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Volumn 123, Issue 13, 2010, Pages 2299-2307

The p75NTR intracellular domain generated by neurotrophin-induced receptor cleavage potentiates Trk signaling

Author keywords

BDNF; Cell cycle; Cerebellar granule neuron; Neurotrophin; NGF; PC12 cell

Indexed keywords

ALPHA SECRETASE; BRAIN DERIVED NEUROTROPHIC FACTOR; GAMMA SECRETASE; NERVE GROWTH FACTOR; NEUROTROPHIN RECEPTOR P75; PROTEIN KINASE B; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; NERVE GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE KINASE A; SECRETASE;

EID: 77954367715     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.062612     Document Type: Article
Times cited : (66)

References (50)
  • 1
    • 4143150863 scopus 로고    scopus 로고
    • From cell death to neuronal regeneration, effects of the p75 neurotrophin receptor depend on interactions with partner subunits
    • Bandtlow, C. and Dechant, G. (2004). From cell death to neuronal regeneration, effects of the p75 neurotrophin receptor depend on interactions with partner subunits. Sci. STKE 2004, pe24.
    • (2004) Sci. STKE , vol.2004
    • Bandtlow, C.1    Dechant, G.2
  • 2
    • 2442463255 scopus 로고    scopus 로고
    • p75NTR is positively promiscuous: Novel partners and new insights
    • Barker, P. A. (2004). p75NTR is positively promiscuous: novel partners and new insights. Neuron 42, 529-533.
    • (2004) Neuron , vol.42 , pp. 529-533
    • Barker, P.A.1
  • 3
    • 33845707629 scopus 로고    scopus 로고
    • High affinity not in the vicinity?
    • Barker, P. A. (2007). High affinity not in the vicinity? Neuron 53, 1-4.
    • (2007) Neuron , vol.53 , pp. 1-4
    • Barker, P.A.1
  • 4
    • 0027966170 scopus 로고
    • LNTR reduces NGF binding to TrkA on PC12 cells
    • Barker, P. A. and Shooter, E. M. (1994). Disruption of NGF binding to the low affinity neurotrophin receptor p75LNTR reduces NGF binding to TrkA on PC12 cells. Neuron 13, 203-215. (Pubitemid 124000857)
    • (1994) Neuron , vol.13 , Issue.1 , pp. 203-215
    • Barker, P.A.1    Shooter, E.M.2
  • 6
    • 0347479233 scopus 로고    scopus 로고
    • Apoptosis induced by p75NTR overexpression requires Jun kinase-dependent phosphorylation of Bad
    • Bhakar, A. L., Howell, J. L., Paul, C. E., Salehi, A. H., Becker, E. B., Said, F., Bonni, A. and Barker, P. A. (2003). Apoptosis induced by p75NTR overexpression requires Jun kinase-dependent phosphorylation of Bad. J. Neurosci. 23, 11373-11381.
    • (2003) J. Neurosci. , vol.23 , pp. 11373-11381
    • Bhakar, A.L.1    Howell, J.L.2    Paul, C.E.3    Salehi, A.H.4    Becker, E.B.5    Said, F.6    Bonni, A.7    Barker, P.A.8
  • 7
    • 45149132553 scopus 로고    scopus 로고
    • Proneurotrophins require endocytosis and intracellular proteolysis to induce TrkA activation
    • Boutilier, J., Ceni, C., Pagdala, P. C., Forgie, A., Neet, K. E. and Barker, P. A. (2008). Proneurotrophins require endocytosis and intracellular proteolysis to induce TrkA activation. J. Biol. Chem. 283, 12709-12716.
    • (2008) J. Biol. Chem. , vol.283 , pp. 12709-12716
    • Boutilier, J.1    Ceni, C.2    Pagdala, P.C.3    Forgie, A.4    Neet, K.E.5    Barker, P.A.6
  • 8
    • 0037762690 scopus 로고    scopus 로고
    • Neurotrophins and their receptors: A convergence point for many signalling pathways
    • Chao, M. V. (2003). Neurotrophins and their receptors: a convergence point for many signalling pathways. Nat. Rev. Neurosci. 4, 299-309.
    • (2003) Nat. Rev. Neurosci. , vol.4 , pp. 299-309
    • Chao, M.V.1
  • 10
    • 0027330994 scopus 로고
    • p75-deficient trigeminal sensory neurons have an altered response to NGF but not to other neurotrophins
    • Davies, A. M., Lee, K. F. and Jaenisch, R. (1993). p75-deficient trigeminal sensory neurons have an altered response to NGF but not to other neurotrophins. Neuron 11, 565-574.
    • (1993) Neuron , vol.11 , pp. 565-574
    • Davies, A.M.1    Lee, K.F.2    Jaenisch, R.3
  • 11
    • 0035985185 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase phosphorylates tumor necrosis factor alpha-converting enzyme at threonine 735, a potential role in regulated shedding
    • Diaz-Rodriguez, E., Montero, J. C., Esparis-Ogando, A., Yuste, L. and Pandiella, A. (2002). Extracellular signal-regulated kinase phosphorylates tumor necrosis factor alpha-converting enzyme at threonine 735, a potential role in regulated shedding. Mol. Biol. Cell 13, 2031-2044.
    • (2002) Mol. Biol. Cell , vol.13 , pp. 2031-2044
    • Diaz-Rodriguez, E.1    Montero, J.C.2    Esparis-Ogando, A.3    Yuste, L.4    Pandiella, A.5
  • 12
    • 20444365447 scopus 로고    scopus 로고
    • MAG induces regulated intramembrane proteolysis of the p75 neurotrophin receptor to inhibit neurite outgrowth
    • Domeniconi, M., Zampieri, N., Spencer, T., Hilaire, M., Mellado, W., Chao, M. V. and Filbin, M. T. (2005). MAG induces regulated intramembrane proteolysis of the p75 neurotrophin receptor to inhibit neurite outgrowth. Neuron 46, 849-855.
    • (2005) Neuron , vol.46 , pp. 849-855
    • Domeniconi, M.1    Zampieri, N.2    Spencer, T.3    Hilaire, M.4    Mellado, W.5    Chao, M.V.6    Filbin, M.T.7
  • 13
    • 0033573049 scopus 로고    scopus 로고
    • Ectodomain shedding of TGF-alpha and other transmembrane proteins is induced by receptor tyrosine kinase activation and MAP kinase signaling cascades
    • Fan, H. and Derynck, R. (1999). Ectodomain shedding of TGF-alpha and other transmembrane proteins is induced by receptor tyrosine kinase activation and MAP kinase signaling cascades. EMBO J. 18, 6962-6972.
    • (1999) EMBO J. , vol.18 , pp. 6962-6972
    • Fan, H.1    Derynck, R.2
  • 14
    • 13844271798 scopus 로고    scopus 로고
    • Nuclear translocation of the p75 neurotrophin receptor cytoplasmic domain in response to neurotrophin binding
    • Frade, J. M. (2005). Nuclear translocation of the p75 neurotrophin receptor cytoplasmic domain in response to neurotrophin binding. J. Neurosci. 25, 1407-1411.
    • (2005) J. Neurosci. , vol.25 , pp. 1407-1411
    • Frade, J.M.1
  • 15
    • 0033213984 scopus 로고    scopus 로고
    • The shedding of membrane-anchored heparin-binding epidermal-like growth factor is regulated by the Raf/mitogen-activated protein kinase cascade and by cell adhesion and spreading
    • Gechtman, Z., Alonso, J. L., Raab, G., Ingber, D. E. and Klagsbrun, M. (1999). The shedding of membrane-anchored heparin-binding epidermal-like growth factor is regulated by the Raf/mitogen-activated protein kinase cascade and by cell adhesion and spreading. J. Biol. Chem. 274, 28828-28835.
    • (1999) J. Biol. Chem. , vol.274 , pp. 28828-28835
    • Gechtman, Z.1    Alonso, J.L.2    Raab, G.3    Ingber, D.E.4    Klagsbrun, M.5
  • 16
    • 0022542457 scopus 로고
    • PC12 cell mutants that possess low- but not high-affinity nerve growth factor receptors neither respond to nor internalize nerve growth factor
    • Green, S. H., Rydel, R. E., Connolly, J. L. and Greene, L. A. (1986). PC12 cell mutants that possess low- but not high-affinity nerve growth factor receptors neither respond to nor internalize nerve growth factor. J. Cell Biol. 102, 830-843.
    • (1986) J. Cell Biol. , vol.102 , pp. 830-843
    • Green, S.H.1    Rydel, R.E.2    Connolly, J.L.3    Greene, L.A.4
  • 17
    • 0346363604 scopus 로고    scopus 로고
    • Acidic substitution of the activation loop tyrosines in TrkA supports nerve growth factor-dependent, but not nerve growth factor-independent, differentiation and cell cycle arrest in the human neuroblastoma cell line, SY5Y
    • Gryz, E. A. and Meakin, S. O. (2003). Acidic substitution of the activation loop tyrosines in TrkA supports nerve growth factor-dependent, but not nerve growth factor-independent, differentiation and cell cycle arrest in the human neuroblastoma cell line, SY5Y. Oncogene 22, 8774-8785.
    • (2003) Oncogene , vol.22 , pp. 8774-8785
    • Gryz, E.A.1    Meakin, S.O.2
  • 18
    • 19644384912 scopus 로고    scopus 로고
    • Components of the REST/CoREST/histone deacetylase repressor complex are disrupted, modified, and translocated in HSV-1-infected cells
    • Gu, H., Liang, Y., Mandel, G. and Roizman, B. (2005). Components of the REST/CoREST/histone deacetylase repressor complex are disrupted, modified, and translocated in HSV-1-infected cells. Proc. Natl. Acad. Sci. USA 102, 7571-7576.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 7571-7576
    • Gu, H.1    Liang, Y.2    Mandel, G.3    Roizman, B.4
  • 19
    • 0027939697 scopus 로고
    • The low affinity NGF receptor, p75, can collaborate with each of the Trks to potentiate functional responses to the neurotrophins
    • Hantzopoulos, P. A., Suri, C., Glass, D. J., Goldfarb, M. P. and Yancopoulos, G. D. (1994). The low affinity NGF receptor, p75, can collaborate with each of the Trks to potentiate functional responses to the neurotrophins. Neuron 13, 187-201.
    • (1994) Neuron , vol.13 , pp. 187-201
    • Hantzopoulos, P.A.1    Suri, C.2    Glass, D.J.3    Goldfarb, M.P.4    Yancopoulos, G.D.5
  • 20
    • 0025774207 scopus 로고
    • High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor
    • Hempstead, B. L., Martin-Zanca, D., Kaplan, D. R., Parada, L. F. and Chao, M. V. (1991). High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor. Nature 350, 678-683. (Pubitemid 21912292)
    • (1991) Nature , vol.350 , Issue.6320 , pp. 678-683
    • Hempstead, B.L.1    Martin-Zanca, D.2    Kaplan, D.R.3    Parada, L.F.4    Chao, M.V.5
  • 21
    • 0026468503 scopus 로고
    • Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiation
    • Hempstead, B. L., Rabin, S. J., Kaplan, L., Reid, S., Parada, L. F. and Kaplan, D. R. (1992). Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiation. Neuron 9, 883-896.
    • (1992) Neuron , vol.9 , pp. 883-896
    • Hempstead, B.L.1    Rabin, S.J.2    Kaplan, L.3    Reid, S.4    Parada, L.F.5    Kaplan, D.R.6
  • 22
    • 0037459048 scopus 로고    scopus 로고
    • The p75 receptor is required for BDNF-induced differentiation of neural precursor cells
    • Hosomi, S., Yamashita, T., Aoki, M. and Tohyama, M. (2003). The p75 receptor is required for BDNF-induced differentiation of neural precursor cells. Biochem. Biophys. Res. Commun. 301, 1011-1015.
    • (2003) Biochem. Biophys. Res. Commun. , vol.301 , pp. 1011-1015
    • Hosomi, S.1    Yamashita, T.2    Aoki, M.3    Tohyama, M.4
  • 23
    • 0033043150 scopus 로고    scopus 로고
    • Expression of Trk receptors in the developing mouse trigeminal ganglion: In vivo evidence for NT-3 activation of TrkA and TrkB in addition to TrkC
    • Huang, E. J., Wilkinson, G. A., Farinas, I., Backus, C., Zang, K., Wong, S. L. and Reichardt, L. F. (1999). Expression of Trk receptors in the developing mouse trigeminal ganglion: in vivo evidence for NT-3 activation of TrkA and TrkB in addition to TrkC. Development 126, 2191-2203.
    • (1999) Development , vol.126 , pp. 2191-2203
    • Huang, E.J.1    Wilkinson, G.A.2    Farinas, I.3    Backus, C.4    Zang, K.5    Wong, S.L.6    Reichardt, L.F.7
  • 24
    • 0036708177 scopus 로고    scopus 로고
    • Role of low-affinity p75 receptor in nerve growth factor-inducible growth arrest of PC12 cells
    • Ito, H., Nomoto, H. and Furukawa, S. (2002). Role of low-affinity p75 receptor in nerve growth factor-inducible growth arrest of PC12 cells. J. Neurosci. Res. 69, 653-661.
    • (2002) J. Neurosci. Res. , vol.69 , pp. 653-661
    • Ito, H.1    Nomoto, H.2    Furukawa, S.3
  • 25
    • 0037446105 scopus 로고    scopus 로고
    • Growth arrest of PC12 cells by nerve growth factor is dependent on the phosphatidylinositol 3-kinase/Akt pathway via p75 neurotrophin receptor
    • Ito, H., Nomoto, H. and Furukawa, S. (2003). Growth arrest of PC12 cells by nerve growth factor is dependent on the phosphatidylinositol 3-kinase/Akt pathway via p75 neurotrophin receptor. J. Neurosci. Res. 72, 211-217.
    • (2003) J. Neurosci. Res. , vol.72 , pp. 211-217
    • Ito, H.1    Nomoto, H.2    Furukawa, S.3
  • 27
    • 0038045714 scopus 로고    scopus 로고
    • Proteolytic processing of the p75 neurotrophin receptor and two homologs generates C-terminal fragments with signaling capability
    • Kanning, K. C., Hudson, M., Amieux, P. S., Wiley, J. C., Bothwell, M. and Schecterson, L. C. (2003). Proteolytic processing of the p75 neurotrophin receptor and two homologs generates C-terminal fragments with signaling capability. J. Neurosci. 23, 5425-5436. (Pubitemid 36807816)
    • (2003) Journal of Neuroscience , vol.23 , Issue.13 , pp. 5425-5436
    • Kanning, K.C.1    Hudson, M.2    Amieux, P.S.3    Wiley, J.C.4    Bothwell, M.5    Schecterson, L.C.6
  • 28
    • 33646052860 scopus 로고    scopus 로고
    • Ligand-dependent cleavage of the P75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neurons
    • Kenchappa, R. S., Zampieri, N., Chao, M. V., Barker, P. A., Teng, H. K., Hempstead, B. L. and Carter, B. D. (2006). Ligand-dependent cleavage of the P75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neurons. Neuron 50, 219-232.
    • (2006) Neuron , vol.50 , pp. 219-232
    • Kenchappa, R.S.1    Zampieri, N.2    Chao, M.V.3    Barker, P.A.4    Teng, H.K.5    Hempstead, B.L.6    Carter, B.D.7
  • 29
    • 0037437998 scopus 로고    scopus 로고
    • Novel functional interactions between Trk kinase and p75 neurotrophin receptor in neuroblastoma cells
    • Lachyankar, M. B., Condon, P. J., Daou, M. C., De, A. K., Levine, J. B., Obermeier, A. and Ross, A. H. (2003). Novel functional interactions between Trk kinase and p75 neurotrophin receptor in neuroblastoma cells. J. Neurosci. Res 71, 157-172.
    • (2003) J. Neurosci. Res , vol.71 , pp. 157-172
    • Lachyankar, M.B.1    Condon, P.J.2    Daou, M.C.3    De, A.K.4    Levine, J.B.5    Obermeier, A.6    Ross, A.H.7
  • 30
    • 0026747063 scopus 로고
    • Targeted mutation of the gene encoding the low affinity NGF receptor leads to deficits in the peripheral sensory nervous system
    • Lee, K.-F., Li, E., Huber, J., Landis, S. C., Sharpe, A. H., Chao, M. V. and Jaenisch, R. (1992a). Targeted mutation of the gene encoding the low affinity NGF receptor leads to deficits in the peripheral sensory nervous system. Cell 69, 737-749.
    • (1992) Cell , vol.69 , pp. 737-749
    • Lee, K.-F.1    Li, E.2    Huber, J.3    Landis, S.C.4    Sharpe, A.H.5    Chao, M.V.6    Jaenisch, R.7
  • 31
    • 0026747063 scopus 로고
    • Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system
    • Lee, K. F., Li, E., Huber, L. J., Landis, S. C., Sharpe, A. H., Chao, M. V. and Jaenisch, R. (1992b). Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system. Cell 69, 737-749.
    • (1992) Cell , vol.69 , pp. 737-749
    • Lee, K.F.1    Li, E.2    Huber, L.J.3    Landis, S.C.4    Sharpe, A.H.5    Chao, M.V.6    Jaenisch, R.7
  • 32
    • 0028196552 scopus 로고
    • p75-deficient embryonic dorsal root sensory and neonatal sympathetic neurons display a decreased sensitivity to NGF
    • Lee, K. F., Davies, A. M. and Jaenisch, R. (1994). p75-deficient embryonic dorsal root sensory and neonatal sympathetic neurons display a decreased sensitivity to NGF. Development 120, 1027-1033.
    • (1994) Development , vol.120 , pp. 1027-1033
    • Lee, K.F.1    Davies, A.M.2    Jaenisch, R.3
  • 33
    • 0027263736 scopus 로고
    • Transfection with trk restores "slow" NGF binding, efficient NGF uptake, and multiple NGF responses to NGF-nonresponsive PC12 cell mutants
    • Loeb, D. M. and Greene, L. A. (1993). Transfection with trk restores "slow" NGF binding, efficient NGF uptake, and multiple NGF responses to NGF-nonresponsive PC12 cell mutants. J. Neurosci. 13, 2919-2929.
    • (1993) J. Neurosci. , vol.13 , pp. 2919-2929
    • Loeb, D.M.1    Greene, L.A.2
  • 36
    • 0035369840 scopus 로고    scopus 로고
    • Trk receptors: Mediators of neurotrophin action
    • Patapoutian, A. and Reichardt, L. F. (2001). Trk receptors: mediators of neurotrophin action. Curr. Opin. Neurobiol. 11, 272-280.
    • (2001) Curr. Opin. Neurobiol. , vol.11 , pp. 272-280
    • Patapoutian, A.1    Reichardt, L.F.2
  • 37
    • 33745700716 scopus 로고    scopus 로고
    • Pro-NGF from Alzheimer's disease and normal human brain displays distinctive abilities to induce processing and nuclear translocation of intracellular domain of p75NTR and apoptosis
    • Podlesniy, P., Kichev, A., Pedraza, C., Saurat, J., Encinas, M., Perez, B., Ferrer, I. and Espinet, C. (2006). Pro-NGF from Alzheimer's disease and normal human brain displays distinctive abilities to induce processing and nuclear translocation of intracellular domain of p75NTR and apoptosis. Am. J. Pathol. 169, 119-131.
    • (2006) Am. J. Pathol. , vol.169 , pp. 119-131
    • Podlesniy, P.1    Kichev, A.2    Pedraza, C.3    Saurat, J.4    Encinas, M.5    Perez, B.6    Ferrer, I.7    Espinet, C.8
  • 39
    • 0035933783 scopus 로고    scopus 로고
    • The p75 neurotrophin receptor activates Akt (protein kinase B) through a phosphatidylinositol 3-kinase-dependent pathway
    • Roux, P. P., Bhakar, A. L., Kennedy, T. E. and Barker, P. A. (2001). The p75 neurotrophin receptor activates Akt (protein kinase B) through a phosphatidylinositol 3-kinase-dependent pathway. J. Biol. Chem. 276, 23097-23104.
    • (2001) J. Biol. Chem. , vol.276 , pp. 23097-23104
    • Roux, P.P.1    Bhakar, A.L.2    Kennedy, T.E.3    Barker, P.A.4
  • 40
    • 32844470038 scopus 로고    scopus 로고
    • AEG3482 is an antiapoptotic compound that inhibits Jun kinase activity and cell death through induced expression of heat shock protein 70
    • Salehi, A. H., Morris, S. J., Ho, W. C., Dickson, K. M., Doucet, G., Milutinovic, S., Durkin, J., Gillard, J. W. and Barker, P. A. (2006). AEG3482 is an antiapoptotic compound that inhibits Jun kinase activity and cell death through induced expression of heat shock protein 70. Chem. Biol. 13, 213-223.
    • (2006) Chem. Biol. , vol.13 , pp. 213-223
    • Salehi, A.H.1    Morris, S.J.2    Ho, W.C.3    Dickson, K.M.4    Doucet, G.5    Milutinovic, S.6    Durkin, J.7    Gillard, J.W.8    Barker, P.A.9
  • 41
    • 65249118446 scopus 로고    scopus 로고
    • Vasculature guides migrating neuronal precursors in the adult mammalian forebrain via brain-derived neurotrophic factor signaling
    • Snapyan, M., Lemasson, M., Brill, M. S., Blais, M., Massouh, M., Ninkovic, J., Gravel, C., Berthod, F., Gotz, M., Barker, P. A. et al. (2009). Vasculature guides migrating neuronal precursors in the adult mammalian forebrain via brain-derived neurotrophic factor signaling. J. Neurosci. 29, 4172-4188.
    • (2009) J. Neurosci. , vol.29 , pp. 4172-4188
    • Snapyan, M.1    Lemasson, M.2    Brill, M.S.3    Blais, M.4    Massouh, M.5    Ninkovic, J.6    Gravel, C.7    Berthod, F.8    Gotz, M.9    Barker, P.A.10
  • 42
    • 21044444181 scopus 로고    scopus 로고
    • ERK-mediated phosphorylation of Thr735 in TNFalpha-converting enzyme and its potential role in TACE protein trafficking
    • Soond, S. M., Everson, B., Riches, D. W. and Murphy, G. (2005). ERK-mediated phosphorylation of Thr735 in TNFalpha-converting enzyme and its potential role in TACE protein trafficking. J. Cell Sci. 118, 2371-2380.
    • (2005) J. Cell Sci. , vol.118 , pp. 2371-2380
    • Soond, S.M.1    Everson, B.2    Riches, D.W.3    Murphy, G.4
  • 43
    • 34147179336 scopus 로고    scopus 로고
    • TrkA receptor activation by nerve growth factor induces shedding of the p75 neurotrophin receptor followed by endosomal gamma-secretase-mediated release of the p75 intracellular domain
    • Urra, S., Escudero, C. A., Ramos, P., Lisbona, F., Allende, E., Covarrubias, P., Parraguez, J. I., Zampieri, N., Chao, M. V., Annaert, W. et al. (2007). TrkA receptor activation by nerve growth factor induces shedding of the p75 neurotrophin receptor followed by endosomal gamma-secretase-mediated release of the p75 intracellular domain. J. Biol. Chem. 282, 7606-7615.
    • (2007) J. Biol. Chem. , vol.282 , pp. 7606-7615
    • Urra, S.1    Escudero, C.A.2    Ramos, P.3    Lisbona, F.4    Allende, E.5    Covarrubias, P.6    Parraguez, J.I.7    Zampieri, N.8    Chao, M.V.9    Annaert, W.10
  • 45
    • 0034803770 scopus 로고    scopus 로고
    • Complete ablation of the neurotrophin receptor p75NTR causes defects both in the nervous and the vascular system
    • von Schack, D., Casademunt, E., Schweigreiter, R., Meyer, M., Bibel, M. and Dechant, G. (2001). Complete ablation of the neurotrophin receptor p75NTR causes defects both in the nervous and the vascular system. Nat. Neurosci. 4, 977-978.
    • (2001) Nat. Neurosci. , vol.4 , pp. 977-978
    • Von Schack, D.1    Casademunt, E.2    Schweigreiter, R.3    Meyer, M.4    Bibel, M.5    Dechant, G.6
  • 46
    • 33845695804 scopus 로고    scopus 로고
    • Structural and Mechanistic Insights into Nerve Growth Factor Interactions with the TrkA and p75 Receptors
    • DOI 10.1016/j.neuron.2006.09.034, PII S0896627306007720
    • Wehrman, T., He, X., Raab, B., Dukipatti, A., Blau, H. and Garcia, K. C. (2007). Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors. Neuron 53, 25-38. (Pubitemid 44969482)
    • (2007) Neuron , vol.53 , Issue.1 , pp. 25-38
    • Wehrman, T.1    He, X.2    Raab, B.3    Dukipatti, A.4    Blau, H.5    Garcia, K.C.6
  • 47
    • 1042278167 scopus 로고    scopus 로고
    • Evidence for a critical role of the tumor necrosis factor alpha convertase (TACE) in ectodomain shedding of the p75 neurotrophin receptor (p75NTR)
    • Weskamp, G., Schlondorff, J., Lum, L., Becherer, J. D., Kim, T. W., Saftig, P., Hartmann, D., Murphy, G. and Blobel, C. P. (2004). Evidence for a critical role of the tumor necrosis factor alpha convertase (TACE) in ectodomain shedding of the p75 neurotrophin receptor (p75NTR). J. Biol. Chem. 279, 4241-4249.
    • (2004) J. Biol. Chem. , vol.279 , pp. 4241-4249
    • Weskamp, G.1    Schlondorff, J.2    Lum, L.3    Becherer, J.D.4    Kim, T.W.5    Saftig, P.6    Hartmann, D.7    Murphy, G.8    Blobel, C.P.9
  • 48
    • 0033230625 scopus 로고    scopus 로고
    • Neurotrophin binding to the p75 receptor modulates Rho activity and axonal outgrowth
    • Yamashita, T., Tucker, K. L. and Barde, Y. A. (1999). Neurotrophin binding to the p75 receptor modulates Rho activity and axonal outgrowth. Neuron 24, 585-593.
    • (1999) Neuron , vol.24 , pp. 585-593
    • Yamashita, T.1    Tucker, K.L.2    Barde, Y.A.3
  • 49
    • 0025782715 scopus 로고
    • Chimeric NGF-EGF receptors define domains responsible for neuronal differentiation
    • Yan, H., Schlessinger, J. and Chao, M. V. (1991). Chimeric NGF-EGF receptors define domains responsible for neuronal differentiation. Science 252, 561-563. (Pubitemid 121000453)
    • (1991) Science , vol.252 , Issue.5005 , pp. 561-563
    • Yan, H.1    Schlessinger, J.2    Chao, M.V.3
  • 50
    • 17644388524 scopus 로고    scopus 로고
    • Cleavage of p75 neurotrophin receptor by alpha-secretase and gamma-secretase requires specific receptor domains
    • Zampieri, N., Xu, C. F., Neubert, T. A. and Chao, M. V. (2005). Cleavage of p75 neurotrophin receptor by alpha-secretase and gamma-secretase requires specific receptor domains. J. Biol. Chem. 280, 14563-14571.
    • (2005) J. Biol. Chem. , vol.280 , pp. 14563-14571
    • Zampieri, N.1    Xu, C.F.2    Neubert, T.A.3    Chao, M.V.4


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