A quantitative analysis of mRNA expression of α1 and β-adrenoceptor subtypes and their functional roles in human normal and obstructed bladders

Journal of Urology

Volumn 170, Issue 2 I, 2003, Pages 649-653

  Nomiya, Masanori ^a   Yamaguchi, Osamu ^a  

^a FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Bladder; Bladder neck obstruction; Muscle, smooth; Prostatic hyperplasia; Receptors, adrenergic

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; BETA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CARBACHOL; CLENBUTEROL; DOBUTAMINE; ISOPRENALINE; MESSENGER RNA; PHENYLEPHRINE;

ARTICLE; BLADDER CONTRACTION; BLADDER OBSTRUCTION; CLINICAL ARTICLE; CONTROLLED STUDY; DETRUSOR MUSCLE; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; PROSTATE HYPERTROPHY; QUANTITATIVE ANALYSIS; RECEPTOR DOWN REGULATION; RECEPTOR INTRINSIC ACTIVITY; RECEPTOR UPREGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0037830662     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ju.0000067621.62736.7c     Document Type: Article

References (20)

1. Chapple, C. R.: Alpha adrenoceptor antagonists in the year 2000: is there anything new? Curr Opin Urol, 11: 9, 2001
2. Fitzpatrick, J. M.: Facts and future lines of research in lower urinary tract symptoms in men and women: an overview of the role of alpha1-adrenoceptor antagonists. BJU Int. suppl., 85: 1, 2000
3. Serels, S. and Stein, M.: Prospective study comparing hyoscynamine, doxazosin, and combination therapy for the treatment of urgency and frequency in women. Neurourol Urodyn, 17: 31, 1998
4. Andersson, K. E.: Mode of action of alpha1-adrenoceptor antagonists in the treatment of lower urinary tract symptoms. BJU Int, suppl., 85: 12, 2000
5. Schwinn, D. A. and Michelotti, G. A.: Alphal-adrenergic receptors in the lower urinary tract and vascular bed: potential role for the alpha1d subtype in filling symptoms and effects of ageing on vascular expression. BJU Int, suppl., 85: 6, 2000
6. Malloy, B. J., Price, D. T., Price, R. R., Bienstock, A. M., Dole, M. K., Funk, B. L. et al: α1-Adrenergic receptor subtypes in human detrusor. J Urol, 160: 937, 1998
7. 1 adrenergic receptor subtypes in human prostate. J Urol, 150: 546, 1993
8. Nasu, K., Moriyama, N., Kawabe, K., Tsujimoto, G., Murai, M., Tanaka, T. et al: Quantification and distribution of alpha1-adrenoceptor subtype mRNAs in human prostate: comparison of benign hypertrophied tissue and non-hypertrophied tissue. Br J Pharmacol, 119: 797, 1996
9. Andersson, K. E.: Pharmacology of lower urinary tract smooth muscles and penile erectile tissues. Pharmacol Rev, 45: 253, 1993
10. Andersson, K.: Alpha1-adrenoceptors and bladder function. Eur Urol, suppl., 36: 96, 1999
11. Bunemann, M., Lee, K. B., Pals-Rylaarsdam, R., Roseberry, A. G. and Hosey, M. M.: Desensitization of G-protein-coupled receptors in the cardiovascular system. Annu Rev Physiol, 61: 169, 1999
12. Rokosh, D. G., Stewart, A. F., Chang, K. C., Bailey, B. A., Karliner, J. S., Camacho, S. A. et al: Alpha1-adrenergic receptor subtype mRNAs are differentially regulated by alpha1-adrenergic and other hypertrophic stimuli in cardiac myocytes in culture and in vivo. Repression of alpha1b and alpha1D but induction of alpha1C. J Biol Chem, 271: 5839, 1996
13. Granneman, J. G., Zhai, Y. and Lahners, K. N.: Selective upregulation of alpha1a-adrenergic receptor protein and mRNA in brown adipose tissue by neural and beta3-adrenergic stimulation. Mol Pharmacol, 51: 644, 1997
14. Hampel, C., Dolber, P. C., Smith, M. P., Savic, S. L., Thüroff, J. W., Thor, K. B. et al: Modulation of bladder α1-adrenergic receptor subtype expression by bladder outlet obstruction. J Urol, 167: 1513, 2002
15. Smith, D. J. and Chapple, C. R.: In vitro response of human bladder smooth muscle in unstable obstructed male bladders: a study of pathophysiological causes? Neurourol Urodyn, 13: 414, 1994
16. Fujimura, T., Tamura, T., Tsutsumi, T., Yamamoto, T., Nakamura, K., Koibuchi, Y. et al: Expression and possible functional role of the β3-adrenoceptor in human and rat detrusor muscle. J Urol, 161: 680, 1999
17. Igawa, Y., Yamazaki, Y., Takeda, H., Kaidoh, K., Akahane, M., Ajisawa, Y. et al: Relaxant effects of isoproterenol and selective β3-adrenoceptor agonists on normal, low compliant and hyperreflexic human bladders. J Urol, 165: 240, 2001
18. Persson, K., Pandita, R. K., Spitsbergen, J. M., Steers, W. D., Tuttle, J. B. and Andersson, K. E.: Spinal and peripheral mechanisms contributing to hyperactive voiding in spontaneously hypertensive rats. Am J Physiol, 275: R1366, 1998
19. Smith, M. S., Schambra, U. B., Wilson, K. H., Page, S. O. and Schwinn, D. A.: Alpha1-adrenergic receptors in human spinal cord: specific localized expression of mRNA encoding alpha1-adrenergic receptor subtypes at four distinct levels. Brain Res Mol Res, 63: 254, 1999
20. Das, A. K., Leggett, R. E., Whitbeck, C., Eagen, G. and Levin, R. M.: Effect of doxazosin on rat urinary bladder function after partial outlet obstruction. Neurourol Urodyn, 21: 160, 2002