-
1
-
-
57349143739
-
Efficient tumour formation by single human melanoma cells
-
Quintana E, Shackleton M, Sabel MS, Fullen DR, Johnson TM, Morrison SJ. Efficient tumour formation by single human melanoma cells. Nature. 2008; 456(7222): 593-598.
-
(2008)
Nature
, vol.456
, Issue.7222
, pp. 593-598
-
-
Quintana, E.1
Shackleton, M.2
Sabel, M.S.3
Fullen, D.R.4
Johnson, T.M.5
Morrison, S.J.6
-
2
-
-
77952502408
-
A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth
-
Roesch A, Fukunaga-Kalabis M, Schmidt EC, et al. A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth. Cell. 2010; 141(4): 583-594.
-
(2010)
Cell
, vol.141
, Issue.4
, pp. 583-594
-
-
Roesch, A.1
Fukunaga-Kalabis, M.2
Schmidt, E.C.3
-
3
-
-
0035499267
-
Stem cells, cancer, and cancer stem cells
-
Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature. 2001; 414(6859): 105-111.
-
(2001)
Nature
, vol.414
, Issue.6859
, pp. 105-111
-
-
Reya, T.1
Morrison, S.J.2
Clarke, M.F.3
Weissman, I.L.4
-
4
-
-
77957952030
-
Brain tumor stem cells as therapeutic targets in models of glioma
-
Laks DR, Visnyei K, Kornblum HI. Brain tumor stem cells as therapeutic targets in models of glioma. Yonsei Med J. 2010; 51(5): 633-640.
-
(2010)
Yonsei Med J
, vol.51
, Issue.5
, pp. 633-640
-
-
Laks, D.R.1
Visnyei, K.2
Kornblum, H.I.3
-
5
-
-
33751217466
-
Tumor morphology and phenotypic evolution driven by selective pressure from the microenvironment
-
Anderson AR, Weaver AM, Cummings PT, Quaranta V. Tumor morphology and phenotypic evolution driven by selective pressure from the microenvironment. Cell. 2006; 127(5): 905-915.
-
(2006)
Cell
, vol.127
, Issue.5
, pp. 905-915
-
-
Anderson, A.R.1
Weaver, A.M.2
Cummings, P.T.3
Quaranta, V.4
-
6
-
-
84856013431
-
Clonal evolution in cancer
-
Greaves M, Maley CC. Clonal evolution in cancer. Nature. 2012; 481(7381): 306-313.
-
(2012)
Nature
, vol.481
, Issue.7381
, pp. 306-313
-
-
Greaves, M.1
Maley, C.C.2
-
7
-
-
0028091194
-
A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
-
Lapidot T, Sirard C, Vormoor J, et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature. 1994; 367(6464): 645-648.
-
(1994)
Nature
, vol.367
, Issue.6464
, pp. 645-648
-
-
Lapidot, T.1
Sirard, C.2
Vormoor, J.3
-
8
-
-
16844378799
-
Leukaemia stem cells and the evolution of cancer-stem-cell research
-
Huntly BJ, Gilliland DG. Leukaemia stem cells and the evolution of cancer-stem-cell research. Nat Rev Cancer. 2005; 5(4): 311-321.
-
(2005)
Nat Rev Cancer
, vol.5
, Issue.4
, pp. 311-321
-
-
Huntly, B.J.1
Gilliland, D.G.2
-
9
-
-
0030789242
-
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
-
Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med. 1997; 3(7): 730-737.
-
(1997)
Nat Med
, vol.3
, Issue.7
, pp. 730-737
-
-
Bonnet, D.1
Dick, J.E.2
-
10
-
-
0032055156
-
High level engraftment of NOD/SCID mice by primitive normal and leukemic hematopoietic cells from patients with chronic myeloid leukemia in chronic phase
-
Wang JC, Lapidot T, Cashman JD, et al. High level engraftment of NOD/SCID mice by primitive normal and leukemic hematopoietic cells from patients with chronic myeloid leukemia in chronic phase. Blood. 1998; 91(7): 2406-2414.
-
(1998)
Blood
, vol.91
, Issue.7
, pp. 2406-2414
-
-
Wang, J.C.1
Lapidot, T.2
Cashman, J.D.3
-
11
-
-
13344262695
-
Normal and leukemic SCID-repopulating cells (SRC) coexist in the bone marrow and peripheral blood from CML patients in chronic phase, whereas leukemic SRC are detected in blast crisis
-
Sirard C, Lapidot T, Vormoor J, et al. Normal and leukemic SCID-repopulating cells (SRC) coexist in the bone marrow and peripheral blood from CML patients in chronic phase, whereas leukemic SRC are detected in blast crisis. Blood. 1996; 87(4): 1539-1548.
-
(1996)
Blood
, vol.87
, Issue.4
, pp. 1539-1548
-
-
Sirard, C.1
Lapidot, T.2
Vormoor, J.3
-
12
-
-
45549101709
-
Multiple myeloma cancer stem cells
-
Huff CA, Matsui W. Multiple myeloma cancer stem cells. J Clin Oncol. 2008; 26(17): 2895-2900.
-
(2008)
J Clin Oncol
, vol.26
, Issue.17
, pp. 2895-2900
-
-
Huff, C.A.1
Matsui, W.2
-
13
-
-
67651092337
-
Circulating clonotypic B cells in classic Hodgkin lymphoma
-
Jones RJ, Gocke CD, Kasamon YL, et al. Circulating clonotypic B cells in classic Hodgkin lymphoma. Blood. 2009; 113(23): 5920-5926.
-
(2009)
Blood
, vol.113
, Issue.23
, pp. 5920-5926
-
-
Jones, R.J.1
Gocke, C.D.2
Kasamon, Y.L.3
-
14
-
-
52549087785
-
Cancer stem cells in solid tumours: Accumulating evidence and unresolved questions
-
Visvader JE, Lindeman GJ. Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer. 2008; 8(10): 755-768.
-
(2008)
Nat Rev Cancer
, vol.8
, Issue.10
, pp. 755-768
-
-
Visvader, J.E.1
Lindeman, G.J.2
-
15
-
-
53149105484
-
Cancer stem cell markers in common cancers-therapeutic implications
-
Klonisch T, Wiechec E, Hombach-Klonisch S, et al. Cancer stem cell markers in common cancers-therapeutic implications. Trends Mol Med. 2008; 14(10): 450-460.
-
(2008)
Trends Mol Med
, vol.14
, Issue.10
, pp. 450-460
-
-
Klonisch, T.1
Wiechec, E.2
Hombach-Klonisch, S.3
-
16
-
-
82255191954
-
Embryonic stem cell-specific signatures in cancer: Insights into genomic regulatory networks and implications for medicine
-
Kim J, Orkin S. Embryonic stem cell-specific signatures in cancer: insights into genomic regulatory networks and implications for medicine. Genome Med. 2011; 3(11): 75.
-
(2011)
Genome Med
, vol.3
, Issue.11
, pp. 75
-
-
Kim, J.1
Orkin, S.2
-
17
-
-
33846474121
-
G-protein-coupled receptors and cancer
-
Dorsam RT, Gutkind JS. G-protein-coupled receptors and cancer. Nat Rev Cancer. 2007; 7(2): 79-94.
-
(2007)
Nat Rev Cancer
, vol.7
, Issue.2
, pp. 79-94
-
-
Dorsam, R.T.1
Gutkind, J.S.2
-
18
-
-
0000437998
-
Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region
-
Hsu SY, Liang SG, Hsueh AJ. Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region. Mol Endocrinol. 1998; 12(12): 1830-1845.
-
(1998)
Mol Endocrinol
, vol.12
, Issue.12
, pp. 1830-1845
-
-
Hsu, S.Y.1
Liang, S.G.2
Hsueh, A.J.3
-
19
-
-
80051926611
-
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
-
de Lau W, Barker N, Low TY, et al. Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. Nature. 2011; 476(7360): 293-297.
-
(2011)
Nature
, vol.476
, Issue.7360
, pp. 293-297
-
-
de Lau, W.1
Barker, N.2
Low, T.Y.3
-
20
-
-
84879778870
-
Structure of stem cell growth factor R-spondin 1 in complex with the ectodomain of its receptor LGR5
-
Peng WC, de Lau W, Forneris F, et al. Structure of stem cell growth factor R-spondin 1 in complex with the ectodomain of its receptor LGR5. Cell Rep. 2013; 3(6): 1885-1892.
-
(2013)
Cell Rep
, vol.3
, Issue.6
, pp. 1885-1892
-
-
Peng, W.C.1
de Lau, W.2
Forneris, F.3
-
21
-
-
35548974423
-
Identification of stem cells in small intestine and colon by marker gene Lgr5
-
Barker N, van Es JH, Kuipers J, et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature. 2007; 449(7165): 1003-1007.
-
(2007)
Nature
, vol.449
, Issue.7165
, pp. 1003-1007
-
-
Barker, N.1
van Es, J.H.2
Kuipers, J.3
-
22
-
-
34848868818
-
Stem cells by any other name
-
Baker M. Stem cells by any other name. Nature. 2007; 449(7161): 389.
-
(2007)
Nature
, vol.449
, Issue.7161
, pp. 389
-
-
Baker, M.1
-
23
-
-
73049116186
-
Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro
-
Barker N, Huch M, Kujala P, et al. Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro. Cell Stem Cell. 2010; 6(1): 25-36.
-
(2010)
Cell Stem Cell
, vol.6
, Issue.1
, pp. 25-36
-
-
Barker, N.1
Huch, M.2
Kujala, P.3
-
24
-
-
55049112939
-
Lgr5 marks cycling, yet long-lived, hair follicle stem cells
-
Jaks V, Barker N, Kasper M, et al. Lgr5 marks cycling, yet long-lived, hair follicle stem cells. Nat Genet. 2008; 40(11): 1291-1299.
-
(2008)
Nat Genet
, vol.40
, Issue.11
, pp. 1291-1299
-
-
Jaks, V.1
Barker, N.2
Kasper, M.3
-
25
-
-
84866926354
-
Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney development
-
Barker N, Rookmaaker MB, Kujala P, et al. Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney development. Cell Rep. 2012; 2(3): 540-552.
-
(2012)
Cell Rep
, vol.2
, Issue.3
, pp. 540-552
-
-
Barker, N.1
Rookmaaker, M.B.2
Kujala, P.3
-
26
-
-
84873131410
-
Lgr5-expressing cells are sufficient and necessary for postnatal mammary gland organogenesis
-
Plaks V, Brenot A, Lawson DA, et al. Lgr5-expressing cells are sufficient and necessary for postnatal mammary gland organogenesis. Cell Rep. 2013; 3(1): 70-78.
-
(2013)
Cell Rep
, vol.3
, Issue.1
, pp. 70-78
-
-
Plaks, V.1
Brenot, A.2
Lawson, D.A.3
-
27
-
-
67349123408
-
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
-
Sato T, Vries RG, Snippert HJ, et al. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature. 2009; 459(7244): 262-265.
-
(2009)
Nature
, vol.459
, Issue.7244
, pp. 262-265
-
-
Sato, T.1
Vries, R.G.2
Snippert, H.J.3
-
28
-
-
78751644734
-
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
-
Sato T, van Es JH, Snippert HJ, et al. Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature. 2011; 469(7330): 415-418.
-
(2011)
Nature
, vol.469
, Issue.7330
, pp. 415-418
-
-
Sato, T.1
van Es, J.H.2
Snippert, H.J.3
-
29
-
-
31544480900
-
Defective postnatal development of the male reproductive tract in LGR4 knockout mice
-
Mendive F, Laurent P, Van Schoore G, Skarnes W, Pochet R, Vassart G. Defective postnatal development of the male reproductive tract in LGR4 knockout mice. Dev Biol. 2006; 290(2): 421-434.
-
(2006)
Dev Biol
, vol.290
, Issue.2
, pp. 421-434
-
-
Mendive, F.1
Laurent, P.2
Van Schoore, G.3
Skarnes, W.4
Pochet, R.5
Vassart, G.6
-
30
-
-
33749008767
-
Leucine-rich repeat-containing G protein-coupled receptor-4 (LGR4, Gpr48) is essential for renal development in mice
-
Kato S, Matsubara M, Matsuo T, et al. Leucine-rich repeat-containing G protein-coupled receptor-4 (LGR4, Gpr48) is essential for renal development in mice. Nephron Exp Nephrol. 2006; 104(2): e63-e75.
-
(2006)
Nephron Exp Nephrol
, vol.104
, Issue.2
-
-
Kato, S.1
Matsubara, M.2
Matsuo, T.3
-
31
-
-
34548678909
-
Eye-open at birth phenotype with reduced keratinocyte motility in LGR4 null mice
-
Kato S, Mohri Y, Matsuo T, et al. Eye-open at birth phenotype with reduced keratinocyte motility in LGR4 null mice. FEBS Lett. 2007; 581(24): 4685-4690.
-
(2007)
FEBS Lett
, vol.581
, Issue.24
, pp. 4685-4690
-
-
Kato, S.1
Mohri, Y.2
Matsuo, T.3
-
32
-
-
61449197690
-
Inactivation of G-protein-coupled receptor 48 (Gpr48/Lgr4) impairs definitive erythropoiesis at midgestation through down-regulation of the ATF4 signaling pathway
-
Song H, Luo J, Luo W, et al. Inactivation of G-protein-coupled receptor 48 (Gpr48/Lgr4) impairs definitive erythropoiesis at midgestation through down-regulation of the ATF4 signaling pathway. J Biol Chem. 2008; 283(52): 36687-36697.
-
(2008)
J Biol Chem
, vol.283
, Issue.52
, pp. 36687-36697
-
-
Song, H.1
Luo, J.2
Luo, W.3
-
33
-
-
49449109436
-
Impaired hair placode formation with reduced expression of hair follicle-related genes in mice lacking Lgr4
-
Mohri Y, Kato S, Umezawa A, Okuyama R, Nishimori K. Impaired hair placode formation with reduced expression of hair follicle-related genes in mice lacking Lgr4. Dev Dyn. 2008; 237(8): 2235-2242.
-
(2008)
Dev Dyn
, vol.237
, Issue.8
, pp. 2235-2242
-
-
Mohri, Y.1
Kato, S.2
Umezawa, A.3
Okuyama, R.4
Nishimori, K.5
-
34
-
-
63849165695
-
Defective development of the gall bladder and cystic duct in Lgr4-hypomorphic mice
-
Yamashita R, Takegawa Y, Sakumoto M, et al. Defective development of the gall bladder and cystic duct in Lgr4-hypomorphic mice. Dev Dyn. 2009; 238(4): 993-1000.
-
(2009)
Dev Dyn
, vol.238
, Issue.4
, pp. 993-1000
-
-
Yamashita, R.1
Takegawa, Y.2
Sakumoto, M.3
-
35
-
-
69049090918
-
Regulation of bone formation and remodeling by G-protein-coupled receptor 48
-
Luo J, Zhou W, Zhou X, et al. Regulation of bone formation and remodeling by G-protein-coupled receptor 48. Development. 2009; 136(16): 2747-2756.
-
(2009)
Development
, vol.136
, Issue.16
, pp. 2747-2756
-
-
Luo, J.1
Zhou, W.2
Zhou, X.3
-
36
-
-
84878143904
-
Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits
-
Styrkarsdottir U, Thorleifsson G, Sulem P, et al. Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits. Nature. 2013; 497(7450): 517-520.
-
(2013)
Nature
, vol.497
, Issue.7450
, pp. 517-520
-
-
Styrkarsdottir, U.1
Thorleifsson, G.2
Sulem, P.3
-
37
-
-
7644230387
-
Neonatal lethality of LGR5 null mice is associated with ankyloglossia and gastrointestinal distension
-
Morita H, Mazerbourg S, Bouley DM, et al. Neonatal lethality of LGR5 null mice is associated with ankyloglossia and gastrointestinal distension. Mol Cell Biol. 2004; 24(22): 9736-9743.
-
(2004)
Mol Cell Biol
, vol.24
, Issue.22
, pp. 9736-9743
-
-
Morita, H.1
Mazerbourg, S.2
Bouley, D.M.3
-
38
-
-
84874730918
-
Intestinal label-retaining cells are secretory precursors expressing Lgr5
-
Buczacki SJ, Zecchini HI, Nicholson AM, et al. Intestinal label-retaining cells are secretory precursors expressing Lgr5. Nature. 2013; 495(7439): 65-69.
-
(2013)
Nature
, vol.495
, Issue.7439
, pp. 65-69
-
-
Buczacki, S.J.1
Zecchini, H.I.2
Nicholson, A.M.3
-
39
-
-
46249128798
-
Bmi1 is expressed in vivo in intestinal stem cells
-
Sangiorgi E, Capecchi MR. Bmi1 is expressed in vivo in intestinal stem cells. Nat Genet. 2008; 40(7): 915-920.
-
(2008)
Nat Genet
, vol.40
, Issue.7
, pp. 915-920
-
-
Sangiorgi, E.1
Capecchi, M.R.2
-
40
-
-
80054041585
-
A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable
-
Tian H, Biehs B, Warming S, et al. A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable. Nature. 2011; 478(7368): 255-259.
-
(2011)
Nature
, vol.478
, Issue.7368
, pp. 255-259
-
-
Tian, H.1
Biehs, B.2
Warming, S.3
-
41
-
-
0037369658
-
Overexpression of orphan G-protein-coupled receptor, Gpr49, in human hepatocellular carcinomas with beta-catenin mutations
-
Yamamoto Y, Sakamoto M, Fujii G, et al. Overexpression of orphan G-protein-coupled receptor, Gpr49, in human hepatocellular carcinomas with beta-catenin mutations. Hepatology. 2003; 37(3): 528-533.
-
(2003)
Hepatology
, vol.37
, Issue.3
, pp. 528-533
-
-
Yamamoto, Y.1
Sakamoto, M.2
Fujii, G.3
-
42
-
-
84873712443
-
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration
-
Huch M, Dorrell C, Boj SF, et al. In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration. Nature. 2013; 494(7436): 247-250.
-
(2013)
Nature
, vol.494
, Issue.7436
, pp. 247-250
-
-
Huch, M.1
Dorrell, C.2
Boj, S.F.3
-
43
-
-
59049087696
-
Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation
-
Zhu L, Gibson P, Currle DS, et al. Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation. Nature. 2009; 457(7229): 603-607.
-
(2009)
Nature
, vol.457
, Issue.7229
, pp. 603-607
-
-
Zhu, L.1
Gibson, P.2
Currle, D.S.3
-
44
-
-
66149148652
-
Prominin-1/CD133 marks stem cells and early progenitors in mouse small intestine
-
2187-2194.e1
-
Snippert HJ, van Es JH, van den Born M, et al. Prominin-1/CD133 marks stem cells and early progenitors in mouse small intestine. Gastroenterology. 2009; 136(7): 2187-2194. e1.
-
(2009)
Gastroenterology
, vol.136
, Issue.7
-
-
Snippert, H.J.1
van Es, J.H.2
van den Born, M.3
-
45
-
-
45749102020
-
CD133 expression is not restricted to stem cells, and both CD133+ and CD133-metastatic colon cancer cells initiate tumors
-
Shmelkov SV, Butler JM, Hooper AT, et al. CD133 expression is not restricted to stem cells, and both CD133+ and CD133-metastatic colon cancer cells initiate tumors. J Clin Invest. 2008; 118(6): 2111-2120.
-
(2008)
J Clin Invest
, vol.118
, Issue.6
, pp. 2111-2120
-
-
Shmelkov, S.V.1
Butler, J.M.2
Hooper, A.T.3
-
46
-
-
38049004813
-
CD133: Molecule of the moment
-
Mizrak D, Brittan M, Alison M. CD133: molecule of the moment. J Pathol. 2008; 214(1): 3-9.
-
(2008)
J Pathol
, vol.214
, Issue.1
, pp. 3-9
-
-
Mizrak, D.1
Brittan, M.2
Alison, M.3
-
47
-
-
59049106578
-
Crypt stem cells as the cells-of-origin of intestinal cancer
-
Barker N, Ridgway RA, van Es JH, et al. Crypt stem cells as the cells-of-origin of intestinal cancer. Nature. 2009; 457(7229): 608-611.
-
(2009)
Nature
, vol.457
, Issue.7229
, pp. 608-611
-
-
Barker, N.1
Ridgway, R.A.2
van Es, J.H.3
-
48
-
-
79960885004
-
LGR5 is a negative regulator of tumourigenicity, antagonizes Wnt signalling and regulates cell adhesion in colorectal cancer cell lines
-
Walker F, Zhang HH, Odorizzi A, Burgess AW. LGR5 is a negative regulator of tumourigenicity, antagonizes Wnt signalling and regulates cell adhesion in colorectal cancer cell lines. PLoS One. 2011; 6(7): e22733.
-
(2011)
PLoS One
, vol.6
, Issue.7
-
-
Walker, F.1
Zhang, H.H.2
Odorizzi, A.3
Burgess, A.W.4
-
49
-
-
78651405682
-
c-Jun N-terminal phosphorylation antagonises recruitment of the Mbd3/NuRD repressor complex
-
Aguilera C, Nakagawa K, Sancho R, Chakraborty A, Hendrich B, Behrens A. c-Jun N-terminal phosphorylation antagonises recruitment of the Mbd3/NuRD repressor complex. Nature. 2011; 469(7329): 231-235.
-
(2011)
Nature
, vol.469
, Issue.7329
, pp. 231-235
-
-
Aguilera, C.1
Nakagawa, K.2
Sancho, R.3
Chakraborty, A.4
Hendrich, B.5
Behrens, A.6
-
50
-
-
84875463275
-
LGR5 promotes survival in human colorectal adenoma cells and is upregulated by PGE2: Implications for targeting adenoma stem cells with NSAIDs
-
Al-Kharusi MR, Smartt HJ, Greenhough A, et al. LGR5 promotes survival in human colorectal adenoma cells and is upregulated by PGE2: implications for targeting adenoma stem cells with NSAIDs. Carcinogenesis. 2013; 34(5): 1150-1157.
-
(2013)
Carcinogenesis
, vol.34
, Issue.5
, pp. 1150-1157
-
-
Al-Kharusi, M.R.1
Smartt, H.J.2
Greenhough, A.3
-
51
-
-
80755141289
-
Methylation of cancer-stem-cell-associated Wnt target genes predicts poor prognosis in colorectal cancer patients
-
de Sousa EMF, Colak S, Buikhuisen J, et al. Methylation of cancer-stem-cell-associated Wnt target genes predicts poor prognosis in colorectal cancer patients. Cell Stem Cell. 2011; 9(5): 476-485.
-
(2011)
Cell Stem Cell
, vol.9
, Issue.5
, pp. 476-485
-
-
de Sousa, E.M.F.1
Colak, S.2
Buikhuisen, J.3
-
52
-
-
67650507032
-
JNK signalling modulates intestinal homeostasis and tumourigenesis in mice
-
Sancho R, Nateri AS, de Vinuesa AG, et al. JNK signalling modulates intestinal homeostasis and tumourigenesis in mice. Embo J. 2009; 28(13): 1843-1854.
-
(2009)
Embo J
, vol.28
, Issue.13
, pp. 1843-1854
-
-
Sancho, R.1
Nateri, A.S.2
de Vinuesa, A.G.3
-
53
-
-
61349150537
-
Transcription factor achaete scute-like 2 controls intestinal stem cell fate
-
van der Flier LG, van Gijn ME, Hatzis P, et al. Transcription factor achaete scute-like 2 controls intestinal stem cell fate. Cell. 2009; 136(5): 903-912.
-
(2009)
Cell
, vol.136
, Issue.5
, pp. 903-912
-
-
van der Flier, L.G.1
van Gijn, M.E.2
Hatzis, P.3
-
54
-
-
51349161304
-
G-protein-coupled receptor GPR49 is up-regulated in basal cell carcinoma and promotes cell proliferation and tumor formation
-
Tanese K, Fukuma M, Yamada T, et al. G-protein-coupled receptor GPR49 is up-regulated in basal cell carcinoma and promotes cell proliferation and tumor formation. Am J Pathol. 2008; 173(3): 835-843.
-
(2008)
Am J Pathol
, vol.173
, Issue.3
, pp. 835-843
-
-
Tanese, K.1
Fukuma, M.2
Yamada, T.3
-
55
-
-
80054898893
-
Lhx2 differentially regulates Sox9, Tcf4 and Lgr5 in hair follicle stem cells to promote epidermal regeneration after injury
-
Mardaryev AN, Meier N, Poterlowicz K, et al. Lhx2 differentially regulates Sox9, Tcf4 and Lgr5 in hair follicle stem cells to promote epidermal regeneration after injury. Development. 2011; 138(22): 4843-4852.
-
(2011)
Development
, vol.138
, Issue.22
, pp. 4843-4852
-
-
Mardaryev, A.N.1
Meier, N.2
Poterlowicz, K.3
-
56
-
-
79952745374
-
Wounding enhances epidermal tumorigenesis by recruiting hair follicle keratinocytes
-
Kasper M, Jaks V, Are A, et al. Wounding enhances epidermal tumorigenesis by recruiting hair follicle keratinocytes. Proc Natl Acad Sci U S A. 2011; 108(10): 4099-4104.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, Issue.10
, pp. 4099-4104
-
-
Kasper, M.1
Jaks, V.2
Are, A.3
-
57
-
-
84881476621
-
Progeny of Lgr5-expressing hair follicle stem cell contributes to papillomavirus-induced tumor development in epidermis
-
da Silva-Diz V, Sole-Sanchez S, Valdes-Gutierrez A, et al. Progeny of Lgr5-expressing hair follicle stem cell contributes to papillomavirus-induced tumor development in epidermis. Oncogene. 2013; 32(32): 3732-3743.
-
(2013)
Oncogene
, vol.32
, Issue.32
, pp. 3732-3743
-
-
da Silva-Diz, V.1
Sole-Sanchez, S.2
Valdes-Gutierrez, A.3
-
58
-
-
63649143888
-
Genetic architecture of mouse skin inflammation and tumour susceptibility
-
Quigley DA, To MD, Perez-Losada J, et al. Genetic architecture of mouse skin inflammation and tumour susceptibility. Nature. 2009; 458(7237): 505-508.
-
(2009)
Nature
, vol.458
, Issue.7237
, pp. 505-508
-
-
Quigley, D.A.1
To, M.D.2
Perez-Losada, J.3
-
59
-
-
80855130470
-
Distinct stem cells contribute to mammary gland development and maintenance
-
Van Keymeulen A, Rocha AS, Ousset M, et al. Distinct stem cells contribute to mammary gland development and maintenance. Nature. 2011; 479(7372): 189-193.
-
(2011)
Nature
, vol.479
, Issue.7372
, pp. 189-193
-
-
Van Keymeulen, A.1
Rocha, A.S.2
Ousset, M.3
-
60
-
-
84867575877
-
Developmental stage-specific contribution of LGR5(+) cells to basal and luminal epithelial lineages in the postnatal mammary gland
-
de Visser KE, Ciampricotti M, Michalak EM, et al. Developmental stage-specific contribution of LGR5(+) cells to basal and luminal epithelial lineages in the postnatal mammary gland. J Pathol. 2012; 228(3): 300-309.
-
(2012)
J Pathol
, vol.228
, Issue.3
, pp. 300-309
-
-
de Visser, K.E.1
Ciampricotti, M.2
Michalak, E.M.3
-
61
-
-
30144432901
-
Purification and unique properties of mammary epithelial stem cells
-
Stingl J, Eirew P, Ricketson I, et al. Purification and unique properties of mammary epithelial stem cells. Nature. 2006; 439(7079): 993-997.
-
(2006)
Nature
, vol.439
, Issue.7079
, pp. 993-997
-
-
Stingl, J.1
Eirew, P.2
Ricketson, I.3
-
62
-
-
30144433093
-
Generation of a functional mammary gland from a single stem cell
-
Shackleton M, Vaillant F, Simpson KJ, et al. Generation of a functional mammary gland from a single stem cell. Nature. 2006; 439(7072): 84-88.
-
(2006)
Nature
, vol.439
, Issue.7072
, pp. 84-88
-
-
Shackleton, M.1
Vaillant, F.2
Simpson, K.J.3
-
63
-
-
79960117895
-
Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs
-
Oskarsson T, Acharyya S, Zhang XH, et al. Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs. Nat Med. 2011; 17(7): 867-874.
-
(2011)
Nat Med
, vol.17
, Issue.7
, pp. 867-874
-
-
Oskarsson, T.1
Acharyya, S.2
Zhang, X.H.3
-
64
-
-
84870940522
-
LGR5 is a marker of poor prognosis in glioblastoma and is required for survival of brain cancer stem-like cells
-
Nakata S, Campos B, Bageritz J, et al. LGR5 is a marker of poor prognosis in glioblastoma and is required for survival of brain cancer stem-like cells. Brain Pathol. 2013; 23(1): 60-72.
-
(2013)
Brain Pathol
, vol.23
, Issue.1
, pp. 60-72
-
-
Nakata, S.1
Campos, B.2
Bageritz, J.3
-
65
-
-
84885170739
-
Lgr4 regulates mammary gland development and stem cell activity through the pluripotency transcription factor Sox2
-
Wang Y, Dong J, Li D, et al. Lgr4 regulates mammary gland development and stem cell activity through the pluripotency transcription factor Sox2. Stem Cells. 2013; 31(9): 1921-1931.
-
(2013)
Stem Cells
, vol.31
, Issue.9
, pp. 1921-1931
-
-
Wang, Y.1
Dong, J.2
Li, D.3
-
66
-
-
0033534768
-
Identification of a novel seven-transmembrane receptor with homology to glycoprotein receptors and its expression in the adult and developing mouse
-
Hermey G, Methner A, Schaller HC, Hermans-Borgmeyer I. Identification of a novel seven-transmembrane receptor with homology to glycoprotein receptors and its expression in the adult and developing mouse. Biochem Biophys Res Commun. 1999; 254(1): 273-279.
-
(1999)
Biochem Biophys Res Commun
, vol.254
, Issue.1
, pp. 273-279
-
-
Hermey, G.1
Methner, A.2
Schaller, H.C.3
Hermans-Borgmeyer, I.4
-
67
-
-
84863660179
-
Wnt-responsive Lgr5-expressing stem cells are hair cell progenitors in the cochlea
-
Shi F, Kempfle JS, Edge AS. Wnt-responsive Lgr5-expressing stem cells are hair cell progenitors in the cochlea. J Neurosci. 2012; 32(28): 9639-9648.
-
(2012)
J Neurosci
, vol.32
, Issue.28
, pp. 9639-9648
-
-
Shi, F.1
Kempfle, J.S.2
Edge, A.S.3
-
68
-
-
84861448404
-
Wnt signaling induces proliferation of sensory precursors in the postnatal mouse cochlea
-
Chai R, Kuo B, Wang T, et al. Wnt signaling induces proliferation of sensory precursors in the postnatal mouse cochlea. Proc Natl Acad Sci U S A. 2012; 109(21): 8167-8172.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, Issue.21
, pp. 8167-8172
-
-
Chai, R.1
Kuo, B.2
Wang, T.3
-
69
-
-
33846100356
-
A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
-
O'Brien CA, Pollett A, Gallinger S, Dick JE. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature. 2007; 445(7123): 106-110.
-
(2007)
Nature
, vol.445
, Issue.7123
, pp. 106-110
-
-
O'Brien, C.A.1
Pollett, A.2
Gallinger, S.3
Dick, J.E.4
-
70
-
-
84881084722
-
LGR5 is a proneural factor and is regulated by OLIG2 in glioma stem-like cells
-
Mao XG, Song SJ, Xue XY, et al. LGR5 is a proneural factor and is regulated by OLIG2 in glioma stem-like cells. Cell Mol Neurobiol. 2013; 33(6): 851-865.
-
(2013)
Cell Mol Neurobiol
, vol.33
, Issue.6
, pp. 851-865
-
-
Mao, X.G.1
Song, S.J.2
Xue, X.Y.3
-
71
-
-
84863721201
-
RNAi screening in glioma stem-like cells identifies PFKFB4 as a key molecule important for cancer cell survival
-
Goidts V, Bageritz J, Puccio L, et al. RNAi screening in glioma stem-like cells identifies PFKFB4 as a key molecule important for cancer cell survival. Oncogene. 2012; 31(27): 3235-3243.
-
(2012)
Oncogene
, vol.31
, Issue.27
, pp. 3235-3243
-
-
Goidts, V.1
Bageritz, J.2
Puccio, L.3
-
72
-
-
42049092067
-
A different view on DNA amplifications indicates frequent, highly complex, and stable amplicons on 12q13-21 in glioma
-
Fischer U, Keller A, Leidinger P, et al. A different view on DNA amplifications indicates frequent, highly complex, and stable amplicons on 12q13-21 in glioma. Mol Cancer Res. 2008; 6(4): 576-584.
-
(2008)
Mol Cancer Res
, vol.6
, Issue.4
, pp. 576-584
-
-
Fischer, U.1
Keller, A.2
Leidinger, P.3
-
73
-
-
77955090106
-
Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy
-
Barretina J, Taylor BS, Banerji S, et al. Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy. Nat Genet. 2010; 42(8): 715-721.
-
(2010)
Nat Genet
, vol.42
, Issue.8
, pp. 715-721
-
-
Barretina, J.1
Taylor, B.S.2
Banerji, S.3
-
74
-
-
80053547469
-
A novel splice variant of the stem cell marker LGR5/GPR49 is correlated with the risk of tumor-related death in soft-tissue sarcoma patients
-
Rot S, Taubert H, Bache M, et al. A novel splice variant of the stem cell marker LGR5/GPR49 is correlated with the risk of tumor-related death in soft-tissue sarcoma patients. BMC Cancer. 2011; 11: 429.
-
(2011)
BMC Cancer
, vol.11
, pp. 429
-
-
Rot, S.1
Taubert, H.2
Bache, M.3
-
75
-
-
84890687876
-
LGR5 is Expressed by Ewing sarcoma and potentiates Wnt/beta-catenin signaling
-
Scannell CA, Pedersen EA, Mosher JT, et al. LGR5 is Expressed by Ewing sarcoma and potentiates Wnt/beta-catenin signaling. Front Oncol. 2013; 3: 81.
-
(2013)
Front Oncol
, vol.3
, pp. 81
-
-
Scannell, C.A.1
Pedersen, E.A.2
Mosher, J.T.3
-
76
-
-
84874728277
-
Expression profiling of stem cell-related genes in neoadjuvant-treated gastric cancer: A NOTCH2, GSK3B and beta-catenin gene signature predicts survival
-
Bauer L, Langer R, Becker K, et al. Expression profiling of stem cell-related genes in neoadjuvant-treated gastric cancer: a NOTCH2, GSK3B and beta-catenin gene signature predicts survival. PLoS One. 2012; 7(9): e44566.
-
(2012)
PLoS One
, vol.7
, Issue.9
-
-
Bauer, L.1
Langer, R.2
Becker, K.3
-
77
-
-
84878878740
-
Lgr5 expression as stem cell marker in human gastric gland and its relatedness with other putative cancer stem cell markers
-
Wu C, Xie Y, Gao F, et al. Lgr5 expression as stem cell marker in human gastric gland and its relatedness with other putative cancer stem cell markers. Gene. 2013; 525(1): 18-25.
-
(2013)
Gene
, vol.525
, Issue.1
, pp. 18-25
-
-
Wu, C.1
Xie, Y.2
Gao, F.3
-
78
-
-
84881517035
-
EMT-induced stemness and tumorigenicity are fueled by the EGFR/Ras pathway
-
Voon DC, Wang H, Koo JK, et al. EMT-induced stemness and tumorigenicity are fueled by the EGFR/Ras pathway. PLoS One. 2013; 8(8): e70427.
-
(2013)
PLoS One
, vol.8
, Issue.8
-
-
Voon, D.C.1
Wang, H.2
Koo, J.K.3
-
79
-
-
84884419449
-
The clinicopathological significance of Lgr5 expression in lung adenocarcinoma
-
Ryuge S, Sato Y, Jiang SX, et al. The clinicopathological significance of Lgr5 expression in lung adenocarcinoma. Lung Cancer. 2013; 82(1): 143-148.
-
(2013)
Lung Cancer
, vol.82
, Issue.1
, pp. 143-148
-
-
Ryuge, S.1
Sato, Y.2
Jiang, S.X.3
-
80
-
-
79955681163
-
The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse
-
Merlos-Suarez A, Barriga FM, Jung P, et al. The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse. Cell Stem Cell. 2011; 8(5): 511-524.
-
(2011)
Cell Stem Cell
, vol.8
, Issue.5
, pp. 511-524
-
-
Merlos-Suarez, A.1
Barriga, F.M.2
Jung, P.3
-
81
-
-
51649111430
-
Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity
-
Vermeulen L, Todaro M, de Sousa Mello F, et al. Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity. Proc Natl Acad Sci U S A. 2008; 105(36): 13427-13432.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, Issue.36
, pp. 13427-13432
-
-
Vermeulen, L.1
Todaro, M.2
de Sousa Mello, F.3
-
82
-
-
77955222623
-
The Wnt/beta-catenin pathway regulates growth and maintenance of colonospheres
-
Kanwar SS, Yu Y, Nautiyal J, Patel BB, Majumdar AP. The Wnt/beta-catenin pathway regulates growth and maintenance of colonospheres. Mol Cancer. 2010; 9: 212.
-
(2010)
Mol Cancer
, vol.9
, pp. 212
-
-
Kanwar, S.S.1
Yu, Y.2
Nautiyal, J.3
Patel, B.B.4
Majumdar, A.P.5
-
83
-
-
84867917224
-
Monoclonal antibodies against Lgr5 identify human colorectal cancer stem cells
-
Kemper K, Prasetyanti PR, De Lau W, Rodermond H, Clevers H, Medema JP. Monoclonal antibodies against Lgr5 identify human colorectal cancer stem cells. Stem Cells. 2012; 30(11): 2378-2386.
-
(2012)
Stem Cells
, vol.30
, Issue.11
, pp. 2378-2386
-
-
Kemper, K.1
Prasetyanti, P.R.2
De Lau, W.3
Rodermond, H.4
Clevers, H.5
Medema, J.P.6
-
84
-
-
84871846692
-
WNT signalling pathways as therapeutic targets in cancer
-
Anastas JN, Moon RT. WNT signalling pathways as therapeutic targets in cancer. Nat Rev Cancer. 2013; 13(1): 11-26.
-
(2013)
Nat Rev Cancer
, vol.13
, Issue.1
, pp. 11-26
-
-
Anastas, J.N.1
Moon, R.T.2
-
85
-
-
79551600015
-
Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways
-
Takebe N, Harris PJ, Warren RQ, Ivy SP. Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways. Nat Rev Clin Oncol. 2011; 8(2): 97-106.
-
(2011)
Nat Rev Clin Oncol
, vol.8
, Issue.2
, pp. 97-106
-
-
Takebe, N.1
Harris, P.J.2
Warren, R.Q.3
Ivy, S.P.4
-
86
-
-
84877929153
-
Wnt signaling in stem and cancer stem cells
-
Holland JD, Klaus A, Garratt AN, Birchmeier W. Wnt signaling in stem and cancer stem cells. Curr Opin Cell Biol. 2013; 25(2): 254-264.
-
(2013)
Curr Opin Cell Biol
, vol.25
, Issue.2
, pp. 254-264
-
-
Holland, J.D.1
Klaus, A.2
Garratt, A.N.3
Birchmeier, W.4
-
87
-
-
0036780743
-
G-protein-coupled receptor oligomerization and its potential for drug discovery
-
George SR, O'Dowd BF, Lee SP. G-protein-coupled receptor oligomerization and its potential for drug discovery. Nat Rev Drug Discov. 2002; 1(10): 808-820.
-
(2002)
Nat Rev Drug Discov
, vol.1
, Issue.10
, pp. 808-820
-
-
George, S.R.1
O'Dowd, B.F.2
Lee, S.P.3
-
88
-
-
80053615320
-
The significance of G protein-coupled receptor crystallography for drug discovery
-
Salon JA, Lodowski DT, Palczewski K. The significance of G protein-coupled receptor crystallography for drug discovery. Pharmacol Rev. 2011; 63(4): 901-937.
-
(2011)
Pharmacol Rev
, vol.63
, Issue.4
, pp. 901-937
-
-
Salon, J.A.1
Lodowski, D.T.2
Palczewski, K.3
-
89
-
-
84865228105
-
New insights for drug design from the X-ray crystallographic structures of G-protein-coupled receptors
-
Jacobson KA, Costanzi S. New insights for drug design from the X-ray crystallographic structures of G-protein-coupled receptors. Mol Pharmacol. 2012; 82(3): 361-371.
-
(2012)
Mol Pharmacol
, vol.82
, Issue.3
, pp. 361-371
-
-
Jacobson, K.A.1
Costanzi, S.2
-
90
-
-
77950518483
-
Establishment of a novel monoclonal antibody against LGR5
-
Sasaki Y, Kosaka H, Usami K, et al. Establishment of a novel monoclonal antibody against LGR5. Biochem Biophys Res Commun. 2010; 394(3): 498-502.
-
(2010)
Biochem Biophys Res Commun
, vol.394
, Issue.3
, pp. 498-502
-
-
Sasaki, Y.1
Kosaka, H.2
Usami, K.3
-
91
-
-
84862230930
-
Adult mammalian stem cells: The role of Wnt, Lgr5 and R-spondins
-
Schuijers J, Clevers H. Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins. EMBO J. 2012; 31(12): 2685-2696.
-
(2012)
EMBO J
, vol.31
, Issue.12
, pp. 2685-2696
-
-
Schuijers, J.1
Clevers, H.2
|