Oxidative stress sensitizes Retinal Pigmented Epithelial (RPE) cells to complement-mediated injury in a natural antibody-, lectin pathway-, and phospholipid epitope-dependent manner

Journal of Biological Chemistry

Volumn 288, Issue 18, 2013, Pages 12753-12765

  Joseph, Kusumam ^a   Kulik, Liudmila ^b   Coughlin, Beth ^a   Kunchithapautham, Kannan ^a   Bandyopadhyay, Mausumi ^a   Thiel, Steffen ^c   Thielens, Nicole M ^d   Holers, V Michael ^b   Rohrer, Bärbel ^a,e  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c AARHUS UNIVERSITY   (Denmark)

^d INSTITUT DE BIOLOGIE STRUCTURALE   (France)

^e RALPH H JOHNSON VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGE-RELATED MACULAR DEGENERATION; ANTIBODY RECOGNITION; CHOROIDAL NEOVASCULARIZATION; COMPLEMENT ACTIVATIONS; LASER INDUCED; MANNAN-BINDING LECTINS; MOLECULAR EVENTS; POTENTIAL LIGAND;

BODY FLUIDS; CELL MEMBRANES; EPITOPES; MAMMALS; MONOLAYERS; OPHTHALMOLOGY; PHOSPHOLIPIDS;

ANTIBODIES;

CELL ANTIBODY; COMPLEMENT; COMPLEMENT COMPONENT C1Q; EPITOPE; FICOLIN; HYDROGEN PEROXIDE; IMMUNOGLOBULIN M ANTIBODY; LECTIN; MANNAN BINDING LECTIN; PHOSPHOLIPID;

ANIMAL CELL; ANTIBODY DETECTION; ANTIGEN ANTIBODY COMPLEX; ANTIGEN BINDING; ANTIGEN FUNCTION; ARTICLE; CELL DAMAGE; CELL LOSS; CELL STRESS; CELL SURFACE; COMPLEMENT ACTIVATION; COMPLEMENT ALTERNATIVE PATHWAY; COMPLEMENT CLASSICAL PATHWAY; COMPLEMENT INHIBITION; COMPLEMENT LECTIN PATHWAY; CONTROLLED STUDY; EMBRYO; FETUS; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; MOLECULAR MECHANICS; MOUSE; NONHUMAN; OXIDATIVE STRESS; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RETINA MACULA AGE RELATED DEGENERATION; SUBRETINAL NEOVASCULARIZATION;

AGE-RELATED MACULAR DEGENERATION; ANTIBODIES; CHOROIDAL NEOVASCULARIZATION; COMPLEMENT SYSTEM; EPITHELIUM; LECTIN COMPLEMENT PATHWAY; LIPID PEROXIDATION; NATURAL ANTIBODIES; OXIDATIVE STRESS; RETINAL PIGMENT EPITHELIUM;

ANIMALS; CELL LINE; COMPLEMENT C1Q; COMPLEMENT PATHWAY, ALTERNATIVE; COMPLEMENT PATHWAY, MANNOSE-BINDING LECTIN; HOMEODOMAIN PROTEINS; HUMANS; HYDROGEN PEROXIDE; IMMUNOGLOBULIN M; MICE; MICE, KNOCKOUT; OXIDANTS; OXIDATIVE STRESS; PHOSPHOLIPIDS; RETINAL PIGMENT EPITHELIUM;

MUS;

EID: 84877125681     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.421891     Document Type: Article

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