C-Jun N-terminal phosphorylation antagonises recruitment of the Mbd3/NuRD repressor complex

Nature

Volumn 469, Issue 7329, 2011, Pages 231-236

  Aguilera, Cristina ^a   Nakagawa, Kentaro ^a,b   Sancho, Rocio ^a   Chakraborty, Atanu ^a   Hendrich, Brian ^c   Behrens, Axel ^a  

^a THE FRANCIS CRICK INSTITUTE   (United Kingdom)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE; ONCOPROTEIN; PROTEIN C JUN; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1;

ALLELE; CANCER; CELL ORGANELLE; DEVELOPMENTAL BIOLOGY; ENZYME ACTIVITY; ESTER; GENE EXPRESSION; GENETIC MARKER; MOLECULAR ANALYSIS; NUMERICAL MODEL; PATHOLOGY; PROTEIN; RODENT; SIGNAL; TUMOR;

ACETYLATION; ARTICLE; CANCER CELL; CELL PROLIFERATION; COLITIS; COLON CANCER; COLON CARCINOGENESIS; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; STEM CELL;

ACETYLATION; ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; COLONIC NEOPLASMS; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTONES; INTESTINES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MI-2 NUCLEOSOME REMODELING AND DEACETYLASE COMPLEX; MICE; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-JUN; RECEPTORS, G-PROTEIN-COUPLED; STEM CELLS; TRANSCRIPTION FACTORS;

MUS;

EID: 78651405682     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature09607     Document Type: Article

References (28)

1. Davis, R. J. Signal transduction by the JNKgroupof MAP kinases. Cell103, 239-252 (2000).
2. Eferl, R. & Wagner, E. F. AP-1: adouble-edgedsword in tumorigenesis. NatureRev. Cancer 3, 859-868 (2003).
3. Sancho, R. et al. JNKsignalling modulates intestinal homeostasisand tumourigenesis in mice. EMBOJ. 28, 1843-1854 (2009).
4. Nateri, A. S., Spencer-Dene, B. & Behrens, A. Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancerdevelopment. Nature437, 281-285 (2005).
5. Pulverer, B. J., Kyriakis, J. M., Avruch, J., Nikolakaki, E. & Woodgett, J. R. Phosphorylationofc-jun mediated by MAPkinases. Nature353, 670-674(1991).
6. Behrens, A., Sibilia, M. & Wagner, E. F. Amino-terminal phosphorylation ofc-Jun regulates stress-induced apoptosis and cellular proliferation. Nature Genet. 21, 326-329(1999).
7. Nateri, A. S., Riera-Sans, L., Da Costa, C. & Behrens, A. The ubiquitin ligase SCFFbw7antagonizesapoptotic JN Ksignaling. Science303, 1374-1378(2004).
8. LeGuezennec, X. et al. MBD2/NuRDand MBD3/NuRD, twodistinctcomplexes with different biochemical and functional properties. Mol. Cell. Biol. 26, 843-851 (2006).
9. Denslow, S. A. & Wade, P. A. Thehuman Mi-2/ NuRDcomplexandgeneregulation Oncogene 26, 5433-5438 (2007).
10. Ahringer, J. NuRD andSIN3 histonedeacetylasecomplexes in development Trends Genet 16, 351-356 (2000).
11. Bowen, N. J., Fujita, N., Kajita, M. & Wade, P. A. Mi-2/NuRD: multiplecomplexesfor many purposes. Biochim. Biophys. Acta 1677, 52-57 (2004).
12. Saito, M. & Ishikawa, F. ThemCpG-bindingdomainof human MBD3doesnotbind to mCpG but interactswith NuRD/Mi2 components HDAC1 and MTA2. J. Biol. Chem. 277, 35434-35439 (2002).
13. Hendrich, B. & Tweedie, S. The methyl-CpG bindingdomain andtheevolvingrole of DNA methylation in animals Trends Genet 19, 269-277 (2003).
14. D'Orazio, D. et al. CooperationoftwoPEA3/AP1sitesinuPAgeneinduction byTPA and FGF-2. Gene201, 179-187 (1997).
15. Angel, P., Hattori, K., Smeal, T. & Karin, M. Thejun proto-oncogene is positively autoregulated by its product, Jun/AP-1. Cell 55, 875-885 (1988).
16. Clayton, A. L., Rose, S., Barratt, M. J. & Mahadevan, L C. Phosphoacetylation of histone H3 on c-fos-and c-jun-associated nucleosomes upon geneactivation. EMBOJ. 19, 3714-3726 (2000).
17. Hendrich, B., Guy, J., Ramsahoye, B., Wilson, V. A. & Bird, A. Closelyrelated proteins MBD2 and MBD3 playdistinctive but interacting roles in mousedevelopment. Genes Dev. 15, 710-723 (2001).
18. El Marjou, F. et al. Tissue-specificand inducibleCre-mediated recombination in thegutepithelium. Genesis39, 186-193 (2004).
19. Barker, N. et al. Identification of stemcells in small intestineandcolon bymarker gene Lgr5. Nature 449, 1003-1007 (2007).
20. Van der Flier, L G. et al. Transcription factorachaetescute-like2 controls intestina stem cell fate. Cell 136, 903-912 (2009).
21. Kaji, K. et al. The NuRDcomponent Mbd3 is required for pluripotencyof embryonic stem cells. Nature Cell Biol. 8, 285-292 (2006).
22. Kaji, K., Nichols, J. & Hendrich, B. Mbd3, acomponentof the NuRD co-repressor complex, is required fordevelopmentof pluripotentcells. Development 134, 1123-1132 (2007).
23. Baichwal, V. R., Park, A. & Tjian, R. Thecell-type-specificactivator region ofc-Jun juxtaposes constitutive and negatively regulated domains. Genes Dev. 6, 1493-1502 (1992).
24. Weiss, C. et al. JNKphosphorylation relievesHDAC3- dependentsuppressionofthe transcriptional activityofc-Jun. EMBOJ. 22, 3686-3695 (2003).
25. Arias, J. et al. Activation ofcAMPand mitogen responsivegenes relieson a common nuclear factor. Nature 370, 226-229 (1994).
26. Nelson, J. D., Denisenko, O. & Bomsztyk, K. Protocol forthefastchromatin mmunoprecipitation (ChIP) method. Nature Protocols 1, 179-185 (2006).
27. Neufert, C., Becker, C & Neurath, M. F. An inducible mouse model of colon carcinogenesis for the analysis of sporadic and inflammation-driven tumor progression. Nature Protocols 2, 1998-2004 (2007).
28. Floer, M. et al. Enoxaparin improvesthecourseofdextransodiumsulfate- induced colitis in syndecan-1-deficient mice. Am. J. Pathol. 176, 146-157 (2010).