 2004 90 2 297 308 2-s2.0-3142777716 10.1111/j.1471-4159.2004. 02487.x (Pubitemid 38938215)
96. Tsakiri N., Kimber I., Rothwell N. J., Pinteaux E., Differential effects of interleukin-1 alpha and beta on interleukin-6 and chemokine synthesis in neurones. Molecular and Cellular Neuroscience 2008 38 2 259 265 2-s2.0-44649187461 10.1016/j.mcn.2008.02.015
97. Tsakiri N., Kimber I., Rothwell N. J., Pinteaux E., Mechanisms of interleukin-6 synthesis and release induced by interleukin-1 and cell depolarisation in neurones. Molecular and Cellular Neuroscience 2008 37 1 110 118 2-s2.0-37349123154 10.1016/j.mcn.2007.09.001 (Pubitemid 350299998)
98. Gosselin R. D., Dansereau M. A., Pohl M., Kitabgi P., Beaudet N., Sarret P., Parsadaniantz S. M., Chemokine network in the nervous system: a new target for pain relief. Current Medicinal Chemistry 2008 15 27 2866 2875 2-s2.0-58149402659 10.2174/092986708786242822
99. Qin X., Wan Y., Wang X., CCL2 and CXCL1 trigger calcitonin gene-related peptide release by exciting primary neciceptive neurons. Journal of Neuroscience Research 2005 82 1 51 62 2-s2.0-27644505189 10.1002/jnr.20612 (Pubitemid 41604797)
100. Thacker M. A., Clark A. K., Bishop T., Grist J., Yip P. K., Moon L. D. F., Thompson S. W. N., Marchand F., McMahon S. B., CCL2 is a key mediator of microglia activation in neuropathic pain states. European Journal of Pain 2009 13 3 263 272 2-s2.0-60949105934 10.1016/j.ejpain.2008.04.017
101. Gao Y., Zhang L., Samad O. A., Suter M. R., Yasuhiko K., Xu Z., Park J., Lind A., Ma Q., Ji R., JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain. Journal of Neuroscience 2009 29 13 4096 4108 2-s2.0-65249114367 10.1523/JNEUROSCI.3623-08. 2009
102. Bajetto A., Bonavia R., Barbero S., Piccioli P., Costa A., Florio T., Schettini G., Glial and neuronal cells express functional chemokine receptor CXCR4 and its natural ligand stromal cell-derived factor 1. Journal of Neurochemistry 1999 73 6 2348 2357 2-s2.0-0032750459 10.1046/j.1471-4159.1999. 0732348.x
103. Bajetto A., Bonavia R., Barbero S., Schettini G., Characterization of chemokines and their receptors in the central nervous system: physiopathological implications. Journal of Neurochemistry 2002 82 6 1311 1329 2-s2.0-0036734848 10.1046/j.1471-4159.2002.01091.x
104. Cartier L., Hartley O., Dubois-Dauphin M., Krause K., Chemokine receptors in the central nervous system: role in brain inflammation and neurodegenerative diseases. Brain Research Reviews 2005 48 1 16 42 2-s2.0-13444278829 10.1016/j.brainresrev.2004.07.021 (Pubitemid 40215781)
105. Harrison J. K., Jiang Y., Chen S., Xia Y., Maciejewski D., Mcnamara R. K., Streit W. J., Salafranca M. N., Adhikari S., Thompson D. A., Botti P., Bacon K. B., Feng L., Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia. Proceedings of the National Academy of Sciences of the United States of America 1998 95 18 10896 10901 2-s2.0-13144279282 10.1073/pnas.95.18.10896 (Pubitemid 28413165)
106. Mennicken F., Maki R., De Souza E. B., Quirion R., Chemokines and chemokine receptors in the CNS: a possible role in neuroinflammation and patterning. Trends in Pharmacological Sciences 1999 20 2 73 78 2-s2.0-0342943444 10.1016/S0165-6147(99)01308-5 (Pubitemid 29322314)
107. Mines M., Ding Y., Fan G., The many roles of Chemokine receptors in neurodegenerative disorders: emerging new therapeutical strategies. Current Medicinal Chemistry 2007 14 23 2456 2470 2-s2.0-35448954048 10.2174/ 092986707782023686 (Pubitemid 47618034)
108. Abbadie C., Lindia J. A., Cumiskey A. M., Peterson L. B., Mudgett J. S., Bayne E. K., DeMartino J. A., MacIntyre D. E., Forrest M. J., Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2. Proceedings of the National Academy of Sciences of the United States of America 2003 100 13 7947 7952 2-s2.0-0037934294 10.1073/pnas.1331358100 (Pubitemid 36760075)
109. Clark A. K., Yip P. K., Grist J., Gentry C., Staniland A. A., Marchand F., Dehvari M., Wotherspoon G., Winter J., Ullah J., Bevan S., Malcangio M., Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain. Proceedings of the National Academy of Sciences of the United States of America 2007 104 25 10655 10660 2-s2.0-34547505414 10.1073/pnas.0610811104 (Pubitemid 47185720)
110. Bogen O., Dina O. A., Gear R. W., Levine J. D., Dependence of monocyte chemoattractant protein 1 induced hyperalgesia on the isolectin B4-binding protein versican. Neuroscience 2009 159 2 780 786 2-s2.0-60849135687 10.1016/j.neuroscience.2008.12.049
111. Milligan E. D., Zapata V., Chacur M., Schoeniger D., Biedenkapp J., O'Connor K. A., Verge G. M., Chapman G., Green P., Foster A. C., Naeve G. S., Maier S. F., Watkins L. R., Evidence that exogenous and endogenous fractalkine can induce spinal nociceptive facilitation in rats. European Journal of Neuroscience 2004 20 9 2294 2302 2-s2.0-8144221210 10.1111/j.1460-9568.2004. 03709.x (Pubitemid 39472392)
112. Manjavachi M. N., Quintão N. L. M., Campos M. M., Deschamps I. K., Yunes R. A., Nunes R. J., Leal P. C., Calixto J. B., The effects of the selective and non-peptide CXCR2 receptor antagonist SB225002 on acute and long-lasting models of nociception in mice. European Journal of Pain 2010 14 1 23 31 2-s2.0-72049129973 10.1016/j.ejpain.2009.01.007
113. Arms L., Girard B. M., Malley S. E., Vizzard M. A., Expression and function of CCL2/CCR2 in rat micturition reflexes and somatic sensitivity with urinary bladder inflammation. American Journal of Physiology 2013 305 1 F111 F122 10.1152/ajprenal.00139.2013
114. Arms L., Girard B. M., Vizzard M. A., Expression and function of CXCL12/CXCR4 in rat urinary bladder with cyclophosphamide-induced cystitis. American Journal of Physiology 2010 298 3 F589 F600 2-s2.0-77649177189 10.1152/ajprenal.00628.2009
115. Smaldone M. C., Vodovotz Y., Tyagi V., Barclay D., Philips B. J., Yoshimura N., Chancellor M. B., Tyagi P., Multiplex analysis of urinary cytokine levels in rat model of cyclophosphamide-induced cystitis. Urology 2009 73 2 421 426 2-s2.0-58649083244 10.1016/j.urology.2008.07.031
116. Vera P. L., Iczkowski K. A., Wang X., Meyer-Siegler K. L., Cyclophosphamide-induced cystitis increases bladder CXCR4 expression and CXCR4-macrophage migration inhibitory factor association. PLoS ONE 2008 3 12 2-s2.0-57549116143 10.1371/journal.pone.0003898 e3898
117. Yuridullah R., Corrow K. A., Malley S. E., Vizzard M. A., Expression of fractalkine and fractalkine receptor in urinary bladder after cyclophosphamide (CYP)-induced cystitis. Autonomic Neuroscience 2006 126-127 380 389 2-s2.0-33744544014 10.1016/j.autneu.2006.02.030 (Pubitemid 43816933)
118. Sakthivel S. K., Singh U. P., Singh S., Taub D. D., Novakovic K. R., Lillard J. W. Jr., CXCL10 blockade protects mice from cyclophosphamide-induced cystitis. Journal of Immune Based Therapies and Vaccines 2008 6 6 2-s2.0-56449123339 10.1186/1476-8518-6-6
119. Mikami S., Nakase H., Yamamoto S., Takeda Y., Yoshino T., Kasahara K., Ueno S., Uza N., Oishi S., Fujii N., Nagasawa T., Chiba T., Blockade of CXCL12/CXCR4 axis ameliorates murine experimental colitis. Journal of Pharmacology and Experimental Therapeutics 2008 327 2 383 392 2-s2.0-54349085334 10.1124/jpet.108.141085
120. Penna G., Mondaini N., Amuchastegui S., Degli Innocenti S., Carini M., Giubilei G., Fibbi B., Colli E., Maggi M., Adorini L., Seminal plasma cytokines and chemokines in prostate inflammation: interleukin 8 as a predictive biomarker in chronic prostatitis/chronic pelvic pain syndrome and benign prostatic hyperplasia. European Urology 2007 51 2 524 533 2-s2.0-33845570300 10.1016/j.eururo.2006.07.016 (Pubitemid 44937795)
121. Ogawa T., Homma T., Igawa Y., Seki S., Ishizuka O., Imamura T., Akahane S., Homma Y., Nishizawa O., CXCR3 binding chemokine and TNFSF14 over expression in bladder urothelium of patients with ulcerative interstitial cystitis. Journal of Urology 2010 183 3 1206 1212 2-s2.0-75849145779 10.1016/j.juro.2009.11.007
122. Tyagi P., Killinger K., Tyagi V., Nirmal J., Chancellor M., Peters K. M., Urinary chemokines as noninvasive predictors of ulcerative interstitial cystitis. Journal of Urology 2012 187 6 2243 2248 2-s2.0-84859498857 10.1016/j.juro.2012.01.034
123. Corcoran A. T., Yoshimura N., Tyagi V., Jacobs B., Leng W., Tyagi P., Mapping the cytokine profile of painful bladder syndrome/interstitial cystitis in human bladder and urine specimens. World Journal of Urology 2013 31 1 241 246 2-s2.0-84858595240 10.1007/s00345-012-0852-y
124. Birder L. A., Kanai A. J., de Groat W. C., Kiss S., Nealen M. L., Burke N. E., Dineley K. E., Watkins S., Reynolds I. J., Caterina M. J., Vanilloid receptor expression suggests a sensory role for urinary bladder epithelial cells. Proceedings of the National Academy of Sciences of the United States of America 2001 98 23 13396 13401 2-s2.0-0035818575 10.1073/pnas.231243698 (Pubitemid 33051374)
125. Birder L. A., Wolf-Johnston A., Buffington C. A., Roppolo J. R., de Groat W. C., Kanai A. J., Altered inducible nitric oxide synthase expression and nitric oxide production in the bladder of cats with feline interstitial cystitis. Journal of Urology 2005 173 2 625 629 2-s2.0-12544255215 10.1097/01.ju.0000145900.22849.1d
126. Apodaca G., Balestreire E., Birder L. A., The Uroepithelial-associated sensory web. Kidney International 2007 72 9 1057 1064 2-s2.0-35348998499 10.1038/sj.ki.5002439 (Pubitemid 47609034)
127. Birder L. A., Urinary bladder urothelium: molecular sensors of chemical/thermal/mechanical stimuli. Vascular Pharmacology 2006 45 4 221 226 2-s2.0-33751224168 10.1016/j.vph.2005.08.027 (Pubitemid 44781214)
128. Birder L. A., Apodaca G., de Groat W. C., Kanai A. J., Adrenergic- and capsaicin-evoked nitric oxide release from urothelium and afferent nerves in urinary bladder. American Journal of Physiology 1998 275 2 F226 F229 2-s2.0-0031846997
129. Birder L. A., de Groat W. C., Mechanisms of disease: involvement of the urothelium in bladder dysfunction. Nature Clinical Practice Urology 2007 4 1 46 54 2-s2.0-33846054863 10.1038/ncpuro0672 (Pubitemid 46062986)
130. Birder L. A., Nakamura Y., Kiss S., Nealen M. L., Barrick S., Kanai A. J., Wang E., Ruiz G., de Groat W. C., Apodaca G., Watkins S., Caterina M. J., Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1. Nature Neuroscience 2002 5 9 856 860 2-s2.0-0036728668 10.1038/nn902 (Pubitemid 34976650)
131. Menetski J., Mistry S., Lu M., Mudgett J. S., Ransohoff R. M., DeMartino J. A., MacIntyre D. E., Abbadie C., Mice overexpressing chemokine ligand 2 (CCL2) in astrocytes display enhanced nociceptive responses. Neuroscience 2007 149 3 706 714 2-s2.0-35448945675 10.1016/j.neuroscience.2007.08.014 (Pubitemid 47633032)
132. van Steenwinckel J., Goazigo A. R., Pommier B., Mauborgne A., Dansereau M., Kitabgi P., Sarret P., Pohl M., Parsadaniantz S. M., CCL2 released from neuronal synaptic vesicles in the spinal cord is a major mediator of local inflammation and pain after peripheral nerve injury. Journal of Neuroscience 2011 31 15 5865 5875 2-s2.0-79955769305 10.1523/JNEUROSCI.5986-10.2011
133. Zhang J., De Koninck Y., Spatial and temporal relationship between monocyte chemoattractant protein-1 expression and spinal glial activation following peripheral nerve injury. Journal of Neurochemistry 2006 97 3 772 783 2-s2.0-33645850108 10.1111/j.1471-4159.2006.03746.x
134. Zhang Z. J., Dong Y. L., Lu Y., Cao S., Zhao Z. Q., Gao Y. J., Chemokine CCL2 and its receptor CCR2 in the medullary dorsal horn are involved in trigeminal neuropathic pain. Journal of Neuroinflammation 2012 9 136 10.1186/1742-2094-9-136
135. Lamotte R. H., Ma C., Hyperexcitable neurons and altered non-neuronal cells in the compressed spinal ganglion. Sheng Li Xue Bao 2008 60 5 597 602
136. Clark A. K., Old E. A., Malcangio M., Neuropathic pain and cytokines: current perspectives. Journal of Pain Research 2013 6 803 814
137. Lindholm D., Heumann R., Meyer M., Thoenen H., Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve. Nature 1987 330 6149 658 659 2-s2.0-0023471275 (Pubitemid 18005581)
138. Bouchelouche K., Alvarez S., Andersen L., Nordling J., Horn T., Bouchelouche P., Monocyte chemoattractant protein-1 production by human detrusor smooth muscle cells. Journal of Urology 2004 171 1 462 466 2-s2.0-0346848806 10.1097/01.ju.0000090192.36436.d5 (Pubitemid 37549212)
139. Bouchelouche K., Alvarez S., Horn T., Nordling J., Bouchelouche P., Human detrusor smooth muscle cells release interleukin-6, interleukin-8, and RANTES in response to proinflammatory cytokines interleukin-1 β and tumor necrosis factor- α Urology 2006 67 1 214 219 2-s2.0-30344459452 10.1016/j.urology.2005.07.049 (Pubitemid 43069300)
140. Watkins L. R., Maier S. F., Implications of immune-to-brain communication for sickness and pain. Proceedings of the National Academy of Sciences of the United States of America 1999 96 14 7710 7713 2-s2.0-0033529231 10.1073/pnas.96.14.7710 (Pubitemid 29328345)
141. Lotz M., Villiger P., Hugli T., Koziol J., Zuraw B. L., Interleukin-6 and interstitial cystitis. Journal of Urology 1994 152 3 869 873 2-s2.0-0028146166 (Pubitemid 24245954)
142. Erickson D. R., Xie S. X., Bhavanandan V. P., Wheeler M. A., Hurst R. E., Demers L. M., Kushner L., Keay S. K., A comparison of multiple urine markers for interstitial cystitis. Journal of Urology 2002 167 6 2461 2469 2-s2.0-0036090424 (Pubitemid 34533146)
143. Tyagi P., Tyagi V., Yoshimura N., Witteemer E., Barclay D., Loughran P. A., Zamora R., Gender-based reciprocal expression of transforming growth factor-ß1 and the inducible nitric oxide synthase in a rat model of cyclophosphamide- induced cystitis. Journal of Inflammation 2009 6 23 2-s2.0-69949111084 10.1186/1476-9255-6-23
144. Herpin A., Lelong C., Favrel P., Transforming growth factor- β -related proteins: an ancestral and widespread superfamily of cytokines in metazoans. Developmental and Comparative Immunology 2004 28 5 461 485 2-s2.0-0842346190 10.1016/j.dci.2003.09.007 (Pubitemid 38177448)
145. Annes J. P., Munger J. S., Rifkin D. B., Making sense of latent TGF β activation. Journal of Cell Science 2003 116 2 217 224 2-s2.0-0037439630 10.1242/jcs.00229 (Pubitemid 36163863)
146. Shi M., Zhu J., Wang R., Chen X., Mi L., Walz T., Springer T. A., Latent TGF- β structure and activation. Nature 2011 474 7351 343 351 2-s2.0-79959250326 10.1038/nature10152
147. Todorovic V., Jurukovski V., Chen Y., Fontana L., Dabovic B., Rifkin D. B., Latent TGF- β binding proteins. International Journal of Biochemistry and Cell Biology 2005 37 1 38 41 2-s2.0-4644313970 10.1016/j.biocel.2004.03.011 (Pubitemid 39286021)
148. Barcellos-Hoff M. H., Dix T. A., Redox-mediated activation of latent transforming growth factor- β 1. Molecular Endocrinology 1996 10 9 1077 1083 2-s2.0-0029736871 10.1210/me.10.9.1077 (Pubitemid 26299216)
149. Lyons R. M., Keski-Oja J., Moses H. L., Proteolytic activation of latent transforming growth factor- β from fibroblast-conditioned medium. Journal of Cell Biology 1988 106 5 1659 1665 2-s2.0-0023916551
150. Murphy-Ullrich J. E., Poczatek M., Activation of latent TGF- β by thrombospondin-1: mechanisms and physiology. Cytokine and Growth Factor Reviews 2000 11 1-2 59 69 2-s2.0-0034109215 10.1016/S1359-6101(99)00029-5 (Pubitemid 30169726)
151. Van der Flier A., Sonnenberg A., Function and interactions of integrins. Cell and Tissue Research 2001 305 3 285 298 2-s2.0-0035724579 10.1007/s004410100417 (Pubitemid 34212122)
152. Massague J., TGF-beta signal transduction. Annual Review of Biochemistry 1998 67 753 791 10.1146/annurev.biochem.67.1.753 (Pubitemid 28411144)
153. Derynck R., Zhang Y. E., Smad-dependent and Smad-independent pathways in TGF- β family signalling. Nature 2003 425 6958 577 584 2-s2.0-0142104985 10.1038/nature02006 (Pubitemid 37280136)
154. Moustakas A., Heldin C., Non-Smad TGF- β signals. Journal of Cell Science 2005 118 16 3573 3584 2-s2.0-24944497786 10.1242/jcs.02554 (Pubitemid 41309405)
155. Yamaguchi K., Shirakabe K., Shibuya H., Irie K., Oishi I., Ueno N., Taniguchi T., Nishida E., Matsumoto K., Identification of a member of the MAPKKK family as a potential Mediator of TGF- β signal transduction. Science 1995 270 5244 2008 2011 2-s2.0-0029551805 (Pubitemid 26097194)
156. Freudlsperger C., Bian Y., Contag Wise S., Burnett J., Coupar J., Yang X., Chen Z., Van Waes C., TGF-beta and NF-kappaB signal pathway cross-talk is mediated through TAK1 and SMAD7 in a subset of head and neck cancers. Oncogene 2013 32 12 1549 1559
157. Lee M. K., Pardoux C., Hall M. C., Lee P. S., Warburton D., Qing J., Smith S. M., Derynck R., TGF- β activates Erk MAP kinase signalling through direct phosphorylation of ShcA. EMBO Journal 2007 26 17 3957 3967 2-s2.0-34548386720 10.1038/sj.emboj.7601818 (Pubitemid 47367487)
158. Yu L., Hébert M. C., Zhang Y. E., TGF- β receptor-activated p38 MAP kinase mediates smad-independent TGF- β responses. EMBO Journal 2002 21 14 3749 3759 2-s2.0-0037099745 10.1093/emboj/cdf366 (Pubitemid 34787048)
159. Engel M. E., McDonnell M. A., Law B. K., Moses H. L., Interdependent SMAD and JNK signaling in transforming growth factor- β-mediated transcription. Journal of Biological Chemistry 1999 274 52 37413 37420 2-s2.0-0033601179 10.1074/jbc.274.52.37413 (Pubitemid 30016827)
160. Li M. O., Wan Y. Y., Sanjabi S., Robertson A. L., Flavell R. A., Transforming growth factor- β regulation of immune responses. Annual Review of Immunology 2006 24 99 146 2-s2.0-33646164362 10.1146/annurev.immunol.24. 021605.090737
161. Ashcroft G. S., Bidirectional regulation of macrophage function by TGF- β Microbes and Infection 1999 1 15 1275 1282 2-s2.0-0033399104 10.1016/S1286-4579(99)00257-9 (Pubitemid 30020322)
162. Gruber B. L., Marchese M. J., Kew R. R., Transforming growth factor- β 1 mediates mast cell chemotaxis. Journal of Immunology 1994 152 12 5860 5867 2-s2.0-0028181253
163. Reibman J., Meixler S., Lee T. C., Gold L. I., Cronstein B. N., Haines K. A., Kolasinski S. L., Weissmann G., Transforming growth factor β 1, a potent chemoattractant for human neutrophils, bypasses classic signal-transduction pathways. Proceedings of the National Academy of Sciences of the United States of America 1991 88 15 6805 6809 2-s2.0-0025953719 10.1073/pnas.88.15.6805 (Pubitemid 21915038)
164. van Royen N., Hoefer I., Buschmann I., Heil M., Kostin S., Deindl E., Vogel S., Korff T., Augustin H., Bode C., Piek J. J., Schaper W., Exogenous application of transforming growth factor beta 1 stimulates arteriogenesis in the peripheral circulation. The FASEB Journal 2002 16 3 432 434 2-s2.0-0036517380
165. Chen S., Tuttle D. L., Oshier J. T., Knot H. J., Streit W. J., Goodenow M. M., Harrison J. K., Transforming growth factor- β 1 increases CXCR4 expression, stromal-derived factor-1 α -stimulated signalling and human immunodeficiency virus-1 entry in human monocyte-derived macrophages. Immunology 2005 114 4 565 574 2-s2.0-16444362796 10.1111/j.1365-2567.2004.02110.x (Pubitemid 40478150)
166. Werner F., Jain M. K., Feinberg M. W., Sibinga N. E. S., Pellacani A., Wiesel P., Chin M. T., Topper J. N., Perrella M. A., Lee M., Transforming growth factor- β 1 inhibition of macrophage activation is mediated via Smad3. Journal of Biological Chemistry 2000 275 47 36653 36658 2-s2.0-0034711282 10.1074/jbc.M004536200 (Pubitemid 32002067)
167. Sorokin L., The impact of the extracellular matrix on inflammation. Nature Reviews Immunology 2010 10 10 712 723 2-s2.0-77957221743 10.1038/nri2852
168. Leask A., Abraham D. J., TGF- β signaling and the fibrotic response. The FASEB Journal 2004 18 7 816 827 2-s2.0-2142646426 10.1096/fj.03-1273rev (Pubitemid 38544500)
169. Gorelik L., Constant S., Flavell R. A., Mechanism of transforming growth factor β -induced inhibition of T helper type 1 differentiation. Journal of Experimental Medicine 2002 195 11 1499 1505 2-s2.0-0037013930 10.1084/jem.20012076 (Pubitemid 34602827)
170. Kehrl J. H., Wakefield L. M., Roberts A. B., Production of transforming growth factor β by human T lymphocytes and its potential role in the regulation of T cell growth. Journal of Experimental Medicine 1986 163 5 1037 1050 2-s2.0-0022465625 (Pubitemid 16000407)
171. Marie J. C., Letterio J. J., Gavin M., Rudensky A. Y., TGF- β 1 maintains suppressor function and Foxp3 expression in CD4 +CD25+ regulatory T cells. Journal of Experimental Medicine 2005 201 7 1061 1067 2-s2.0-17144400393 10.1084/jem.20042276 (Pubitemid 40524674)
172. Gorelik L., Fields P. E., Flavell R. A., Cutting edge: TGF- β inhibits Th type 2 development through inhibition of GATA-3 expression. Journal of Immunology 2000 165 9 4773 4777 2-s2.0-0034327176
173. Thomas D. A., Massagué J., TGF- β directly targets cytotoxic T cell functions during tumor evasion of immune surveillance. Cancer Cell 2005 8 5 369 380 2-s2.0-27644457376 10.1016/j.ccr.2005.10.012 (Pubitemid 41579832)
174. Lebman D. A., Edmiston J. S., The role of TGF- β in growth, differentiation, and maturation of B lymphocytes. Microbes and Infection 1999 1 15 1297 1304 2-s2.0-0033378589 10.1016/S1286-4579(99)00254-3 (Pubitemid 30020325)
175. Heldin C., Landström M., Moustakas A., Mechanism of TGF- β signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition. Current Opinion in Cell Biology 2009 21 2 166 176 2-s2.0-63749105896 10.1016/j.ceb.2009.01.021
176. Kee B. L., Rivera R. R., Murre C., Id3 inhibits B lymphocyte progenitor growth and survival in response to TGF- β Nature Immunology 2001 2 3 242 247 2-s2.0-0035289643 10.1038/85303 (Pubitemid 33706001)
177. Smeland E. B., Blomhoff H. K., Holte H., Ruud E., Beiske K., Funderud S., Godal T., Ohlsson R., Transforming growth factor type β (TGF β) inhibits G1 to S transition, but not activation of human B lymphocytes. Experimental Cell Research 1987 171 1 213 222 2-s2.0-0023253216 (Pubitemid 17153634)
178. Perlman R., Schiemann W. P., Brooks M. W., Lodish H. F., Weinberg R. A., TGF- β -induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation. Nature Cell Biology 2001 3 8 708 714 2-s2.0-0034906821 10.1038/35087019 (Pubitemid 32734248)
179. Kehrl J. H., Thevenin C., Rieckmann P., Fauci A. S., Transforming growth factor- β suppresses human B lymphocyte Ig production by inhibiting synthesis and the switch from the membrane form to the secreted form of Ig mRNA. Journal of Immunology 1991 146 11 4016 4023 2-s2.0-0025780301
180. Cazac B. B., Roes J., TGF- β receptor controls B cell responsiveness and induction of IgA in vivo. Immunity 2000 13 4 443 451 2-s2.0-0033697670
181. Levine J. D., Fields H. L., Basbaum A. I., Peptides and the primary afferent nociceptor. Journal of Neuroscience 1993 13 6 2273 2286 2-s2.0-0027225257 (Pubitemid 23151745)
182. Chalazonitis A., Kalberg J., Twardzik D. R., Morrison R. S., Kessler J. A., Transforming growth factor β has neurotrophic actions on sensory neurons in vitro and is synergistic with nerve growth factor. Developmental Biology 1992 152 1 121 132 2-s2.0-0026636723
183. Zhu Y., Colak T., Shenoy M., Liu L., Mehta K., Pai R., Zou B., Xie X. S., Pasricha P. J., Transforming growth factor beta induces sensory neuronal hyperexcitability, and contributes to pancreatic pain and hyperalgesia in rats with chronic pancreatitis. Molecular Pain 2012 8 65 10.1186/1744-8069-8-65
184. Utreras E., Keller J., Terse A., Prochazkova M., Iadarola M. J., Kulkarni A. B., Transforming growth factor-beta1 regulates Cdk5 activity in primary sensory neurons. Journal of Biological Chemistry 2012 287 20 16917 16929 10.1074/jbc.M111.329979
185. Utreras E., Prochazkova M., Terse A., Gross J., Keller J., Iadarola M. J., Kulkarni A. B., TGF-beta1 sensitizes TRPV1 through Cdk5 signaling in odontoblast-like cells. Molecular Pain 2013 9 24 10.1186/1744-8069-9-24
186. Lantero A., Tramullas M., Díaz A., Hurlé M. A., Transforming growth factor- β in normal nociceptive processing and pathological pain models. Molecular Neurobiology 2012 45 1 76 86 2-s2.0-84856745428 10.1007/s12035-011-8221-1
187. O'Callaghan J. P., Miller D. B., Spinal glia and chronic pain. Metabolism 2010 59 supplement 1 S21 S26 2-s2.0-77956595936 10.1016/j.metabol.2010.07.011
188. Abutbul S., Shapiro J., Szaingurten-Solodkin I., Levy N., Carmy Y., Baron R., Jung S., Monsonego A., TGF- β signaling through SMAD2/3 induces the quiescent microglial phenotype within the CNS environment. GLIA 2012 2-s2.0-84859768284 10.1002/glia.22343
189. Echeverry S., Shi X. Q., Haw A., Liu H., Zhang Z., Zhang J., Transforming growth factor- β 1 impairs neuropathic pain through pleiotropic effects. Molecular Pain 2009 5 16 2-s2.0-65349147156 10.1186/1744-8069-5-16
190. Xiao B., Bai X., Zhang G., Link H., Transforming growth factor- β 1 induces apoptosis of rat microglia without relation to bcl-2 oncoprotein expression. Neuroscience Letters 1997 226 2 71 74 2-s2.0-0030978460 10.1016/S0304-3940(97)00234-6 (Pubitemid 27190408)
191. Gonzalez E. J., Girard B. M., Vizzard M. A., Expression and function of transforming growth factor-beta isoforms and cognate receptors in the rat urinary bladder following cyclophosphamide-induced cystitis. American Journal of Physiology 2013 305 9 F1265 F1276 10.1152/ajprenal.00042.2013
192. Zhang Q. L., Qiao L. Y., Regulation of IGF-1 but not TGF-beta1 by NGF in the smooth muscle of the inflamed urinary bladder. Regulatory Peptides 2012 177 1-3 73 78 10.1016/j.regpep.2012.05.088
193. Apostolidis A., Jacques T. S., Freeman A., Kalsi V., Popat R., Gonzales G., Datta S. N., Ghazi-Noori S., Elneil S., Dasgupta P., Fowler C. J., Histological changes in the urothelium and suburothelium of human overactive bladder following intradetrusor injections of botulinum neurotoxin type A for the treatment of neurogenic or idiopathic detrusor overactivity. European Urology 2008 53 6 1245 1253 2-s2.0-42749096406 10.1016/j.eururo.2008.02.037
194. Compérat E., Reitz A., Delcourt A., Capron F., Denys P., Chartier-Kastler E., Histologic features in the urinary bladder wall affected from neurogenic overactivity-a comparison of inflammation, oedema and fibrosis with and without injection of botulinum toxin type A. European Urology 2006 50 5 1058 1064 2-s2.0-33749259443 10.1016/j.eururo.2006.01.025 (Pubitemid 44486475)
195. Steers W., Discussion. Pathogenesis of the overactive bladder and its attendant risk factors. BJU International 2000 85 supplement 3 69 71 2-s2.0-0034043758
196. Tyagi P., Barclay D., Zamora R., Yoshimura N., Peters K., Vodovotz Y., Chancellor M., Urine cytokines suggest an inflammatory response in the overactive bladder: a pilot study. International Urology and Nephrology 2010 42 3 629 635 2-s2.0-77956547107 10.1007/s11255-009-9647-5