Muscarinic receptors stimulate cell proliferation in the human urothelium-derived cell line UROtsa

Pharmacological Research

Volumn 64, Issue 4, 2011, Pages 420-425

  Arrighi, Nicola ^a   Bodei, Serena ^a   Lucente, Alessandra ^a   Michel, Martin C ^b   Zani, Danilo ^a   Simeone, Claudio ^a   Cunico, Sergio Cosciani ^a   Spano, Pierfranco ^a   Sigala, Sandra ^a  

^a UNIVERSITY OF BRESCIA   (Italy)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Acetylcholine; Cell proliferation; Muscarinic receptors; UROtsa cell line

Indexed keywords

ACETYLCHOLINE; ADENYLATE CYCLASE; BETA ACTIN; CARBACHOL; CARNITINE ACETYLTRANSFERASE; CHOLINE ACETYLTRANSFERASE; COMPLEMENTARY DNA; DARIFENACIN; FORSKOLIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; INOSITOL TRISPHOSPHATE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; MUSCARINIC M4 RECEPTOR; MUSCARINIC M5 RECEPTOR; MUSCARINIC RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR;

ARTICLE; CELL PROLIFERATION; CHOLINERGIC SYSTEM; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; UROTHELIUM;

ACETYLCHOLINE; CELL LINE; CELL PROLIFERATION; HUMANS; PHOSPHATIDYLINOSITOL 3-KINASES; RECEPTORS, MUSCARINIC; SECOND MESSENGER SYSTEMS; UROTHELIUM;

EID: 80052961269     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2011.06.009     Document Type: Article

References (39)

1. L.A. Birder, A.S. Wolf-Johnston, M.K. Chib, C.A. Buffington, J.R. Roppolo, and A.T. Hanna-Mitchell Beyond neurons: involvement of urothelial and glial cells in bladder function Neurourol Urodyn 29 2010 88 96
2. K.E. Andersson Antimuscarinic mechanisms and the overactive detrusor: an update Eur Urol 59 2011 377 386
3. I. Wessler, H. Kilbinger, F. Bittinger, R. Unger, and C.J. Kirkpatrick The non-neuronal cholinergic system in humans: expression, function and pathophysiology Life Sci 72 2003 2055 2061 (Pubitemid 36298947)
4. M. Yoshida, A. Inadome, Y. Maeda, Y. Satoji, K. Masunaga, and Y. Sugiyama Non-neuronal cholinergic system in human bladder urothelium Urology 67 2006 425 430 (Pubitemid 43189886)
5. K.S. Lips, J. Wunsch, S. Zarghooni, T. Bschleipfer, K. Schukowski, and W. Weidner Acetylcholine and molecular components of its synthesis and release machinery in the urothelium Eur Urol 51 2007 1042 1053 (Pubitemid 46281424)
6. M. Yoshida, K. Masunaga, Y. Satoji, Y. Maeda, T. Nagata, and A. Inadome Basic and clinical aspects of non-neuronal acetylcholine: expression of non-neuronal acetylcholine in urothelium and its clinical significance J Pharmacol Sci 106 2008 193 198 (Pubitemid 351366337)
7. S.S. Hegde Muscarinic receptors in the bladder: from basic research to therapeutics Br J Pharmacol 147 Suppl 2 2006 S80 S87
8. D. Giglio, and G. Tobin Muscarinic receptor subtypes in the lower urinary tract Pharmacology 83 2009 259 269
9. D.M. Daly, R. Chess-Williams, C. Chapple, and D. Grundy The inhibitory role of acetylcholine and muscarinic receptors in bladder afferent activity Eur Urol 58 2010 22 28
10. S. Zarghooni, J. Wunsch, M. Bodenbenner, D. Brüggmann, S.A. Grando, and U. Schwantes Expression of muscarinic and nicotinic acetylcholine receptors in the mouse urothelium Life Sci 80 2007 2308 2313 (Pubitemid 46818267)
11. T. Bschleipfer, K. Schukowski, W. Weidner, S.A. Grando, U. Schwantes, and W. Kummer Expression and distribution of cholinergic receptors in the human urothelium Life Sci 80 2007 2303 2307 (Pubitemid 46818274)
12. K.J. Mansfield, L. Liu, F.J. Mitchelson, K.H. Moore, R.J. Millard, and E. Burcher Muscarinic receptor subtypes in human bladder detrusor and mucosa, studied by radioligand binding and quantitative competitive RT-PCR: changes in ageing Br J Pharmacol 44 2005 1089 1099 (Pubitemid 40593007)
13. N. Arrighi, S. Bodei, A. Peroni, G. Mirabella, D. Zani, and C. Simeone Detection of muscarinic receptor subtypes in human urinary bladder mucosa: age and gender-dependent modifications Neurourol Urodyn 27 2008 421 428 (Pubitemid 351991208)
14. S. Tyagi, P. Tyagi, S. Van-le, N. Yoshimura, M.B. Chancellor, and F. de Miguel Qualitative and quantitative expression profile of muscarinic receptors in human urothelium and detrusor J Urol 176 2006 1673 1678 (Pubitemid 44307245)
15. G. Jositsch, T. Papadakis, R.V. Haberberger, M. Wolff, J. Wess, and W. Kummer Suitability of muscarinic acetylcholine receptor antibodies for immunohistochemistry evaluated on tissue sections of receptor gene-deficient mice Naunyn Schmiedebergs Arch Pharmacol 379 2009 389 395
16. W. Pradidarcheep, J. Stallen, W.T. Labruyre, N.F. Dabhoiwala, M.C. Michel, and W.H. Lamers Lack of specificity of commercially available antisera against muscarinergic and adrenergic receptors Naunyn Schmiedebergs Arch Pharmacol 379 2009 397 402
17. M.P. Caulfield, and N.J. Birdsall International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors Pharmacol Rev 50 1998 279 290 (Pubitemid 28304029)
18. I. Wessler, and C.J. Kirkpatrick Acetylcholine beyond neurons: the non-neuronal cholinergic system in humans Br J Pharmacol 154 2008 1558 1571
19. R. Gosens, J. Zaagsma, H. Meurs, and A.J. Halayko Muscarinic receptor signaling in the pathophysiology of asthma and COPD Respiratory Res 7 2006 73 76
20. S. Matthiesen, A. Bahulayan, O. Holz, and K. Racké MAPK pathway mediates muscarinic receptor-induced human lung fibroblast proliferation Life Sci 80 2007 2259 2262 (Pubitemid 46818284)
21. R. Gosens, J. Zaagsma, M.G. Bromhaar, A. Nelemans, and H. Meurs Acetylcholine: a novel regulator of airway smooth muscle remodelling? Eur J Pharmacol 500 2004 193 201 (Pubitemid 39304008)
22. N. Shah, S. Khurana, K. Cheng, and J.P. Raufman Muscarinic receptors and ligands in cancer Am J Physiol Cell Physiol 296 2009 C221 C232
23. M.M. Barendrecht, P. Chichester, M.C. Michel, and R.M. Levin Effect of short-term outlet obstruction on rat bladder nerve density and contractility Auton Autacoid Pharmacol 27 2007 47 53 (Pubitemid 44952844)
24. J.L. Petzoldt, I.M. Leigh, P.C. Duffy, C. Sexton, and J.R.W. Masters Immortalisation of human urothelial cells Urol Res 23 1995 377 380 (Pubitemid 26015191)
25. M.R. Rossi, J.R. Masters, S. Park, J.H. Todd, S.H. Garrett, and M.A. Sens The immortalized UROtsa cell line as a potential cell culture model of human urothelium Environ Health Perspect 109 2001 801 808 (Pubitemid 32910302)
26. M. Pizzi, F. Boroni, A. Bianchetti, C. Moraitis, I. Sarnico, and M. Benarese Expression of functional NR1/NR2B-type NMDA receptors in neuronally differentiated SK-N-SH human cell line Eur J Neurosci 16 2002 2342 2350 (Pubitemid 36056959)
27. S. Rozen, and H.J. Skaletsky Primer3 on the WWW for general users and for biologist programmers S. Krawetz, S. Misener, Bioinformatics Methods and Protocols: Methods in Molecular Biology 2000 Humana Press Totowa, NJ 365 386
28. S. Sigala, P. Rizzonelli, E. Zanelli, A. Forgione, C. Missale, and P.F. Spano Low doses of l-sulpiride down-regulate striatal and cortical dopamine receptors and β-adrenoceptor Eur J Pharmacol 199 1991 247 253
29. S. Matthiesen, A. Bahulayan, S. Kempkens, S. Haag, M. Fuhrmann, and C. Stichnote Muscarinic receptors mediate stimulation of human lung fibroblast proliferation Am J Respir Cell Mol Biol 35 2006 621 627 (Pubitemid 44901851)
30. S. Sigala, I. Faraoni, D. Botticini, M. Paez-Pereda, C. Missale, and E. Bonmassar Suppression of telomerase, reexpression of KAI1, and abrogation of tumorigenicity by nerve growth factor in prostate cancer cell lines Clin Cancer Res 5 1999 1211 1218 (Pubitemid 29233240)
31. A. Belo, K. Cheng, A. Chahdi, J. Shant, G. Xie, and S. Khurana Muscarinic receptor agonists stimulate human colon cancer cell migration and invasion Am J Physiol Gastrointest Liver Physiol. 300 2011 G749 60
32. X. Tong, F. Zhao, and C.B. Thompson The molecular determinants of de novo nucleotide biosynthesis in cancer cells Curr Opin Genet Dev 19 2009 32 37
33. J.S. Gutkind, E.A. Novotny, M.R. Brann, and K.C. Robbins Muscarinic acetylcholine receptor subtypes as agonist-dependent oncogenes Proc Natl Acad Sci USA 88 1991 4703 4707 (Pubitemid 21914610)
34. E.H. Wu, and Y.H. Wong Activation of muscarinic M4 receptor augments NGF-induced pro-survival Akt signaling in PC12 cells Cell Signal 18 2006 285 293 (Pubitemid 41661344)
35. P.J. Stork, and J.M. Schmitt Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation Trends Cell Biol 12 2002 258 266 (Pubitemid 34634174)
36. G. Tobin, D. Giglio, and O. Lundgren Muscarinic receptor subtypes in the alimentary tract J Physiol Pharmacol 60 2009 3 21
37. R.M. Eglen Muscarinic receptor subtypes in neuronal and non-neuronal cholinergic function Auton Autacoid Pharmacol 26 2006 219 233 (Pubitemid 43898622)
38. N. Zinner Darifenacin: a muscarinic M3-selective receptor antagonist for the treatment of overactive bladder Expert Opin Pharmacother 8 2007 511 523 (Pubitemid 46416419)
39. M. Mitsuya, T. Mase, Y. Tsuchiya, K. Kawakami, H. Hattori, and K. Kobayashi J-104129, a novel muscarinic M3 receptor antagonist with high selectivity for M3 over M2 receptors Bioorg Med Chem 7 1999 2555 2567 (Pubitemid 30122758)