The pharmacological rationale for combining muscarinic receptor antagonists and β-adrenoceptor agonists in the treatment of airway and bladder disease

Current Opinion in Pharmacology

Volumn 16, Issue 1, 2014, Pages 31-42

  Dale, Philippa R ^a   Cernecka, Hana ^b,c   Schmidt, Martina ^b,c   Dowling, Mark R ^d   Charlton, Steven J ^d   Pieper, Michael P ^e   Michel, Martin C ^e,f  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

^c UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^d NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^e BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^f JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BRONCHODILATING AGENT; MESSENGER RNA; MUSCARINIC M3 RECEPTOR ANTAGONIST; MUSCARINIC RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR;

ACETYLCHOLINE RELEASE; ARTICLE; BLADDER CONTRACTION; BLADDER DISEASE; BRONCHUS HYPERREACTIVITY; CHRONIC OBSTRUCTIVE LUNG DISEASE; DRUG CLASSIFICATION; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; GENE EXPRESSION REGULATION; HUMAN; INTRACELLULAR SIGNALING; MOLECULAR INTERACTION; NEUROTRANSMITTER RELEASE; NONHUMAN; OUTCOME ASSESSMENT; OVERACTIVE BLADDER; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; RESPIRATORY EPITHELIUM; RESPIRATORY TRACT DISEASE; SMOOTH MUSCLE RELAXATION; SMOOTH MUSCLE TONE; TREATMENT DURATION; TREATMENT RESPONSE; ANIMAL; COMBINATION DRUG THERAPY; LUNG DISEASES, OBSTRUCTIVE; METABOLISM; URINARY BLADDER DISEASES;

ADRENERGIC BETA-AGONISTS; ANIMALS; DRUG THERAPY, COMBINATION; HUMANS; LUNG DISEASES, OBSTRUCTIVE; MUSCARINIC ANTAGONISTS; RECEPTORS, ADRENERGIC, BETA; RECEPTORS, MUSCARINIC; URINARY BLADDER DISEASES;

EID: 84897431084     PISSN: 14714892     EISSN: 14714973     Source Type: Journal    
DOI: 10.1016/j.coph.2014.03.003     Document Type: Review

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