Excitatory cholinergic and purinergic signaling in bladder are equally susceptible to botulinum neurotoxin a consistent with co-release of transmitters from efferent fibers

Journal of Pharmacology and Experimental Therapeutics

Volumn 334, Issue 3, 2010, Pages 1080-1086

  Lawrence, Gary W ^a   Aoki, K Roger ^b   Dolly, J Oliver ^a  

^a DUBLIN CITY UNIVERSITY   (Ireland)

^b ALLERGAN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ADENOSINE TRIPHOSPHATE; ATROPINE; BOTULINUM TOXIN A; NEUROTRANSMITTER; SYNAPTOBREVIN; TETRODOTOXIN; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; PURINERGIC RECEPTOR; SNAP25 PROTEIN, RAT; SYNAPTOBREVIN 1; SYNAPTOSOMAL ASSOCIATED PROTEIN 25;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER; CONTROLLED STUDY; DESENSITIZATION; DRUG ACTIVITY; DRUG EFFICACY; DRUG INHIBITION; DRUG MECHANISM; EFFERENT NERVE; ELECTROSTIMULATION; MUSCLE CONTRACTION; MUSCLE INNERVATION; NERVE EXCITABILITY; NEUROMUSCULAR TRANSMISSION; NONHUMAN; OVERACTIVE BLADDER; PRIORITY JOURNAL; RAT; SENSORY NERVE; ANIMAL; ANTAGONISTS AND INHIBITORS; CHOLINERGIC SYSTEM; DRUG EFFECTS; IMMUNOLOGY; IN VITRO STUDY; METABOLISM; NERVE FIBER; PHYSIOLOGY; SIGNAL TRANSDUCTION; SMOOTH MUSCLE;

ADENOSINE TRIPHOSPHATE; ANIMALS; BOTULINUM TOXINS, TYPE A; ELECTRIC STIMULATION; IN VITRO TECHNIQUES; MUSCLE CONTRACTION; MUSCLE, SMOOTH; NERVE FIBERS; NEURONS, EFFERENT; NEUROTRANSMITTER AGENTS; PARASYMPATHETIC NERVOUS SYSTEM; RATS; RECEPTORS, PURINERGIC; SIGNAL TRANSDUCTION; SYNAPTOSOMAL-ASSOCIATED PROTEIN 25; TETRODOTOXIN; URINARY BLADDER; VESICLE-ASSOCIATED MEMBRANE PROTEIN 1;

EID: 77956247429     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.110.169342     Document Type: Article

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