Mechanisms of disease: Involvement of the urothelium in bladder dysfunction

Nature Clinical Practice Urology

Volumn 4, Issue 1, 2007, Pages 46-54

  Birder, Lori A ^a   de Groat, William C ^b  

^a Renal Electrolyte Division   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Barrier function; Neuron like properties; Sensor function; Transducer function

Indexed keywords

ACETYLCHOLINE; ADENOSINE TRIPHOSPHATE; ADRENERGIC RECEPTOR; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; BOTULINUM TOXIN; CAPSAICIN; MUSCARINIC RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; NITRIC OXIDE; NITRIC OXIDE DONOR; PURINE RECEPTOR; RESINIFERATOXIN; VANILLOID RECEPTOR 1;

BLADDER DYSFUNCTION; BLADDER FUNCTION; BLADDER INJURY; BLADDER INNERVATION; BLADDER NECK STENOSIS; CELL FUNCTION; CLINICAL FEATURE; DISEASE ACTIVITY; DISEASE COURSE; DRUG MECHANISM; ENDOTHELIUM CELL; ESCHERICHIA COLI; HUMAN; HYPERSENSITIVITY REACTION; INTERSTITIAL CYSTITIS; NERVE EXCITABILITY; NERVE STIMULATION; NEUROTRANSMISSION; NONHUMAN; OVERACTIVE BLADDER; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROSTATE HYPERTROPHY; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SENSORY NERVE CONDUCTION; SIGNAL TRANSDUCTION; URINARY TRACT INFECTION; UROTHELIUM;

HUMANS; URINARY BLADDER DISEASES; UROTHELIUM;

EID: 33846054863     PISSN: 17434270     EISSN: 17434289     Source Type: Journal    
DOI: 10.1038/ncpuro0672     Document Type: Review

References (80)

1. Apodaca G (2004) The uroepithelium: Not just a passive barrier. Traffic 5: 117-128
2. Lewis SA (2000) Everything you wanted to know about the bladder epithelium but were afraid to ask. Am J Physiol Renal Physiol 278: F867-F874
3. Wang E et al. (2003) Hydrostatic pressure-regulated ion transport in bladder uroepithelium. Am J Physiol Renal Physiol 285: F651-F663
4. Tammela T et al. (1993) Urothelial permeability of the isolated whole bladder. Neurourol Urodyn 12: 39-47
5. Romih R et al. (2005) Differentiation of epithelial cells in the urinary tract. Cell Tissue Res 320: 259-268
6. Martin BF (1972) Cell replacement and differentiation in transitional epithelium: A histological and autoradiographic study of the guinea-pig bladder and ureter. J. Anatomy 112: 433-455
7. Hicks M (1975) The mammalian urinary bladder: An accommodating organ. Biol Rev 50: 215-246
8. Brady CM et al. (2004) Parallel changes in bladder suburothelial vanilloid receptor TRPV1 and pan-neuronal marker PGP9.5 immunoreactivity in patients with neurogenic detrusor overactivity after intravesical resiniferatoxin treatment. BJU Int 93: 770-776
9. Acharya P et al. (2004) Distribution of the tight junction proteins ZO-1, occludin, and claudin-4, -8, and -12 in bladder epithelium. Am J Physiol Renal Physiol 287: F305-F318
10. Parsons CL et al. (1979) Antibacterial activity of bladder surface mucin duplicated by exogenous glycosaminoglycan (heparin). Infect Immun 24: 552-557
11. Lavelle J et al. (2002) Bladder permeability barrier: Recovery from selective injury of surface epithelial cells. Am J Physiol Renal Physiol 283: F242-F253
12. Bassuk JA et al. (2003) Induction of urothelial cell proliferation by fibroblast growth factor-7 in RAG1-deficient mice. Adv Exp Med Biol 539: 623-633
13. de Boer WI et al. (1996) Functions of fibroblast and transforming growth factors in primary organ-like cultures of normal human urothelium. Lab Invest 75: 147-156
14. Anderson G et al. (2003) Intracellular bacterial biofilm-like pods in urinary tract infections. Science 301: 105-107
15. Apodaca G et al. (2003) Disruption of bladder epithelium barrier function after spinal cord injury. Am J Physiol Renal Physiol 284: F966-F976
16. Truschel ST et al. (2001) Involvement of nitric oxide (NO) in bladder afferent and urothelial abnormalities following chronic spinal cord injury [abstract #842.9]. Soc Neurosci Abstr Program
17. Keay SK et al. (2004) An antiproliferative factor from interstitial cystitis patients is a Frizzled 8 protein-related sialoglycopeptide. Proc Natl Acad Sci USA 101: 11803-11808
18. Conrads TP et al.: CKAP4/p63 is a receptor for the frizzled-8 protein-related antiproliferative factor from interstitial cystitis patients. J Biol Chem, in press
19. Schilling J and Hultgren S (2002) Recent advances into the pathogenesis of recurrent urinary tract infections: The bladder as a reservoir for uropathogenic Escherichia coli. Int J Antimicrob Agents 19: 457-460
20. Birder L et al. (2001) Vanilloid receptor expression suggests a sensory role for urinary bladder epithelial cells. Proc Natl Acad Sci USA 98: 13396-13401
21. Birder L et al. (2002) Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1. Nat Neurosci 5: 856-860
22. Dickson A et al. (2006) Peptidergic sensory and parasympathetic fiber sprouting in the mucosa of the rat urinary bladder in a chronic model of cyclophosphamide-induced cystitis. Neuroscience 139: 671-685
23. Jen PY et al. (1995) Immunohistochemical localization of neuromarkers and neuropeptides in human fetal and neonatal urinary bladder. Br J Pharmacol 75: 230-235
24. Kunze A et al. (2006) Quantitative immunohistochemical study of the innervation of the guinea-pig lower urinary tract. Br J Urol 98: 424-429
25. Sui GP et al. (2002) Gap junctions and connexin expression in human suburothelial interstitial cells. BJU Int 90: 118-129
26. Wiseman OJ et al. (2002) The ultrastructure of bladder lamina propria nerves in healthy subjects and patients with detrusor hyperreflexia. J Urol 168: 2040-2045
27. Brading AF and McCloskey KD (2005) Mechanisms of disease: Specialized interstitial cells of the urinary tract - an assessment of current knowledge. Nat Clin Pract Urol 2: 546-554
28. Birder L et al. (2002) Beta-adrenoceptor agonists stimulate endothelial nitric oxide synthase in rat urinary bladder urothelial cells. J Neurosci 22: 8063-8070
29. Birder L et al. (2003) Feline interstitial cystitis results in mechanical hypersensitivity and altered ATP release from bladder urothelium. Am J Physiol Renal Physiol 285: F423-F429
30. Burnstock G (2001) Purine-mediated signalling in pain and visceral perception. Trends Pharmacol Sci 22: 182-188
31. Chess-Williams R (2002) Muscarinic receptors of the urinary bladder: detrusor, urothelial and prejunctional. Auton Autacoid Pharmacol 22: 133-145
32. Chopra B et al. (2005) Expression and function of bradykinin B1 and B2 receptors in normal and inflamed rat urinary bladder urothelium. J Physiol 562: 859-871
33. Ferguson DR et al. (1997) ATP is released from rabbit urinary bladder epithelial cells by hydrostatic pressure changes - an possible sensory mechanism? J Physiol 505: 503-511
34. Beckel J et al. (2006) Expression of functional nicotinic acetylcholine receptors in rat bladder epithelial cells. Am J Physiol 290: F103-F110
35. Petruska JC and Mendell LM (2004) The many functions of nerve growth factor: Multiple actions on nociceptors. Neurosci Lett 361: 168-171
36. Wolf-Johnston AS et al. (2003) Increased NGF and TRPV1 expression in urinary bladder and sensory neurons from cats with feline interstitial cystitis [abstract 608.4]. Soc Neurosci Abstr Program
37. Ossovskaya VS and Bunnett NW (2005) Protease-activated receptors: contribution to physiology and disease. Physiol Rev 84: 579-621
38. Carattino MD et al. (2005) Mutations in the pore region modify epithelial sodium channel gating by shear stress. J Biol Chem 280: 4393-4401
39. Kanai AJ et al. (2006) Origin of spontaneous activity in neonatal and adult rat bladders and its enhancement by stretch and muscarinic agonists. Am J Physiol Renal Physiol, in press
40. Wang E et al. (2005) ATP and purinergic receptor-dependent membrane traffic in bladder umbrella cells. J Clin Invest 115: 2412-2422
41. 3-deficient mice. Nature 407: 1011-1015
42. 3-immunoreactive nerve fibres in neurogenic detrusor overactivity and the effect of intravesical resiniferatoxin. Eur Urol 46: 247-253
43. Sun Y et al. (2001) Augmented stretch activated adenosine triphosphate release from bladder uroepithelial cells in patients with interstitial cystitis. J Urol 166: 1951-1956
44. Burnstock G (2006) Purinergic signaling. Br J Pharmacol 147 (Suppl 1): S172-S181
45. Andersson KE and Hedlund P (2002) Pharmacologic perspective on the physiology of the lower urinary tract. Urology 60: 13-20
46. Tominaga M et al. (2001) Potentiation of capsaicin receptor activation by metabotropic ATP receptors: A possible mechanism for ATP-evoked pain and hypersensitivity. Proc Natl Acad Sci USA 29: 820-825
47. Nickel JC (2003) Interstitial cystitis - an elusive clinical target? J Urol 170: 816-817
48. Parsons CL et al. (1998) The role of urinary potassium in the pathogenesis and diagnosis of interstitial cystitis. J Urol 159: 1862-1867
49. Gillenwater JY and Wein AJ (1998) Summary of the National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases workshop on interstitial cystitis, National Institutes of Health, Bethesda, Maryland, August 28-29, 1987. J Urol 140: 203-206
50. Birder L et al. (2004) Alterations in P2X and P2Y purinergic receptor expression in urinary bladder from normal cats and cats with interstitial cystitis. Am J Physiol Renal Physiol 287: F1084-F1091
51. Wellner MC and Isenberg G (1994) Stretch effects on whole-cell currents of guinea pig urinary bladder myocytes. J Physiol 480: 439-448
52. Caterina MJ (2001) The vanilloid receptor: A molecular gateway to the pain pathway. Ann Rev Neurosci 24: 602-607
53. Caterina MJ et al. (1997) The capsaicin receptor: A heat activated ion channel in the pain pathway. Nature 389: 816-824
54. Maggi CA (1992) Therapeutic potential of capsaicin-like molecules: studies in animals and humans. Life Sci 51: 1777-1781
55. Chancellor MB and de Groat WC (1999) Intravesical capsaicin and resiniferatoxin therapy: Spicing up the ways to treat the overactive bladder. J Urol 162: 3-11
56. Staskin DR and MacDiarmid SA (2006) Using anticholinergics to treat overactive bladder: The issue of treatment tolerability. Am J Med 119: 9-15
57. Pathak AS and Aboseif SR (2005) Overactive bladder: Drug therapy versus nerve stimulation. Nat Clin Pract Urol 2: 310-311
58. Abrams P et al. (2006) Muscarinic receptors: Their distribution and function in body systems, and the implications for treating overactive bladder. Br J Pharmacol 148: 565-578
59. Hegde SS (2006) Muscarinic receptors in the bladder: From basic research to therapeutics. Br J Pharmacol 147 (Suppl 2): S80-S87
60. Yoshida M et al. (2006) Non-neuronal cholinergic system in human bladder urothelium. Urology 67: 425-430
61. Tiwari A and Naruganahalli KS (2006) Current and emerging investigational medical therapies for the treatment of overactive bladder. Expert Opin Investig Drugs 15: 1017-1037
62. Chancellor MB (2005) Urgency, botulinum toxin and how botulinum toxin can help urgency. J Urol 174: 818
63. Toft BR and Nordling J (2006) Recent developments of intravesical therapy of painful bladder syndrome/interstitial cystitis: A review. Current Opin Urol 16: 268-272
64. Apostolidis A et al. (2006) Proposed mechanism for the efficacy of injected botulinum toxin in the treatment of human detrusor overactivity. Eur Urol 49: 644-650
65. Smith CP et al. (2005) Enhanced ATP release from rat bladder urothelium during chronic bladder inflammation: Effect of botulinum toxin A. Neurochem Int 47: 291-297
66. Birder L et al. (1998) Adrenergic- and capsaicin-evoked nitric oxide release from urothelium and afferent nerves in urinary bladder. Am J Physiol Renal Physiol 275: F226-F229
67. Inoue T and Gabella G (1991) A vascular network closely linked to the epithelium of the urinary bladder of the rat. Cell Tissue Res 263: 137-143
68. Toh KL and Ng CK (2006) Urodynamic studies in the evaluation of young men presenting with lower urinary tract symptoms. Int J Urol 13: 520-523
69. Yassin A et al. (2006) Alpha-adrenoceptors are a common demoninator in the pathophysiology of erectile function and BPH/LUTS - implications for clinical practice. Andrologia 38: 1-12
70. 1D-adrenoceptor. J Urol 174: 370-374
71. 1D adrenergic receptors in the rat urothelium facilitates the micturition reflex. J Urol 175: 358-364
72. Buffington CA et al. (2002) Norepinephrine content and adrenoceptor function in the bladder of cats with feline interstitial cystitis. J Urol 167: 1876-1880
73. Birder L et al. (2005) Altered inducible nitric oxide synthase expression and nitric oxide production in urinary bladder from cats with feline interstitial cystitis. J Urol 173: 625-629
74. Andersson KE and Persson K (1995) Nitric oxide synthase and the lower urinary tract: Possible implications for physiology and pathophysiology. Scand J Urol Nephrol Suppl 175: 43-53
75. Pandita RK et al. (2000) Intravesical oxyhemoglobin initiates bladder overactivity in conscious, normal rats. J Urol 164: 545-550
76. de Groat WC et al. (1997) Modification of urinary bladder function after spinal cord injury. Adv Neurol 72: 347-364
77. Ozawa H et al. (1999) Effect of intravesical nitric oxide therapy on cyclophosphamide-induced cystitis. J Urol 162: 2211-2216
78. Korkmaz A et al. (2005) Peroxynitrite may be involved in bladder damage caused by cyclophosphamide in rats. J Urol 173: 1793-1796
79. Hosseini A et al. (2004) Nitric oxide as an objective marker for evaluation of treatment response in patients with classic interstitial cystitis. J Urol 172: 2261-2265
80. Kolios G et al. (2004) Nitric oxide in inflammatory bowel disease: A universal messenger in an unsolved puzzle. Immunology 113: 427-437