Putting the structure into complement

Immunobiology

Volumn 217, Issue 11, 2012, Pages 1117-1121

  Lea, Susan M ^a   Johnson, Steven ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Complement; Protein complexes; Regulation; Structure

Indexed keywords

ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; CD59 ANTIGEN; COMPLEMENT; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C3B; COMPLEMENT COMPONENT C5; COMPLEMENT COMPONENT C6; COMPLEMENT FACTOR D; COMPLEMENT FACTOR H; COMPLEMENT MEMBRANE ATTACK COMPLEX;

ALLOSTERISM; COMPLEMENT ACTIVATION; COMPLEMENT SYSTEM; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN STRUCTURE; REVIEW;

EID: 84866049104     PISSN: 01712985     EISSN: 18783279     Source Type: Journal    
DOI: 10.1016/j.imbio.2012.07.005     Document Type: Review

References (65)

1. Alcorlo M., Martinez-Barricarte R., Fernandez F.J., Rodriguez-Gallego C., Round A., Vega M.C., Harris C.L., de Cordoba S.R., Llorca O. Unique structure of iC3b resolved at a resolution of 24 A by 3D-electron microscopy. Proc. Natl. Acad. Sci. USA 2011, 108:13236-13240.
2. Aleshin A.E., Discipio R.G., Stec B., Liddington R.C. Crystal structure of c5b-6 suggests structural basis for priming assembly of the membrane attack complex. J. Biol. Chem. 2012, 287:19642-19652.
3. Aleshin A.E., Schraufstatter I.U., Stec B., Bankston L.A., Liddington R.C., DiScipio R.G. Structure of complement C6 suggests a mechanism for initiation and unidirectional, sequential assembly of membrane attack complex (MAC). J. Biol. Chem. 2012, 287:10210-10222.
4. Arlaud G.J., Barlow P.N., Gaboriaud C., Gros P., Narayana S.V. Deciphering complement mechanisms: the contributions of structural biology. Mol. Immunol. 2007, 44:3809-3822.
5. Barlow P.N., Norman D.G., Steinkasserer A., Horne T.J., Pearce J., Driscoll P.C., Sim R.B., Campbell I.D. Solution structure of the fifth repeat of factor H: a second example of the complement control protein module. Biochemistry 1992, 31:3626-3634.
6. Barlow P.N., Steinkasserer A., Norman D.G., Kieffer B., Wiles A.P., Sim R.B., Campbell I.D. Solution structure of a pair of complement modules by nuclear magnetic resonance. J. Mol. Biol. 1993, 232:268-284.
7. Blaum B.S., Deakin J.A., Johansson C.M., Herbert A.P., Barlow P.N., Lyon M., Uhrin D. Lysine and arginine side chains in glycosaminoglycan-protein complexes investigated by NMR, cross-linking, and mass spectrometry: a case study of the factor H-heparin interaction. J. Am. Chem. Soc. 2010, 132:6374-6381.
8. Bubeck D., Roversi P., Donev R., Morgan B.P., Llorca O., Lea S.M. Structure of human complement C8, a precursor to membrane attack. J. Mol. Biol. 2011, 405:325-330.
9. Chen X., Yu Y., Mi L.Z., Walz T., Springer T.A. Molecular basis for complement recognition by integrin alphaXbeta2. Proc. Natl. Acad. Sci. USA 2012, 109:4586-4591.
10. Dobo J., Harmat V., Beinrohr L., Sebestyen E., Zavodszky P., Gal P. MASP-1, a promiscuous complement protease: structure of its catalytic region reveals the basis of its broad specificity. J. Immunol. 2009, 183:1207-1214.
11. Forneris F., Ricklin D., Wu J., Tzekou A., Wallace R.S., Lambris J.D., Gros P. Structures of C3b in complex with factors B and D give insight into complement convertase formation. Science 2010, 330:1816-1820.
12. Fredslund F., Laursen N.S., Roversi P., Jenner L., Oliveira C.L., Pedersen J.S., Nunn M.A., Lea S.M., Discipio R., Sottrup-Jensen L., Andersen G.R. Structure of and influence of a tick complement inhibitor on human complement component 5. Nat. Immunol. 2008, 9:753-760.
13. Gaboriaud C., Frachet P., Thielens N.M., Arlaud G.J. The human c1q globular domain: structure and recognition of non-immune self ligands. Front. Immunol. 2011, 2:92.
14. Gal P., Dobo J., Zavodszky P., Sim R.B. Early complement proteases: C1r C 1s and MASPs. A structural insight into activation and functions. Mol. Immunol. 2009, 46:2745-2752.
15. Garcia B.L., Ramyar K.X., Tzekou A., Ricklin D., McWhorter W.J., Lambris J.D., Geisbrecht B.V. Molecular basis for complement recognition and inhibition determined by crystallographic studies of the staphylococcal complement inhibitor (SCIN) bound to C3c and C3b. J. Mol. Biol. 2010, 402:17-29.
16. Garlatti V., Martin L., Lacroix M., Gout E., Arlaud G.J., Thielens N.M., Gaboriaud C. Structural insights into the recognition properties of human ficolins. J. Innate Immun. 2010, 2:17-23.
17. Gilbert R.J., Rossjohn J., Parker M.W., Tweten R.K., Morgan P.J., Mitchell T.J., Errington N., Rowe A.J., Andrew P.W., Byron O. Self-interaction of pneumolysin, the pore-forming protein toxin of Streptococcus pneumoniae. J. Mol. Biol. 1998, 284:1223-1237.
18. Gout E., Moriscot C., Doni A., Dumestre-Perard C., Lacroix M., Perard J., Schoehn G., Mantovani A., Arlaud G.J., Thielens N.M. M-ficolin interacts with the long pentraxin PTX3: a novel case of cross-talk between soluble pattern-recognition molecules. J. Immunol. 2011, 186:5815-5822.
19. Gros P. In self-defense. Nat. Struct. Mol. Biol. 2011, 18:401-402.
20. Gros P., Milder F.J., Janssen B.J. Complement driven by conformational changes. Nat. Rev. Immunol. 2008, 8:48-58.
21. Hadders M.A., Beringer D.X., Gros P. Structure of C8alpha-MACPF reveals mechanism of membrane attack in complement immune defense. Science 2007, 317:1552-1554.
22. Hadders M.A., Bubeck D., Roversi P., Hakobyan S., Forneris F., Morgan B.P., Pangburn M.K., Llorca O., Lea S.M., Gros P. Assembly and regulation of the membrane attack complex based on structures of C5b6 and sC5b9. Cell Rep. 2012, 1:1-8.
23. Huber R., Scholze H., Paques E.P., Deisenhofer J. Crystal structure analysis and molecular model of human C3a anaphylatoxin. Hoppe-Seyler's Z. Physiol. Chem. 1980, 361:1389-1399.
24. Janssen B.J., Christodoulidou A., McCarthy A., Lambris J.D., Gros P. Structure of C3b reveals conformational changes that underlie complement activity. Nature 2006, 444:213-216.
25. Janssen B.J., Gomes L., Koning R.I., Svergun D.I., Koster A.J., Fritzinger D.C., Vogel C.W., Gros P. Insights into complement convertase formation based on the structure of the factor B-cobra venom factor complex. EMBO J. 2009, 28:2469-2478.
26. Janssen B.J., Gros P. Conformational complexity of complement component C3. Adv. Exp. Med. Biol. 2006, 586:291-312.
27. Janssen B.J., Gros P. Structural insights into the central complement component C3. Mol. Immunol. 2007, 44:3-10.
28. Janssen B.J., Huizinga E.G., Raaijmakers H.C., Roos A., Daha M.R., Nilsson-Ekdahl K., Nilsson B., Gros P. Structures of complement component C3 provide insights into the function and evolution of immunity. Nature 2005, 437:505-511.
29. Jenkins H.T., Mark L., Ball G., Persson J., Lindahl G., Uhrin D., Blom A.M., Barlow P.N. Human C4b-binding protein, structural basis for interaction with streptococcal M protein, a major bacterial virulence factor. J. Biol. Chem. 2006, 281:3690-3697.
30. Jing H., Babu Y.S., Moore D., Kilpatrick J.M., Liu X.Y., Volanakis J.E., Narayana S.V. Structures of native and complexed complement factor D: implications of the atypical His57 conformation and self-inhibitory loop in the regulation of specific serine protease activity. J. Mol. Biol. 1998, 282:1061-1081.
31. Kajander T., Lehtinen M.J., Hyvarinen S., Bhattacharjee A., Leung E., Isenman D.E., Meri S., Goldman A., Jokiranta T.S. Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complement. Proc. Natl. Acad. Sci. USA 2011, 108:2897-2902.
32. Khan S., Nan R., Gor J., Mulloy B., Perkins S.J. Bivalent and co-operative binding of complement Factor H to heparan sulfate and heparin. Biochem. J. 2012, 444:417-428.
33. Krishnan V., Ponnuraj K., Xu Y., Macon K., Volanakis J.E., Narayana S.V. The crystal structure of cobra venom factor: a cofactor for C3- and C5-convertase CVFBb. Structure 2009, 17:611-619.
34. Lang A., Szilagyi K., Major B., Gal P., Zavodszky P., Perczel A. Intermodule cooperativity in the structure and dynamics of consecutive complement control modules in human C1r: structural biology. FEBS J. 2010, 277:3986-3998.
35. Laursen N.S., Andersen K.R., Braren I., Spillner E., Sottrup-Jensen L., Andersen G.R. Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex. EMBO J. 2011, 30:606-616.
36. Law R.H., Lukoyanova N., Voskoboinik I., Caradoc-Davies T.T., Baran K., Dunstone M.A., D'Angelo M.E., Orlova E.V., Coulibaly F., Verschoor S., Browne K.A., Ciccone A., Kuiper M.J., Bird P.I., Trapani J.A., Saibil H.R., Whisstock J.C. The structural basis for membrane binding and pore formation by lymphocyte perforin. Nature 2010, 468:447-451.
37. Li K., Gor J., Perkins S.J. Self-association and domain rearrangements between complement C3 and C3u provide insight into the activation mechanism of C3. Biochem. J. 2010, 431:63-72.
38. Lovelace L.L., Chiswell B., Slade D.J., Sodetz J.M., Lebioda L. Crystal structure of complement protein C8gamma in complex with a peptide containing the C8gamma binding site on C8alpha: implications for C8gamma ligand binding. Mol. Immunol. 2008, 45:750-756.
39. Lovelace L.L., Cooper C.L., Sodetz J.M., Lebioda L. Structure of human C8 protein provides mechanistic insight into membrane pore formation by complement. J. Biol. Chem. 2011, 286:17585-17592.
40. Lukacik P., Roversi P., White J., Esser D., Smith G.P., Billington J., Williams P.A., Rudd P.M., Wormald M.R., Harvey D.J., Crispin M.D., Radcliffe C.M., Dwek R.A., Evans D.J., Morgan B.P., Smith R.A., Lea S.M. Complement regulation at the molecular level: the structure of decay-accelerating factor. Proc. Natl. Acad. Sci. USA 2004, 101:1279-1284.
41. Milder F.J., Gomes L., Schouten A., Janssen B.J., Huizinga E.G., Romijn R.A., Hemrika W., Roos A., Daha M.R., Gros P. Factor B structure provides insights into activation of the central protease of the complement system. Nat. Struct. Mol. Biol. 2007, 14:224-228.
42. Morgan H.P., Mertens H.D., Guariento M., Schmidt C.Q., Soares D.C., Svergun D.I., Herbert A.P., Barlow P.N., Hannan J.P. Structural analysis of the C-terminal region (modules 18-20) of complement regulator factor H (FH). PLoS One 2012, 7:e32187.
43. Morgan H.P., Schmidt C.Q., Guariento M., Blaum B.S., Gillespie D., Herbert A.P., Kavanagh D., Mertens H.D., Svergun D.I., Johansson C.M., Uhrin D., Barlow P.N., Hannan J.P. Structural basis for engagement by complement factor H of C3b on a self surface. Nat. Struct. Mol. Biol. 2011, 18:463-470.
44. Nagar B., Jones R.G., Diefenbach R.J., Isenman D.E., Rini J.M. X-ray crystal structure of C3d: a C3 fragment and ligand for complement receptor 2. Science 1998, 280:1277-1281.
45. Narayana S.V., Carson M., el-Kabbani O., Kilpatrick J.M., Moore D., Chen X., Bugg C.E., Volanakis J.E., DeLucas L.J. Structure of human factor D. A complement system protein at 2.0A resolution. J. Mol. Biol. 1994, 235:695-708.
46. Norman D.G., Barlow P.N., Baron M., Day A.J., Sim R.B., Campbell I.D. Three-dimensional structure of a complement control protein module in solution. J. Mol. Biol. 1991, 219:717-725.
47. Ortlund E., Parker C.L., Schreck S.F., Ginell S., Minor W., Sodetz J.M., Lebioda L. Crystal structure of human complement protein C8gamma at 1.2A resolution reveals a lipocalin fold and a distinct ligand binding site. Biochemistry 2002, 41:7030-7037.
48. Perkins S.J., Nan R., Li K., Khan S., Abe Y. Analytical ultracentrifugation combined with X-ray and neutron scattering: experiment and modelling. Methods 2011, 54:181-199.
49. Perkins S.J., Nan R., Li K., Khan S., Miller A. Complement factor H-ligand interactions: self-association, multivalency and dissociation constants. Immunobiology 2012, 217:281-297.
50. Perkins S.J., Nan R., Okemefuna A.I., Li K., Khan S., Miller A. Multiple interactions of complement Factor H with its ligands in solution: a progress report. Adv. Exp. Med. Biol. 2010, 703:25-47.
51. Perkins S.J., Okemefuna A.I., Nan R. Unravelling protein-protein interactions between complement factor H and C-reactive protein using a multidisciplinary strategy. Biochem. Soc. Trans. 2010, 38:894-900.
52. Persson B.D., Schmitz N.B., Santiago C., Zocher G., Larvie M., Scheu U., Casasnovas J.M., Stehle T. Structure of the extracellular portion of CD46 provides insights into its interactions with complement proteins and pathogens. PLoS Pathog. 2010, 6:e1001122.
53. Phelan M.M., Thai C.T., Soares D.C., Ogata R.T., Barlow P.N., Bramham J. Solution structure of factor I-like modules from complement C7 reveals a pair of follistatin domains in compact pseudosymmetric arrangement. J. Biol. Chem. 2009, 284:19637-19649.
54. Prosser B.E., Johnson S., Roversi P., Herbert A.P., Blaum B.S., Tyrrell J., Jowitt T.A., Clark S.J., Tarelli E., Uhrin D., Barlow P.N., Sim R.B., Day A.J., Lea S.M. Structural basis for complement factor H linked age-related macular degeneration. J. Exp. Med. 2007, 204:2277-2283.
55. Rooijakkers S.H., Wu J., Ruyken M., van Domselaar R., Planken K.L., Tzekou A., Ricklin D., Lambris J.D., Janssen B.J., van Strijp J.A., Gros P. Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor. Nat. Immunol. 2009, 10:721-727.
56. Rossjohn J., Feil S.C., McKinstry W.J., Tweten R.K., Parker M.W. Structure of a cholesterol-binding, thiol-activated cytolysin and a model of its membrane form. Cell 1997, 89:685-692.
57. Roversi P., Johnson S., Caesar J.J., McLean F., Leath K.J., Tsiftsoglou S.A., Morgan B.P., Harris C.L., Sim R.B., Lea S.M. Structural basis for complement factor I control and its disease-associated sequence polymorphisms. Proc. Natl. Acad. Sci. USA 2011, 108:12839-12844.
58. Schmidt C.Q., Herbert A.P., Hocking H.G., Uhrin D., Barlow P.N. Translational mini-review series on complement factor H: structural and functional correlations for factor H. Clin. Exp. Immunol. 2008, 151:14-24.
59. Serruto D., Rappuoli R., Scarselli M., Gros P., van Strijp J.A. Molecular mechanisms of complement evasion: learning from staphylococci and meningococci. Nature reviews. Microbiology 2010, 8:393-399.
60. Slade D.J., Lovelace L.L., Chruszcz M., Minor W., Lebioda L., Sodetz J.M. Crystal structure of the MACPF domain of human complement protein C8 alpha in complex with the C8 gamma subunit. J. Mol. Biol. 2008, 379:331-342.
61. Springer T.A. Complement and the multifaceted functions of VWA and integrin I domains. Structure 2006, 14:1611-1616.
62. Teillet F., Gaboriaud C., Lacroix M., Martin L., Arlaud G.J., Thielens N.M. Crystal structure of the CUB1-EGF-CUB2 domain of human MASP-1/3 and identification of its interaction sites with mannan-binding lectin and ficolins. J. Biol. Chem. 2008, 283:25715-25724.
63. Torreira E., Tortajada A., Montes T., Rodriguez de Cordoba S., Llorca O. 3D structure of the C3bB complex provides insights into the activation and regulation of the complement alternative pathway convertase. Proc. Natl. Acad. Sci. USA 2009, 106:882-887.
64. Torreira E., Tortajada A., Montes T., Rodriguez de Cordoba S., Llorca O. Coexistence of closed and open conformations of complement factor B in the alternative pathway C3bB(Mg2+) proconvertase. J. Immunol. 2009, 183:7347-7351.
65. Wu J., Wu Y.Q., Ricklin D., Janssen B.J., Lambris J.D., Gros P. Structure of complement fragment C3b-factor H and implications for host protection by complement regulators. Nat. Immunol. 2009, 10:728-733.