LGR5 is a marker of poor prognosis in glioblastoma and is required for survival of brain cancer stem-like cells

Brain Pathology

Volumn 23, Issue 1, 2013, Pages 60-72

  Nakata, Susumu ^a,f   Campos, Benito ^b   Bageritz, Josephine ^a   Lorenzo Bermejo, Justo ^a,c   Becker, Natalia ^a   Engel, Felix ^a   Acker, Till ^d   Momma, Stefan ^e   Herold Mende, Christel ^b   Lichter, Peter ^a   Radlwimmer, Bernhard ^a   Goidts, Violaine ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^d UNIVERSITY HOSPITAL GIESSEN   (Germany)

^e GOETHE UNIVERSITY MEDICAL SCHOOL   (Germany)

^f AICHI CANCER CENTER HOSPITAL   (Japan)

Author keywords

apoptosis; cancer stem cell; glioblastoma; glioma; LGR5

Indexed keywords

BIOLOGICAL MARKER; CD133 ANTIGEN; CELL ADHESION MOLECULE; G PROTEIN COUPLED RECEPTOR; LEUCINE RICH REPEAT CONTAINING G PROTEIN COUPLE RECEPTOR 5; MESSENGER RNA; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER PROGNOSIS; CANCER STEM CELL; CANCER SURVIVAL; CARCINOGENESIS; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; GENE EXPRESSION; GENE SILENCING; GLIOBLASTOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION;

ANTIGENS, CD; APOPTOSIS; BRAIN NEOPLASMS; CELL DIFFERENTIATION; CELL SURVIVAL; CELLS, CULTURED; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC VECTORS; GLIOBLASTOMA; GLYCOPROTEINS; HUMANS; LENTIVIRUS; NEOPLASTIC STEM CELLS; NEURAL CELL ADHESION MOLECULE L1; PEPTIDES; PROGNOSIS; RECEPTORS, G-PROTEIN-COUPLED; RNA, SMALL INTERFERING; STATISTICS AS TOPIC; TISSUE ARRAY ANALYSIS;

EID: 84870940522     PISSN: 10156305     EISSN: 17503639     Source Type: Journal    
DOI: 10.1111/j.1750-3639.2012.00618.x     Document Type: Article

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