Transforming growth factor-β1 induces apoptosis of rat microglia without relation to bcl-2 oncoprotein expression

Neuroscience Letters

Volumn 226, Issue 2, 1997, Pages 71-74

  Xiao, Bao Gou ^a   Bai, Xue Feng ^a   Zhang, Guang Xian ^a   Link, Hans ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Apoptosis; Bcl 2; Microglia; Transforming growth factor 1

Indexed keywords

CYTOKINE; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; APOPTOSIS; ARTICLE; ASTROCYTE; CELL CULTURE; CONTROLLED STUDY; GENE EXPRESSION; IMMUNOCYTOCHEMISTRY; MICROGLIA; NEWBORN; NONHUMAN; OLIGODENDROGLIA; ONCOGENE; PRIORITY JOURNAL; RAT;

ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; ASTROCYTES; BRAIN; CYTOKINES; DNA FRAGMENTATION; HUMANS; MICROGLIA; OLIGODENDROGLIA; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, INBRED LEW; RECOMBINANT PROTEINS; RNA, MESSENGER; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA;

EID: 0030978460     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(97)00234-6     Document Type: Article

References (20)

1. da Cunha A., Vitkovie L. Simultaneous preparation of four cell type enriched glial cultures from rat cerebral cortex. J. Tissue Cult. Methods. 13:1991;31-38.
2. Hassouna I., Wickert H., Zimmermann M., Gillardon F. Increase in bax expression in substantia nigra following 1-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine (MPTP) treatment of mice. Neurosci. Lett. 204:1996;85-88.
3. Hofman F.M., von Hanwehr R.I., Dinarello C.A., Mizel S.B., Hinton D., Merrill J.E. Immunoregulatory molecules and IL-2 receptors identified in multiple sclerosis brain. J. Immunol. 136:1986;3239-3245.
4. Issazadeh S., Mustafa M., Ljungdahl Å., Höjeberg B., Elde R., Dagerlind Å., Olsson T. Interferon-γ, interleukin-4 and transforming growth factor-β in experimental allergic encephalomyelitis on Lewis rats; dynamics of cellular mRNA expression in the central nervous system and lymphoid cells. J. Neurosci. Res. 40:1995;579-590.
5. Link J., Söderström M., Olsson T., Hojeberg B., Ljungdahl Å., Link H. Increased IFN-γ, IL-4 and TGF-β in multiple sclerosis. Ann. Neurol. 36:1994;379-386.
6. Link J. Interferon-γ, interleukin-4 and transforming growth factor-β mRNA expression in multiple sclerosis and myasthenia gravis. Acta Neurol. Scand. 90:(Suppl. 158):1994;1-58.
7. Lomo J., Blomhoff H.K., Beiske K., Stokke T., Smeland E.B. TGF-β1 and cyclic AMP promote apoptosis in resting human B lymphocytes. J. Immunol. 154:1995;1634-1643.
8. Louis J.C., Magal E., Takayama S., Varon S. CNTF protection of oligodendrocytes against natural and tumor necrosis factor-induced death. Science. 259:1993;689-692.
9. Matzinger P. The JAM test. A simple assay for DNA fragmentation and cell death. J. Immunol. Methods. 145:1991;185-192.
10. Nunez G., London L., Hocknbery D., Alexander M., McKearn J.P., Korsmeyer S.J. Deregulated bcl-2 gene expression selectively prolongs survival of growth factor-derived hemopoietic cell lines. J. Immunol. 144:1990;3602-3610.
11. Oltvai Z.N., Milliman C.L., Korsmeyer S.J. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell. 74:1993;609-619.
12. Robertson P.L., Markovac J., Datta S.C., Gold G.W. Transforming growth factor beta stimulates phosphoinositol metabolism and translocation of protein kinase C in cultured astrocytes. Neurosci. Lett. 93:1988;107-113.
13. Schluesener H.J. Transforming growth factors type-β1 and β2 suppress rat astrocytes autoantigen presentation and antagonize hyperinduction of class II major histocompatibility complex antigen expression by interferon-γ and tumor necrosis factor-α J. Neuroimmunol. 27:1990;41-47.
14. Selmaj E., Raine C.S., Farooq M., Norton W.T., Brosnan C.F. Cytokine cytotoxicity against oligodendrocytes: apoptosis induced by lymphotoxin. J. Immunol. 147:1991;1522-1529.
15. Selmaj K., Cross A.H., Farooq M., Brosnan C.F., Raine C.S. Non-specific oligodendrocyte cytotoxicity mediated by soluble products of activated T cell lines. J. Neuroimmunol. 35:1991;261-267.
16. Toru-delbauffe D., Baghdassarian-Chalaye D., Gavaret J.M., Courtin F., Pomerance M., Pierre M. Effects of transforming growth factor-β1 on astroglial cells in culture. J. Neurochem. 54:1990;1056-1061.
17. Vanhaesebroeck B., Reed J.C., DeValck D., Grooten J., Miyashita T., Tanaka S., Beyaert R., Van Roy F., Fiers W. Effect of bcl-2 proto-oncogene expression on cellular sensitivity to tumor necrosis factor-mediated cytotoxicity. Oncogene. 8:1993;1075-1081.
18. Veis D.J., Sorenson C.M., Shutter J.R., Korsmeyer S.J. Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell. 75:1993;229-240.
19. Weller M., Constam D.B., Malipiero U., Fontana A. Transforming growth factor-β2 induces apoptosis of murine T cell clones without down-regulating bcl-2 mRNA expression. Eur. J. Immunol. 24:1994;1293-1300.
20. Yin X.M., Oltvai Z.N., Korsmeyer S.J. BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax. Nature. 369:1994;321-323.