Protein kinase C potentiates homologous desensitization of the β2-adrenoceptor in bovine tracheal smooth muscle

European Journal of Pharmacology

Volumn 529, Issue 1-3, 2006, Pages 151-156

  Boterman, Mark ^a   Smits, Steven R J G ^a   Meurs, Herman ^a   Zaagsma, Johan ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

2 adrenoceptor desensitization; Airway smooth muscle; Fenoterol; GF 109203X; Phorbol 12 myristate 13 acetate; Protein kinase C

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; BETA 2 ADRENERGIC RECEPTOR; FENOTEROL; ISOPRENALINE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; PROTEIN KINASE C ACTIVATOR;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DESENSITIZATION; DRUG EFFECT; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYME INHIBITION; INCUBATION TIME; MUSCLE RELAXATION; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE; TRACHEA;

ADRENERGIC BETA-AGONISTS; ANIMALS; CATTLE; DOSE-RESPONSE RELATIONSHIP, DRUG; FENOTEROL; ISOPROTERENOL; METHACHOLINE CHLORIDE; MUSCLE RELAXATION; MUSCLE, SMOOTH; PROTEIN KINASE C; RECEPTORS, ADRENERGIC, BETA-2; TETRADECANOYLPHORBOL ACETATE; TRACHEA;

EID: 29344461277     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2005.10.064     Document Type: Article

References (36)

1. 2+ and cyclic AMP signalling systems in smooth muscle Cell. Signal. 3 1991 371 385
2. P.J. Barnes Pharmacology of airway smooth muscle Am. J. Respir. Crit Care Med. 158 1998 S123 S132
3. R. Beasley, N. Pearce, J. Crane, and C. Burgess β-Agonists: what is the evidence that their use increases the risk of asthma morbidity and mortality? J. Allergy Clin. Immunol. 104 1999 S18 S30
4. S.K. Bohm, E.F. Grady, and N.W. Bunnett Regulatory mechanisms that modulate signalling by G-protein-coupled receptors Biochem. J. 322 Pt 1 1997 1 18
5. M. Boterman, C.R. Elzinga, D. Wagemakers, P.B. Eppens, J. Zaagsma, and H. Meurs Potentiation of beta-adrenoceptor function in bovine tracheal smooth muscle by inhibition of protein kinase C Eur. J. Pharmacol. 516 2005 85 92
6. 2-adrenergic receptors at the level of receptor phosphorylation and desensitization Mol. Pharmacol. 56 1999 813 823
7. T.T. Chuang, H. LeVine III, and A. De Blasi Phosphorylation and activation of β-adrenergic receptor kinase by protein kinase C. J. Biol. Chem. 270 1995 18660 18665
8. R.B. Clark, B.J. Knoll, and R. Barber Partial agonists and G protein-coupled receptor desensitization Trends Pharmacol. Sci. 20 1999 279 286
9. M. Cong, S.J. Perry, F.T. Lin, I.D. Fraser, L.A. Hu, W. Chen, J.A. Pitcher, J.D. Scott, and R.J. Lefkowitz Regulation of membrane targeting of the G protein-coupled receptor kinase 2 by protein kinase A and its anchoring protein AKAP79 J. Biol. Chem. 276 2001 15192 15199
10. A. De Blasi, G. Parruti, and M. Sallese Regulation of G protein-coupled receptor kinase subtypes in activated T lymphocytes. Selective increase of β-adrenergic receptor kinase 1 and 2 J. Clin. Invest. 95 1995 10
11. 2-adrenergic receptor J. Biol. Chem. 271 1996 13796 13803
12. B.M. Grandordy, J.C. Mak, and P.J. Barnes Modulation of airway smooth muscle β-adrenoceptor function by a muscarinic agonist Life Sci. 54 1994 185 191
13. I.P. Hall The β-agonist controversy revisited Lancet 363 2004 183 184
14. R.J. Hancox, R.E. Aldridge, J.O. Cowan, E.M. Flannery, G.P. Herbison, C.R. McLachlan, G.I. Town, and D.R. Taylor Tolerance to beta-agonists during acute bronchoconstriction Eur. Respir. J. 14 1999 283 287
15. M.D. Houslay 'Crosstalk': a pivotal role for protein kinase C in modulating relationships between signal transduction pathways Eur. J. Biochem. 195 1991 9 27
16. L. Iacovelli, R. Franchetti, M. Masini, and B.A. De GRK2 and β-arrestin 1 as negative regulators of thyrotropin receptor-stimulated response Mol. Endocrinol. 10 1996 1138 1146
17. J.G. Krupnick, and J.L. Benovic The role of receptor kinases and arrestins in G protein-coupled receptor regulation Annu. Rev. Pharmacol. Toxicol. 38 1998 289 319
18. 2-adrenergic receptor desensitization J. Biol. Chem. 265 1990 3202 3211
19. 2-adrenergic receptor facilitate sequestration Biochemistry 35 1996 4155 4160
20. H. Meurs, H.F. Kauffman, A. Timmermans, F.T. van Amsterdam, G.H. Koeter, and V.K. de Phorbol 12-myristate 13-acetate induces beta-adrenergic receptor uncoupling and non-specific desensitization of adenylate cyclase in human mononuclear leukocytes Biochem. Pharmacol. 35 1986 4217 4222
21. 3-adrenoceptor-mediated relaxation of rat oesophagus smooth muscle by protein kinase C Eur. J. Pharmacol. 495 2004 75 81
22. G. Parruti, F. Peracchia, M. Sallese, G. Ambrosini, M. Masini, D. Rotilio, and B.A. De Molecular analysis of human β-arrestin-1: cloning, tissue distribution, and regulation of expression. Identification of two isoforms generated by alternative splicing J. Biol. Chem. 268 1993 9753 9761
23. 2AR-adenylyl cyclase pathway in human airway smooth muscle Am. J. Respir. Cell Mol. Biol. 19 1998 338 348
24. 2-adrenergic receptor by β-adrenergic receptor kinase, cAMP-dependent protein kinase, and protein kinase C occurs via distinct molecular mechanisms Biochemistry 31 1992 3193 3197
25. J.A. Pitcher, N.J. Freedman, and R.J. Lefkowitz G protein-coupled receptor kinases Annu. Rev. Biochem. 67 1998 653 692
26. N.J. Pyne, M.W. Grady, D. Shehnaz, P.A. Stevens, S. Pyne, and I.W. Rodger Muscarinic blockade of β-adrenoceptor-stimulated adenylyl cyclase: the role of stimulatory and inhibitory guanine-nucleotide binding regulatory proteins (Gs and Gi) Br. J. Pharmacol. 107 1992 881 887
27. M.R. Sears, D.R. Taylor, C.G. Print, D.C. Lake, Q.Q. Li, E.M. Flannery, D.M. Yates, M.K. Lucas, and G.P. Herbison Regular inhaled beta-agonist treatment in bronchial asthma Lancet 336 1990 1391 1396
28. S.A. Shore, and P.E. Moore Regulation of β-adrenergic responses in airway smooth muscle Respir. Physiol Neurobiol. 137 2003 179 195
29. D.R. Sibley, and R.J. Lefkowitz Molecular mechanisms of receptor desensitization using the β-adrenergic receptor-coupled adenylate cyclase system as a model Nature 317 1985 124 129
30. R.H. Stoffel, J.A. Pitcher, and R.J. Lefkowitz Targeting G protein-coupled receptor kinases to their receptor substrates J. Membr. Biol. 157 1997 1 8
31. T.J. Torphy Action of mediators on airway smooth muscle: functional antagonism as a mechanism for bronchodilator drugs Agents Actions Suppl. 23 1988 37 53
32. D. Toullec, P. Pianetti, H. Coste, P. Bellevergue, T. Grand-Perret, M. Ajakane, V. Baudet, P. Boissin, E. Boursier, and F. Loriolle The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C J. Biol. Chem. 266 1991 15771 15781
33. 2-adrenergic receptor using phosphoserine-specific antibodies Mol. Pharmacol. 65 2004 196 206
34. B.L. Webb, M.A. Lindsay, P.J. Barnes, and M.A. Giembycz Protein kinase C isoenzymes in airway smooth muscle Biochem. J. 324 1997 167 175
35. R. Winstel, S. Freund, C. Krasel, E. Hoppe, and M.J. Lohse Protein kinase cross-talk: membrane targeting of the β-adrenergic receptor kinase by protein kinase C Proc. Natl. Acad. Sci. U. S. A. 93 1996 2105 2109
36. N. Yuan, J. Friedman, B.S. Whaley, and R.B. Clark cAMP-dependent protein kinase and protein kinase C consensus site mutations of the β-adrenergic receptor. Effect on desensitization and stimulation of adenylylcyclase J. Biol. Chem. 269 1994 23032 23038