Gender-based reciprocal expression of transforming growth factor-ß1 and the inducible nitric oxide synthase in a rat model of cyclophosphamide- induced cystitis

Journal of Inflammation

Volumn 6, Issue , 2009, Pages

  Tyagi, Pradeep ^a   Tyagi, Vikas ^b   Yoshimura, Naoki ^b   Witteemer, Erich ^b   Barclay, Derek ^c   Loughran, Patricia A ^c   Zamora, Ruben ^c,d  

^a WILLIAM BEAUMONT HOSPITAL   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^d UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHOSPHAMIDE; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE; NITRITE; NITROUS OXIDE; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOTOXICITY; FEMALE; IMMUNOCYTOCHEMISTRY; INTERSTITIAL CYSTITIS; MALE; MICTURITION; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; PROTEIN URINE LEVEL; RAT; SEX DIFFERENCE; TISSUE LEVEL; UROTHELIUM;

ANIMALIA; RATTUS;

EID: 69949111084     PISSN: None     EISSN: 14769255     Source Type: Journal    
DOI: 10.1186/1476-9255-6-23     Document Type: Article

References (60)

1. Severe hemorrhagic cystitis associated with prolonged oral cyclophosphamide therapy: case report and literature review. RQ Hu H Mehter T Nadasdy A Satoskar DN Spetie BH Rovin L Hebert, Rheumatol Int 2008 28 11 1161 1164 10.1007/s00296-008-0581-0 18398616
2. Pathophysiological aspects of cyclophosphamide and ifosfamide induced hemorrhagic cystitis; implication of reactive oxygen and nitrogen species as well as PARP activation. A Korkmaz T Topal S Oter, Cell Biol Toxicol 2007 23 303 312 10.1007/s10565-006-0078-0 17225077 (Pubitemid 46919119)
3. Cyclophosphamide cystitis identification of acrolein as the causative agent. PJ Cox, Biochem Pharmacol 1979 28 2045 2049 10.1016/0006-2952(79)90222-3 475846 (Pubitemid 9214911)
4. Multiplex analysis of urinary cytokine levels in rat model of cyclophosphamide-induced cystitis. MC Smaldone Y Vodovotz V Tyagi D Barclay BJ Philips N Yoshimura MB Chancellor P Tyagi, Urology 2009 73 421 426 10.1016/j.urology.2008.07.031 18848347
5. Cyclophosphamide induced cystitis: role of nitric oxide synthase, cyclooxygenase-1 and 2, and NK(1) receptors. BE Linares-Fernandez AB Alfieri, J Urol 2007 177 1531 1536 10.1016/j.juro.2006.11.072 17382773 (Pubitemid 46435995)
6. TGF-beta1 reduces the heterogeneity of astrocytic cyclooxygenase-2 and nitric oxide synthase-2 gene expression in a stimulus-independent manner. ME Hamby JA Hewett SJ Hewett, Prostaglandins Other Lipid Mediat 2008 85 115 124 10.1016/j.prostaglandins.2007.11.004 18194875
7. Synergistic Regulation of COX-2 Expression by Bombesin and Transforming Growth Factor-beta. YS Guo Z Chen XD Wen TC Ko CM Townsend Jr MR Hellmich, Dig Dis Sci 2008 53 8 2045 2052 10.1007/s10620-007-0122-9 18095163
8. Induction of COX-2 expression by acrolein in the rat model of hemorrhagic cystitis. FY Macedo F Baltazar LC Mourao PR Almeida JM Mota FC Schmitt RA Ribeiro, Exp Toxicol Pathol 2008 59 425 430 10.1016/j.etp.2007.10.010 18234483
9. Localization and expression of inducible nitric oxide synthase in biopsies from patients with interstitial cystitis. LR Koskela T Thiel I Ehren PJ De Verdier NP Wiklund, J Urol 2008 180 737 741 10.1016/j.juro.2008.03.184 18554637
10. Over expression of platelet-derived endothelial cell growth factor/thymidine phosphorylase in patients with interstitial cystitis and bladder carcinoma. T Ueda M Tamaki O Ogawa N Yoshimura, J Urol 2002 167 347 351 10.1016/S0022-5347(05)65466-3 11743354
11. Latency-Associated Peptide Identifies a Novel CD4+CD25+ Regulatory T Cell Subset with TGF{beta}-Mediated Function and Enhanced Suppression of Experimental Autoimmune Encephalomyelitis. ML Chen BS Yan Y Bando VK Kuchroo HL Weiner, J Immunol 2008 180 7327 7337 18490732
12. Airway epithelial cells modify immune responses by inducing an anti-inflammatory microenvironment. AK Mayer H Bartz F Fey LM Schmidt AH Dalpke, Eur J Immunol 2008 38 1689 1699 10.1002/eji.200737936 18421791
13. Cutting Edge: Foxp3+CD4+CD25+ Regulatory T Cells Induced by IL-2 and TGF-{beta} Are Resistant to Th17 Conversion by IL-6. SG Zheng J Wang DA Horwitz, J Immunol 2008 180 7112 7116 18490709
14. TGF-beta in renal injury and disease. EP Bottinger, Semin Nephrol 2007 27 309 320 10.1016/j.semnephrol.2007.02.009 17533008 (Pubitemid 46802921)
15. Dual roles of immunoregulatory cytokine TGF-beta in the pathogenesis of autoimmunity-mediated organ damage. V Saxena DW Lienesch M Zhou R Bommireddy M Azhar T Doetschman RR Singh, J Immunol 2008 180 1903 1912 18209088
16. Making sense of latent TGF beta activation. JP Annes JS Munger DB Rifkin, J Cell Sci 2003 116 217 224 10.1242/jcs.00229 12482908 (Pubitemid 36163863)
17. Transforming growth factor-beta in critical illness. R Zamora Y Vodovotz, Crit Care Med 2005 33 S478 481 10.1097/01.CCM.0000191725.59611.14 16340427 (Pubitemid 41785994)
18. Control of nitric oxide production by transforming growth factor-beta1: mechanistic insights and potential relevance to human disease. Y Vodovotz, Nitric Oxide 1997 1 3 17 10.1006/niox.1996.0105 9701040 (Pubitemid 28078123)
19. Changing the pathogenetic roadmap of liver fibrosis? Where did it start; where will it go? OA Gressner MS Rizk E Kovalenko R Weiskirchen AM Gressner, J Gastroenterol Hepatol 2008 23 7 Part 1 1024 1035 10.1111/j.1440-1746.2008.05345. x 18505415 (Pubitemid 352019381)
20. [Interstitial cystitis: reevaluation of patients who do no respond to standard treatments]. GE Lemack PE Zimmern, Prog Urol 2001 11 239 244 11400485
21. Can histological assessment predict the outcome in interstitial cystitis? JP MacDermott GC Charpied H Tesluk AR Stone, Br J Urol 1991 67 44 47 10.1111/j.1464-410X.1991.tb15068.x 1704276
22. The histology of interstitial cystitis. WL Lynes SD Flynn LD Shortliffe TA Stamey, Am J Surg Pathol 1990 14 969 976 2403198
23. Cyclophosphamide-induced hemorrhagic cystitis in rats that underwent colocystoplasty: experimental study. J Rodo X Farre E Martin, J Urol 2001 165 660 666 10.1097/00005392-200102000-00090 11176454 (Pubitemid 32060496)
24. Sex, time-of-day and estrous variations in behavioral and bladder histological consequences of cyclophosphamide-induced cystitis in rats. K Bon M Lanteri-Minet D Menetrey KJ Berkley, Pain 1997 73 423 429 10.1016/S0304-3959(97) 00134-6 9469534 (Pubitemid 28021848)
25. Involvement of estrogen in the pathogenesis of cyclophosphamide-induced cystitis in rats. M Terado M Nomura K Mineta H Nishii N Fujimoto T Sasaguri Y Sasaguri T Matsumoto, Endocrine 2005 26 55 63 10.1385/ENDO:26:1:055 15805586
26. Strikingly higher interleukin (IL)-1alpha, IL-1beta and soluble interleukin-1 receptor antagonist (sIL-1RA) but similar IL-2, sIL-2R, IL-3, IL-4, IL-6, sIL-6R, IL-10, tumour necrosis factor (TNF)-alpha, transforming growth factor (TGF)-beta and interferon IFN-gamma urine levels in healthy females compared to healthy males: protection against urinary tract injury? M Sadeghi V Daniel C Naujokat R Weimer G Opelz, Clin Exp Immunol 2005 142 312 317 10.1111/j.1365-2249.2005.02924.x 16232218 (Pubitemid 41565247)
27. Gender and human chronic renal disease. S Silbiger J Neugarten, Gend Med 2008 5 Suppl A S3 S10 10.1016/j.genm.2008.03.002 18395681
28. Upregulation of macrophage migration inhibitory factor (MIF) and CD74, receptor for MIF, in rat bladder during persistent cyclophosphamide-induced inflammation. PL Vera X Wang KL Meyer-Siegler, Exp Biol Med (Maywood) 2008 233 620 626 10.3181/0709-RM-240 18375833 (Pubitemid 351657363)
29. Modified microassay for serum nitrite and nitrate. Y Vodovotz, Biotechniques 1996 20 390 392 394 8679195
30. Regulation of transforming growth factor beta1 by nitric oxide. Y Vodovotz L Chesler H Chong SJ Kim JT Simpson W DeGraff GW Cox AB Roberts DA Wink MH Barcellos-Hoff, Cancer Res 1999 59 2142 2149 10232601
31. Perspectives series: host/pathogen interactions. Mechanisms of nitric oxide-related antimicrobial activity. FC Fang, J Clin Invest 1997 99 2818 2825 10.1172/JCI119473 9185502
32. Inducible nitric oxide synthase activity is essential for inhibition of prostatic tumor growth by interferon-beta gene therapy. MV Olson J Lee F Zhang A Wang Z Dong, Cancer Gene Ther 2006 13 676 685 10.1038/sj.cgt.7700941 16470211 (Pubitemid 44268951)
33. Regulation of TGF-beta1 gene transcription in human prostate cancer cells by nitric oxide. D Wang S Lu Z Dong, Prostate 2007 67 1825 1833 10.1002/pros.20669 17941092 (Pubitemid 350228734)
34. Differential regulation of macrophage arginine metabolism: a proposed role in wound healing. JD Shearer JR Richards CD Mills MD Caldwell, Am J Physiol 1997 272 E181 190 9124321
35. TNF-alpha, TGF-beta and NO relationship in sera from tuberculosis (TB) patients of different severity. G Fiorenza L Rateni MA Farroni C Bogue DG Dlugovitzky, Immunol Lett 2005 98 45 48 10.1016/j.imlet.2004.09.008 15790507 (Pubitemid 40409817)
36. Evidence for control of nitric oxide synthesis by intracellular transforming growth factor-beta1 in tumor cells. Implications for tumor development. P Lagadec S Raynal B Lieubeau N Onier L Arnould V Saint-Giorgio DA Lawrence JF Jeannin, Am J Pathol 1999 154 1867 1876 10362813
37. Cross-talk between nitric oxide and transforming growth factor-beta1 in malaria. Y Vodovotz R Zamora MJ Lieber S Luckhart, Curr Mol Med 2004 4 787 797 10.2174/1566524043359999 15579025 (Pubitemid 39369296)
38. TGF-beta regulates production of NO in pulmonary artery smooth muscle cells by inhibiting expression of NOS. J Finder WW Stark Jr DK Nakayama D Geller K Wasserloos BR Pitt P Davies, Am J Physiol 1995 268 L862 867 7539224
39. Role of TGF-beta in vascular development and vascular reactivity. MA Perrella MK Jain ME Lee, Miner Electrolyte Metab 1998 24 136 143 10.1159/000057361 9525696 (Pubitemid 28098183)
40. The sympathetic adrenomedullary system, but not the hypothalamic- pituitary-adrenal axis, participates in aorta adaptive response to stress: nitric oxide involvement. CM Navarro-Oliveira VS Vassilieff S Cordellini, Auton Neurosci 2000 83 140 147 10.1016/S1566-0702(00)00157-0 11593765
41. Transforming growth factor-beta 1 and cortisol in differentially reared primates. EL Smith OA Batuman RC Trost JD Coplan LA Rosenblum, Brain Behav Immun 2002 16 140 149 10.1006/brbi.2001.0629 11908923 (Pubitemid 35425570)
42. Latent transforming growth factor-beta activation in mammary gland: regulation by ovarian hormones affects ductal and alveolar proliferation. KB Ewan G Shyamala SA Ravani Y Tang R Akhurst L Wakefield MH Barcellos-Hoff, Am J Pathol 2002 160 2081 2093 12057913
43. Transforming growth factor beta1 in the human endometrium. Cyclic variation, increased expression by estradiol and progesterone, and regulation of plasminogen activators and plasminogen activator inhibitor-1. B Casslen T Sandberg B Gustavsson R Willen M Nilbert, Biol Reprod 1998 58 1343 1350 10.1095/biolreprod58.6.1343 9623591 (Pubitemid 28248747)
44. TGF-beta 1 is an organizer of responses to neurodegeneration. CE Finch NJ Laping TE Morgan NR Nichols GM Pasinetti, J Cell Biochem 1993 53 314 322 10.1002/jcb.240530408 8300749
45. Effect of intravesical nitric oxide therapy on cyclophosphamide-induced cystitis. H Ozawa MB Chancellor SY Jung T Yokoyama MO Fraser Y Yu WC de Groat N Yoshimura, J Urol 1999 162 2211 2216 10.1016/S0022-5347(05)68161-X 10569621
46. Inflammatory factor profiles one hour following vocal fold injury. NV Welham X Lim I Tateya DM Bless, Ann Otol Rhinol Laryngol 2008 117 145 152 18357839
47. Deactivation of macrophages by transforming growth factor-beta. S Tsunawaki M Sporn A Ding C Nathan, Nature 1988 334 260 262 10.1038/334260a0 3041283 (Pubitemid 18173378)
48. Urinary transforming growth factor-beta-induced gene-h3 (betaig-h3) as a sensitive predictor in chronic cyclosporine nephrotoxicity. CD Kim YJ Cho SH Park SW Ha EG Lee YJ Kim TH Kwon IS Kim YL Kim, Transplant Proc 2006 38 1314 1319 10.1016/j.transproceed.2006.02.070 16797290 (Pubitemid 43912720)
49. Hydrogen peroxide-mediated transcriptional induction of macrophage colony-stimulating factor by TGF-beta1. YH Hong HB Peng V La Fata JK Liao, J Immunol 1997 159 2418 2423 9278333
50. TGF-beta1 triggers oxidative modifications and enhances apoptosis in HIT cells through accumulation of reactive oxygen species by suppression of catalase and glutathione peroxidase. KN Islam Y Kayanoki H Kaneto K Suzuki M Asahi J Fujii N Taniguchi, Free Radic Biol Med 1997 22 1007 1017 10.1016/S0891-5849(96) 00493-5 9034240 (Pubitemid 27084138)
51. The role of TGF-beta-1 protein and TGF-beta-R-1 receptor in immune escape mechanism in bladder cancer. A Helmy OA Hammam TR El Lithy MM El Deen Wishahi, MedGenMed 2007 9 34 18311384
52. Nitric oxide as an objective marker for evaluation of treatment response in patients with classic interstitial cystitis. A Hosseini I Ehren NP Wiklund, J Urol 2004 172 2261 2265 10.1097/01.ju.0000144761.69398.be 15538244 (Pubitemid 39507504)
53. Tumor necrosis factor-alpha and interleukin-1beta mediate the production of nitric oxide involved in the pathogenesis of ifosfamide induced hemorrhagic cystitis in mice. RA Ribeiro HC Freitas MC Campos CC Santos FC Figueiredo GA Brito FQ Cunha, J Urol 2002 167 2229 2234 10.1016/S0022-5347(05)65134-8 11956484
54. Mixed connective tissue disease following interstitial cystitis. M Seishima H Shimizu Z Oyama K Isogai, Eur J Dermatol 2001 11 45 47 11174138
55. Transforming growth factor-beta1-induced hypertrophy and matrix expression in human bladder smooth muscle cells. PS Howard U Kucich DE Coplen Y He, Urology 2005 66 1349 1353 10.1016/j.urology.2005.06.124 16360482 (Pubitemid 41797330)
56. Stromal hyperplasia in male bladders upon loss of transforming growth factor-beta signaling in fibroblasts. AR Sharif-Afshar JM Donohoe JCt Pope MC Adams JW Brock 3rd NA Bhowmick, J Urol 2005 174 1704 1707 discussion 1707 10.1097/01.ju.0000164720.72732.9c 16148686 (Pubitemid 41318668)
57. Prevalence, diagnosis, characterization, and treatment of prostatitis, interstitial cystitis, and epididymitis in outpatient urological practice: the Canadian PIE Study. JC Nickel JM Teichman M Gregoire J Clark J Downey, Urology 2005 66 935 940 10.1016/j.urology.2005.05.007 16286098 (Pubitemid 41587135)
58. Cyclophosphamide-induced hemorrhagic cystitis successfully treated with conjugated estrogens. P Kopterides M Theodorakopoulou S Mentzelopoulos A Armaganidis, Am J Hematol 2005 80 166 167 10.1002/ajh.20403 16184578 (Pubitemid 41434208)
59. Estradiol reverses renal injury in Alb/TGF-beta1 transgenic mice. J Blush J Lei W Ju S Silbiger J Pullman J Neugarten, Kidney Int 2004 66 2148 2154 10.1111/j.1523-1755.2004.66005.x 15569304 (Pubitemid 41115278)
60. 17beta-Estradiol attenuates diabetic kidney disease by regulating extracellular matrix and transforming growth factor-beta protein expression and signaling. A Dixon C Maric, Am J Physiol Renal Physiol 2007 293 F1678 1690 10.1152/ajprenal.00079.2007 17686959 (Pubitemid 350086005)