Trk-dependent ADAM17 activation facilitates neurotrophin survival signaling

FASEB Journal

Volumn 25, Issue 6, 2011, Pages 2061-2070

  Kommaddi, Reddy P ^a   Thomas, Rhalena ^a   Ceni, Claire ^a   Daigneault, Kathleen ^a   Barker, Philip A ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

secretase; secretase; BDNF; NGF; p75NTR; TrkA

Indexed keywords

A DISINTEGRIN AND METALLOPROTEASE 17; ADAM PROTEIN; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; NEUROTROPHIN; NEUROTROPHIN RECEPTOR P75; PROTEIN TYROSINE KINASE A; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION;

ADAM PROTEINS; ANIMALS; CEREBELLUM; GENE SILENCING; NERVE GROWTH FACTORS; NEURONS; PC12 CELLS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, NERVE GROWTH FACTOR; RECEPTOR, TRKA; SIGNAL TRANSDUCTION;

EID: 79957926130     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.10-173740     Document Type: Article

References (31)

1. Beattie, M. S., Harrington, A. W., Lee, R., Kim, J. Y., Boyce, S. L., Longo, F. M., Bresnahan, J. C., Hempstead, B. L., and Yoon, S. O. (2002) ProNGF induces p75-mediated death of oligodendrocytes following spinal cord injury. Neuron 36, 375-386
2. Nykjaer, A., Lee, R., Teng, K. K., Jansen, P., Madsen, P., Nielsen, M. S., Jacobsen, C., Kliemannel, M., Schwarz, E., Willnow, T. E., Hempstead, B. L., and Petersen, C. M. (2004) Sortilin is essential for proNGF-induced neuronal cell death. Nature 427, 843-848
3. Harrington, A. W., Leiner, B., Blechschmitt, C., Arevalo, J. C., Lee, R., Morl, K., Meyer, M., Hempstead, B. L., Yoon, S. O., and Giehl, K. M. (2004) Secreted proNGF is a pathophysiological death-inducing ligand after adult CNS injury. Proc. Natl. Acad. Sci. U. S. A. 101, 6226-6230
4. Davies, A. M., Lee, K. F., and Jaenisch, R. (1993) p75-deficient trigeminal sensory neurons have an altered response to NGF but not to other neurotrophins. Neuron 11, 565-574
5. Ito, H., Nomoto, H., and Furukawa, S. (2002) Role of low-affinity p75 receptor in nerve growth factor-inducible growth arrest of PC12 cells. J. Neurosci. Res. 69, 653-661 (Pubitemid 34966878)
6. Ito, H., Nomoto, H., and Furukawa, S. (2003) Growth arrest of PC12 cells by nerve growth factor is dependent on the phosphatidylinositol 3-kinase/Akt pathway via p75 neurotrophin receptor. J. Neurosci. Res. 72, 211-217 (Pubitemid 36389888)
7. Lee, K. F., Davies, A. M., and Jaenisch, R. (1994) p75-deficient embryonic dorsal root sensory and neonatal sympathetic neurons display a decreased sensitivity to NGF. Development 120, 1027-1033 (Pubitemid 24111565)
8. Yan, H., Schlessinger, J., and Chao, M. V. (1991) Chimeric NGF-EGF receptors define domains responsible for neuronal differentiation. Science 252, 561-563
9. Von Schack, D., Casademunt, E., Schweigreiter, R., Meyer, M., Bibel, M., and Dechant, G. (2001) Complete ablation of the neurotrophin receptor p75NTR causes defects both in the nervous and the vascular system. Nat. Neurosci. 4, 977-978 (Pubitemid 32924135)
10. Yamashita, T., Tucker, K. L., and Barde, Y. A. (1999) Neurotrophin binding to the p75 receptor modulates Rho activity and axonal outgrowth. Neuron 24, 585-593
11. Domeniconi, M., Zampieri, N., Spencer, T., Hilaire, M., Mellado, W., Chao, M. V., and Filbin, M. T. (2005) MAG induces regulated intramembrane proteolysis of the p75 neurotrophin receptor to inhibit neurite outgrowth. Neuron 46, 849-855
12. Kenchappa, R. S., Zampieri, N., Chao, M. V., Barker, P. A., Teng, H. K., Hempstead, B. L., and Carter, B. D. (2006) Ligand-dependent cleavage of the P75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neurons. Neuron 50, 219-232
13. Urra, S., Escudero, C. A., Ramos, P., Lisbona, F., Allende, E., Covarrubias, P., Parraguez, J. I., Zampieri, N., Chao, M. V., Annaert, W., and Bronfman, F. C. (2007) TrkA receptor activation by nerve growth factor induces shedding of the p75 neurotrophin receptor followed by endosomal gamma-secretase-mediated release of the p75 intracellular domain. J. Biol. Chem. 282, 7606-7615
14. Ceni, C., Kommaddi, R. P., Thomas, R., Vereker, E., Liu, X., McPherson, P. S., Ritter, B., and Barker, P. A. (2010) The p75NTR intracellular domain generated by neurotrophin-induced receptor cleavage potentiates Trk signaling. J. Cell Sci. 123, 2299-2307
15. Pruessmeyer, J., and Ludwig, A. (2009) The good, the bad and the ugly substrates for ADAM10 and ADAM17 in brain pathology, inflammation and cancer. Semin. Cell. Dev. Biol. 20, 164-174
16. Weskamp, G., Schlondorff, J., Lum, L., Becherer, J. D., Kim, T. W., Saftig, P., Hartmann, D., Murphy, G., and Blobel, C. P. (2004) Evidence for a critical role of the tumor necrosis factor alpha convertase (TACE) in ectodomain shedding of the p75 neurotrophin receptor (p75NTR). J. Biol. Chem. 279, 4241-4249 (Pubitemid 38199011)
17. Kenchappa, R. S., Tep, C., Korade, Z., Urra, S., Bronfman, F. C., Yoon, S. O., and Carter, B. D. (2010) p75 neurotrophin receptor-mediated apoptosis in sympathetic neurons involves a biphasic activation of JNK and up-regulation of tumor necrosis factor-alpha-converting enzyme/ADAM17. J. Biol. Chem. 285, 20358-20368
18. Rousseau, S., Papoutsopoulou, M., Symons, A., Cook, D., Lucocq, J. M., Prescott, A. R., O'Garra, A., Ley, S. C., and Cohen, P. (2008) TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF alpha in LPS-stimulated macrophages. J. Cell Sci. 121, 149-154 (Pubitemid 351228446)
19. Majdan, M., Lachance, C., Gloster, A., Aloyz, R., Zeindler, C., Bamji, S., Bhakar, A., Belliveau, D., Fawcett, J., Miller, F. D., and Barker, P. A. (1997) Transgenic mice expressing the intracellular domain of the p75 neurotrophin receptor undergo neuronal apoptosis. J. Neurosci. 17, 6988-6998
20. Zampieri, N., Xu, C. F., Neubert, T. A., and Chao, M. V. (2005) Cleavage of p75 neurotrophin receptor by alpha-secretase and gamma-secretase requires specific receptor domains. J. Biol. Chem. 280, 14563-14571
21. Smith, P. K., Krohn, R. I., Hermanson, G. T., Mallia, A. K., Gartner, F. H., Provenzano, M. D., Fujimoto, E. K., Goeke, N. M., Olson, B. J., and Klenk, D. C. (1985) Measurement of protein using bicinchoninic acid. Anal. Biochem. 150, 76-85
22. Kanning, K. C., Hudson, M., Amieux, P. S., Wiley, J. C., Bothwell, M., and Schecterson, L. C. (2003) Proteolytic processing of the p75 neurotrophin receptor and two homologs generates C-terminal fragments with signaling capability. J. Neurosci. 23, 5425-5436
23. Frade, J. M. (2005) Nuclear translocation of the p75 neurotrophin receptor cytoplasmic domain in response to neurotrophin binding. J. Neurosci. 25, 1407-1411
24. Fan, H., and Derynck, R. (1999) Ectodomain shedding of TGF-alpha and other transmembrane proteins is induced by receptor tyrosine kinase activation and MAP kinase signaling cascades. EMBO J. 18, 6962-6972 (Pubitemid 30000449)
25. Barker, P. A. (2007) High affinity not in the vicinity? Neuron 53, 1-4
26. Bandtlow, C., and Dechant, G. (2004) From cell death to neuronal regeneration, effects of the p75 neurotrophin receptor depend on interactions with partner subunits. Sci. STKE 2004, pe24
27. Barker, P. A. (2004) p75NTR is positively promiscuous: novel partners and new insights. Neuron 42, 529-533
28. Nykjaer, A., Willnow, T. E., and Petersen, C. M. (2005) p75NTR-live or let die. Curr. Opin. Neurobiol. 15, 49-57
29. Le Gall, S. M., Bobe, P., Reiss, K., Horiuchi, K., Niu, X. D., Lundell, D., Gibb, D. R., Conrad, D., Saftig, P., and Blobel, C. P. (2009) ADAMs 10 and 17 represent differentially regulated components of a general shedding machinery for membrane proteins such as transforming growth factor alpha, L-selectin, and tumor necrosis factor alpha. Mol. Biol. Cell 20, 1785-1794
30. Diaz-Rodriguez, E., Montero, J. C., Esparis-Ogando, A., Yuste, L., and Pandiella, A. (2002) Extracellular signal-regulated kinase phosphorylates tumor necrosis factor alpha-converting enzyme at threonine 735: a potential role in regulated shedding. Mol. Biol. Cell 13, 2031-2044 (Pubitemid 34651490)
31. Soond, S. M., Everson, B., Riches, D. W., and Murphy, G. (2005) ERK-mediated phosphorylation of Thr735 in TNFα-converting enzyme and its potential role in TACE protein trafficking. J. Cell Sci. 118, 2371-2380 (Pubitemid 40873077)