Expression profiling of stem cell-related genes in neoadjuvant-treated gastric cancer: A NOTCH2, GSK3B and β-catenin gene signature predicts survival

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Bauer, Lukas ^a   Langer, Rupert ^a   Becker, Karen ^a   Hapfelmeier, Alexander ^c   Ott, Katja ^b   Novotny, Alexander ^a   Höfler, Heinz ^a,d   Keller, Gisela ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CISPLATIN; DOCETAXEL; EPIRUBICIN; FLUOROURACIL; FOLINIC ACID; GLYCOGEN SYNTHASE KINASE 3BETA; NOTCH2 RECEPTOR; OCTAMER TRANSCRIPTION FACTOR 4; OXALIPLATIN; PACLITAXEL; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; NOTCH2 PROTEIN, HUMAN;

ADD ON THERAPY; ADULT; AGED; ARTICLE; BETA CATENIN GENE; BIOINFORMATICS; CANCER ADJUVANT THERAPY; CANCER GRADING; CANCER PROGNOSIS; CANCER RESISTANCE; CANCER STAGING; CANCER STEM CELL; CANCER SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DRUG EFFICACY; DRUG RESPONSE; FEMALE; GENE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE IDENTIFICATION; GENE LOCATION; GENETIC CORRELATION; GENETIC DATABASE; GSK3B GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MULTIPLE CYCLE TREATMENT; NOTCH2 GENE; OVERALL SURVIVAL; POU5F1 GENE; PREDICTIVE VALUE; QUANTITATIVE STUDY; REAL TIME POLYMERASE CHAIN REACTION; STOMACH CANCER; TUMOR REGRESSION; UPREGULATION; ADJUVANT CHEMOTHERAPY; GENETICS; METABOLISM; MIDDLE AGED; PATHOLOGY; STOMACH TUMOR; SURVIVAL RATE;

BETA CATENIN; CHEMOTHERAPY, ADJUVANT; FEMALE; GENE EXPRESSION PROFILING; GLYCOGEN SYNTHASE KINASE 3; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; NEOPLASTIC STEM CELLS; RECEPTOR, NOTCH2; STOMACH NEOPLASMS; SURVIVAL RATE;

EID: 84874728277     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0044566     Document Type: Article

References (51)

1. Lordick F, Siewert JR (2005) Recent advances in multimodal treatment for gastric cancer: a review. Gastric Cancer 8: 78-85.
2. Becker K, Langer R, Reim D, Novotny A, Meyer zum Buschenfelde C, et al. (2011) Significance of histopathological tumor regression after neoadjuvant chemotherapy in gastric adenocarcinomas: a summary of 480 cases. Ann Surg 253: 934-939.
3. Reya T, Morrison SJ, Clarke MF, Weissman IL (2001) Stem cells, cancer, and cancer stem cells. Nature 414: 105-111.
4. O'Brien CA, Kreso A, Jamieson CH (2010) Cancer stem cells and self-renewal. Clin Cancer Res 16: 3113-3120.
5. Clevers H (2011) The cancer stem cell: premises, promises and challenges. Nat Med 17: 313-319.
6. Li X, Lewis MT, Huang J, Gutierrez C, Osborne CK, et al. (2008) Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy. J Natl Cancer Inst 100: 672-679.
7. Lee HE, Kim JH, Kim YJ, Choi SY, Kim SW, et al. (2011) An increase in cancer stem cell population after primary systemic therapy is a poor prognostic factor in breast cancer. Br J Cancer 104: 1730-1738.
8. Shats I, Gatza ML, Chang JT, Mori S, Wang J, et al. (2011) Using a stem cellbased signature to guide therapeutic selection in cancer. Cancer Res 71: 1772-1780.
9. Ben-Porath I, Thomson MW, Carey VJ, Ge R, Bell GW, et al. (2008) An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet 40: 499-507.
10. Wang T, Ong CW, Shi J, Srivastava S, Yan B, et al. (2011) Sequential expression of putative stem cell markers in gastric carcinogenesis. British Journal of Cancer 105: 658-665.
11. Wakamatsu Y, Sakamoto N, Oo HZ, Naito Y, Uraoka N, et al. (2012) Expression of cancer stem cell markers ALDH1, CD44 and CD133 in primary tumor and lymph node metastasis of gastric cancer. Pathology International 62: 112-119.
12. Takebe N, Ivy SP (2010) Controversies in cancer stem cells: targeting embryonic signaling pathways. Clin Cancer Res 16: 3106-3112.
13. Takaishi S, Okumura T, Wang TC (2008) Gastric cancer stem cells. J Clin Oncol 26: 2876-2882.
14. Vries RG, Huch M, Clevers H (2010) Stem cells and cancer of the stomach and intestine. Mol Oncol 4: 373-384.
15. Saikawa Y, Fukuda K, Takahashi T, Nakamura R, Takeuchi H, et al. (2010) Gastric carcinogenesis and the cancer stem cell hypothesis. Gastric Cancer 13: 11-24.
16. Qiao XT, Gumucio DL (2011) Current molecular markers for gastric progenitor cells and gastric cancer stem cells. J Gastroenterol 46: 855-865.
17. Houghton J, Stoicov C, Nomura S, Rogers AB, Carlson J, et al. (2004) Gastric cancer originating from bone marrow-derived cells. Science 306: 1568-1571.
18. Barker N, Huch M, Kujala P, van de Wetering M, Snippert HJ, et al. (2010) Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro. Cell Stem Cell 6: 25-36.
19. Zhang C, Li C, He F, Cai Y, Yang H (2011) Identification of CD44+CD24+ gastric cancer stem cells. J Cancer Res Clin Oncol 137: 1679-1686.
20. Rocco A, Liguori E, Pirozzi G, Tirino V, Compare D, et al. (2012) CD133 and CD44 cell surface markers do not identify cancer stem cells in primary human gastric tumours. J Cell Physiol227: 2686-2693.
21. Schuhmacher CP, Fink U, Becker K, Busch R, Dittler HJ, et al. (2001) Neoadjuvant therapy for patients with locally advanced gastric carcinoma with etoposide, doxorubicin, and cisplatinum. Closing results after 5 years of followup. Cancer 91: 918-927.
22. Ott K, Sendler A, Becker K, Dittler HJ, Helmberger H, et al. (2003) Neoadjuvant chemotherapy with cisplatin, 5-FU, and leucovorin (PLF) in locally advanced gastric cancer: a prospective phase II study. Gastric Cancer 6: 159-167.
23. Vittinghoff E, McCulloch CE (2007) Relaxing the rule of ten events per variable in logistic and Cox regression. Am J Epidemiol 165: 710-718.
24. Peduzzi P, Concato J, Feinstein AR, Holford TR (1995) Importance of events per independent variable in proportional hazards regression analysis. II. Accuracy and precision of regression estimates. J Clin Epidemiol 48: 1503-1510.
25. Napieralski R, Ott K, Kremer M, Specht K, Vogelsang H, et al. (2005) Combined GADD45A and thymidine phosphorylase expression levels predict response and survival of neoadjuvant-treated gastric cancer patients. Clin Cancer Res 11: 3025-3031.
26. Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, et al. (2002) Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 3: RESEARCH0034.
27. Schmittgen TD, Livak KJ (2008) Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 3: 1101-1108.
28. Hothorn T, Zeileis A (2008) Generalized maximally selected statistics. Biometrics 64: 1263-1269.
29. de Hoon MJ, Imoto S, Nolan J, Miyano S (2004) Open source clustering software. Bioinformatics 20: 1453-1454.
30. Saldanha AJ (2004) Java Treeview-extensible visualization of microarray data. Bioinformatics 20: 3246-3248.
31. Cho JY, Lim JY, Cheong JH, Park YY, Yoon SL, et al. (2011) Gene expression signature-based prognostic risk score in gastric cancer. Clin Cancer Res 17: 1850-1857.
32. McShane LM, Altman DG, Sauerbrei W, Taube SE, Gion M, et al. (2005) REporting recommendations for tumour MARKer prognostic studies (REMARK). Br J Cancer 93: 387-391.
33. Chen X, Leung SY, Yuen ST, Chu KM, Ji J, et al. (2003) Variation in gene expression patterns in human gastric cancers. Mol Biol Cell 14: 3208-3215.
34. Zhao Y, Simon R (2008) BRB-ArrayTools Data Archive for human cancer gene expression: a unique and efficient data sharing resource. Cancer Inform 6: 9-15.
35. MacDonald BT, Tamai K, He X (2009) Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell 17: 9-26.
36. Ooi CH, Ivanova T, Wu J, Lee M, Tan IB, et al. (2009) Oncogenic pathway combinations predict clinical prognosis in gastric cancer. PLoS Genet 5: e1000676.
37. Freeman TJ, Smith JJ, Chen X, Washington MK, Roland JT, et al. (2012) Smad4-mediated signaling inhibits intestinal neoplasia by inhibiting expression of beta-catenin. Gastroenterology 142: 562-571 e562.
38. Vermeulen L, De Sousa EMF, van der Heijden M, Cameron K, de Jong JH, etal. (2010) Wnt activity defines colon cancer stem cells and is regulated by the microenvironment. Nat Cell Biol 12: 468-476.
39. Filiz AI, Senol Z, Sucullu I, Kurt Y, Demirbas S, et al. (2010) The survival effect of E-cadherin and catenins in colorectal carcinomas. Colorectal Dis 12: 1223-1230.
40. Nabais S, Machado JC, Lopes C, Seruca R, Carneiro F, et al. (2003) Patterns of beta-catenin expression in gastric carcinoma: clinicopathological relevance and mutation analysis. Int J Surg Pathol 11: 1-9.
41. Grabsch H, Takeno S, Noguchi T, Hommel G, Gabbert HE, et al. (2001) Different patterns of beta-catenin expression in gastric carcinomas: relationship with clinicopathological parameters and prognostic outcome. Histopathology 39: 141-149.
42. Zeng X, Tamai K, Doble B, Li S, Huang H, et al. (2005) A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation. Nature 438:873-877.
43. Luo J (2009) Glycogen synthase kinase 3beta (GSK3beta) in tumorigenesis and cancer chemotherapy. Cancer Lett 273: 194-200.
44. Espinosa L, Ingles-Esteve J, Aguilera C, Bigas A (2003) Phosphorylation by glycogen synthase kinase-3 beta down-regulates Notch activity, a link for Notch and Wnt pathways. J Biol Chem 278: 32227-32235.
45. Espinosa I, Catasus L, Canet B, D'Angelo E, Munoz J, et al. (2011) Gene expression analysis identifies two groups of ovarian high-grade serous carcinomas with different prognosis. Mod Pathol 24: 846-854.
46. Yeh TS, Wu CW, Hsu KW, Liao WJ, Yang MC, et al. (2009) The activated Notch1 signal pathway is associated with gastric cancer progression through cyclooxygenase-2. Cancer Res 69: 5039-5048.
47. Tseng YC, Tsai YH, Tseng MJ, Hsu KW, Yang MC, et al. (2011) Notch2-induced COX-2 expression enhancing gastric cancer progression. Mol Carcinog.
48. Li DW, Wu Q, Peng ZH, Yang ZR, Wang Y (2007) [Expression and significance of Notch1 and PTEN in gastric cancer]. Ai Zheng 26: 1183-1187.
49. de Sousa EMF, Colak S, Buikhuisen J, Koster J, Cameron K, et al. (2011) Methylation of cancer-stem-cell-associated Wnt target genes predicts poor prognosis in colorectal cancer patients. Cell Stem Cell 9: 476-485.
50. Groth C, Fortini ME (2012) Therapeutic approaches to modulating Notch signaling: Current challenges and future prospects. Semin Cell Dev Biol.
51. Saigusa S, Tanaka K, Toiyama Y, Yokoe T, Okugawa Y, et al. (2009) Correlation of CD133, OCT4, and SOX2 in rectal cancer and their association with distant recurrence after chemoradiotherapy. Ann Surg Oncol 16: 3488-3498.