-
1
-
-
0019826665
-
Establishment in culture of pluripotential cells from mouse embryos.
-
10.1038/292154a0, 7242681
-
Evans MJ, Kaufman MH. Establishment in culture of pluripotential cells from mouse embryos. Nature 1981, 292:154-156. 10.1038/292154a0, 7242681.
-
(1981)
Nature
, vol.292
, pp. 154-156
-
-
Evans, M.J.1
Kaufman, M.H.2
-
2
-
-
0001007610
-
Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells.
-
10.1073/pnas.78.12.7634, 349323, 6950406
-
Martin GR. Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc Natl Acad Sci USA 1981, 78:7634-7638. 10.1073/pnas.78.12.7634, 349323, 6950406.
-
(1981)
Proc Natl Acad Sci USA
, vol.78
, pp. 7634-7638
-
-
Martin, G.R.1
-
3
-
-
0037806031
-
The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells.
-
10.1016/S0092-8674(03)00393-3, 12787504
-
Mitsui K, Tokuzawa Y, Itoh H, Segawa K, Murakami M, Takahashi K, Maruyama M, Maeda M, Yamanaka S. The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell 2003, 113:631-642. 10.1016/S0092-8674(03)00393-3, 12787504.
-
(2003)
Cell
, vol.113
, pp. 631-642
-
-
Mitsui, K.1
Tokuzawa, Y.2
Itoh, H.3
Segawa, K.4
Murakami, M.5
Takahashi, K.6
Maruyama, M.7
Maeda, M.8
Yamanaka, S.9
-
4
-
-
0038143611
-
Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells.
-
10.1016/S0092-8674(03)00392-1, 12787505
-
Chambers I, Colby D, Robertson M, Nichols J, Lee S, Tweedie S, Smith A. Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 2003, 113:643-655. 10.1016/S0092-8674(03)00392-1, 12787505.
-
(2003)
Cell
, vol.113
, pp. 643-655
-
-
Chambers, I.1
Colby, D.2
Robertson, M.3
Nichols, J.4
Lee, S.5
Tweedie, S.6
Smith, A.7
-
5
-
-
0037227099
-
Multipotent cell lineages in early mouse development depend on SOX2 function.
-
10.1101/gad.224503, 195970, 12514105
-
Avilion AA, Nicolis SK, Pevny LH, Perez L, Vivian N, Lovell-Badge R. Multipotent cell lineages in early mouse development depend on SOX2 function. Genes Dev 2003, 17:126-140. 10.1101/gad.224503, 195970, 12514105.
-
(2003)
Genes Dev
, vol.17
, pp. 126-140
-
-
Avilion, A.A.1
Nicolis, S.K.2
Pevny, L.H.3
Perez, L.4
Vivian, N.5
Lovell-Badge, R.6
-
6
-
-
0032582513
-
Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4.
-
10.1016/S0092-8674(00)81769-9, 9814708
-
Nichols J, Zevnik B, Anastassiadis K, Niwa H, Klewe-Nebenius D, Chambers I, Scholer H, Smith A. Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell 1998, 95:379-391. 10.1016/S0092-8674(00)81769-9, 9814708.
-
(1998)
Cell
, vol.95
, pp. 379-391
-
-
Nichols, J.1
Zevnik, B.2
Anastassiadis, K.3
Niwa, H.4
Klewe-Nebenius, D.5
Chambers, I.6
Scholer, H.7
Smith, A.8
-
7
-
-
33747195353
-
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.
-
10.1016/j.cell.2006.07.024, 16904174
-
Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006, 126:663-676. 10.1016/j.cell.2006.07.024, 16904174.
-
(2006)
Cell
, vol.126
, pp. 663-676
-
-
Takahashi, K.1
Yamanaka, S.2
-
8
-
-
36248966518
-
Induction of pluripotent stem cells from adult human fibroblasts by defined factors.
-
10.1016/j.cell.2007.11.019, 18035408
-
Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007, 131:861-872. 10.1016/j.cell.2007.11.019, 18035408.
-
(2007)
Cell
, vol.131
, pp. 861-872
-
-
Takahashi, K.1
Tanabe, K.2
Ohnuki, M.3
Narita, M.4
Ichisaka, T.5
Tomoda, K.6
Yamanaka, S.7
-
9
-
-
34249908901
-
In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state.
-
10.1038/nature05944, 17554336
-
Wernig M, Meissner A, Foreman R, Brambrink T, Ku M, Hochedlinger K, Bernstein BE, Jaenisch R. In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature 2007, 448:318-324. 10.1038/nature05944, 17554336.
-
(2007)
Nature
, vol.448
, pp. 318-324
-
-
Wernig, M.1
Meissner, A.2
Foreman, R.3
Brambrink, T.4
Ku, M.5
Hochedlinger, K.6
Bernstein, B.E.7
Jaenisch, R.8
-
10
-
-
36749043230
-
Induced pluripotent stem cell lines derived from human somatic cells.
-
10.1126/science.1151526, 18029452
-
Yu J, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, Tian S, Nie J, Jonsdottir GA, Ruotti V, Stewart R, Slukvin II, Thomson JA. Induced pluripotent stem cell lines derived from human somatic cells. Science 2007, 318:1917-1920. 10.1126/science.1151526, 18029452.
-
(2007)
Science
, vol.318
, pp. 1917-1920
-
-
Yu, J.1
Vodyanik, M.A.2
Smuga-Otto, K.3
Antosiewicz-Bourget, J.4
Frane, J.L.5
Tian, S.6
Nie, J.7
Jonsdottir, G.A.8
Ruotti, V.9
Stewart, R.10
Slukvin, I.I.11
Thomson, J.A.12
-
11
-
-
38049187707
-
Reprogramming of human somatic cells to pluripotency with defined factors.
-
10.1038/nature06534, 18157115
-
Park IH, Zhao R, West JA, Yabuuchi A, Huo H, Ince TA, Lerou PH, Lensch MW, Daley GQ. Reprogramming of human somatic cells to pluripotency with defined factors. Nature 2008, 451:141-146. 10.1038/nature06534, 18157115.
-
(2008)
Nature
, vol.451
, pp. 141-146
-
-
Park, I.H.1
Zhao, R.2
West, J.A.3
Yabuuchi, A.4
Huo, H.5
Ince, T.A.6
Lerou, P.H.7
Lensch, M.W.8
Daley, G.Q.9
-
12
-
-
71449125977
-
Forcing cells to change lineages.
-
10.1038/nature08533, 19956253
-
Graf T, Enver T. Forcing cells to change lineages. Nature 2009, 462:587-594. 10.1038/nature08533, 19956253.
-
(2009)
Nature
, vol.462
, pp. 587-594
-
-
Graf, T.1
Enver, T.2
-
13
-
-
77953808473
-
Next-generation genomics: an integrative approach.
-
Hawkins RD, Hon GC, Ren B. Next-generation genomics: an integrative approach. Nat Rev Genet 2010, 11:476-486.
-
(2010)
Nat Rev Genet
, vol.11
, pp. 476-486
-
-
Hawkins, R.D.1
Hon, G.C.2
Ren, B.3
-
14
-
-
79551517793
-
Recent advances in charting protein-protein interaction: mass spectrometry-based approaches.
-
10.1016/j.copbio.2010.09.007, 20934865
-
Gavin AC, Maeda K, Kuhner S. Recent advances in charting protein-protein interaction: mass spectrometry-based approaches. Curr Opin Biotechnol 2011, 22:42-49. 10.1016/j.copbio.2010.09.007, 20934865.
-
(2011)
Curr Opin Biotechnol
, vol.22
, pp. 42-49
-
-
Gavin, A.C.1
Maeda, K.2
Kuhner, S.3
-
15
-
-
14544280255
-
The silent revolution: RNA interference as basic biology, research tool, and therapeutic.
-
10.1146/annurev.med.56.082103.104606, 15660519
-
Dykxhoorn DM, Lieberman J. The silent revolution: RNA interference as basic biology, research tool, and therapeutic. Annu Rev Med 2005, 56:401-423. 10.1146/annurev.med.56.082103.104606, 15660519.
-
(2005)
Annu Rev Med
, vol.56
, pp. 401-423
-
-
Dykxhoorn, D.M.1
Lieberman, J.2
-
16
-
-
70350139218
-
Stem cell biology meets systems biology.
-
10.1242/dev.040758, 19820180
-
Roeder I, Radtke F. Stem cell biology meets systems biology. Development 2009, 136:3525-3530. 10.1242/dev.040758, 19820180.
-
(2009)
Development
, vol.136
, pp. 3525-3530
-
-
Roeder, I.1
Radtke, F.2
-
17
-
-
70349445264
-
Systems biology of stem cell fate and cellular reprogramming.
-
2928569, 19738627
-
Macarthur BD, Ma'ayan A, Lemischka IR. Systems biology of stem cell fate and cellular reprogramming. Nat Rev Mol Cell Biol 2009, 10:672-681. 2928569, 19738627.
-
(2009)
Nat Rev Mol Cell Biol
, vol.10
, pp. 672-681
-
-
Macarthur, B.D.1
Ma'ayan, A.2
Lemischka, I.R.3
-
18
-
-
0035499267
-
Stem cells, cancer, and cancer stem cells.
-
10.1038/35102167, 11689955
-
Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature 2001, 414:105-111. 10.1038/35102167, 11689955.
-
(2001)
Nature
, vol.414
, pp. 105-111
-
-
Reya, T.1
Morrison, S.J.2
Clarke, M.F.3
Weissman, I.L.4
-
19
-
-
68549135405
-
Common themes of dedifferentiation in somatic cell reprogramming and cancer.
-
10.1101/sqb.2008.73.041, 19150965
-
Daley GQ. Common themes of dedifferentiation in somatic cell reprogramming and cancer. Cold Spring Harb Symp Quant Biol 2008, 73:171-174. 10.1101/sqb.2008.73.041, 19150965.
-
(2008)
Cold Spring Harb Symp Quant Biol
, vol.73
, pp. 171-174
-
-
Daley, G.Q.1
-
20
-
-
77957757417
-
A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs.
-
10.1016/j.cell.2010.09.010, 3018841, 20946988
-
Kim J, Woo AJ, Chu J, Snow JW, Fujiwara Y, Kim CG, Cantor AB, Orkin SH. A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs. Cell 2010, 143:313-324. 10.1016/j.cell.2010.09.010, 3018841, 20946988.
-
(2010)
Cell
, vol.143
, pp. 313-324
-
-
Kim, J.1
Woo, A.J.2
Chu, J.3
Snow, J.W.4
Fujiwara, Y.5
Kim, C.G.6
Cantor, A.B.7
Orkin, S.H.8
-
21
-
-
58949102947
-
Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells.
-
10.1016/j.stem.2008.11.015, 2670853, 19200802
-
Somervaille TC, Matheny CJ, Spencer GJ, Iwasaki M, Rinn JL, Witten DM, Chang HY, Shurtleff SA, Downing JR, Cleary ML. Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells. Cell Stem Cell 2009, 4:129-140. 10.1016/j.stem.2008.11.015, 2670853, 19200802.
-
(2009)
Cell Stem Cell
, vol.4
, pp. 129-140
-
-
Somervaille, T.C.1
Matheny, C.J.2
Spencer, G.J.3
Iwasaki, M.4
Rinn, J.L.5
Witten, D.M.6
Chang, H.Y.7
Shurtleff, S.A.8
Downing, J.R.9
Cleary, M.L.10
-
22
-
-
41449118521
-
Module map of stem cell genes guides creation of epithelial cancer stem cells.
-
10.1016/j.stem.2008.02.009, 2628721, 18397753
-
Wong DJ, Liu H, Ridky TW, Cassarino D, Segal E, Chang HY. Module map of stem cell genes guides creation of epithelial cancer stem cells. Cell Stem Cell 2008, 2:333-344. 10.1016/j.stem.2008.02.009, 2628721, 18397753.
-
(2008)
Cell Stem Cell
, vol.2
, pp. 333-344
-
-
Wong, D.J.1
Liu, H.2
Ridky, T.W.3
Cassarino, D.4
Segal, E.5
Chang, H.Y.6
-
23
-
-
42649112047
-
An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors.
-
10.1038/ng.127, 2912221, 18443585
-
Ben-Porath I, Thomson MW, Carey VJ, Ge R, Bell GW, Regev A, Weinberg RA. An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet 2008, 40:499-507. 10.1038/ng.127, 2912221, 18443585.
-
(2008)
Nat Genet
, vol.40
, pp. 499-507
-
-
Ben-Porath, I.1
Thomson, M.W.2
Carey, V.J.3
Ge, R.4
Bell, G.W.5
Regev, A.6
Weinberg, R.A.7
-
24
-
-
79952213086
-
Using a stem cell-based signature to guide therapeutic selection in cancer.
-
10.1158/0008-5472.CAN-10-1735, 21169407
-
Shats I, Gatza ML, Chang JT, Mori S, Wang J, Rich J, Nevins JR. Using a stem cell-based signature to guide therapeutic selection in cancer. Cancer Res 2011, 71:1772-1780. 10.1158/0008-5472.CAN-10-1735, 21169407.
-
(2011)
Cancer Res
, vol.71
, pp. 1772-1780
-
-
Shats, I.1
Gatza, M.L.2
Chang, J.T.3
Mori, S.4
Wang, J.5
Rich, J.6
Nevins, J.R.7
-
25
-
-
78651100119
-
Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures.
-
10.1073/pnas.1017001108, 3012457, 21149740
-
Mizuno H, Spike BT, Wahl GM, Levine AJ. Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures. Proc Natl Acad Sci USA 2010, 107:22745-22750. 10.1073/pnas.1017001108, 3012457, 21149740.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 22745-22750
-
-
Mizuno, H.1
Spike, B.T.2
Wahl, G.M.3
Levine, A.J.4
-
26
-
-
65049086409
-
Embryonic stem cell markers expression in cancers.
-
10.1016/j.bbrc.2009.02.156, 19268426
-
Schoenhals M, Kassambara A, De Vos J, Hose D, Moreaux J, Klein B. Embryonic stem cell markers expression in cancers. Biochem Biophys Res Commun 2009, 383:157-162. 10.1016/j.bbrc.2009.02.156, 19268426.
-
(2009)
Biochem Biophys Res Commun
, vol.383
, pp. 157-162
-
-
Schoenhals, M.1
Kassambara, A.2
De Vos, J.3
Hose, D.4
Moreaux, J.5
Klein, B.6
-
27
-
-
33645381936
-
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells.
-
10.1038/ng1760, 16518401
-
Loh YH, Wu Q, Chew JL, Vega VB, Zhang W, Chen X, Bourque G, George J, Leong B, Liu J, Wong KY, Sung KW, Lee CW, Zhao XD, Chiu KP, Lipovich L, Kuznetsov VA, Robson P, Stanton LW, Wei CL, Ruan Y, Lim B, Ng HH. The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet 2006, 38:431-440. 10.1038/ng1760, 16518401.
-
(2006)
Nat Genet
, vol.38
, pp. 431-440
-
-
Loh, Y.H.1
Wu, Q.2
Chew, J.L.3
Vega, V.B.4
Zhang, W.5
Chen, X.6
Bourque, G.7
George, J.8
Leong, B.9
Liu, J.10
Wong, K.Y.11
Sung, K.W.12
Lee, C.W.13
Zhao, X.D.14
Chiu, K.P.15
Lipovich, L.16
Kuznetsov, V.A.17
Robson, P.18
Stanton, L.W.19
Wei, C.L.20
Ruan, Y.21
Lim, B.22
Ng, H.H.23
more..
-
28
-
-
25144525014
-
Core transcriptional regulatory circuitry in human embryonic stem cells.
-
10.1016/j.cell.2005.08.020, 3006442, 16153702
-
Boyer LA, Lee TI, Cole MF, Johnstone SE, Levine SS, Zucker JP, Guenther MG, Kumar RM, Murray HL, Jenner RG, Gifford DK, Melton DA, Jaenisch R, Young RA. Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 2005, 122:947-956. 10.1016/j.cell.2005.08.020, 3006442, 16153702.
-
(2005)
Cell
, vol.122
, pp. 947-956
-
-
Boyer, L.A.1
Lee, T.I.2
Cole, M.F.3
Johnstone, S.E.4
Levine, S.S.5
Zucker, J.P.6
Guenther, M.G.7
Kumar, R.M.8
Murray, H.L.9
Jenner, R.G.10
Gifford, D.K.11
Melton, D.A.12
Jaenisch, R.13
Young, R.A.14
-
29
-
-
33751092246
-
A protein interaction network for pluripotency of embryonic stem cells.
-
10.1038/nature05284, 17093407
-
Wang J, Rao S, Chu J, Shen X, Levasseur DN, Theunissen TW, Orkin SH. A protein interaction network for pluripotency of embryonic stem cells. Nature 2006, 444:364-368. 10.1038/nature05284, 17093407.
-
(2006)
Nature
, vol.444
, pp. 364-368
-
-
Wang, J.1
Rao, S.2
Chu, J.3
Shen, X.4
Levasseur, D.N.5
Theunissen, T.W.6
Orkin, S.H.7
-
30
-
-
77949900026
-
An Oct4-centered protein interaction network in embryonic stem cells.
-
10.1016/j.stem.2010.02.014, 2860243, 20362541
-
van den Berg DL, Snoek T, Mullin NP, Yates A, Bezstarosti K, Demmers J, Chambers I, Poot RA. An Oct4-centered protein interaction network in embryonic stem cells. Cell Stem Cell 2010, 6:369-381. 10.1016/j.stem.2010.02.014, 2860243, 20362541.
-
(2010)
Cell Stem Cell
, vol.6
, pp. 369-381
-
-
van den Berg, D.L.1
Snoek, T.2
Mullin, N.P.3
Yates, A.4
Bezstarosti, K.5
Demmers, J.6
Chambers, I.7
Poot, R.A.8
-
31
-
-
77949881949
-
An expanded Oct4 interaction network: implications for stem cell biology, development, and disease.
-
10.1016/j.stem.2010.03.004, 2860244, 20362542
-
Pardo M, Lang B, Yu L, Prosser H, Bradley A, Babu MM, Choudhary J. An expanded Oct4 interaction network: implications for stem cell biology, development, and disease. Cell Stem Cell 2010, 6:382-395. 10.1016/j.stem.2010.03.004, 2860244, 20362542.
-
(2010)
Cell Stem Cell
, vol.6
, pp. 382-395
-
-
Pardo, M.1
Lang, B.2
Yu, L.3
Prosser, H.4
Bradley, A.5
Babu, M.M.6
Choudhary, J.7
-
32
-
-
40749104852
-
An extended transcriptional network for pluripotency of embryonic stem cells.
-
10.1016/j.cell.2008.02.039, 18358816
-
Kim J, Chu J, Shen X, Wang J, Orkin SH. An extended transcriptional network for pluripotency of embryonic stem cells. Cell 2008, 132:1049-1061. 10.1016/j.cell.2008.02.039, 18358816.
-
(2008)
Cell
, vol.132
, pp. 1049-1061
-
-
Kim, J.1
Chu, J.2
Shen, X.3
Wang, J.4
Orkin, S.H.5
-
33
-
-
50549089957
-
Disease-specific induced pluripotent stem cells.
-
10.1016/j.cell.2008.07.041, 2633781, 18691744
-
Park IH, Arora N, Huo H, Maherali N, Ahfeldt T, Shimamura A, Lensch MW, Cowan C, Hochedlinger K, Daley GQ. Disease-specific induced pluripotent stem cells. Cell 2008, 134:877-886. 10.1016/j.cell.2008.07.041, 2633781, 18691744.
-
(2008)
Cell
, vol.134
, pp. 877-886
-
-
Park, I.H.1
Arora, N.2
Huo, H.3
Maherali, N.4
Ahfeldt, T.5
Shimamura, A.6
Lensch, M.W.7
Cowan, C.8
Hochedlinger, K.9
Daley, G.Q.10
-
34
-
-
50149098605
-
Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons.
-
10.1126/science.1158799, 18669821
-
Dimos JT, Rodolfa KT, Niakan KK, Weisenthal LM, Mitsumoto H, Chung W, Croft GF, Saphier G, Leibel R, Goland R, Wichterle H, Henderson CE, Eggan K. Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. Science 2008, 321:1218-1221. 10.1126/science.1158799, 18669821.
-
(2008)
Science
, vol.321
, pp. 1218-1221
-
-
Dimos, J.T.1
Rodolfa, K.T.2
Niakan, K.K.3
Weisenthal, L.M.4
Mitsumoto, H.5
Chung, W.6
Croft, G.F.7
Saphier, G.8
Leibel, R.9
Goland, R.10
Wichterle, H.11
Henderson, C.E.12
Eggan, K.13
-
35
-
-
48149112769
-
Pluripotent human stem cell lines: what we can learn about cancer initiation.
-
10.1016/j.molmed.2008.06.005, 18635398
-
Werbowetski-Ogilvie TE, Bhatia M. Pluripotent human stem cell lines: what we can learn about cancer initiation. Trends Mol Med 2008, 14:323-332. 10.1016/j.molmed.2008.06.005, 18635398.
-
(2008)
Trends Mol Med
, vol.14
, pp. 323-332
-
-
Werbowetski-Ogilvie, T.E.1
Bhatia, M.2
-
36
-
-
78751662908
-
The Polycomb complex PRC2 and its mark in life.
-
10.1038/nature09784, 21248841
-
Margueron R, Reinberg D. The Polycomb complex PRC2 and its mark in life. Nature 2011, 469:343-349. 10.1038/nature09784, 21248841.
-
(2011)
Nature
, vol.469
, pp. 343-349
-
-
Margueron, R.1
Reinberg, D.2
-
37
-
-
33646882068
-
Polycomb complexes repress developmental regulators in murine embryonic stem cells.
-
10.1038/nature04733, 16625203
-
Boyer LA, Plath K, Zeitlinger J, Brambrink T, Medeiros LA, Lee TI, Levine SS, Wernig M, Tajonar A, Ray MK, Bell GW, Otte AP, Vidal M, Gifford DK, Young RA, Jaenisch R. Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature 2006, 441:349-353. 10.1038/nature04733, 16625203.
-
(2006)
Nature
, vol.441
, pp. 349-353
-
-
Boyer, L.A.1
Plath, K.2
Zeitlinger, J.3
Brambrink, T.4
Medeiros, L.A.5
Lee, T.I.6
Levine, S.S.7
Wernig, M.8
Tajonar, A.9
Ray, M.K.10
Bell, G.W.11
Otte, A.P.12
Vidal, M.13
Gifford, D.K.14
Young, R.A.15
Jaenisch, R.16
-
38
-
-
33646865180
-
Control of developmental regulators by Polycomb in human embryonic stem cells.
-
10.1016/j.cell.2006.02.043, 16630818
-
Lee TI, Jenner RG, Boyer LA, Guenther MG, Levine SS, Kumar RM, Chevalier B, Johnstone SE, Cole MF, Isono K, Koseki H, Fuchikami T, Abe K, Murray HL, Zucker JP, Yuan B, Bell GW, Herbolsheimer E, Hannett NM, Sun K, Odom DT, Otte AP, Volkert TL, Bartel DP, Melton DA, Gifford DK, Jaenisch R, Young RA. Control of developmental regulators by Polycomb in human embryonic stem cells. Cell 2006, 125:301-313. 10.1016/j.cell.2006.02.043, 16630818.
-
(2006)
Cell
, vol.125
, pp. 301-313
-
-
Lee, T.I.1
Jenner, R.G.2
Boyer, L.A.3
Guenther, M.G.4
Levine, S.S.5
Kumar, R.M.6
Chevalier, B.7
Johnstone, S.E.8
Cole, M.F.9
Isono, K.10
Koseki, H.11
Fuchikami, T.12
Abe, K.13
Murray, H.L.14
Zucker, J.P.15
Yuan, B.16
Bell, G.W.17
Herbolsheimer, E.18
Hannett, N.M.19
Sun, K.20
Odom, D.T.21
Otte, A.P.22
Volkert, T.L.23
Bartel, D.P.24
Melton, D.A.25
Gifford, D.K.26
Jaenisch, R.27
Young, R.A.28
more..
-
39
-
-
78650253763
-
Genome-wide identification of polycomb-associated RNAs by RIP-seq.
-
10.1016/j.molcel.2010.12.011, 3021903, 21172659
-
Zhao J, Ohsumi TK, Kung JT, Ogawa Y, Grau DJ, Sarma K, Song JJ, Kingston RE, Borowsky M, Lee JT. Genome-wide identification of polycomb-associated RNAs by RIP-seq. Mol Cell 2010, 40:939-953. 10.1016/j.molcel.2010.12.011, 3021903, 21172659.
-
(2010)
Mol Cell
, vol.40
, pp. 939-953
-
-
Zhao, J.1
Ohsumi, T.K.2
Kung, J.T.3
Ogawa, Y.4
Grau, D.J.5
Sarma, K.6
Song, J.J.7
Kingston, R.E.8
Borowsky, M.9
Lee, J.T.10
-
40
-
-
79952135845
-
PRC2 complexes with JARID2, and esPRC2p48 in ES cells to modulate ES cell pluripotency and somatic cell reprogramming.
-
10.1002/stem.578, 21732481
-
Zhang Z, Jones A, Sun CW, Li C, Chang CW, Joo HY, Dai Q, Mysliwiec MR, Wu LC, Guo Y, Yang W, Liu K, Pawlik KM, Erdjument-Bromage H, Tempst P, Lee Y, Min J, Townes TM, Wang H. PRC2 complexes with JARID2, and esPRC2p48 in ES cells to modulate ES cell pluripotency and somatic cell reprogramming. Stem Cells 2011, 29:229-240. 10.1002/stem.578, 21732481.
-
(2011)
Stem Cells
, vol.29
, pp. 229-240
-
-
Zhang, Z.1
Jones, A.2
Sun, C.W.3
Li, C.4
Chang, C.W.5
Joo, H.Y.6
Dai, Q.7
Mysliwiec, M.R.8
Wu, L.C.9
Guo, Y.10
Yang, W.11
Liu, K.12
Pawlik, K.M.13
Erdjument-Bromage, H.14
Tempst, P.15
Lee, Y.16
Min, J.17
Townes, T.M.18
Wang, H.19
-
41
-
-
77953086963
-
ESCs require PRC2 to direct the successful reprogramming of differentiated cells toward pluripotency.
-
10.1016/j.stem.2010.04.013, 20569692
-
Pereira CF, Piccolo FM, Tsubouchi T, Sauer S, Ryan NK, Bruno L, Landeira D, Santos J, Banito A, Gil J, Koseki H, Merkenschlager M, Fisher AG. ESCs require PRC2 to direct the successful reprogramming of differentiated cells toward pluripotency. Cell Stem Cell 2010, 6:547-556. 10.1016/j.stem.2010.04.013, 20569692.
-
(2010)
Cell Stem Cell
, vol.6
, pp. 547-556
-
-
Pereira, C.F.1
Piccolo, F.M.2
Tsubouchi, T.3
Sauer, S.4
Ryan, N.K.5
Bruno, L.6
Landeira, D.7
Santos, J.8
Banito, A.9
Gil, J.10
Koseki, H.11
Merkenschlager, M.12
Fisher, A.G.13
-
42
-
-
1642430733
-
Myc pathways provoking cell suicide and cancer.
-
10.1038/sj.onc.1207261, 14663479
-
Nilsson JA, Cleveland JL. Myc pathways provoking cell suicide and cancer. Oncogene 2003, 22:9007-9021. 10.1038/sj.onc.1207261, 14663479.
-
(2003)
Oncogene
, vol.22
, pp. 9007-9021
-
-
Nilsson, J.A.1
Cleveland, J.L.2
-
43
-
-
56749184298
-
Reflecting on 25 years with MYC.
-
10.1038/nrc2231, 19029958
-
Meyer N, Penn LZ. Reflecting on 25 years with MYC. Nat Rev Cancer 2008, 8:976-990. 10.1038/nrc2231, 19029958.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 976-990
-
-
Meyer, N.1
Penn, L.Z.2
-
44
-
-
44649117905
-
Integration of external signaling pathways with the core transcriptional network in embryonic stem cells.
-
10.1016/j.cell.2008.04.043, 18555785
-
Chen X, Xu H, Yuan P, Fang F, Huss M, Vega VB, Wong E, Orlov YL, Zhang W, Jiang J, Loh YH, Yeo HC, Yeo ZX, Narang V, Govindarajan KR, Leong B, Shahab A, Ruan Y, Bourque G, Sung WK, Clarke ND, Wei CL, Ng HH. Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell 2008, 133:1106-1117. 10.1016/j.cell.2008.04.043, 18555785.
-
(2008)
Cell
, vol.133
, pp. 1106-1117
-
-
Chen, X.1
Xu, H.2
Yuan, P.3
Fang, F.4
Huss, M.5
Vega, V.B.6
Wong, E.7
Orlov, Y.L.8
Zhang, W.9
Jiang, J.10
Loh, Y.H.11
Yeo, H.C.12
Yeo, Z.X.13
Narang, V.14
Govindarajan, K.R.15
Leong, B.16
Shahab, A.17
Ruan, Y.18
Bourque, G.19
Sung, W.K.20
Clarke, N.D.21
Wei, C.L.22
Ng, H.H.23
more..
-
45
-
-
37549008674
-
C-Myc is dispensable for direct reprogramming of mouse fibroblasts.
-
10.1016/j.stem.2007.12.001, 18371415
-
Wernig M, Meissner A, Cassady JP, Jaenisch R. c-Myc is dispensable for direct reprogramming of mouse fibroblasts. Cell Stem Cell 2008, 2:10-12. 10.1016/j.stem.2007.12.001, 18371415.
-
(2008)
Cell Stem Cell
, vol.2
, pp. 10-12
-
-
Wernig, M.1
Meissner, A.2
Cassady, J.P.3
Jaenisch, R.4
-
46
-
-
38049028459
-
Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts.
-
10.1038/nbt1374, 18059259
-
Nakagawa M, Koyanagi M, Tanabe K, Takahashi K, Ichisaka T, Aoi T, Okita K, Mochiduki Y, Takizawa N, Yamanaka S. Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nat Biotechnol 2008, 26:101-106. 10.1038/nbt1374, 18059259.
-
(2008)
Nat Biotechnol
, vol.26
, pp. 101-106
-
-
Nakagawa, M.1
Koyanagi, M.2
Tanabe, K.3
Takahashi, K.4
Ichisaka, T.5
Aoi, T.6
Okita, K.7
Mochiduki, Y.8
Takizawa, N.9
Yamanaka, S.10
-
47
-
-
37549005086
-
Why myc? An unexpected ingredient in the stem cell cocktail.
-
10.1016/j.stem.2007.12.004, 18371417
-
Knoepfler PS. Why myc? An unexpected ingredient in the stem cell cocktail. Cell Stem Cell 2008, 2:18-21. 10.1016/j.stem.2007.12.004, 18371417.
-
(2008)
Cell Stem Cell
, vol.2
, pp. 18-21
-
-
Knoepfler, P.S.1
-
48
-
-
33745558509
-
Myc influences global chromatin structure.
-
10.1038/sj.emboj.7601152, 1500848, 16724113
-
Knoepfler PS, Zhang XY, Cheng PF, Gafken PR, McMahon SB, Eisenman RN. Myc influences global chromatin structure. EMBO J 2006, 25:2723-2734. 10.1038/sj.emboj.7601152, 1500848, 16724113.
-
(2006)
EMBO J
, vol.25
, pp. 2723-2734
-
-
Knoepfler, P.S.1
Zhang, X.Y.2
Cheng, P.F.3
Gafken, P.R.4
McMahon, S.B.5
Eisenman, R.N.6
-
49
-
-
78650467973
-
Open chromatin in pluripotency and reprogramming.
-
10.1038/nrm3036, 21179060
-
Gaspar-Maia A, Alajem A, Meshorer E, Ramalho-Santos M. Open chromatin in pluripotency and reprogramming. Nat Rev Mol Cell Biol 2011, 12:36-47. 10.1038/nrm3036, 21179060.
-
(2011)
Nat Rev Mol Cell Biol
, vol.12
, pp. 36-47
-
-
Gaspar-Maia, A.1
Alajem, A.2
Meshorer, E.3
Ramalho-Santos, M.4
-
50
-
-
46149110511
-
An RNAi screen of chromatin proteins identifies Tip60-p400 as a regulator of embryonic stem cell identity.
-
10.1016/j.cell.2008.05.031, 18614019
-
Fazzio TG, Huff JT, Panning B. An RNAi screen of chromatin proteins identifies Tip60-p400 as a regulator of embryonic stem cell identity. Cell 2008, 134:162-174. 10.1016/j.cell.2008.05.031, 18614019.
-
(2008)
Cell
, vol.134
, pp. 162-174
-
-
Fazzio, T.G.1
Huff, J.T.2
Panning, B.3
-
51
-
-
69349103956
-
The Ink4/Arf locus is a barrier for iPS cell reprogramming.
-
10.1038/nature08290, 19668188
-
Li H, Collado M, Villasante A, Strati K, Ortega S, Canamero M, Blasco MA, Serrano M. The Ink4/Arf locus is a barrier for iPS cell reprogramming. Nature 2009, 460:1136-1139. 10.1038/nature08290, 19668188.
-
(2009)
Nature
, vol.460
, pp. 1136-1139
-
-
Li, H.1
Collado, M.2
Villasante, A.3
Strati, K.4
Ortega, S.5
Canamero, M.6
Blasco, M.A.7
Serrano, M.8
-
52
-
-
71449109765
-
Direct cell reprogramming is a stochastic process amenable to acceleration.
-
10.1038/nature08592, 2789972, 19898493
-
Hanna J, Saha K, Pando B, van Zon J, Lengner CJ, Creyghton MP, van Oudenaarden A, Jaenisch R. Direct cell reprogramming is a stochastic process amenable to acceleration. Nature 2009, 462:595-601. 10.1038/nature08592, 2789972, 19898493.
-
(2009)
Nature
, vol.462
, pp. 595-601
-
-
Hanna, J.1
Saha, K.2
Pando, B.3
van Zon, J.4
Lengner, C.J.5
Creyghton, M.P.6
van Oudenaarden, A.7
Jaenisch, R.8
-
53
-
-
69349098834
-
Stem cells: the promises and perils of p53.
-
10.1038/4601085a, 2974062, 19713919
-
Krizhanovsky V, Lowe SW. Stem cells: the promises and perils of p53. Nature 2009, 460:1085-1086. 10.1038/4601085a, 2974062, 19713919.
-
(2009)
Nature
, vol.460
, pp. 1085-1086
-
-
Krizhanovsky, V.1
Lowe, S.W.2
-
54
-
-
69349098273
-
Immortalization eliminates a roadblock during cellular reprogramming into iPS cells.
-
10.1038/nature08285, 19668190
-
Utikal J, Polo JM, Stadtfeld M, Maherali N, Kulalert W, Walsh RM, Khalil A, Rheinwald JG, Hochedlinger K. Immortalization eliminates a roadblock during cellular reprogramming into iPS cells. Nature 2009, 460:1145-1148. 10.1038/nature08285, 19668190.
-
(2009)
Nature
, vol.460
, pp. 1145-1148
-
-
Utikal, J.1
Polo, J.M.2
Stadtfeld, M.3
Maherali, N.4
Kulalert, W.5
Walsh, R.M.6
Khalil, A.7
Rheinwald, J.G.8
Hochedlinger, K.9
-
55
-
-
0242367242
-
Comment on "'Stemness': transcriptional profiling of embryonic and adult stem cells" and "a stem cell molecular signature".
-
author reply 393
-
Fortunel NO, Otu HH, Ng HH, Chen J, Mu X, Chevassut T, Li X, Joseph M, Bailey C, Hatzfeld JA, Hatzfeld A, Usta F, Vega VB, Long PM, Libermann TA, Lim B. Comment on "'Stemness': transcriptional profiling of embryonic and adult stem cells" and "a stem cell molecular signature". Science 2003, 302:393. author reply 393.
-
(2003)
Science
, vol.302
, pp. 393
-
-
Fortunel, N.O.1
Otu, H.H.2
Ng, H.H.3
Chen, J.4
Mu, X.5
Chevassut, T.6
Li, X.7
Joseph, M.8
Bailey, C.9
Hatzfeld, J.A.10
Hatzfeld, A.11
Usta, F.12
Vega, V.B.13
Long, P.M.14
Libermann, T.A.15
Lim, B.16
-
56
-
-
0242272438
-
Comment on " 'Stemness': transcriptional profiling of embryonic and adult stem cells" and "a stem cell molecular signature".
-
author reply 393
-
Evsikov AV, Solter D. Comment on " 'Stemness': transcriptional profiling of embryonic and adult stem cells" and "a stem cell molecular signature". Science 2003, 302:393. author reply 393.
-
(2003)
Science
, vol.302
, pp. 393
-
-
Evsikov, A.V.1
Solter, D.2
-
57
-
-
0141816752
-
EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells.
-
10.1073/pnas.1933744100, 208805, 14500907
-
Kleer CG, Cao Q, Varambally S, Shen R, Ota I, Tomlins SA, Ghosh D, Sewalt RG, Otte AP, Hayes DF, Sabel MS, Livant D, Weiss SJ, Rubin MA, Chinnaiyan AM. EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells. Proc Natl Acad Sci USA 2003, 100:11606-11611. 10.1073/pnas.1933744100, 208805, 14500907.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 11606-11611
-
-
Kleer, C.G.1
Cao, Q.2
Varambally, S.3
Shen, R.4
Ota, I.5
Tomlins, S.A.6
Ghosh, D.7
Sewalt, R.G.8
Otte, A.P.9
Hayes, D.F.10
Sabel, M.S.11
Livant, D.12
Weiss, S.J.13
Rubin, M.A.14
Chinnaiyan, A.M.15
-
58
-
-
18644382388
-
The polycomb group protein EZH2 is involved in progression of prostate cancer.
-
10.1038/nature01075, 12374981
-
Varambally S, Dhanasekaran SM, Zhou M, Barrette TR, Kumar-Sinha C, Sanda MG, Ghosh D, Pienta KJ, Sewalt RG, Otte AP, Rubin MA, Chinnaiyan AM. The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature 2002, 419:624-629. 10.1038/nature01075, 12374981.
-
(2002)
Nature
, vol.419
, pp. 624-629
-
-
Varambally, S.1
Dhanasekaran, S.M.2
Zhou, M.3
Barrette, T.R.4
Kumar-Sinha, C.5
Sanda, M.G.6
Ghosh, D.7
Pienta, K.J.8
Sewalt, R.G.9
Otte, A.P.10
Rubin, M.A.11
Chinnaiyan, A.M.12
-
59
-
-
34748925353
-
The stem cell identity of testicular cancer.
-
10.1007/s12015-007-0002-x, 17873381
-
Clark AT. The stem cell identity of testicular cancer. Stem Cell Rev 2007, 3:49-59. 10.1007/s12015-007-0002-x, 17873381.
-
(2007)
Stem Cell Rev
, vol.3
, pp. 49-59
-
-
Clark, A.T.1
-
60
-
-
70350641014
-
SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas.
-
10.1038/ng.465, 2783775, 19801978
-
Bass AJ, Watanabe H, Mermel CH, Yu S, Perner S, Verhaak RG, Kim SY, Wardwell L, Tamayo P, Gat-Viks I, Ramos AH, Woo MS, Weir BA, Getz G, Beroukhim R, O'Kelly M, Dutt A, Rozenblatt-Rosen O, Dziunycz P, Komisarof J, Chirieac LR, Lafargue CJ, Scheble V, Wilbertz T, Ma C, Rao S, Nakagawa H, Stairs DB, Lin L, Giordano TJ, et al. SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. Nat Genet 2009, 41:1238-1242. 10.1038/ng.465, 2783775, 19801978.
-
(2009)
Nat Genet
, vol.41
, pp. 1238-1242
-
-
Bass, A.J.1
Watanabe, H.2
Mermel, C.H.3
Yu, S.4
Perner, S.5
Verhaak, R.G.6
Kim, S.Y.7
Wardwell, L.8
Tamayo, P.9
Gat-Viks, I.10
Ramos, A.H.11
Woo, M.S.12
Weir, B.A.13
Getz, G.14
Beroukhim, R.15
O'Kelly, M.16
Dutt, A.17
Rozenblatt-Rosen, O.18
Dziunycz, P.19
Komisarof, J.20
Chirieac, L.R.21
Lafargue, C.J.22
Scheble, V.23
Wilbertz, T.24
Ma, C.25
Rao, S.26
Nakagawa, H.27
Stairs, D.B.28
Lin, L.29
Giordano, T.J.30
more..
-
61
-
-
0344063368
-
Oct-3/4 is a dose-dependent oncogenic fate determinant.
-
10.1016/S1535-6108(03)00270-8, 14667503
-
Gidekel S, Pizov G, Bergman Y, Pikarsky E. Oct-3/4 is a dose-dependent oncogenic fate determinant. Cancer Cell 2003, 4:361-370. 10.1016/S1535-6108(03)00270-8, 14667503.
-
(2003)
Cancer Cell
, vol.4
, pp. 361-370
-
-
Gidekel, S.1
Pizov, G.2
Bergman, Y.3
Pikarsky, E.4
-
62
-
-
79952550805
-
Expression of OCT4 pseudogenes in human tumours: lessons from glioma and breast carcinoma.
-
10.1002/path.2827, 21341266
-
Zhao S, Yuan Q, Hao H, Guo Y, Liu S, Zhang Y, Wang J, Liu H, Wang F, Liu K, Ling EA, Hao A. Expression of OCT4 pseudogenes in human tumours: lessons from glioma and breast carcinoma. J Pathol 2011, 223:672-682. 10.1002/path.2827, 21341266.
-
(2011)
J Pathol
, vol.223
, pp. 672-682
-
-
Zhao, S.1
Yuan, Q.2
Hao, H.3
Guo, Y.4
Liu, S.5
Zhang, Y.6
Wang, J.7
Liu, H.8
Wang, F.9
Liu, K.10
Ling, E.A.11
Hao, A.12
-
63
-
-
27144549266
-
Oct4 pseudogenes are transcribed in cancers.
-
10.1016/j.bbrc.2005.09.157, 16229821
-
Suo G, Han J, Wang X, Zhang J, Zhao Y, Dai J. Oct4 pseudogenes are transcribed in cancers. Biochem Biophys Res Commun 2005, 337:1047-1051. 10.1016/j.bbrc.2005.09.157, 16229821.
-
(2005)
Biochem Biophys Res Commun
, vol.337
, pp. 1047-1051
-
-
Suo, G.1
Han, J.2
Wang, X.3
Zhang, J.4
Zhao, Y.5
Dai, J.6
-
64
-
-
31144438305
-
Cancer biology: signatures guide drug choice.
-
10.1038/439274a, 16421553
-
Downward J. Cancer biology: signatures guide drug choice. Nature 2006, 439:274-275. 10.1038/439274a, 16421553.
-
(2006)
Nature
, vol.439
, pp. 274-275
-
-
Downward, J.1
-
65
-
-
31144453233
-
BRAF mutation predicts sensitivity to MEK inhibition.
-
10.1038/nature04304, 16273091
-
Solit DB, Garraway LA, Pratilas CA, Sawai A, Getz G, Basso A, Ye Q, Lobo JM, She Y, Osman I, Golub TR, Sebolt-Leopold J, Sellers WR, Rosen N. BRAF mutation predicts sensitivity to MEK inhibition. Nature 2006, 439:358-362. 10.1038/nature04304, 16273091.
-
(2006)
Nature
, vol.439
, pp. 358-362
-
-
Solit, D.B.1
Garraway, L.A.2
Pratilas, C.A.3
Sawai, A.4
Getz, G.5
Basso, A.6
Ye, Q.7
Lobo, J.M.8
She, Y.9
Osman, I.10
Golub, T.R.11
Sebolt-Leopold, J.12
Sellers, W.R.13
Rosen, N.14
-
66
-
-
31144459985
-
Oncogenic pathway signatures in human cancers as a guide to targeted therapies.
-
10.1038/nature04296, 16273092
-
Bild AH, Yao G, Chang JT, Wang Q, Potti A, Chasse D, Joshi MB, Harpole D, Lancaster JM, Berchuck A, Olson JA, Marks JR, Dressman HK, West M, Nevins JR. Oncogenic pathway signatures in human cancers as a guide to targeted therapies. Nature 2006, 439:353-357. 10.1038/nature04296, 16273092.
-
(2006)
Nature
, vol.439
, pp. 353-357
-
-
Bild, A.H.1
Yao, G.2
Chang, J.T.3
Wang, Q.4
Potti, A.5
Chasse, D.6
Joshi, M.B.7
Harpole, D.8
Lancaster, J.M.9
Berchuck, A.10
Olson, J.A.11
Marks, J.R.12
Dressman, H.K.13
West, M.14
Nevins, J.R.15
-
67
-
-
33749335282
-
The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease.
-
10.1126/science.1132939, 17008526
-
Lamb J, Crawford ED, Peck D, Modell JW, Blat IC, Wrobel MJ, Lerner J, Brunet JP, Subramanian A, Ross KN, Reich M, Hieronymus H, Wei G, Armstrong SA, Haggarty SJ, Clemons PA, Wei R, Carr SA, Lander ES, Golub TR. The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science 2006, 313:1929-1935. 10.1126/science.1132939, 17008526.
-
(2006)
Science
, vol.313
, pp. 1929-1935
-
-
Lamb, J.1
Crawford, E.D.2
Peck, D.3
Modell, J.W.4
Blat, I.C.5
Wrobel, M.J.6
Lerner, J.7
Brunet, J.P.8
Subramanian, A.9
Ross, K.N.10
Reich, M.11
Hieronymus, H.12
Wei, G.13
Armstrong, S.A.14
Haggarty, S.J.15
Clemons, P.A.16
Wei, R.17
Carr, S.A.18
Lander, E.S.19
Golub, T.R.20
more..
-
68
-
-
33845876254
-
The Connectivity Map: a new tool for biomedical research.
-
10.1038/nrc2044, 17186018
-
Lamb J. The Connectivity Map: a new tool for biomedical research. Nat Rev Cancer 2007, 7:54-60. 10.1038/nrc2044, 17186018.
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 54-60
-
-
Lamb, J.1
-
69
-
-
33749433916
-
Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators.
-
10.1016/j.ccr.2006.09.005, 17010675
-
Hieronymus H, Lamb J, Ross KN, Peng XP, Clement C, Rodina A, Nieto M, Du J, Stegmaier K, Raj SM, Maloney KN, Clardy J, Hahn WC, Chiosis G, Golub TR. Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators. Cancer Cell 2006, 10:321-330. 10.1016/j.ccr.2006.09.005, 17010675.
-
(2006)
Cancer Cell
, vol.10
, pp. 321-330
-
-
Hieronymus, H.1
Lamb, J.2
Ross, K.N.3
Peng, X.P.4
Clement, C.5
Rodina, A.6
Nieto, M.7
Du, J.8
Stegmaier, K.9
Raj, S.M.10
Maloney, K.N.11
Clardy, J.12
Hahn, W.C.13
Chiosis, G.14
Golub, T.R.15
-
70
-
-
77957682878
-
MicroRNA gene regulatory pathways in the establishment and maintenance of ESC identity.
-
10.1016/j.stem.2010.06.011, 20621047
-
Martinez NJ, Gregory RI. MicroRNA gene regulatory pathways in the establishment and maintenance of ESC identity. Cell Stem Cell 2010, 7:31-35. 10.1016/j.stem.2010.06.011, 20621047.
-
(2010)
Cell Stem Cell
, vol.7
, pp. 31-35
-
-
Martinez, N.J.1
Gregory, R.I.2
-
71
-
-
48449084118
-
Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells.
-
10.1016/j.cell.2008.07.020, 2586071, 18692474
-
Marson A, Levine SS, Cole MF, Frampton GM, Brambrink T, Johnstone S, Guenther MG, Johnston WK, Wernig M, Newman J, Calabrese JM, Dennis LM, Volkert TL, Gupta S, Love J, Hannett N, Sharp PA, Bartel DP, Jaenisch R, Young RA. Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell 2008, 134:521-533. 10.1016/j.cell.2008.07.020, 2586071, 18692474.
-
(2008)
Cell
, vol.134
, pp. 521-533
-
-
Marson, A.1
Levine, S.S.2
Cole, M.F.3
Frampton, G.M.4
Brambrink, T.5
Johnstone, S.6
Guenther, M.G.7
Johnston, W.K.8
Wernig, M.9
Newman, J.10
Calabrese, J.M.11
Dennis, L.M.12
Volkert, T.L.13
Gupta, S.14
Love, J.15
Hannett, N.16
Sharp, P.A.17
Bartel, D.P.18
Jaenisch, R.19
Young, R.A.20
more..
-
72
-
-
0035902140
-
The Hedgehog and Wnt signalling pathways in cancer.
-
10.1038/35077219, 11357142
-
Taipale J, Beachy PA. The Hedgehog and Wnt signalling pathways in cancer. Nature 2001, 411:349-354. 10.1038/35077219, 11357142.
-
(2001)
Nature
, vol.411
, pp. 349-354
-
-
Taipale, J.1
Beachy, P.A.2
-
73
-
-
79551600015
-
Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways.
-
10.1038/nrclinonc.2010.196, 21151206
-
Takebe N, Harris PJ, Warren RQ, Ivy SP. Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways. Nat Rev Clin Oncol 2011, 8:97-106. 10.1038/nrclinonc.2010.196, 21151206.
-
(2011)
Nat Rev Clin Oncol
, vol.8
, pp. 97-106
-
-
Takebe, N.1
Harris, P.J.2
Warren, R.Q.3
Ivy, S.P.4
-
74
-
-
41149174852
-
Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cells.
-
10.1101/gad.1642408, 2275428,2275428, 18347094
-
Cole MF, Johnstone SE, Newman JJ, Kagey MH, Young RA. Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cells. Genes Dev 2008, 22:746-755. 10.1101/gad.1642408, 2275428,2275428, 18347094.
-
(2008)
Genes Dev
, vol.22
, pp. 746-755
-
-
Cole, M.F.1
Johnstone, S.E.2
Newman, J.J.3
Kagey, M.H.4
Young, R.A.5
-
75
-
-
58149378334
-
Genome-wide analysis reveals Sall4 to be a major regulator of pluripotency in murine-embryonic stem cells.
-
10.1073/pnas.0809321105, 2604985, 19060217
-
Yang J, Chai L, Fowles TC, Alipio Z, Xu D, Fink LM, Ward DC, Ma Y. Genome-wide analysis reveals Sall4 to be a major regulator of pluripotency in murine-embryonic stem cells. Proc Natl Acad Sci USA 2008, 105:19756-19761. 10.1073/pnas.0809321105, 2604985, 19060217.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 19756-19761
-
-
Yang, J.1
Chai, L.2
Fowles, T.C.3
Alipio, Z.4
Xu, D.5
Fink, L.M.6
Ward, D.C.7
Ma, Y.8
-
76
-
-
78649551191
-
Differential roles of Sall4 isoforms in embryonic stem cell pluripotency.
-
10.1128/MCB.00419-10, 2976381, 20837710
-
Rao S, Zhen S, Roumiantsev S, McDonald LT, Yuan GC, Orkin SH. Differential roles of Sall4 isoforms in embryonic stem cell pluripotency. Mol Cell Biol 2010, 30:5364-5380. 10.1128/MCB.00419-10, 2976381, 20837710.
-
(2010)
Mol Cell Biol
, vol.30
, pp. 5364-5380
-
-
Rao, S.1
Zhen, S.2
Roumiantsev, S.3
McDonald, L.T.4
Yuan, G.C.5
Orkin, S.H.6
-
77
-
-
54949135186
-
Sall4 regulates distinct transcription circuitries in different blastocyst-derived stem cell lineages.
-
10.1016/j.stem.2008.08.004, 18804426
-
Lim CY, Tam WL, Zhang J, Ang HS, Jia H, Lipovich L, Ng HH, Wei CL, Sung WK, Robson P, Yang H, Lim B. Sall4 regulates distinct transcription circuitries in different blastocyst-derived stem cell lineages. Cell Stem Cell 2008, 3:543-554. 10.1016/j.stem.2008.08.004, 18804426.
-
(2008)
Cell Stem Cell
, vol.3
, pp. 543-554
-
-
Lim, C.Y.1
Tam, W.L.2
Zhang, J.3
Ang, H.S.4
Jia, H.5
Lipovich, L.6
Ng, H.H.7
Wei, C.L.8
Sung, W.K.9
Robson, P.10
Yang, H.11
Lim, B.12
-
78
-
-
72249104107
-
Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells.
-
10.1016/j.cell.2009.12.003, 2810107, 20064376
-
Shen X, Kim W, Fujiwara Y, Simon MD, Liu Y, Mysliwiec MR, Yuan GC, Lee Y, Orkin SH. Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells. Cell 2009, 139:1303-1314. 10.1016/j.cell.2009.12.003, 2810107, 20064376.
-
(2009)
Cell
, vol.139
, pp. 1303-1314
-
-
Shen, X.1
Kim, W.2
Fujiwara, Y.3
Simon, M.D.4
Liu, Y.5
Mysliwiec, M.R.6
Yuan, G.C.7
Lee, Y.8
Orkin, S.H.9
-
79
-
-
72249119297
-
Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells.
-
10.1016/j.cell.2009.12.002, 2911953, 20064375
-
Peng JC, Valouev A, Swigut T, Zhang J, Zhao Y, Sidow A, Wysocka J. Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells. Cell 2009, 139:1290-1302. 10.1016/j.cell.2009.12.002, 2911953, 20064375.
-
(2009)
Cell
, vol.139
, pp. 1290-1302
-
-
Peng, J.C.1
Valouev, A.2
Swigut, T.3
Zhang, J.4
Zhao, Y.5
Sidow, A.6
Wysocka, J.7
-
80
-
-
64349096829
-
A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal.
-
10.1101/gad.1769609, 2666338, 19339689
-
Hu G, Kim J, Xu Q, Leng Y, Orkin SH, Elledge SJ. A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal. Genes Dev 2009, 23:837-848. 10.1101/gad.1769609, 2666338, 19339689.
-
(2009)
Genes Dev
, vol.23
, pp. 837-848
-
-
Hu, G.1
Kim, J.2
Xu, Q.3
Leng, Y.4
Orkin, S.H.5
Elledge, S.J.6
-
81
-
-
6944244084
-
A module map showing conditional activity of expression modules in cancer.
-
10.1038/ng1434, 15448693
-
Segal E, Friedman N, Koller D, Regev A. A module map showing conditional activity of expression modules in cancer. Nat Genet 2004, 36:1090-1098. 10.1038/ng1434, 15448693.
-
(2004)
Nat Genet
, vol.36
, pp. 1090-1098
-
-
Segal, E.1
Friedman, N.2
Koller, D.3
Regev, A.4
|