Models of inflammation of the lower urinary tract

Neurourology and Urodynamics

Volumn 30, Issue 5, 2011, Pages 673-682

  Bjorling, Dale E ^a,b   Wang, Zun Yi ^a   Bushman, Wade ^b  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

Bladder; Inflammation; Models; Pain; Prostate

Indexed keywords

ANTIGEN INDUCED CYSTITIS; AUTOIMMUNE CYSTITIS; CYSTITIS; DISEASE MODEL; INTERSTITIAL CYSTITIS; LOWER URINARY TRACT INFLAMMATION; NEUROGENIC CYSTITIS; NONHUMAN; PROSTATITIS; REVIEW; URINARY TRACT INFLAMMATION; VIRAL INDUCED CYSTITIS;

AFFERENT PATHWAYS; ANIMALS; CYSTITIS; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; MALE; MECHANOTRANSDUCTION, CELLULAR; PROSTATE; PROSTATITIS; URINARY BLADDER;

EID: 79959849591     PISSN: 07332467     EISSN: 15206777     Source Type: Journal    
DOI: 10.1002/nau.21078     Document Type: Review

References (150)

1. Ambulatory Care Visits to Physician Offices, Hospital Outpatient Departments, and Emergency Departments: United States, 1999-2000. Vital and Health Statistics. Series 13, No. 157. Hyattsville, MD: National Center for Health Statistics, Centers for Disease Control and Prevention, U.S. Dept. of Health and Human Services, September 2004.
2. Nicolle LE, Bradley S, Colgan R, et al. Infectious Diseases Society of America guidelines for the diagnosis and treatment of asymptomatic bacteriuria in adults. Clin Infect Dis 2005;40:643-54. (Pubitemid 40381336)
3. Berry SH, Bogart LM, Pham C, et al. Development, validation and testing of an epidemiological case definition of interstitial cystitis/painful bladder syndrome. J Urol 2010;183:1848-52.
4. Clemens JQ, Joyce GF, Wise M, et al. Interstitial cystitis and painful bladder syndrome. In: Litwin MS, Saigal CS, editors. Urologic diseases in America. Washington, DC: US Department of Health and Human Services, National Institutes of Health, US Government Printing Office, NIH Publication 07- 511; 2007. pp 123-54.
5. Wyndaele JJ, Van Dyck J, Toussaint N. Cystoscopy and bladder biopsies in patients with bladder pain syndrome carried out following ESSIC guidelines. Scand J Urol Nephrol 2009;43:471-5.
6. Erickson DR, Tomaszewski JE, Kunselman AR, et al. Urine markers do not predict biopsy findings or presence of bladder ulcers in interstitial cystitis/ painful bladder syndrome. J Urol 2008;179:1850-6.
7. Delongchamps NB, de la Roza G, Chandan V, et al. Evaluation of prostatitis in autopsied prostates - Is chronic inflammation more associated with benign prostatic hyperplasia or cancer? J Urol 2008;179:1736-40.
8. Di Silverio F, Gentile V, De Matteis A, et al. Distribution of inflammation, pre-malignant lesions, incidental carcinoma in histologically confirmed benign prostatic hyperplasia: A retrospective analysis. Eur Urol 2003;43: 164-75. (Pubitemid 36221971)
9. Nickel JC, Downey J, Young I, et al. Asymptomatic inflammation and/or infection in benign prostatic hyperplasia. BJU Inter 1999;84:976-81.
10. Nickel JC, Elhilali M, Vallancien G. Benign prostatic hyperplasia (BPH) and prostatitis: Prevalence of painful ejaculation in men with clinical BPH. BJU Int 2005;95:571-4. (Pubitemid 40311475)
11. O'Sullivan M, Murphy C, Deasy C, et al. Effects of transurethral resection of prostate on the quality of life of patients with benign prostatic hyperplasia. J Am Coll Surg 2004;198:394-403. (Pubitemid 38283730)
12. Bjorling DE, Wang ZY, Boldon K, et al. Bacterial cystitis is accompanied by increased peripheral thermal sensitivity in mice. J Urol 2008;179:759-63.
13. Hopkins WJ, Gendron-Fitzpatrick A, Balish E, et al. Time course and host responses to Escherichia coli urinary tract infection in genetically distinct mouse strains. Infect Immun 1998;66:2798-802. (Pubitemid 28261786)
14. Birder LA. TRPs in bladder diseases. Biochim Biophys Acta 2007;1772:879-84. (Pubitemid 47176378)
15. Cruz F, Dinis P. Resiniferatoxin and botulinum toxin type A for treatment of lower urinary tract symptoms. Neurourol Urodyn 2007;26:920-7. (Pubitemid 47548229)
16. Dinis P, Charrua A, Avelino A, et al. Intravesical resiniferatoxin decreases spinal c-fos expression and increases bladder volume to reflex micturition in rats with chronic inflamed urinary bladders. BJU Int 2004;94:153-7. (Pubitemid 38980326)
17. Cayan S, Coşkun B, Bozlu M, et al. Botulinum toxin type A may improve bladder function in a rat chemical cystitis model. Urol Res 2003;30:399-404. (Pubitemid 36285659)
18. Krhut J, Zvara P. Intravesical instillation of botulinum toxin A: An in vivo murine study and pilot clinical trial. Int Urol Nephrol 2010; Jun 20, Epub ahead of print.
19. Osbaldiston GW, Taussig RA. Clinical report on 46 cases of feline urological syndrome. Vet Med Small Anim Clin 1970;65:461-8.
20. Fabricant CG. Urolithiasis: A review with recent viral studies. Feline Pract 1973;3:22-30.
21. Fabricant CG. Herpesvirus induced feline urolithiasis. A review. Comp Immunol Microbiol Infect Dis 1979;9:460-6.
22. Fabricant CG, Gillespie JH. Identification and characterization of a second feline herpesvirus. Infect Immun 1974;9:460-6.
23. Martens JG, McConnell S, Swanson CL. The role of infectious agents in naturally occurring feline urologic syndrome. Vet Clin North Am Small Anim Pract 1984;14:503-11.
24. Barsanti JA, Finco DR, Shotts EB, et al. Feline urologic syndrome: Further investigation into etiology. J Am Anim Hosp Assoc 1982;18:391-5.
25. Kruger JM, Osborne CA, Goyal SM, et al. Clinical evaluation of cats with lower urinary tract disease. J Am Vet Med Assoc 1991;199:211-6.
26. Lees GE. Epidemiology of naturally occurring bacterial urinary tract infection. Vet Clin North Am Small Anim Pract 1984;14:471-9.
27. Buffington CAT, Blaisdell JL, Binns SP, et al. Decreased urine glycosaminoglycan (GAG) excretion in cats with inflammatory bladder syndrome [AUA Annual Meeting, abstract 1186]. J Urol 1993;149:509A.
28. Gao X, Buffington CA, Au JL. Effect of interstitial cystitis on drug absorption from urinary bladder. J Pharmacol Exp Ther 1994;271:818-23. (Pubitemid 24377770)
29. Birder LA. Urothelial signaling. Auton Neurosci 2010;153:33-40.
30. Sahbaie P, Shi X, Guo TZ, et al. Role of substance P signaling in enhanced nociceptive sensitization and local cytokine production after incision. Pain 2009;145:341-9.
31. Pezet S, McMahon SB. Neurotrophins: Mediators and modulators of pain. Annu Rev Neurosci 2006;29:507-38. (Pubitemid 44476854)
32. Birder LA, Wolf-Johnston AS, Chib MK, et al. Beyond neurons: Involvement of urothelial and glial cells in bladder function. Neurourol Urodyn 2010;29:88-96.
33. Marchand JE, Sant GR, Kream RM. Increased expression of substance P receptor-encoding mRNA in bladder biopsies from patients with interstitial cystitis. Br J Urol 1998;81:224-8. (Pubitemid 28316456)
34. Lowe EM, Anand P, Terenghi G, et al. Increased nerve growth factor levels in the urinary bladder of women with idiopathic sensory urgency and interstitial cystitis. Br J Urol 1997;79:572-7. (Pubitemid 28321098)
35. Birder LA, Ruan HZ, Chopra B, et al. Alterations in P2X and P2Y purinergic receptor expression in urinary bladder from normal cats and cats with interstitial cystitis. Am J Physiol Renal Physiol 2004;287:F1084-91.
36. Birder LA, Barrick SR, Roppolo JR, et al. Feline interstitial cystitis results in mechanical hypersensitivity and altered ATP release from bladder urothelium. Am J Physiol Renal Physiol 2003;285:F423-9.
37. Sun Y, Keay S, Lehrfeld TJ, et al. Changes in adenosine triphosphate-stimulated ATP release suggest association between cytokine and purinergic signaling in bladder urothelial cells. Urology 2009;74:1163-8.
38. Sun Y, Chai TC. Augmented extracellular ATP signaling in bladder urothelial cells from patients with interstitial cystitis. Am J Physiol Cell Physiol 2006;290:C27-34.
39. Westropp JL, Buffington CA. In vivo models of interstitial cystitis. J Urol 2002;167:694-702.
40. Julius D, Basbaum AI. Molecular mechanisms of nociception. Nature 2001;413:203-10. (Pubitemid 32867885)
41. Lundberg JM, Brodin E, Hua X, et al. Vascular permeability changes and smooth muscle contraction in relation to capsaicin-sensitive substance P afferents in the guinea-pig. Acta Physiol Scand 1984;120:217-27. (Pubitemid 14155267)
42. Abelli L, Nappi F, Perretti F, et al. Microvascular leakage induced by substance P in rat urinary bladder: Involvement of cyclo-oxygenase metabolites of arachidonic acid. J Auton Pharmacol 1992;12:269-76.
43. Kowalski ML, Sliwinska-Kowalska M, Kaliner MA. Neurogenic inflammation, vascular permeability, and mast cells. II. Additional evidence indicating that mast cells are not involved in neurogenic inflammation. J Immunol 1990;145:1214-21. (Pubitemid 20258726)
44. Sharkey KA. Substance P and calcitonin gene-related peptide (CGRP) in gastrointestinal inflammation. Ann N Y Acad Sci 1992;664:425-42. (Pubitemid 23022870)
45. Yonehara N, Imai Y, Shibutani T, et al. Participation of substance P in inflammatory responses. Adv Exp Med Biol 1989;247B:529-34.
46. Pan XQ, Gonzalez JA, Chang S, et al. Experimental colitis triggers the release of substance P and calcitonin gene-related peptide in the urinary bladder via TRPV1 signaling pathways. Exp Neurol 2010;225:262-73.
47. Trevisani M, Campi B, Gatti R, et al. The influence of alpha1-adrenoreceptors on neuropeptide release from primary sensory neurons of the lower urinary tract. Eur Urol 2007;52:901-8. (Pubitemid 47126136)
48. Holzer P. Local effector functions of capsaicin-sensitive sensory nerve endings: Involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. Neuroscience 1988;24:739-68.
49. Donnerer J, Amann R, Schuligoi R, et al. Complete recovery by nerve growth factor of neuropeptide content and function in capsaicin-impaired sensory neurons. Brain Res 1996;741:103-8. (Pubitemid 26426304)
50. Geppetti P, Nassini R, Materazzi S, et al. The concept of neurogenic inflammation. BJU Int 2008;101:2-6. (Pubitemid 351328798)
51. Avelino A, Cruz F. TRPV1 (vanilloid receptor) in the urinary tract: Expression, function and clinical applications. Naunyn Schmiedebergs Arch Pharmacol 2006;373:287-99. (Pubitemid 43999780)
52. Mourtzoukou EG, Iavazzo C, Falagas ME. Resiniferatoxin in the treatment of interstitial cystitis: A systematic review. Int Urogynecol J Pelvic Floor Dysfunct 2008;19:1571-6.
53. Dimitrakov J, Kroenke K, Steers WD, et al. Pharmacologic management of painful bladder syndrome/interstitial cystitis: A systematic review. Arch Intern Med 2007;167:1922-9. (Pubitemid 47606630)
54. Lecci A, Giuliani S, Patacchini R, et al. Evidence against a peripheral role of tachykinins in the initiation of micturition reflex in rats. J Pharmacol Exp Ther 1993;264:1327-32. (Pubitemid 23318629)
55. Maggi CA, Patacchini R, Santicioli P, et al. Tachykinin antagonists and capsaicin- induced contraction of the rat isolated urinary bladder: Evidence for tachykinin-mediated cotransmission. Br J Pharmacol 1991;103:1535-41.
56. Bjorling DE, Saban MR, Saban R. Neurogenic inflammation of Guinea-pig bladder. Mediators Inflamm 1994;3:189-97. (Pubitemid 24250409)
57. Saban MR, Saban R, Bjorling D, et al. Involvement of leukotrienes, TNFalpha, and the LFA-1/ICAM-1 interaction in substance P-induced granulocyte infiltration. J Leukoc Biol 1997;61:445-51. (Pubitemid 27219838)
58. Saban R, Franz J, Bjorling DE. Spontaneously released substance P and bradykinin from isolated guinea-pig bladder. Br J Urol 1997;79:516-24. (Pubitemid 28321091)
59. Saban MR, Saban R, Bjorling DE. Kinetics of peptide-induced release of inflammatory mediators by the urinary bladder. Br J Urol 1997;80:742-7. (Pubitemid 28316337)
60. Dundore PA, Schwartz AM, Semerjian H. Mast cell counts are not useful in the diagnosis of nonulcerative interstitial cystitis. J Urol 1996;155:885-7. (Pubitemid 26052671)
61. Sant GR, Kempuraj D, Marchand JE, et al. The mast cell in interstitial cystitis: Role in pathophysiology and pathogenesis. Urology 2007;69:34-40.
62. Larsen MS, Mortensen S, Nordling J, et al. Quantifying mast cells in bladder pain syndrome by immunohistochemical analysis. BJU Int 2008;102:204-7. (Pubitemid 351852591)
63. Elbadawi AE, Light JK. Distinctive ultrastructural pathology of nonulcerative interstitial cystitis: New observations and their potential significance in pathogenesis. Urol Int 1996;56:137-62.
64. Letourneau R, Pang X, Sant GR, et al. Intragranular activation of bladder mast cells and their association with nerve processes in interstitial cystitis. Br J Urol 1996;77:41-54.
65. Saban R, Keith IM, Bjorling DE. Neuropeptide-mast cell interaction in interstitial cystitis. In: Sant GR, editor. Interstitial cystitis. Philadelphia: Lippincott-Raven; 1997. pp 53-66.
66. Theoharides TC, Sant GR, el-Mansoury M, et al. Activation of bladder mast cells in interstitial cystitis: A light and electron microscopic study. J Urol 1995;153:629-36.
67. Renzetti LM, Paciorek PM, Tannu SA, et al. Pharmacological evidence for tumor necrosis factor as a mediator of allergic inflammation in the airways. J Pharmacol Exp Ther 1996;278:847-53. (Pubitemid 27167054)
68. Theoharides TC, Sant GR. The mast cell as a neuroimmunoendocrine effector in interstitial cystitis. In: Sant GR, editor. Interstitial cystitis. Philadelphia: Lippincott-Raven; 1997. pp 101-8.
69. Welker P, Grabbe J, Grützkau A, et al. Effects of nerve growth factor (NGF) and other fibroblast-derived growth factors on immature human mast cells (HMC-1). Immunology 1998;94:310-7. (Pubitemid 28318594)
70. Ishizaka T, Ishizaka K. Activation of mast cells for mediator release through IgE receptors. Prog Allergy 1984;34:188-235. (Pubitemid 14163360)
71. Bjorling DE, Jerde TJ, Zine MJ, et al. Mast cells mediate the severity of experimental cystitis in mice. J Urol 1999;162:231-6. (Pubitemid 29420932)
72. Feinberg SM, Malkiel S, McIntire FC. The effect of stress factors of asthma induced in guinea pigs by aerosolized antigens. J Allergy 1953;24:302-8.
73. Saban R, Christensen M, Keith I, et al. Experimental model for the study of bladder mast cell degranulation and smooth muscle contraction. Semin Urol 1991;9:88-101.
74. Saban R, Saban MR, Nguyen NB, et al. Mast cell regulation of inflammation and gene expression during antigen-induced bladder inflammation in mice. Physiol Genomics 2001;7:35-43.
75. McDonald DM, Bowden JJ, Baluk P, et al. Neurogenic inflammation. A model for studying efferent actions of sensory nerves. Adv Exp Med Biol 1996;410:453-62.
76. Baluk P, Thurston G, Murphy TJ, et al. Neurogenic plasma leakage in mouse airways. Br J Pharmacol 1999;126:522-8. (Pubitemid 29057605)
77. McDonald DM, Thurston G, Baluk P. Endothelial gaps as sites for plasma leakage in inflammation. Microcirculation 1999;6:7-22. (Pubitemid 129672559)
78. Saban R, Saban MR, Nguyen NB, et al. Neurokinin-1 (NK-1) receptor is required in antigen-induced cystitis. Am J Pathol 2000;156:775-80. (Pubitemid 30626934)
79. Bjorling DE, Saban MR, Bruskewitz RC, et al. Response of the isolated guinea pig bladder to exogenous and endogenous leukotrienes. J Urol 1994;152:1281-6. (Pubitemid 24283498)
80. Saban R, Undem BJ, Keith IM, et al. Differential release of prostaglandins and leukotrienes by sensitized guinea pig urinary bladder layers upon antigen challenge. J Urol 1994;152:544-9. (Pubitemid 24221270)
81. Koziol JA. Epidemiology of interstitial cystitis. Urol Clin North Am 1994;21:7-20. (Pubitemid 24032763)
82. Jasmin L, Carstens E, Basbaum AI. Interneurons presynaptic to rat tail-flick motoneurons as mapped by transneuronal transport of pseudorabiesvirus: Few have long ascending collaterals. Neuroscience 1997;76:859-76. (Pubitemid 27013424)
83. Jasmin L, Janni G, Manz HJ, et al. Activation of CNS circuits producing a neurogenic cystitis: Evidence for centrally induced peripheral inflammation. J Neurosci 1998;18:10016-29. (Pubitemid 28543776)
84. Rudick CN, Schaeffer AJ, Klumpp DJ. Pharmacologic attenuation of pelvic pain in a murine model of interstitial cystitis. BMC Urol 2009;9:16.
85. Rudick CN, Bryce PJ, Guichelaar LA, et al. Mast cell-derived histamine mediates cystitis pain. PLoS ONE 2008;3:e2096.
86. Rudick CN, Chen MC, Mongiu AK, et al. Organ cross talk modulates pelvic pain. Am J Physiol Regul Integr Comp Physiol 2007;293:R1191-8.
87. Chen MC, Keshavan P, Gregory GD, et al. RANTES mediates TNF-dependent lamina propria mast cell accumulation and barrier dysfunction in neurogenic cystitis. Am J Physiol Renal Physiol 2007;292:F1372-9.
88. Doggweiler R, Jasmin L, Schmidt RA. Neurogenically mediated cystitis in rats: An animal model. J Urol 1998;160:1551-6. (Pubitemid 29480576)
89. Silk MR. Bladder antibodies in interstitial cystitis. J Urol 1970;103:307-9.
90. Anderson JB, Parivar F, Lee G, et al. The enigma of interstitial cystitis-An autoimmune disease? Br J Urol 1989;63:58-63.
91. Jokinen EJ, Alfthan OS, Oravisto KJ. Antitissue antibodies in interstitial cystitis. Clin Exp Immunol 1972;11:333-9.
92. Mattila J, Harmoinen A, Hällström O. Serum immunoglobulin and complement alterations in interstitial cystitis. Eur Urol 1983;9:350-2. (Pubitemid 14245421)
93. Ochs RL, Stein TW, Jr., Peebles CL, et al. Autoantibodies in interstitial cystitis. J Urol 1994;151:587-92. (Pubitemid 24054690)
94. Lee KL, Chen MY, Yeh JH, et al. Lower urinary tract symptoms in female patients with rheumatoid arthritis. Scand J Rheumatol 2006;35:96-101.
95. Leppilahti M, Tammela TL, Huhtala H, et al. Interstitial cystitis-like urinary symptoms among patients with Sjogren's syndrome: A population-based study in Finland. Am J Med 2003;115:62-5.
96. van de Merwe JP. Interstitial cystitis and systemic autoimmune diseases. Nat Clin Pract Urol 2007;4:484-91.
97. Peeker R, Atanasiu L, Logadottir Y. Intercurrent autoimmune conditions in classic and non-ulcer interstitial cystitis. Scand J Urol Nephrol 2003; 37:60-3. (Pubitemid 36246216)
98. Bullock AD, Becich MJ, Klutke CG, et al. Experimental autoimmune cystitis: A potential murine model for ulcerative interstitial cystitis. J Urol 1992; 148:1951-6.
99. Phull H, Salkini M, Purves T, et al. Angiotensin II plays a role in acute murine experimental autoimmune cystitis. BJU Int 2007;100:664-7. (Pubitemid 47205478)
100. Lin YH, Liu G, Kavran M, et al. Lower urinary tract phenotype of experimental autoimmune cystitis in mouse: A potential animal model for interstitial cystitis. BJU Int 2008;102:1724-30.
101. Luber-Narod J, Austin-Ritchie T, Banner B, et al. Experimental autoimmune cystitis in the Lewis rat: A potential animal model for interstitial cystitis. Urol Res 1996;24:367-73. (Pubitemid 27022456)
102. Liu W, Deyoung BR, Chen X, et al. RDP58 inhibits T cell-mediated bladder inflammation in an autoimmune cystitis model. J Autoimmun 2008;30: 257-65.
103. Liu W, Evanoff DP, Chen X, et al. Urinary bladder epithelium antigen induces CD8+ T cell tolerance, activation, and autoimmune response. J Immunol 2007;178:539-46. (Pubitemid 46033638)
104. Cox PJ. Cyclophosphamide cystitis-Identification of acrolein as the causative agent. Biochem Pharmacol 1979;28:2045-9. (Pubitemid 9214911)
105. Lanteri-Minet M, Bon K, de Pommery J, et al. Cyclophosphamide cystitis as a model of visceral pain in rats: Model elaboration and spinal structures involved as revealed by the expression of c-Fos and Krox-24 proteins. Exp Brain Res 1995;105:220-32.
106. Jerde TJ, Bjorling DE, Steinberg H, et al. Determination of mouse bladder inflammatory response to E. coli lipopolysaccharide. Urol Res 2000;28: 269-73. (Pubitemid 30663756)
107. Saban MR, Saban R, Hammond TG, et al. LPS-sensory peptide communication in experimental cystitis. Am J Physiol Renal Physiol 2002;282: F202-10.
108. Olsson LE, Wheeler MA, Sessa WC, et al. Bladder instillation and intraperitoneal injection of Escherichia coli lipopolysaccharide up-regulate cytokines and iNOS in rat urinary bladder. J Pharmacol Exp Ther 1998;284: 1203-8. (Pubitemid 28130852)
109. Stein PC, Pham H, Ito T, et al. Bladder injury model induced in rats by exposure to protamine sulfate followed by bacterial endotoxin. J Urol 1996;155:1133-8. (Pubitemid 26052730)
110. Meyer-Siegler KL, Ordorica RC, Vera PL. Macrophage migration inhibitory factor is upregulated in an endotoxin-induced model of bladder inflammation in rats. J Interferon Cytokine Res 2004;24:55-63. (Pubitemid 38147267)
111. Weng TI, Chen WJ, Liu SH. Bladder instillation of Escherichia coli lipopolysaccharide alters the muscle contractions in rat urinary bladder via a protein kinase C-related pathway. Toxicol Appl Pharmacol 2005;208: 163-9. (Pubitemid 41377132)
112. Wille PR, Vitor R, Gabilan NH, et al. Plasma extravasation mediated by lipopolysaccharide- induction of kinin B1 receptors in rat tissues. Mediators Inflamm 2001;10:163-7. (Pubitemid 32735309)
113. Tapping RI, Akashi S, Miyake K, et al. Toll-like receptor 4, but not toll-like receptor 2, is a signaling receptor for Escherichia and Salmonella lipopolysaccharides. J Immunol 2000;165:5780-7.
114. Takeuchi O, Hoshino K, Kawai T, et al. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 1999;11:443-51. (Pubitemid 29504199)
115. Schilling JD, Mulvey MA, Vincent CD, et al. Bacterial invasion augments epithelial cytokine responses to Escherichia coli through a lipopolysaccharide- dependent mechanism. J Immunol 2001;166:1148-55. (Pubitemid 32060274)
116. Rouanet C, Locht C. Boosting BCG to protect against TB. Expert Rev Respir Med 2010;4:339-48.
117. Sexton WJ, Wiegand LR, Correa JJ, et al. Bladder cancer: A review of nonmuscle invasive disease. Cancer Control 2010;17:256-68.
118. Saban MR, Simpson C, Davis C, et al. Discriminators of mouse bladder response to intravesical Bacillus Calmette-Guerin (BCG). BMC Immunol 2007;8:6.
119. McMahon SB, Abel C. A model for the study of visceral pain states: Chronic inflammation of the chronic decerebrate rat urinary bladder by irritant chemicals. Pain 1987;28:109-27. (Pubitemid 17210463)
120. Rivas DA, Chancellor MB, Shupp-Byrne S, et al. Molecular marker for development of interstitial cystitis in rat model: Isoactin gene expression. J Urol 1997;157:1937-40. (Pubitemid 27171815)
121. Hauser PJ, Buethe DA, Califano J, et al. Restoring barrier function to acid damaged bladder by intravesical chondroitin sulfate. J Urol 2009;182: 2477-82.
122. Fraser MO, Chuang YC, Tyagi P, et al. Intravesical liposome administration- A novel treatment for hyperactive bladder in the rat. Urology 2003;61:656-63. (Pubitemid 36294213)
123. Birder LA, Nakamura Y, Kiss S, et al. Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1. Nat Neurosci 2002;5:856-60. (Pubitemid 34976650)
124. Arms L, Girard BM, Vizzard MA. Expression and function of CXCL12/CXCR4 in rat urinary bladder with cyclophosphamide-induced cystitis. Am J Physiol Renal Physiol 2010;298:F589-600.
125. Cheppudira BP, Girard BM, Malley SE, et al. Upregulation of vascular endothelial growth factor isoform VEGF-164 and receptors (VEGFR-2, Npn-1, and Npn-2) in rats with cyclophosphamide-induced cystitis. Am J Physiol Renal Physiol 2008;295:F826-36.
126. Cheppudira BP, Girard BM, Malley SE, et al. Involvement of JAK-STAT signaling/ function after cyclophosphamide-induced bladder inflammation in female rats. Am J Physiol Renal Physiol 2009;297:F1038-44.
127. Corrow KA, Vizzard MA. Phosphorylation of extracellular signal-regulated kinases in bladder afferent pathways with cyclophosphamide-induced cystitis. Neuroscience 2009;163:1353-62.
128. Girard BM, Malley SE, Braas KM, et al. Exaggerated expression of inflammatory mediators in vasoactive intestinal polypeptide knockout (VIP-/-) mice with cyclophosphamide (CYP)-induced cystitis. J Mol Neurosci 2008;36:188-99.
129. Girard BM, Wolf-Johnston A, Braas KM, et al. PACAP-mediated ATP release from rat urothelium and regulation of PACAP/VIP and receptor mRNA in micturition pathways after cyclophosphamide (CYP)-induced cystitis. J Mol Neurosci 2008;36:310-20.
130. Rubin JS, Rubin RT. Cyclophosphamide hemorrhagic cystitis. J Urol 1966;96:313-6.
131. Locher GW, Cooper EH. Repair of rat urinary bladder epithelium following injury by cyclophosphamide. Invest Urol 1970;8:116-123.
132. Okamura T, Garland EM, Taylor RJ, et al. The effect of cyclophosphamide administration on the kidney of the rat. Toxicol Lett 1992;63: 261-76.
133. Kalota SJ, Stein PC, Parsons CL. Prevention of acrolein-induced bladder injury by pentosanpolysulfate. J Urol 1992;148:163-6.
134. Sakata T, Smith RA, Garland EM, et al. Rat urinary bladder epithelial lesions induced by acrolein. J Environ Pathol Toxicol Oncol 1989;9:159-69. (Pubitemid 19159719)
135. Fraiser L, Kehrer JP. Murine strain differences in metabolism and bladder toxicity of cyclophosphamide. Toxicology 1992;75:257-72.
136. Bjorling DE, Elkahwaji JE, Bushman W, et al. Acute acrolein-induced cystitis in mice. BJU Int 2007;99:1523-9. (Pubitemid 47164796)
137. Abrams P, Cardozo L, Fall M, et al. The standardisation of terminology of lower urinary tract function: Report from the Standardisation Subcommittee of the International Continence Society. Neurourol Urodyn 2002;21:167-78. (Pubitemid 34195211)
138. Chapple CR, Roehrborn CG. A shifted paradigm for the further understanding, evaluation, and treatment of lower urinary tract symptoms in men: Focus on the bladder. Eur Urol 2006;49:651-8. (Pubitemid 43374725)
139. Dmochowski RR. Bladder outlet obstruction: Etiology and evaluation. Rev Urol 2005;7:S3-13.
140. Knutson T, Edlund C, Fall M, et al. BPH with coexisting overactive bladder dysfunction - An everyday urological dilemma. Neurourol Urodyn 2001;20:237-47. (Pubitemid 32377204)
141. Mirone V, Imbimbo C, Longo N, et al. The detrusor muscle: An innocent victim of bladder outlet obstruction. Eur Urol 2007;51:57-66. (Pubitemid 44821527)
142. Gomes CM, Nunes RV, Araújo RM, et al. Urodynamic evaluation of patients with lower urinary tract symptoms and small prostate volume. Urol Int 2008;81:129-34.
143. Nickel JC. Prostatic inflammation in benign prostatic hyperplasia - The third component? Can J Urol 1994;1:1-4.
144. Krieger JN, Riley DE. Prostatitis: What is the role of infection. Int J Antimicrob Agents 2002;19:475-9.
145. Hochreiter WW, Duncan JL, Schaeffer AJ. Evaluation of the bacterial flora of the prostate using a 16S rRNA gene based polymerase chain reaction. J Urol 2000;163:127-30.
146. Weiss J, Wein A, Jacobs J, et al. Use of nitrofurantoin macrocrystals after transurethral prostatectomy. J Urol 1983;130:479-80. (Pubitemid 13001188)
147. Kirby RS, Lowe D, Bultitude MI, et al. Intra-prostatic urinary reflux: An aetiological factor in abacterial prostatitis. Br J Urol 1982;54:729-31. (Pubitemid 13179611)
148. Pontari MA, Ruggieri MR. Mechanisms in prostatitis/chronic pelvic pain syndrome. J Urol 2004;172:839-45. (Pubitemid 39096404)
149. Elkahwaji JE, Zhong W, Hopkins WJ, Bushman W. Chronic bacterial infection and inflammation incite reactive hyperplasia in a mouse model of chronic prostatitis. Prostate 2007;67:14-21. (Pubitemid 46013463)
150. Uehling DT, Hopkins WJ, Jensen J, et al. Vaginal immunization against induced cystitis in monkeys. J Urol 1987;137:327-9. (Pubitemid 17016669)