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Volumn 289, Issue 12, 2014, Pages 8067-8085

p75 neurotrophin receptor cleavage by α- and γ-secretases is required for neurotrophin-mediated proliferation of brain tumor-initiating cells

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; BRAIN; TUMORS;

EID: 84896992005     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.513762     Document Type: Article
Times cited : (55)

References (106)
  • 3
    • 0035256772 scopus 로고    scopus 로고
    • Gliomagenesis: Genetic alterations and mouse models
    • Holland, E. C. (2001) Gliomagenesis: genetic alterations and mouse models. Nat. Rev. Genet. 2, 120-129
    • (2001) Nat. Rev. Genet. , vol.2 , pp. 120-129
    • Holland, E.C.1
  • 4
    • 65349121788 scopus 로고    scopus 로고
    • Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-Year analysis of the EORTC-NCIC trial
    • Stupp, R., Hegi, M. E., Mason, W. P., van den Bent, M. J., Taphoorn, M. J., and Janzer, R. C. (2009) Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet. Oncol. 10, 459-466
    • (2009) Lancet. Oncol. , vol.10 , pp. 459-466
    • Stupp, R.1    Hegi, M.E.2    Mason, W.P.3    Van Den Bent, M.J.4    Taphoorn, M.J.5    Janzer, R.C.6
  • 5
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • Cancer Genome Atlas Research Network
    • Cancer Genome Atlas Research Network (2008) Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455, 1061-1068
    • (2008) Nature , vol.455 , pp. 1061-1068
  • 6
    • 52949127312 scopus 로고    scopus 로고
    • An integrated genomic analysis of human glioblastoma multiforme
    • Parsons, D. W., Jones, S., Zhang, X., Lin, J. C., Leary, R. J., and Angenendt, P. (2008) An integrated genomic analysis of human glioblastoma multiforme. Science 321, 1807-1812
    • (2008) Science , vol.321 , pp. 1807-1812
    • Parsons, D.W.1    Jones, S.2    Zhang, X.3    Lin, J.C.4    Leary, R.J.5    Angenendt, P.6
  • 13
    • 33646358694 scopus 로고    scopus 로고
    • Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines
    • DOI 10.1016/j.ccr.2006.03.030, PII S1535610806001176
    • Lee, J., Kotliarova, S., Kotliarov, Y., Li, A., Su, Q., Donin, N. M., Pastorino, S., Purow, B. W., Christopher, N., Zhang, W., Park, J. K., and Fine, H. A. (2006) Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell 9, 391-403 (Pubitemid 43668737)
    • (2006) Cancer Cell , vol.9 , Issue.5 , pp. 391-403
    • Lee, J.1    Kotliarova, S.2    Kotliarov, Y.3    Li, A.4    Su, Q.5    Donin, N.M.6    Pastorino, S.7    Purow, B.W.8    Christopher, N.9    Zhang, W.10    Park, J.K.11    Fine, H.A.12
  • 15
    • 33845317573 scopus 로고    scopus 로고
    • Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
    • DOI 10.1038/nature05236, PII NATURE05236
    • Bao, S., Wu, Q., McLendon, R. E., Hao, Y., Shi, Q., Hjelmeland, A. B., Dewhirst, M. W., Bigner, D. D., and Rich, J. N. (2006) Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 444, 756-760 (Pubitemid 44949604)
    • (2006) Nature , vol.444 , Issue.7120 , pp. 756-760
    • Bao, S.1    Wu, Q.2    McLendon, R.E.3    Hao, Y.4    Shi, Q.5    Hjelmeland, A.B.6    Dewhirst, M.W.7    Bigner, D.D.8    Rich, J.N.9
  • 16
    • 60849117508 scopus 로고    scopus 로고
    • PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells
    • Bleau, A. M., Hambardzumyan, D., Ozawa, T., Fomchenko, E. I., Huse, J. T., Brennan, C. W., and Holland, E. C. (2009) PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells. Cell Stem Cell 4, 226-235
    • (2009) Cell Stem Cell , vol.4 , pp. 226-235
    • Bleau, A.M.1    Hambardzumyan, D.2    Ozawa, T.3    Fomchenko, E.I.4    Huse, J.T.5    Brennan, C.W.6    Holland, E.C.7
  • 17
    • 84865203983 scopus 로고    scopus 로고
    • A restricted cell population propagates glioblastoma growth after chemotherapy
    • Chen, J., Li, Y., Yu, T. S., McKay, R. M., Burns, D. K., Kernie, S. G., and Parada, L. F. (2012) A restricted cell population propagates glioblastoma growth after chemotherapy. Nature 488, 522-526
    • (2012) Nature , vol.488 , pp. 522-526
    • Chen, J.1    Li, Y.2    Yu, T.S.3    McKay, R.M.4    Burns, D.K.5    Kernie, S.G.6    Parada, L.F.7
  • 19
    • 56849085242 scopus 로고    scopus 로고
    • γ-Secretase represents a therapeutic target for the treatment of invasive glioma mediated by the p75 neurotrophin receptor
    • Wang, L., Rahn, J. J., Lun, X., Sun, B., Kelly, J. J., Weiss, S., Robbins, S. M., Forsyth, P. A., and Senger, D. L. (2008) γ-Secretase represents a therapeutic target for the treatment of invasive glioma mediated by the p75 neurotrophin receptor. PLoS Biol. 6, e289
    • (2008) PLoS Biol. , vol.6
    • Wang, L.1    Rahn, J.J.2    Lun, X.3    Sun, B.4    Kelly, J.J.5    Weiss, S.6    Robbins, S.M.7    Forsyth, P.A.8    Senger, D.L.9
  • 20
    • 0037762690 scopus 로고    scopus 로고
    • Neurotrophins and their receptors. A convergence point for many signalling pathways
    • Chao, M. V. (2003) Neurotrophins and their receptors. A convergence point for many signalling pathways. Nat. Rev. Neurosci. 4, 299-309
    • (2003) Nat. Rev. Neurosci. , vol.4 , pp. 299-309
    • Chao, M.V.1
  • 22
    • 0025165823 scopus 로고
    • Proliferation and differentiation of neuronal stem cells regulated by nerve growth factor
    • Cattaneo, E., and McKay, R. (1990) Proliferation and differentiation of neuronal stem cells regulated by nerve growth factor. Nature 347, 762-765
    • (1990) Nature , vol.347 , pp. 762-765
    • Cattaneo, E.1    McKay, R.2
  • 23
    • 0031807952 scopus 로고    scopus 로고
    • Evidence for the participation of nerve growth factor and its low- affinity receptor (p75(NTR)) in the regulation of the myogenic program
    • DOI 10.1002/(SICI)1097-4652(199807)176:1<10::A
    • Seidl, K., Erck, C., and Buchberger, A. (1998) Evidence of the participation of nerve growth factor and its low affinity receptor (p75NTR) in regulation of the myogenic program. J. Cell Physiol. 176, 10-21 (Pubitemid 28277190)
    • (1998) Journal of Cellular Physiology , vol.176 , Issue.1 , pp. 10-21
    • Seidl, K.1    Erck, C.2    Buchberger, A.3
  • 24
    • 34248361975 scopus 로고    scopus 로고
    • p75 neurotrophin receptor expression defines a population of BDNF-responsive neurogenic precursor cells
    • DOI 10.1523/JNEUROSCI.0654-07.2007
    • Young, K. M., Merson, T. D., Sotthibundhu, A., Coulson, E. J., and Bartlett, P. F. (2007) p75 neurotrophin receptor expression defines a population of BDNF responsive neurogenic precursor cells. J. Neurosci. 27, 5146-5155 (Pubitemid 46741778)
    • (2007) Journal of Neuroscience , vol.27 , Issue.19 , pp. 5146-5155
    • Young, K.M.1    Merson, T.D.2    Sotthibundhu, A.3    Coulson, E.J.4    Bartlett, P.F.5
  • 25
    • 17644388524 scopus 로고    scopus 로고
    • Cleavage of p75 neurotrophin receptor by α-secretase and γ-secretase requires specific receptor domains
    • DOI 10.1074/jbc.M412957200
    • Zampieri, N., Xu, C. F., Neubert, T. A., and Chao, M. V. (2005) Cleavage of p75 neurotrophin receptor by α-secretase and γ-secretase requires specific receptor domains. J. Biol. Chem. 280, 14563-14571 (Pubitemid 40562799)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.15 , pp. 14563-14571
    • Zampieri, N.1    Xu, C.-F.2    Neubert, T.A.3    Chao, M.V.4
  • 26
    • 33646052860 scopus 로고    scopus 로고
    • Ligand-dependent cleavage of the P75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neurons
    • Kenchappa, R. S., Zampieri, N., Chao, M. V., Barker, P. A., Teng, H. K., Hempstead, B. L., and Carter, B. D. (2006) Ligand-dependent cleavage of the P75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neurons. Neuron 50, 219-232
    • (2006) Neuron , vol.50 , pp. 219-232
    • Kenchappa, R.S.1    Zampieri, N.2    Chao, M.V.3    Barker, P.A.4    Teng, H.K.5    Hempstead, B.L.6    Carter, B.D.7
  • 27
    • 77953744202 scopus 로고    scopus 로고
    • P75NTR mediated apoptosis in sympathetic neurons involves a biphasic activation of JNK and up regulation of TACE/ADAM17
    • Kenchappa, R. S., Tep, C., Korade, Z., Urra, S., Bronfman, F. C., Yoon, S. O., and Carter, B. D. (2010) P75NTR mediated apoptosis in sympathetic neurons involves a biphasic activation of JNK and up regulation of TACE/ADAM17. J. Biol. Chem. 285, 20358-20368
    • (2010) J. Biol. Chem. , vol.285 , pp. 20358-20368
    • Kenchappa, R.S.1    Tep, C.2    Korade, Z.3    Urra, S.4    Bronfman, F.C.5    Yoon, S.O.6    Carter, B.D.7
  • 31
    • 84869884311 scopus 로고    scopus 로고
    • Neurotrophins and their receptors in breast cancer
    • Hondermarck, H. (2012) Neurotrophins and their receptors in breast cancer. Cytokine Growth Factor Rev. 23, 357-365
    • (2012) Cytokine Growth Factor Rev. , vol.23 , pp. 357-365
    • Hondermarck, H.1
  • 32
    • 0026264892 scopus 로고
    • The MTT-assay as a rapid test for cell proliferation and cell killing: Application to human peripheral blood lymphocytes (PBL)
    • Weichert, H., Blechschmidt, I., Schroder, S., and Ambrosius, H. (1991) The MTT-assay as a rapid test for cell proliferation and cell killing: application to human peripheral blood lymphocytes (PBL). Allerg. Immunol. (Leipz.) 37, 139-144
    • (1991) Allerg. Immunol. (Leipz.) , vol.37 , pp. 139-144
    • Weichert, H.1    Blechschmidt, I.2    Schroder, S.3    Ambrosius, H.4
  • 33
    • 84876323870 scopus 로고    scopus 로고
    • Tyrosine 23 phosphorylation of annexin A2 promotes proliferation, invasion, and Stat3 phosphorylation in the nucleus of human breast cancer SK-BR-3 cells
    • Wang, Y. Q., Zhang, F., Tian, R., Ji, W., Zhou, Y., Sun, X. M., Liu, Y., Wang, Z. Y., and Niu, R. F. (2012) Tyrosine 23 phosphorylation of annexin A2 promotes proliferation, invasion, and Stat3 phosphorylation in the nucleus of human breast cancer SK-BR-3 cells. Cancer Biol. Med. 9, 248-253
    • (2012) Cancer Biol. Med. , vol.9 , pp. 248-253
    • Wang, Y.Q.1    Zhang, F.2    Tian, R.3    Ji, W.4    Zhou, Y.5    Sun, X.M.6    Liu, Y.7    Wang, Z.Y.8    Niu, R.F.9
  • 34
    • 0027361196 scopus 로고
    • The cell proliferation-associated antigen of antibody Ki-67: A very large, ubiquitous nuclear protein with numerous repeated elements, representing a new kind of cell cycle-maintaining proteins
    • DOI 10.1083/jcb.123.3.513
    • Schlüter, C., Duchrow, M., Wohlenberg, C., Becker, M. H., Key, G., Flad, H. D., and Gerdes, J. (1993) The cell proliferation-associated antigen Ki-67: a very large, ubiquitous nuclear protein with numerous repeated elements, representing a new kind of cell cycle-maintaining proteins. J. Cell Biol. 123, 513-522 (Pubitemid 23324910)
    • (1993) Journal of Cell Biology , vol.123 , Issue.3 , pp. 513-522
    • Schluter, C.1    Duchrow, M.2    Wohlenberg, C.3    Becker, M.H.G.4    Key, G.5    Flad, H.D.6    Gerdes, J.7
  • 36
    • 0025774207 scopus 로고
    • High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor
    • Hempstead, B. L., Martin-Zanca, D., Kaplan, D. R., Parada, L. F., and Chao, M. V. (1991) High affinity NGF binding requires co-expression of the trk proto-oncogene and the low-affinity NGF receptor. Nature 350, 678-683 (Pubitemid 21912292)
    • (1991) Nature , vol.350 , Issue.6320 , pp. 678-683
    • Hempstead, B.L.1    Martin-Zanca, D.2    Kaplan, D.R.3    Parada, L.F.4    Chao, M.V.5
  • 37
    • 0027966170 scopus 로고
    • Disruption of NGF binding to the low affinity neurotrophin receptor p75LNTR reduces NGF binding to TrkA in PC12 cells
    • Barker, P. A., and Shooter, E. M. (1994) Disruption of NGF binding to the low affinity neurotrophin receptor p75LNTR reduces NGF binding to TrkA in PC12 cells. Neuron 13, 203-215
    • (1994) Neuron , vol.13 , pp. 203-215
    • Barker, P.A.1    Shooter, E.M.2
  • 38
    • 1942487757 scopus 로고    scopus 로고
    • The p75 neurotrophin receptor enhances TrkA signalling by binding to Shc and augmenting its phosphorylation
    • DOI 10.1111/j.1471-4159.2004.02344.x
    • Epa, W. R., Markovska, K., and Barrett, G. L. (2004) The p75 neurotrophin receptor enhances TrkA signaling by binding to Shc and augmenting its phosphorylation. J. Neurochem. 89, 344-353 (Pubitemid 38495983)
    • (2004) Journal of Neurochemistry , vol.89 , Issue.2 , pp. 344-353
    • Epa, W.R.1    Markovska, K.2    Barrett, G.L.3
  • 39
    • 84896983676 scopus 로고    scopus 로고
    • A neurotrophin signaling cascade coordinates sympathetic neuron development through differential control of TrkA trafficking and retrograde signaling
    • Kuruvilla, R., Zweifel, L. S., and Glebova, N. O., Lonze, B. E., Valdez, G., Ye, H., Ginty, D. D. (2004) A neurotrophin signaling cascade coordinates sympathetic neuron development through differential control of TrkA trafficking and retrograde signaling. Cell 39, 57-68
    • (2004) Cell , vol.39 , pp. 57-68
    • Kuruvilla, R.1    Zweifel, L.S.2    Glebova, N.O.3    Lonze, B.E.4    Valdez, G.5    Ye, H.6    Ginty, D.D.7
  • 41
    • 0035882380 scopus 로고    scopus 로고
    • A prosurvival function for the p75 receptor death domain mediated via the caspase recruitment domain receptor-interacting protein 2
    • Khursigara, G., Bertin, J., Yano, H., Moffett, H., DiStefano, P. S., and Chao, M. V. (2001) A prosurvival function for the p75 receptor death domain mediated via the caspase recruitment domain receptor-interacting protein 2. J. Neurosci. 21, 5854-5863 (Pubitemid 32737718)
    • (2001) Journal of Neuroscience , vol.21 , Issue.16 , pp. 5854-5863
    • Khursigara, G.1    Bertin, J.2    Yano, H.3    Moffett, H.4    DiStefano, P.S.5    Chao, M.V.6
  • 42
    • 0033613831 scopus 로고    scopus 로고
    • Association of the p75 neurotrophin receptor with TRAF6
    • DOI 10.1074/jbc.274.5.2597
    • Khursigara, G., Orlinick, J. R., and Chao, M. V. (1999) Association of the p75 neurotrophin receptor with TRAF6. J. Biol. Chem. 274, 2597-2600 (Pubitemid 29075333)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.5 , pp. 2597-2600
    • Khursigara, G.1    Orlinick, J.R.2    Chao, M.V.3
  • 43
    • 0025220956 scopus 로고
    • Regulation of Schwann cell surface and truncated nerve growth factor receptors in vitro by axonal components
    • DiStefano, P. S., and Chelsea, D. M. (1990) Regulation of Schwann cell surface and truncated nerve growth factor receptors in vitro by axonal components. Brain Res. 534, 340-344
    • (1990) Brain Res. , vol.534 , pp. 340-344
    • DiStefano, P.S.1    Chelsea, D.M.2
  • 44
    • 0027281156 scopus 로고
    • Involvement of a metalloprotease in low-affinity nerve growth factor receptor truncation: Inhibition of truncation in vitro and in vivo
    • DiStefano, P. S., Chelsea, D. M., Schick, C. M., and McKelvy, J. F. (1993) Involvement of a metalloprotease in low-affinity nerve growth factor receptor truncation: inhibition of truncation in vitro and in vivo. J. Neurosci. 13, 2405-2414 (Pubitemid 23151757)
    • (1993) Journal of Neuroscience , vol.13 , Issue.6 , pp. 2405-2414
    • DiStefano, P.S.1    Chelsea, D.M.2    Schick, C.M.3    McKelvy, J.F.4
  • 46
    • 79957926130 scopus 로고    scopus 로고
    • Trk-dependent ADAM17 activation facilitates neurotrophin survival signaling
    • Kommaddi, R. P., Thomas, R., Ceni, C., Daigneault, K., and Barker, P. A. (2011) Trk-dependent ADAM17 activation facilitates neurotrophin survival signaling. FASEB J. 25, 2061-2070
    • (2011) FASEB J. , vol.25 , pp. 2061-2070
    • Kommaddi, R.P.1    Thomas, R.2    Ceni, C.3    Daigneault, K.4    Barker, P.A.5
  • 47
    • 0038045714 scopus 로고    scopus 로고
    • Proteolytic processing of the p75 neurotrophin receptor and two homologs generates C-terminal fragments with signaling capability
    • Kanning, K. C., Hudson, M., Amieux, P. S., Wiley, J. C., Bothwell, M., and Schecterson, L. C. (2003) Proteolytic processing of the p75 neurotrophin receptor and two homologs generates C-terminal fragments with signaling capability. J. Neurosci. 23, 5425-5436 (Pubitemid 36807816)
    • (2003) Journal of Neuroscience , vol.23 , Issue.13 , pp. 5425-5436
    • Kanning, K.C.1    Hudson, M.2    Amieux, P.S.3    Wiley, J.C.4    Bothwell, M.5    Schecterson, L.C.6
  • 49
    • 20444365447 scopus 로고    scopus 로고
    • MAG induces regulated intramembrane proteolysis of the p75 neurotrophin receptor to inhibit neurite outgrowth
    • DOI 10.1016/j.neuron.2005.05.029, PII S0896627305004769
    • Domeniconi, M., Zampieri, N., Spencer, T., Hilaire, M., Mellado, W., Chao, M. V., and Filbin, M. T. (2005)MAGinduces regulated intramembrane proteolysis of the p75 neurotrophin receptor to inhibit neurite outgrowth. Neuron 46, 849-855 (Pubitemid 40805346)
    • (2005) Neuron , vol.46 , Issue.6 , pp. 849-855
    • Domeniconi, M.1    Zampieri, N.2    Spencer, T.3    Hilaire, M.4    Mellado, W.5    Chao, M.V.6    Filbin, M.T.7
  • 50
    • 77954367715 scopus 로고    scopus 로고
    • The p75NTR intracellular domain generated by neurotrophin-induced receptor cleavage potentiates Trk signaling
    • Ceni, C., Kommaddi, R. P., Thomas, R., Vereker, E., Liu, X., McPherson, P. S., Ritter, B., and Barker, P. A. (2010) The p75NTR intracellular domain generated by neurotrophin-induced receptor cleavage potentiates Trk signaling. J. Cell Sci. 123, 2299-2307
    • (2010) J. Cell Sci. , vol.123 , pp. 2299-2307
    • Ceni, C.1    Kommaddi, R.P.2    Thomas, R.3    Vereker, E.4    Liu, X.5    McPherson, P.S.6    Ritter, B.7    Barker, P.A.8
  • 51
    • 79960171677 scopus 로고    scopus 로고
    • p75(NTR) expression and nuclear localization of p75(NTR) intracellular domain in spiral ganglion Schwann cells following deafness correlate with cell proliferation
    • Provenzano, M. J., Minner, S. A., Zander, K., Clark, J. J., Kane, C. J., Green, S. H., and Hansen, M. R. (2011) p75(NTR) expression and nuclear localization of p75(NTR) intracellular domain in spiral ganglion Schwann cells following deafness correlate with cell proliferation. Mol. Cell Neurosci. 47, 306-315
    • (2011) Mol. Cell Neurosci. , vol.47 , pp. 306-315
    • Provenzano, M.J.1    Minner, S.A.2    Zander, K.3    Clark, J.J.4    Kane, C.J.5    Green, S.H.6    Hansen, M.R.7
  • 52
    • 77949322236 scopus 로고    scopus 로고
    • Nuclear localization of the p75 neurotrophin receptor intracellular domain
    • Parkhurst, C. N., Zampieri, N., and Chao, M. V. (2010) Nuclear localization of the p75 neurotrophin receptor intracellular domain. J. Biol. Chem. 285, 5361-5368
    • (2010) J. Biol. Chem. , vol.285 , pp. 5361-5368
    • Parkhurst, C.N.1    Zampieri, N.2    Chao, M.V.3
  • 53
    • 79953045754 scopus 로고    scopus 로고
    • TGF-β1 promotes motility and invasiveness of glioma cells through activation of ADAM17
    • Lu, Y., Jiang, F., Zheng, X., Katakowski, M., Buller, B., To, S. S., and Chopp, M. (2011) TGF-β1 promotes motility and invasiveness of glioma cells through activation of ADAM17. Oncol. Rep. 25, 1329-1335
    • (2011) Oncol. Rep. , vol.25 , pp. 1329-1335
    • Lu, Y.1    Jiang, F.2    Zheng, X.3    Katakowski, M.4    Buller, B.5    To, S.S.6    Chopp, M.7
  • 54
    • 67649095267 scopus 로고    scopus 로고
    • ADAM17 promotes breast cancer cell malignant phenotype through EGFR-PI3K-AKT activation
    • Zheng, X., Jiang, F., Katakowski, M., Zhang, Z. G., Lu, Q. E., and Chopp, M. (2009) ADAM17 promotes breast cancer cell malignant phenotype through EGFR-PI3K-AKT activation. Cancer Biol. Ther. 8, 1045-1054
    • (2009) Cancer Biol. Ther. , vol.8 , pp. 1045-1054
    • Zheng, X.1    Jiang, F.2    Katakowski, M.3    Zhang, Z.G.4    Lu, Q.E.5    Chopp, M.6
  • 55
    • 0036727125 scopus 로고    scopus 로고
    • γ-Secretase mediated proteolysis in cell-surface-receptor signaling
    • Fortini, M. E. (2002) γ-Secretase mediated proteolysis in cell-surface-receptor signaling. Nat. Rev. Mol. Cell Biol. 3, 673-684
    • (2002) Nat. Rev. Mol. Cell Biol. , vol.3 , pp. 673-684
    • Fortini, M.E.1
  • 56
    • 34147179336 scopus 로고    scopus 로고
    • TrkA receptor activation by nerve growth factor induces shedding of the p75 neurotrophin receptor followed by endosomal γ-secretase-mediated release of the p75 intracellular domain
    • DOI 10.1074/jbc.M610458200
    • Urra, S., Escudero, C. A., Ramos, P., Lisbona, F., Allende, E., Covarrubias, P., Parraguez, J. I., Zampieri, N., Chao, M. V., Annaert, W., and Bronfman, F. C. (2007) TrkA receptor activation by nerve growth factor induces shedding of the p75 neurotrophin receptor followed by endosomal γ-secretase-mediated release of the p75 intracellular domain. J. Biol. Chem. 282, 7606-7615 (Pubitemid 47093700)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.10 , pp. 7606-7615
    • Urra, S.1    Escudero, C.A.2    Ramos, P.3    Lisbona, F.4    Allende, E.5    Covarrubias, P.6    Parraguez, J.I.7    Zampieri, N.8    Chao, M.V.9    Annaert, W.10    Bronfman, F.C.11
  • 57
    • 0035933783 scopus 로고    scopus 로고
    • The p75 neurotrophin receptor activates Akt (protein kinase B) through a phosphatidylinositol 3-kinase-dependent pathway
    • Roux, P. P., Bhakar, A. L., Kennedy, T. E., and Barker, P. A. (2001) The p75 neurotrophin receptor activates Akt (protein kinase B) through a phosphatidylinositol 3-kinase-dependent pathway. J. Biol. Chem. 276, 23097-24104
    • (2001) J. Biol. Chem. , vol.276 , pp. 23097-24104
    • Roux, P.P.1    Bhakar, A.L.2    Kennedy, T.E.3    Barker, P.A.4
  • 60
    • 84880671154 scopus 로고    scopus 로고
    • Pro-BDNF and its receptors are upregulated in glioma and inhibit the growth of glioma cells in vitro
    • Xiong, J., Zhou, L., Yang, M., Lim, Y., Zhu, Y. H., Fu, D. L., Li, Z. W., Zhong, J. H., Xiao, Z. C., and Zhou, X. F. (2013) Pro-BDNF and its receptors are upregulated in glioma and inhibit the growth of glioma cells in vitro. Neuro. Oncol. 15, 990-1007
    • (2013) Neuro. Oncol. , vol.15 , pp. 990-1007
    • Xiong, J.1    Zhou, L.2    Yang, M.3    Lim, Y.4    Zhu, Y.H.5    Fu, D.L.6    Li, Z.W.7    Zhong, J.H.8    Xiao, Z.C.9    Zhou, X.F.10
  • 61
    • 80555135912 scopus 로고    scopus 로고
    • Oxygen-dependent cleavage of the p75 neurotrophin receptor triggers stabilization of HIF-1α
    • Le Moan, N., Houslay, D. M., Christian, F., Houslay, M. D., and Akassoglou, K. (2011) Oxygen-dependent cleavage of the p75 neurotrophin receptor triggers stabilization of HIF-1α. Mol. Cell 44, 476-490
    • (2011) Mol. Cell , vol.44 , pp. 476-490
    • Le Moan, N.1    Houslay, D.M.2    Christian, F.3    Houslay, M.D.4    Akassoglou, K.5
  • 63
    • 33646694787 scopus 로고    scopus 로고
    • Brain tumor stem cells
    • DOI 10.1203/01.pdr.0000203568.63482.f9, PII 0000645020060400100009
    • Nakano, I., and Kornblum, H. I. (2006) Brain tumor stem cells. Pediatr. Res. 59, 54R-8R (Pubitemid 43740036)
    • (2006) Pediatric Research , vol.59 , Issue.4 PART 2
    • Nakano, I.1    Kornblum, H.I.2
  • 64
    • 0027132080 scopus 로고
    • Mediation of NGF-stimulated extracellular matrix invasion by the human melanoma low-affinity p75 neurotrophin receptor: Melanoma p75 functions independently of trkA
    • Herrmann, J. L., Menter, D. G., Hamada, J., Marchetti, D., Nakajima, M., and Nicolson, G. L. (1993) Mediation of NGF-stimulated extracellular matrix invasion by the human melanoma low-affinity p75 neurotrophin receptor: melanoma p75 functions independently of trkA. Mol. Biol. Cell 4, 1205-1216 (Pubitemid 24007581)
    • (1993) Molecular Biology of the Cell , vol.4 , Issue.11 , pp. 1205-1216
    • Herrmann, J.L.1    Menter, D.G.2    Hamada, J.-I.3    Marchetti, D.4    Nakajima, M.5    Nicolson, G.L.6
  • 66
    • 3242803059 scopus 로고    scopus 로고
    • p75 neurotrophin receptor functions as a survival receptor in brain-metastatic melanoma cells
    • Marchetti, D., Aucoin, R., Blust, J., Murry, B., and Greiter-Wilke, A. (2004) p75 neurotrophin receptor functions as a survival receptor in brain-metastatic melanoma cells. J. Cell Biochem. 91, 206-215
    • (2004) J. Cell Biochem. , vol.91 , pp. 206-215
    • Marchetti, D.1    Aucoin, R.2    Blust, J.3    Murry, B.4    Greiter-Wilke, A.5
  • 67
    • 32344450355 scopus 로고    scopus 로고
    • NTR tumor suppressor induces cell cycle arrest facilitating caspase mediated apoptosis in prostate tumor cells
    • DOI 10.1016/j.bbrc.2006.01.073, PII S0006291X06001598
    • Khwaja, F., Tabassum, A., Allen, J., and Djakiew, D. (2006) The p75(NTR) tumor suppressor induces cell cycle arrest facilitating caspase mediated apoptosis in prostate tumor cells. Biochem. Biophys. Res. Commun. 341, 1184-1192 (Pubitemid 43221790)
    • (2006) Biochemical and Biophysical Research Communications , vol.341 , Issue.4 , pp. 1184-1192
    • Khwaja, F.1    Tabassum, A.2    Allen, J.3    Djakiew, D.4
  • 68
    • 0037457654 scopus 로고    scopus 로고
    • NTR tumor suppressor induces caspase-mediated apoptosis in bladder tumor cells
    • DOI 10.1002/ijc.11038
    • Tabassum, A., Khwaja, F., and Djakiew, D. (2003) The p75(NTR) tumor suppressor induces caspase-mediated apoptosis in bladder tumor cells. Int. J. Cancer 105, 47-52 (Pubitemid 36418484)
    • (2003) International Journal of Cancer , vol.105 , Issue.1 , pp. 47-52
    • Tabassum, A.1    Khwaja, F.2    Djakiew, D.3
  • 69
    • 34250839385 scopus 로고    scopus 로고
    • p75 neurotrophin receptor suppresses the proliferation of human gastric cancer cells
    • DOI 10.1593/neo.07175
    • Jin, H., Pan, Y., Zhao, L., Zhai, H., Li, X., Sun, L., He, L., Chen, Y., Hong, L., Du, Y., and Fan, D. (2007) p75 neurotrophin receptor suppresses the proliferation of human gastric cancer cells. Neoplasia 9, 471-478 (Pubitemid 46983449)
    • (2007) Neoplasia , vol.9 , Issue.6 , pp. 471-478
    • Jin, H.1    Pan, Y.2    Zhao, L.3    Zhai, H.4    Li, X.5    Sun, L.6    He, L.7    Chen, Y.8    Hong, L.9    Du, Y.10    Fan, D.11
  • 74
    • 57649220776 scopus 로고    scopus 로고
    • An efficient method for derivation and propagation of glioblastoma cell lines that conserves the molecular profile of their original tumours
    • Fael Al-Mayhani, T. M., Ball, S. L., Zhao, J. W., Fawcett, J., Ichimura, K., Collins, P. V., and Watts, C. (2009) An efficient method for derivation and propagation of glioblastoma cell lines that conserves the molecular profile of their original tumours. J. Neurosci. Methods 176, 192-199
    • (2009) J. Neurosci. Methods , vol.176 , pp. 192-199
    • Fael Al-Mayhani, T.M.1    Ball, S.L.2    Zhao, J.W.3    Fawcett, J.4    Ichimura, K.5    Collins, P.V.6    Watts, C.7
  • 75
    • 33845610993 scopus 로고    scopus 로고
    • Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells
    • DOI 10.1038/nature05349, PII NATURE05349
    • Piccirillo, S. G., Reynolds, B. A., Zanetti, N., Lamorte, G., Binda, E., Broggi, G., Brem, H., Olivi, A., Dimeco, F., and Vescovi, A. L. (2006) Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells. Nature 444, 761-765 (Pubitemid 44949605)
    • (2006) Nature , vol.444 , Issue.7120 , pp. 761-765
    • Piccirillo, S.G.M.1    Reynolds, B.A.2    Zanetti, N.3    Lamorte, G.4    Binda, E.5    Broggi, G.6    Brem, H.7    Olivi, A.8    Dimeco, F.9    Vescovi, A.L.10
  • 76
    • 33747874155 scopus 로고    scopus 로고
    • Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors
    • DOI 10.1158/0008-5472.CAN-06-0858
    • Fan, X., Matsui, W., Khaki, L., Stearns, D., Chun, J., Li, Y. M., and Eberhart, C. G. (2006) Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors. Cancer Res. 66, 7445-7452 (Pubitemid 44289197)
    • (2006) Cancer Research , vol.66 , Issue.15 , pp. 7445-7452
    • Fan, X.1    Matsui, W.2    Khaki, L.3    Stearns, D.4    Chun, J.5    Li, Y.-M.6    Eberhart, C.G.7
  • 78
    • 33846237601 scopus 로고    scopus 로고
    • HEDGEHOG-GLI1 Signaling Regulates Human Glioma Growth, Cancer Stem Cell Self-Renewal, and Tumorigenicity
    • DOI 10.1016/j.cub.2006.11.033, PII S0960982206025140
    • Clement, V., Sanchez, P., de Tribolet, N., Radovanovic, I., and Ruiz i Altaba, A. (2007) HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity. Curr. Biol. 17, 165-172 (Pubitemid 46107823)
    • (2007) Current Biology , vol.17 , Issue.2 , pp. 165-172
    • Clement, V.1    Sanchez, P.2    De Tribolet, N.3    Radovanovic, I.4    Ruiz, A.A.5
  • 79
    • 70349653550 scopus 로고    scopus 로고
    • Targeted inhibition of the Hedgehog pathway in established malignant glioma xenografts enhances survival
    • Sarangi, A., Valadez, J. G., Rush, S., Abel, T. W., Thompson, R. C., and Cooper, M. K. (2009) Targeted inhibition of the Hedgehog pathway in established malignant glioma xenografts enhances survival. Oncogene 28, 3468-3476
    • (2009) Oncogene , vol.28 , pp. 3468-3476
    • Sarangi, A.1    Valadez, J.G.2    Rush, S.3    Abel, T.W.4    Thompson, R.C.5    Cooper, M.K.6
  • 80
    • 33745689524 scopus 로고    scopus 로고
    • Metalloproteinase disintegrins ADAM8 and ADAM19 are highly regulated in human primary brain tumors and their expression levels and activities are associated with invasiveness
    • DOI 10.1097/01.jnen.0000229240.51490.d3, PII 0000507220060500000010
    • Wildeboer, D., Naus, S., Amy Sang, Q. X., Bartsch, J. W., and Pagenstecher, A. (2006) Metalloproteinase disintegrins ADAM8 and ADAM19 are highly regulated in human primary brain tumors and their expression levels and activities are associated with invasiveness. J. Neuropathol. Exp. Neurol. 65, 516-527 (Pubitemid 44297273)
    • (2006) Journal of Neuropathology and Experimental Neurology , vol.65 , Issue.5 , pp. 516-527
    • Wildeboer, D.1    Naus, S.2    Sang, Q.-X.A.3    Bartsch, J.W.4    Pagenstecher, A.5
  • 81
    • 34147105872 scopus 로고    scopus 로고
    • ADAMs in cancer cell proliferation and progression
    • DOI 10.1111/j.1349-7006.2007.00434.x
    • Mochizuki, S., and Okada, Y. (2007) ADAMs in cancer cell proliferation and progression. Cancer. Sci. 98, 621-628 (Pubitemid 46563436)
    • (2007) Cancer Science , vol.98 , Issue.5 , pp. 621-628
    • Mochizuki, S.1    Okada, Y.2
  • 82
    • 65549120390 scopus 로고    scopus 로고
    • ADAM-10-mediated N-cadherin cleavage is protein kinase C-α dependent and promotes glioblastoma cell migration
    • Kohutek, Z. A., diPierro, C. G., Redpath, G. T., and Hussaini, I. M. (2009) ADAM-10-mediated N-cadherin cleavage is protein kinase C-α dependent and promotes glioblastoma cell migration. J. Neurosci. 29, 4605-4615
    • (2009) J. Neurosci. , vol.29 , pp. 4605-4615
    • Kohutek, Z.A.1    DiPierro, C.G.2    Redpath, G.T.3    Hussaini, I.M.4
  • 83
    • 7244238000 scopus 로고    scopus 로고
    • ADAM12 is selectively overexpressed in human glioblastomas and is associated with glioblastoma cell proliferation and shedding of heparin-binding epidermal growth factor
    • Kodama, T., Ikeda, E., Okada, A., Ohtsuka, T., Shimoda, M., Shiomi, T., Yoshida, K., Nakada, M., Ohuchi, E., and Okada, Y. (2004) ADAM12 is selectively overexpressed in human glioblastomas and is associated with glioblastoma cell proliferation and shedding of heparin-binding epidermal growth factor. Am. J. Pathol. 165, 1743-1753 (Pubitemid 39435171)
    • (2004) American Journal of Pathology , vol.165 , Issue.5 , pp. 1743-1753
    • Kodama, T.1    Ikeda, E.2    Okada, A.3    Ohtsuka, T.4    Shimoda, M.5    Shiomi, T.6    Yoshida, K.7    Nakada, M.8    Ohuchi, E.9    Okada, Y.10
  • 84
    • 1542510624 scopus 로고    scopus 로고
    • Cannabinoids Induce Cancer Cell Proliferation via Tumor Necrosis Factor α-Converting Enzyme (TACE/ADAM17)-Mediated Transactivation of the Epidermal Growth Factor Receptor
    • DOI 10.1158/0008-5472.CAN-03-3720
    • Hart, S., Fischer, O. M., and Ullrich, A. (2004) Cannabinoids induce cancer cell proliferation via tumor necrosis factor α-converting enzyme (TACE/ADAM17)-mediated transactivation of the epidermal growth factor receptor. Cancer Res. 64, 1943-1950 (Pubitemid 38339438)
    • (2004) Cancer Research , vol.64 , Issue.6 , pp. 1943-1950
    • Hart, S.1    Fischer, O.M.2    Ullrich, A.3
  • 86
    • 84866184063 scopus 로고    scopus 로고
    • A-disintegrin and metalloprotease (ADAM) 10 and 17 promote self-renewal of brain tumor sphere forming cells
    • Bulstrode, H., Jones, L. M., Siney, E. J., Sampson, J. M., Ludwig, A., Gray, W. P., and Willaime-Morawek, S. (2012) A-disintegrin and metalloprotease (ADAM) 10 and 17 promote self-renewal of brain tumor sphere forming cells. Cancer Lett. 326, 79-87
    • (2012) Cancer Lett. , vol.326 , pp. 79-87
    • Bulstrode, H.1    Jones, L.M.2    Siney, E.J.3    Sampson, J.M.4    Ludwig, A.5    Gray, W.P.6    Willaime-Morawek, S.7
  • 87
    • 76849107016 scopus 로고    scopus 로고
    • Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation
    • Xu, P., and Derynck, R. (2010) Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation. Mol. Cell 37, 551-566
    • (2010) Mol. Cell , vol.37 , pp. 551-566
    • Xu, P.1    Derynck, R.2
  • 88
    • 0035985185 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase phosphorylates tumor necrosis factor α-converting enzyme at threonine 735: A potential role in regulated shedding
    • DOI 10.1091/mbc.01-11-0561
    • Díaz-Rodriguez, E., Montero, J. C., Esparís-Ogando, A., Yuste, L., and Pandiella, A. (2002) Extracellular signal regulated kinase phosphorylates tumor necrosis factor α-converting enzyme at threonine 735: a potential role in regulated shedding. Mol. Biol. Cell 13, 2031-2044 (Pubitemid 34651490)
    • (2002) Molecular Biology of the Cell , vol.13 , Issue.6 , pp. 2031-2044
    • Diaz-Rodriguez, E.1    Montero, J.C.2    Esparis-Ogando, A.3    Yuste, L.4    Pandiella, A.5
  • 89
    • 0037118248 scopus 로고    scopus 로고
    • A RIP tide in neuronal signal transduction
    • DOI 10.1016/S0896-6273(02)00704-3
    • Ebinu, J. O., and Yankner, B. A. (2002) A RIP tide in neuronal signal transduction. Neuron 34, 499-502 (Pubitemid 34628747)
    • (2002) Neuron , vol.34 , Issue.4 , pp. 499-502
    • Ebinu, J.O.1    Yankner, B.A.2
  • 90
    • 80053951339 scopus 로고    scopus 로고
    • Differential profiling studies of N-linked glycoproteins in glioblastoma cancer stem cells upon treatment with γ-secretase inhibitor
    • Dai, L., Liu, Y., He, J., Flack, C. G., Talsma, C. E., Crowley, J. G., Muraszko, K. M., Fan, X., and Lubman, D. M. (2011) Differential profiling studies of N-linked glycoproteins in glioblastoma cancer stem cells upon treatment with γ-secretase inhibitor. Proteomics 11, 4021-4028
    • (2011) Proteomics , vol.11 , pp. 4021-4028
    • Dai, L.1    Liu, Y.2    He, J.3    Flack, C.G.4    Talsma, C.E.5    Crowley, J.G.6    Muraszko, K.M.7    Fan, X.8    Lubman, D.M.9
  • 91
    • 79951780026 scopus 로고    scopus 로고
    • Notch signaling contributes to the maintenance of both nomal neural stem cells and patient-derived glioma stem cells
    • Hu, Y. Y., Zheng, M. H., Cheng, G., Li, L., Liang, L., Gao, F., Wei, Y. N., Fu, L. A., and Han, H. (2011) Notch signaling contributes to the maintenance of both nomal neural stem cells and patient-derived glioma stem cells. BMC Cancer 11, 82
    • (2011) BMC Cancer , vol.11 , pp. 82
    • Hu, Y.Y.1    Zheng, M.H.2    Cheng, G.3    Li, L.4    Liang, L.5    Gao, F.6    Wei, Y.N.7    Fu, L.A.8    Han, H.9
  • 95
    • 0033231183 scopus 로고    scopus 로고
    • The zinc finger protein NRIF interacts with the neurotrophin receptor p75(NTR) and participates in programmed cell death
    • DOI 10.1093/emboj/18.21.6050
    • Casademunt, E., Carter, B. D., Benzel, I., Frade, J. M., Dechant, G., and Barde, Y. A. (1999) The zinc finger protein NRIF interacts with the neurotrophin receptor (p75NTR) and participates in programmed cell death. EMBO J. 18, 6050-6061 (Pubitemid 29515681)
    • (1999) EMBO Journal , vol.18 , Issue.21 , pp. 6050-6061
    • Casademunt, E.1    Carter, B.D.2    Benzel, I.3    Frade, J.M.4    Dechant, G.5    Barde, Y.-A.6
  • 96
    • 0037408391 scopus 로고    scopus 로고
    • The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI
    • Yamashita, T., and Tohyama, M. (2003) The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI. Nat. Neurosci. 6, 461-467 (Pubitemid 36514693)
    • (2003) Nature Neuroscience , vol.6 , Issue.5 , pp. 461-467
    • Yamashita, T.1    Tohyama, M.2
  • 97
    • 0033695190 scopus 로고    scopus 로고
    • NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis
    • Salehi, A. H., Roux, P. P., Kubu, C. J., Zeindler, C., Bhakar, A., Tannis, L. L., Verdi, J. M., and Barker, P. A. (2000) NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis. Neuron 27, 279-288
    • (2000) Neuron , vol.27 , pp. 279-288
    • Salehi, A.H.1    Roux, P.P.2    Kubu, C.J.3    Zeindler, C.4    Bhakar, A.5    Tannis, L.L.6    Verdi, J.M.7    Barker, P.A.8
  • 99
    • 1842456983 scopus 로고    scopus 로고
    • The p75NTR-interacting protein SC1 inhibits cell cycle progression by transcriptional repression of cyclin E
    • DOI 10.1083/jcb.200301106
    • Chittka, A., Arevalo, J. C., Rodriguez-Guzman, M., Pérez, P., Chao, M. V., and Sendtner, M. (2004) The p75NTR-interacting protein SC1 inhibits cell cycle progression by transcriptional repression of cyclin E. J. Cell Biol. 164, 985-996 (Pubitemid 38429125)
    • (2004) Journal of Cell Biology , vol.164 , Issue.7 , pp. 985-996
    • Chittka, A.1    Arevalo, J.C.2    Rodriguez-Guzman, M.3    Perez, P.4    Chao, M.V.5    Sendtner, M.6
  • 100
    • 33645278637 scopus 로고    scopus 로고
    • Bex1, a novel interactor of the p75 neurotrophin receptor, links neurotrophin signaling to the cell cycle
    • Vilar, M., Murillo-Carretero, M., Mira, H., Magnusson, K., Besset, V., and Ibáñez, C. F. (2006) Bex1, a novel interactor of the p75 neurotrophin receptor, links neurotrophin signaling to the cell cycle. EMBO J. 25, 1219-1230
    • (2006) EMBO J. , vol.25 , pp. 1219-1230
    • Vilar, M.1    Murillo-Carretero, M.2    Mira, H.3    Magnusson, K.4    Besset, V.5    Ibáñez, C.F.6
  • 101
    • 0038798665 scopus 로고    scopus 로고
    • Neurotrophin-induced melanoma cell migration is mediated through the actin-bundling protein fascin
    • DOI 10.1038/sj.onc.1206561
    • Shonukan, O., Bagayogo, I., McCrea, P., Chao, M., and Hempstead, B. (2003) Neurotrophin-induced melanoma cell migration is mediated through the actin-bundling protein fascin. Oncogene 22, 3616-3623 (Pubitemid 36765321)
    • (2003) Oncogene , vol.22 , Issue.23 , pp. 3616-3623
    • Shonukan, T.1    Bagayogo, I.2    McCrea, P.D.3    Chao, M.4    Hempstead, B.5
  • 102
    • 27844442187 scopus 로고    scopus 로고
    • TRAF6-mediated ubiquitination regulates nuclear translocation of NRIF, the p75 receptor interactor
    • DOI 10.1038/sj.emboj.7600845, PII 7600845
    • Geetha, T., Kenchappa, R. S., Wooten, M. W., and Carter, B. D. (2005) TRAF6-mediated ubiquitination regulates nuclear translocation of NRIF, the p75 receptor interactor. EMBO J. 24, 3859-3868 (Pubitemid 41637993)
    • (2005) EMBO Journal , vol.24 , Issue.22 , pp. 3859-3868
    • Geetha, T.1    Kenchappa, R.S.2    Wooten, M.W.3    Carter, B.D.4
  • 105
    • 78649364332 scopus 로고    scopus 로고
    • Hypoxia-inducible factors and the response to hypoxic stress
    • Majmundar, A. J., Wong, W. J., and Simon, M. C. (2010) Hypoxia-inducible factors and the response to hypoxic stress. Mol Cell. 40, 294-309
    • (2010) Mol Cell , vol.40 , pp. 294-309
    • Majmundar, A.J.1    Wong, W.J.2    Simon, M.C.3
  • 106
    • 65649115060 scopus 로고    scopus 로고
    • Hypoxia helps glioma to fight therapy
    • Amberger-Murphy, V. (2009) Hypoxia helps glioma to fight therapy. Curr. Cancer Drug Targets 9, 381-390
    • (2009) Curr. Cancer Drug Targets , vol.9 , pp. 381-390
    • Amberger-Murphy, V.1


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