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Volumn 33, Issue 6, 2013, Pages 851-865

LGR5 is a proneural factor and is regulated by OLIG2 in Glioma stem-like cells

Author keywords

Bioinformatics; Cancer stem cell; Glioblastoma multiforme; Neuronal differentiation; WNT

Indexed keywords

G PROTEIN COUPLED RECEPTOR; LEUCINE RICH REPEAT CONTAINING G PROTEIN COUPLED RECEPTOR 5; OLIGODENDROCYTE TRANSCRIPTION FACTOR 2; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; LGR5 PROTEIN, HUMAN; NERVE PROTEIN; OLIG2 PROTEIN, HUMAN;

EID: 84881084722     PISSN: 02724340     EISSN: 15736830     Source Type: Journal    
DOI: 10.1007/s10571-013-9951-6     Document Type: Article
Times cited : (14)

References (74)
  • 1
    • 67349232018 scopus 로고    scopus 로고
    • In situ hybridization reveals developmental regulation of ErbB1-4 mRNA expression in mouse midbrain: Implication of ErbB receptors for dopaminergic neurons
    • 19298847 10.1016/j.neuroscience.2009.03.022 1:CAS:528: DC%2BD1MXls1Oru7Y%3D
    • Abe Y, Namba H, Zheng Y, Nawa H (2009) In situ hybridization reveals developmental regulation of ErbB1-4 mRNA expression in mouse midbrain: implication of ErbB receptors for dopaminergic neurons. Neuroscience 161:95-110
    • (2009) Neuroscience , vol.161 , pp. 95-110
    • Abe, Y.1    Namba, H.2    Zheng, Y.3    Nawa, H.4
  • 3
    • 58049097515 scopus 로고    scopus 로고
    • Olig2-induced neural stem cell differentiation involves downregulation of Wnt signaling and induction of Dickkopf-1 expression
    • 19093005 10.1371/journal.pone.0003917
    • Ahn SM, Byun K, Kim D, Lee K, Yoo JS, Kim SU, Jho EH, Simpson RJ, Lee B (2008) Olig2-induced neural stem cell differentiation involves downregulation of Wnt signaling and induction of Dickkopf-1 expression. PLoS ONE 3:e3917
    • (2008) PLoS ONE , vol.3 , pp. 3917
    • Ahn, S.M.1    Byun, K.2    Kim, D.3    Lee, K.4    Yoo, J.S.5    Kim, S.U.6    Jho, E.H.7    Simpson, R.J.8    Lee, B.9
  • 4
    • 31344457174 scopus 로고    scopus 로고
    • Oligodendroglial-specific transcriptional factor SOX10 is ubiquitously expressed in human gliomas
    • 16205963 10.1007/s11060-005-5533-x 1:CAS:528:DC%2BD28Xis1Sgsrc%3D
    • Bannykh SI, Stolt CC, Kim J, Perry A, Wegner M (2006) Oligodendroglial-specific transcriptional factor SOX10 is ubiquitously expressed in human gliomas. J Neurooncol 76:115-127
    • (2006) J Neurooncol , vol.76 , pp. 115-127
    • Bannykh, S.I.1    Stolt, C.C.2    Kim, J.3    Perry, A.4    Wegner, M.5
  • 9
    • 34447128096 scopus 로고    scopus 로고
    • Hoxd1 is expressed by oligodendroglial cells and binds to a region of the human myelin oligodendrocyte glycoprotein promoter in vitro
    • 17554625 10.1007/s10571-007-9150-4 1:CAS:528:DC%2BD2sXnsVCjsb8%3D
    • Booth J, Nicolay DJ, Doucette JR, Nazarali AJ (2007) Hoxd1 is expressed by oligodendroglial cells and binds to a region of the human myelin oligodendrocyte glycoprotein promoter in vitro. Cell Mol Neurobiol 27:641-650
    • (2007) Cell Mol Neurobiol , vol.27 , pp. 641-650
    • Booth, J.1    Nicolay, D.J.2    Doucette, J.R.3    Nazarali, A.J.4
  • 13
    • 77249144782 scopus 로고    scopus 로고
    • Neural stem cell systems: Physiological players or in vitro entities?
    • 20107441 10.1038/nrn2938 1:CAS:528:DC%2BC3cXhtFChu7g%3D
    • Conti L, Cattaneo E (2010) Neural stem cell systems: physiological players or in vitro entities? Nat Rev Neurosci 11:176-187
    • (2010) Nat Rev Neurosci , vol.11 , pp. 176-187
    • Conti, L.1    Cattaneo, E.2
  • 16
    • 34548680319 scopus 로고    scopus 로고
    • Sox10 has a broad expression pattern in gliomas and enhances platelet-derived growth factor-B-induced gliomagenesis
    • 17855658 10.1158/1541-7786.MCR-07-0113 1:CAS:528:DC%2BD2sXhtVaktrrF
    • Ferletta M, Uhrbom L, Olofsson T, Ponten F, Westermark B (2007) Sox10 has a broad expression pattern in gliomas and enhances platelet-derived growth factor-B-induced gliomagenesis. Mol Cancer Res 5:891-897
    • (2007) Mol Cancer Res , vol.5 , pp. 891-897
    • Ferletta, M.1    Uhrbom, L.2    Olofsson, T.3    Ponten, F.4    Westermark, B.5
  • 17
    • 33645474441 scopus 로고    scopus 로고
    • Gene expression in poorly differentiated papillary thyroid carcinomas
    • 16676402 10.1089/thy.2006.16.161 1:CAS:528:DC%2BD28Xit1Omsbw%3D
    • Fluge O, Bruland O, Akslen LA, Lillehaug JR, Varhaug JE (2006) Gene expression in poorly differentiated papillary thyroid carcinomas. Thyroid 16:161-175
    • (2006) Thyroid , vol.16 , pp. 161-175
    • Fluge, O.1    Bruland, O.2    Akslen, L.A.3    Lillehaug, J.R.4    Varhaug, J.E.5
  • 18
    • 53249143863 scopus 로고    scopus 로고
    • DOCK10-mediated Cdc42 activation is necessary for amoeboid invasion of melanoma cells
    • 18835169 10.1016/j.cub.2008.08.053 1:CAS:528:DC%2BD1cXht1ent7fJ
    • Gadea G, Sanz-Moreno V, Self A, Godi A, Marshall CJ (2008) DOCK10-mediated Cdc42 activation is necessary for amoeboid invasion of melanoma cells. Curr Biol 18:1456-1465
    • (2008) Curr Biol , vol.18 , pp. 1456-1465
    • Gadea, G.1    Sanz-Moreno, V.2    Self, A.3    Godi, A.4    Marshall, C.J.5
  • 20
    • 67349197237 scopus 로고    scopus 로고
    • LGR5 deficiency deregulates Wnt signaling and leads to precocious Paneth cell differentiation in the fetal intestine
    • 19394326 10.1016/j.ydbio.2009.04.020 1:CAS:528:DC%2BD1MXmvFygsrg%3D
    • Garcia MI, Ghiani M, Lefort A, Libert F, Strollo S, Vassart G (2009) LGR5 deficiency deregulates Wnt signaling and leads to precocious Paneth cell differentiation in the fetal intestine. Dev Biol 331:58-67
    • (2009) Dev Biol , vol.331 , pp. 58-67
    • Garcia, M.I.1    Ghiani, M.2    Lefort, A.3    Libert, F.4    Strollo, S.5    Vassart, G.6
  • 21
    • 0345700241 scopus 로고    scopus 로고
    • Thyroid hormone receptors/THR genes in human cancer
    • 12668276 10.1016/S0304-3835(02)00614-6 1:CAS:528:DC%2BD3sXisV2mtrw%3D
    • Gonzalez-Sancho JM, Garcia V, Bonilla F, Munoz A (2003) Thyroid hormone receptors/THR genes in human cancer. Cancer Lett 192:121-132
    • (2003) Cancer Lett , vol.192 , pp. 121-132
    • Gonzalez-Sancho, J.M.1    Garcia, V.2    Bonilla, F.3    Munoz, A.4
  • 23
    • 78650679999 scopus 로고    scopus 로고
    • An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates
    • 21151121 10.1038/nn.2710 1:CAS:528:DC%2BC3cXhsFGgtrjN
    • Guo T, Mandai K, Condie BG, Wickramasinghe SR, Capecchi MR, Ginty DD (2011) An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates. Nat Neurosci 14:31-36
    • (2011) Nat Neurosci , vol.14 , pp. 31-36
    • Guo, T.1    Mandai, K.2    Condie, B.G.3    Wickramasinghe, S.R.4    Capecchi, M.R.5    Ginty, D.D.6
  • 24
    • 70350570381 scopus 로고    scopus 로고
    • Transforming growth-interacting factor (TGIF) regulates proliferation and differentiation of human myeloid leukemia cells
    • 19699159 10.1016/j.molonc.2009.07.004 1:CAS:528:DC%2BC3cXjvFGju78%3D
    • Hamid R, Brandt SJ (2009) Transforming growth-interacting factor (TGIF) regulates proliferation and differentiation of human myeloid leukemia cells. Mol Oncol 3:451-463
    • (2009) Mol Oncol , vol.3 , pp. 451-463
    • Hamid, R.1    Brandt, S.J.2
  • 25
    • 40749094918 scopus 로고    scopus 로고
    • SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis
    • 18337816 10.1038/nature06781 1:CAS:528:DC%2BD1cXjt1Gnurg%3D
    • Han HJ, Russo J, Kohwi Y, Kohwi-Shigematsu T (2008) SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis. Nature 452:187-193
    • (2008) Nature , vol.452 , pp. 187-193
    • Han, H.J.1    Russo, J.2    Kohwi, Y.3    Kohwi-Shigematsu, T.4
  • 26
    • 59149083885 scopus 로고    scopus 로고
    • P34SEI-1 inhibits apoptosis through the stabilization of the X-linked inhibitor of apoptosis protein: P34SEI-1 as a novel target for anti-breast cancer strategies
    • 19176394 10.1158/0008-5472.CAN-08-1189 1:CAS:528:DC%2BD1MXhtFOksLw%3D
    • Hong SW, Kim CJ, Park WS, Shin JS, Lee SD, Ko SG, Jung SI, Park IC, An SK, Lee WK, Lee WJ, Jin DH, Lee MS (2009) p34SEI-1 inhibits apoptosis through the stabilization of the X-linked inhibitor of apoptosis protein: p34SEI-1 as a novel target for anti-breast cancer strategies. Cancer Res 69:741-746
    • (2009) Cancer Res , vol.69 , pp. 741-746
    • Hong, S.W.1    Kim, C.J.2    Park, W.S.3    Shin, J.S.4    Lee, S.D.5    Ko, S.G.6    Jung, S.I.7    Park, I.C.8    An, S.K.9    Lee, W.K.10    Lee, W.J.11    Jin, D.H.12    Lee, M.S.13
  • 27
    • 37549066863 scopus 로고    scopus 로고
    • Discovery of epigenetically silenced genes by methylated DNA immunoprecipitation in colon cancer cells
    • 18089774 10.1158/0008-5472.CAN-07-2687 1:CAS:528:DC%2BD2sXhsVCjs7zE
    • Jacinto FV, Ballestar E, Ropero S, Esteller M (2007) Discovery of epigenetically silenced genes by methylated DNA immunoprecipitation in colon cancer cells. Cancer Res 67:11481-11486
    • (2007) Cancer Res , vol.67 , pp. 11481-11486
    • Jacinto, F.V.1    Ballestar, E.2    Ropero, S.3    Esteller, M.4
  • 29
    • 33644603226 scopus 로고    scopus 로고
    • Angiomotin and angiomotin like proteins, their expression and correlation with angiogenesis and clinical outcome in human breast cancer
    • 16430777 10.1186/1471-2407-6-16 1:CAS:528:DC%2BD2sXksVaht7s%3D
    • Jiang WG, Watkins G, Douglas-Jones A, Holmgren L, Mansel RE (2006) Angiomotin and angiomotin like proteins, their expression and correlation with angiogenesis and clinical outcome in human breast cancer. BMC Cancer 6:16
    • (2006) BMC Cancer , vol.6 , pp. 16
    • Jiang, W.G.1    Watkins, G.2    Douglas-Jones, A.3    Holmgren, L.4    Mansel, R.E.5
  • 30
    • 60849097553 scopus 로고    scopus 로고
    • Cancer stem cells: Controversial or just misunderstood?
    • 19265659 10.1016/j.stem.2009.02.003 1:CAS:528:DC%2BD1MXjvVSqsL0%3D
    • Jordan CT (2009) Cancer stem cells: controversial or just misunderstood? Cell Stem Cell 4:203-205
    • (2009) Cell Stem Cell , vol.4 , pp. 203-205
    • Jordan, C.T.1
  • 31
    • 34248198548 scopus 로고    scopus 로고
    • Identification of genes directly regulated by the oncogene ZNF217 using chromatin immunoprecipitation (ChIP)-chip assays
    • 17259635 10.1074/jbc.M611752200 1:CAS:528:DC%2BD2sXjtlCitbk%3D
    • Krig SR, Jin VX, Bieda MC, O'Geen H, Yaswen P, Green R, Farnham PJ (2007) Identification of genes directly regulated by the oncogene ZNF217 using chromatin immunoprecipitation (ChIP)-chip assays. J Biol Chem 282:9703-9712
    • (2007) J Biol Chem , vol.282 , pp. 9703-9712
    • Krig, S.R.1    Jin, V.X.2    Bieda, M.C.3    O'Geen, H.4    Yaswen, P.5    Green, R.6    Farnham, P.J.7
  • 32
    • 33749186806 scopus 로고    scopus 로고
    • Selection of neural differentiation-specific genes by comparing profiles of random differentiation
    • 16627687 10.1634/stemcells.2005-0325 1:CAS:528:DC%2BD28XhtFKiu77J
    • Lee MS, Jun DH, Hwang CI, Park SS, Kang JJ, Park HS, Kim J, Kim JH, Seo JS, Park WY (2006) Selection of neural differentiation-specific genes by comparing profiles of random differentiation. Stem Cells 24:1946-1955
    • (2006) Stem Cells , vol.24 , pp. 1946-1955
    • Lee, M.S.1    Jun, D.H.2    Hwang, C.I.3    Park, S.S.4    Kang, J.J.5    Park, H.S.6    Kim, J.7    Kim, J.H.8    Seo, J.S.9    Park, W.Y.10
  • 33
    • 37549005215 scopus 로고    scopus 로고
    • Olig1 and Sox10 interact synergistically to drive myelin basic protein transcription in oligodendrocytes
    • 18160645 10.1523/JNEUROSCI.4456-07.2007 1:CAS:528:DC%2BD1cXktVGjuw%3D%3D
    • Li H, Lu Y, Smith HK, Richardson WD (2007) Olig1 and Sox10 interact synergistically to drive myelin basic protein transcription in oligodendrocytes. J Neurosci 27:14375-14382
    • (2007) J Neurosci , vol.27 , pp. 14375-14382
    • Li, H.1    Lu, Y.2    Smith, H.K.3    Richardson, W.D.4
  • 36
    • 0037023529 scopus 로고    scopus 로고
    • Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection
    • 11955448 10.1016/S0092-8674(02)00678-5 1:CAS:528:DC%2BD38XjtVOntLw%3D
    • Lu QR, Sun T, Zhu Z, Ma N, Garcia M, Stiles CD, Rowitch DH (2002) Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection. Cell 109:75-86
    • (2002) Cell , vol.109 , pp. 75-86
    • Lu, Q.R.1    Sun, T.2    Zhu, Z.3    Ma, N.4    Garcia, M.5    Stiles, C.D.6    Rowitch, D.H.7
  • 37
    • 34147114722 scopus 로고    scopus 로고
    • The neuronal channel NALCN contributes resting sodium permeability and is required for normal respiratory rhythm
    • 17448995 10.1016/j.cell.2007.02.041 1:CAS:528:DC%2BD2sXlsVWls7Y%3D
    • Lu B, Su Y, Das S, Liu J, Xia J, Ren D (2007) The neuronal channel NALCN contributes resting sodium permeability and is required for normal respiratory rhythm. Cell 129:371-383
    • (2007) Cell , vol.129 , pp. 371-383
    • Lu, B.1    Su, Y.2    Das, S.3    Liu, J.4    Xia, J.5    Ren, D.6
  • 38
    • 45549097099 scopus 로고    scopus 로고
    • Inactivation of gadd45a sensitizes epithelial cancer cells to ionizing radiation in vivo resulting in prolonged survival
    • 18483238 10.1158/0008-5472.CAN-07-5533 1:CAS:528:DC%2BD1cXlvVOit70%3D
    • Lu X, Yang C, Hill R, Yin C, Hollander MC, Fornace AJ Jr, Van Dyke T (2008) Inactivation of gadd45a sensitizes epithelial cancer cells to ionizing radiation in vivo resulting in prolonged survival. Cancer Res 68:3579-3583
    • (2008) Cancer Res , vol.68 , pp. 3579-3583
    • Lu, X.1    Yang, C.2    Hill, R.3    Yin, C.4    Hollander, M.C.5    Fornace, Jr.A.J.6    Van Dyke, T.7
  • 39
    • 38049144159 scopus 로고    scopus 로고
    • FA2H is responsible for the formation of 2-hydroxy galactolipids in peripheral nervous system myelin
    • 17901466 10.1194/jlr.M700400-JLR200 1:CAS:528:DC%2BD1cXktVajtg%3D%3D
    • Maldonado EN, Alderson NL, Monje PV, Wood PM, Hama H (2008) FA2H is responsible for the formation of 2-hydroxy galactolipids in peripheral nervous system myelin. J Lipid Res 49:153-161
    • (2008) J Lipid Res , vol.49 , pp. 153-161
    • Maldonado, E.N.1    Alderson, N.L.2    Monje, P.V.3    Wood, P.M.4    Hama, H.5
  • 41
    • 60049090606 scopus 로고    scopus 로고
    • Progress on potential strategies to target brain tumor stem cells
    • 18781384 10.1007/s10571-008-9310-1
    • Mao XG, Zhang X, Zhen HN (2009b) Progress on potential strategies to target brain tumor stem cells. Cell Mol Neurobiol 29:141-155
    • (2009) Cell Mol Neurobiol , vol.29 , pp. 141-155
    • Mao, X.G.1    Zhang, X.2    Zhen, H.N.3
  • 42
    • 79959728686 scopus 로고    scopus 로고
    • Overexpression of ZNF217 in glioblastoma contributes to the maintenance of glioma stem cells regulated by hypoxia-inducible factors
    • 21483406 10.1038/labinvest.2011.56 1:CAS:528:DC%2BC3MXotlCjsL0%3D
    • Mao XG, Yan M, Xue XY, Zhang X, Ren HG, Guo G, Wang P, Zhang W, Huo JL (2011) Overexpression of ZNF217 in glioblastoma contributes to the maintenance of glioma stem cells regulated by hypoxia-inducible factors. Lab Invest 91:1068-1078
    • (2011) Lab Invest , vol.91 , pp. 1068-1078
    • Mao, X.G.1    Yan, M.2    Xue, X.Y.3    Zhang, X.4    Ren, H.G.5    Guo, G.6    Wang, P.7    Zhang, W.8    Huo, J.L.9
  • 43
    • 33947305781 scopus 로고    scopus 로고
    • ARACNE: An algorithm for the reconstruction of gene regulatory networks in a mammalian cellular context
    • 16723010 10.1186/1471-2105-7-S1-S7
    • Margolin AA, Nemenman I, Basso K, Wiggins C, Stolovitzky G, Dalla Favera R, Califano A (2006) ARACNE: an algorithm for the reconstruction of gene regulatory networks in a mammalian cellular context. BMC Bioinformatics 7(Suppl 1):S7
    • (2006) BMC Bioinformatics , vol.7 , Issue.SUPPL. 1 , pp. 7
    • Margolin, A.A.1    Nemenman, I.2    Basso, K.3    Wiggins, C.4    Stolovitzky, G.5    Dalla Favera, R.6    Califano, A.7
  • 44
    • 77949421679 scopus 로고    scopus 로고
    • Role of the cytoplasmic domain of the L1 cell adhesion molecule in brain development
    • 20127821 10.1002/cne.22267 1:CAS:528:DC%2BC3cXivVentL4%3D
    • Nakamura Y, Lee S, Haddox CL, Weaver EJ, Lemmon VP (2010) Role of the cytoplasmic domain of the L1 cell adhesion molecule in brain development. J Comp Neurol 518:1113-1132
    • (2010) J Comp Neurol , vol.518 , pp. 1113-1132
    • Nakamura, Y.1    Lee, S.2    Haddox, C.L.3    Weaver, E.J.4    Lemmon, V.P.5
  • 47
    • 67650741664 scopus 로고    scopus 로고
    • Cell types to order: Temporal specification of CNS stem cells
    • 19427192 10.1016/j.conb.2009.04.003 1:CAS:528:DC%2BD1MXptVGktLw%3D
    • Okano H, Temple S (2009) Cell types to order: temporal specification of CNS stem cells. Curr Opin Neurobiol 19:112-119
    • (2009) Curr Opin Neurobiol , vol.19 , pp. 112-119
    • Okano, H.1    Temple, S.2
  • 48
    • 34250360278 scopus 로고    scopus 로고
    • Amplification of zinc finger gene 217 (ZNF217) and cancer: When good fingers go bad
    • 17572303 1:CAS:528:DC%2BD2sXmsFKmtbo%3D
    • Quinlan KG, Verger A, Yaswen P, Crossley M (2007) Amplification of zinc finger gene 217 (ZNF217) and cancer: when good fingers go bad. Biochim Biophys Acta 1775:333-340
    • (2007) Biochim Biophys Acta , vol.1775 , pp. 333-340
    • Quinlan, K.G.1    Verger, A.2    Yaswen, P.3    Crossley, M.4
  • 49
    • 65549104473 scopus 로고    scopus 로고
    • Quantitative analysis of mitotic Olig2 cells in adult human brain and gliomas: Implications for glioma histogenesis and biology
    • 18837053 10.1002/glia.20780
    • Rhee W, Ray S, Yokoo H, Hoane ME, Lee CC, Mikheev AM, Horner PJ, Rostomily RC (2009) Quantitative analysis of mitotic Olig2 cells in adult human brain and gliomas: implications for glioma histogenesis and biology. Glia 57:510-523
    • (2009) Glia , vol.57 , pp. 510-523
    • Rhee, W.1    Ray, S.2    Yokoo, H.3    Hoane, M.E.4    Lee, C.C.5    Mikheev, A.M.6    Horner, P.J.7    Rostomily, R.C.8
  • 50
    • 77952092774 scopus 로고    scopus 로고
    • Stable expression of neurogenin 1 induces LGR5, a novel stem cell marker, in an immortalized human neural stem cell line HB1.F3
    • 19813087 10.1007/s10571-009-9466-3
    • Satoh JI, Obayashi S, Tabunoki H, Wakana T, Kim SU (2009) Stable expression of neurogenin 1 induces LGR5, a novel stem cell marker, in an immortalized human neural stem cell line HB1.F3. Cell Mol Neurobiol 30:415-426
    • (2009) Cell Mol Neurobiol , vol.30 , pp. 415-426
    • Satoh, J.I.1    Obayashi, S.2    Tabunoki, H.3    Wakana, T.4    Kim, S.U.5
  • 52
    • 65649123826 scopus 로고    scopus 로고
    • IRF4: Immunity. Malignancy! Therapy?
    • 19383829 10.1158/1078-0432.CCR-08-1845 1:CAS:528:DC%2BD1MXltFOrt7k%3D
    • Shaffer AL, Emre NC, Romesser PB, Staudt LM (2009) IRF4: Immunity. Malignancy! Therapy? Clin Cancer Res 15:2954-2961
    • (2009) Clin Cancer Res , vol.15 , pp. 2954-2961
    • Shaffer, A.L.1    Emre, N.C.2    Romesser, P.B.3    Staudt, L.M.4
  • 53
    • 0242490780 scopus 로고    scopus 로고
    • Cytoscape: A software environment for integrated models of biomolecular interaction networks
    • 14597658 10.1101/gr.1239303 1:CAS:528:DC%2BD3sXovFWrtr4%3D
    • Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B, Ideker T (2003) Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res 13:2498-2504
    • (2003) Genome Res , vol.13 , pp. 2498-2504
    • Shannon, P.1    Markiel, A.2    Ozier, O.3    Baliga, N.S.4    Wang, J.T.5    Ramage, D.6    Amin, N.7    Schwikowski, B.8    Ideker, T.9
  • 57
    • 65349115320 scopus 로고    scopus 로고
    • SSEA-1 is an enrichment marker for tumor-initiating cells in human glioblastoma
    • 19427293 10.1016/j.stem.2009.03.003 1:CAS:528:DC%2BD1MXlvVGjtLc%3D
    • Son MJ, Woolard K, Nam DH, Lee J, Fine HA (2009) SSEA-1 is an enrichment marker for tumor-initiating cells in human glioblastoma. Cell Stem Cell 4:440-452
    • (2009) Cell Stem Cell , vol.4 , pp. 440-452
    • Son, M.J.1    Woolard, K.2    Nam, D.H.3    Lee, J.4    Fine, H.A.5
  • 59
    • 51349161304 scopus 로고    scopus 로고
    • G-protein-coupled receptor GPR49 is up-regulated in basal cell carcinoma and promotes cell proliferation and tumor formation
    • 18688030 10.2353/ajpath.2008.071091 1:CAS:528:DC%2BD1cXhtFCitL7F
    • Tanese K, Fukuma M, Yamada T, Mori T, Yoshikawa T, Watanabe W, Ishiko A, Amagai M, Nishikawa T, Sakamoto M (2008) G-protein-coupled receptor GPR49 is up-regulated in basal cell carcinoma and promotes cell proliferation and tumor formation. Am J Pathol 173:835-843
    • (2008) Am J Pathol , vol.173 , pp. 835-843
    • Tanese, K.1    Fukuma, M.2    Yamada, T.3    Mori, T.4    Yoshikawa, T.5    Watanabe, W.6    Ishiko, A.7    Amagai, M.8    Nishikawa, T.9    Sakamoto, M.10
  • 60
    • 23044488232 scopus 로고    scopus 로고
    • Oncogenic transformation by SEI-1 is associated with chromosomal instability
    • 16061626 10.1158/0008-5472.CAN-05-0351 1:CAS:528:DC%2BD2MXmvFSlsbo%3D
    • Tang DJ, Hu L, Xie D, Wu QL, Fang Y, Zeng Y, Sham JS, Guan XY (2005) Oncogenic transformation by SEI-1 is associated with chromosomal instability. Cancer Res 65:6504-6508
    • (2005) Cancer Res , vol.65 , pp. 6504-6508
    • Tang, D.J.1    Hu, L.2    Xie, D.3    Wu, Q.L.4    Fang, Y.5    Zeng, Y.6    Sham, J.S.7    Guan, X.Y.8
  • 61
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • TCGA 10.1038/nature07385
    • TCGA (2008) Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455:1061-1068
    • (2008) Nature , vol.455 , pp. 1061-1068
  • 63
    • 79960885004 scopus 로고    scopus 로고
    • LGR5 is a negative regulator of tumourigenicity, antagonizes Wnt signalling and regulates cell adhesion in colorectal cancer cell lines
    • 21829496 10.1371/journal.pone.0022733 1:CAS:528:DC%2BC3MXhtVyks7nN
    • Walker F, Zhang HH, Odorizzi A, Burgess AW (2011) LGR5 is a negative regulator of tumourigenicity, antagonizes Wnt signalling and regulates cell adhesion in colorectal cancer cell lines. PLoS ONE 6:e22733
    • (2011) PLoS ONE , vol.6 , pp. 22733
    • Walker, F.1    Zhang, H.H.2    Odorizzi, A.3    Burgess, A.W.4
  • 64
    • 77957348924 scopus 로고    scopus 로고
    • The thyroid hormone receptor alpha1 protein is expressed in embryonic postmitotic neurons and persists in most adult neurons
    • 20739404 10.1210/me.2010-0175 1:CAS:528:DC%2BC3cXhtlCktbrL
    • Wallis K, Dudazy S, van Hogerlinden M, Nordstrom K, Mittag J, Vennstrom B (2010) The thyroid hormone receptor alpha1 protein is expressed in embryonic postmitotic neurons and persists in most adult neurons. Mol Endocrinol 24:1904-1916
    • (2010) Mol Endocrinol , vol.24 , pp. 1904-1916
    • Wallis, K.1    Dudazy, S.2    Van Hogerlinden, M.3    Nordstrom, K.4    Mittag, J.5    Vennstrom, B.6
  • 65
    • 65649142176 scopus 로고    scopus 로고
    • Expression of mutant p53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine model
    • 19477430 10.1016/j.ccr.2009.04.001 1:CAS:528:DC%2BD1MXntlegtbs%3D
    • Wang Y, Yang J, Zheng H, Tomasek GJ, Zhang P, McKeever PE, Lee EY, Zhu Y (2009) Expression of mutant p53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine model. Cancer Cell 15:514-526
    • (2009) Cancer Cell , vol.15 , pp. 514-526
    • Wang, Y.1    Yang, J.2    Zheng, H.3    Tomasek, G.J.4    Zhang, P.5    McKeever, P.E.6    Lee, E.Y.7    Zhu, Y.8
  • 66
    • 0035847575 scopus 로고    scopus 로고
    • Coordinated expression of Hoxa2, Hoxd1 and Pax6 in the developing diencephalon
    • 11209945 10.1097/00001756-200102120-00030 1:CAS:528:DC%2BD3MXhtFKgs70%3D
    • Wolf LV, Yeung JM, Doucette JR, Nazarali AJ (2001) Coordinated expression of Hoxa2, Hoxd1 and Pax6 in the developing diencephalon. NeuroReport 12:329-333
    • (2001) NeuroReport , vol.12 , pp. 329-333
    • Wolf, L.V.1    Yeung, J.M.2    Doucette, J.R.3    Nazarali, A.J.4
  • 67
    • 77950461380 scopus 로고    scopus 로고
    • Identification of the role of Smad interacting protein 1 (SIP1) in glioma
    • 19806322 10.1007/s11060-009-0015-1 1:CAS:528:DC%2BC3cXjtFygsLs%3D
    • Xia M, Hu M, Wang J, Xu Y, Chen X, Ma Y, Su L (2010) Identification of the role of Smad interacting protein 1 (SIP1) in glioma. J Neurooncol 97:225-232
    • (2010) J Neurooncol , vol.97 , pp. 225-232
    • Xia, M.1    Hu, M.2    Wang, J.3    Xu, Y.4    Chen, X.5    Ma, Y.6    Su, L.7
  • 68
    • 0037369658 scopus 로고    scopus 로고
    • Overexpression of orphan G-protein-coupled receptor, Gpr49, in human hepatocellular carcinomas with beta-catenin mutations
    • 12601349 10.1053/jhep.2003.50029 1:CAS:528:DC%2BD3sXit1ylsb0%3D
    • Yamamoto Y, Sakamoto M, Fujii G, Tsuiji H, Kenetaka K, Asaka M, Hirohashi S (2003) Overexpression of orphan G-protein-coupled receptor, Gpr49, in human hepatocellular carcinomas with beta-catenin mutations. Hepatology 37:528-533
    • (2003) Hepatology , vol.37 , pp. 528-533
    • Yamamoto, Y.1    Sakamoto, M.2    Fujii, G.3    Tsuiji, H.4    Kenetaka, K.5    Asaka, M.6    Hirohashi, S.7
  • 69
    • 34247511439 scopus 로고    scopus 로고
    • Gadd45a, the gene induced by the mood stabilizer valproic acid, regulates neurite outgrowth through JNK and the substrate paxillin in N1E-115 neuroblastoma cells
    • 17428471 10.1016/j.yexcr.2007.02.019 1:CAS:528:DC%2BD2sXkslOiur0%3D
    • Yamauchi J, Miyamoto Y, Murabe M, Fujiwara Y, Sanbe A, Fujita Y, Murase S, Tanoue A (2007) Gadd45a, the gene induced by the mood stabilizer valproic acid, regulates neurite outgrowth through JNK and the substrate paxillin in N1E-115 neuroblastoma cells. Exp Cell Res 313:1886-1896
    • (2007) Exp Cell Res , vol.313 , pp. 1886-1896
    • Yamauchi, J.1    Miyamoto, Y.2    Murabe, M.3    Fujiwara, Y.4    Sanbe, A.5    Fujita, Y.6    Murase, S.7    Tanoue, A.8
  • 70
    • 0037057668 scopus 로고    scopus 로고
    • SATB1 targets chromatin remodelling to regulate genes over long distances
    • 12374985 10.1038/nature01084 1:CAS:528:DC%2BD38Xns1Ont74%3D
    • Yasui D, Miyano M, Cai S, Varga-Weisz P, Kohwi-Shigematsu T (2002) SATB1 targets chromatin remodelling to regulate genes over long distances. Nature 419:641-645
    • (2002) Nature , vol.419 , pp. 641-645
    • Yasui, D.1    Miyano, M.2    Cai, S.3    Varga-Weisz, P.4    Kohwi-Shigematsu, T.5
  • 71
    • 52049107819 scopus 로고    scopus 로고
    • Zebrafish orthologue of mental retardation protein IL1RAPL1 regulates presynaptic differentiation
    • 18657618 10.1016/j.mcn.2008.06.013 1:CAS:528:DC%2BD1cXhtFCnsr%2FF
    • Yoshida T, Mishina M (2008) Zebrafish orthologue of mental retardation protein IL1RAPL1 regulates presynaptic differentiation. Mol Cell Neurosci 39:218-228
    • (2008) Mol Cell Neurosci , vol.39 , pp. 218-228
    • Yoshida, T.1    Mishina, M.2
  • 72
    • 16644384244 scopus 로고    scopus 로고
    • IL1RAPL1 is associated with mental retardation in patients with complex glycerol kinase deficiency who have deletions extending telomeric of DAX1
    • 15300857 10.1002/humu.9269
    • Zhang YH, Huang BL, Niakan KK, McCabe LL, McCabe ER, Dipple KM (2004) IL1RAPL1 is associated with mental retardation in patients with complex glycerol kinase deficiency who have deletions extending telomeric of DAX1. Hum Mutat 24:273
    • (2004) Hum Mutat , vol.24 , pp. 273
    • Zhang, Y.H.1    Huang, B.L.2    Niakan, K.K.3    McCabe, L.L.4    McCabe, E.R.5    Dipple, K.M.6
  • 73
    • 0037023492 scopus 로고    scopus 로고
    • The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification
    • 11955447 10.1016/S0092-8674(02)00677-3 1:CAS:528:DC%2BD38XjtVOntL8%3D
    • Zhou Q, Anderson DJ (2002) The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification. Cell 109:61-73
    • (2002) Cell , vol.109 , pp. 61-73
    • Zhou, Q.1    Anderson, D.J.2
  • 74
    • 55749103552 scopus 로고    scopus 로고
    • Absence of 2-hydroxylated sphingolipids is compatible with normal neural development but causes late-onset axon and myelin sheath degeneration
    • 18815260 10.1523/JNEUROSCI.0458-08.2008
    • Zoller I, Meixner M, Hartmann D, Bussow H, Meyer R, Gieselmann V, Eckhardt M (2008) Absence of 2-hydroxylated sphingolipids is compatible with normal neural development but causes late-onset axon and myelin sheath degeneration. J Neurosci 28:9741-9754
    • (2008) J Neurosci , vol.28 , pp. 9741-9754
    • Zoller, I.1    Meixner, M.2    Hartmann, D.3    Bussow, H.4    Meyer, R.5    Gieselmann, V.6    Eckhardt, M.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.