메뉴 건너뛰기




Volumn 289, Issue 9, 2014, Pages 6225-6235

Platelet-derived Growth Factor-C (PDGF-C) induces anti-apoptotic effects on macrophages through Akt and bad phosphorylation

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED MACROPHAGES; ANTI-APOPTOTIC EFFECTS; BREAST CANCER CELLS; POLY POLYMERASE; SIGNALING PATHWAYS; SURVIVAL MECHANISMS; TUMOR PROGRESSIONS; TUMOR-ASSOCIATED MACROPHAGES;

EID: 84896867662     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.508994     Document Type: Article
Times cited : (43)

References (82)
  • 2
    • 0028589148 scopus 로고
    • Platelet-derived growth factor receptor signals
    • Claesson-Welsh, L. (1994) Platelet-derived growth factor receptor signals. J. Biol. Chem. 269, 32023-32026
    • (1994) J. Biol. Chem. , vol.269 , pp. 32023-32026
    • Claesson-Welsh, L.1
  • 3
    • 84862933330 scopus 로고    scopus 로고
    • Platelet-derived growth factor-C (PDGF-C) activation by serine proteases: Implications for breast cancer progression
    • Hurst, N. J., Jr., Najy, A. J., Ustach, C. V., Movilla, L., and Kim, H. R. (2012) Platelet-derived growth factor-C (PDGF-C) activation by serine proteases: implications for breast cancer progression. Biochem. J. 441, 909-918
    • (2012) Biochem. J. , vol.441 , pp. 909-918
    • Hurst Jr., N.J.1    Najy, A.J.2    Ustach, C.V.3    Movilla, L.4    Kim, H.R.5
  • 4
    • 0032768156 scopus 로고    scopus 로고
    • Role of PDGF-B and PDGFR-β in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse
    • Hellström, M., Kalén, M., Lindahl, P., Abramsson, A., and Betsholtz, C. (1999) Role of PDGF-B and PDGFR-β in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse. Development 126, 3047-3055 (Pubitemid 29378170)
    • (1999) Development , vol.126 , Issue.14 , pp. 3047-3055
    • Hellstrom, M.1    Kalen, M.2    Lindahl, P.3    Abramsson, A.4    Betsholtz, C.5
  • 5
    • 0022404365 scopus 로고
    • A significant part of macrophage-derived growth factor consists of at least two forms of PDGF
    • Shimokado, K., Raines, E. W., Madtes, D. K., Barrett, T. B., Benditt, E. P., and Ross, R. (1985) A significant part of macrophage-derived growth factor consists of at least two forms of PDGF. Cell 43, 277-286 (Pubitemid 16199714)
    • (1985) Cell , vol.43 , Issue.1 , pp. 277-286
    • Shimokado, K.1    Raines, E.W.2    Madtes, D.K.3
  • 6
    • 0029671164 scopus 로고    scopus 로고
    • Interferon-γ modulates lung macrophage production of PDGF-BB and fibroblast growth
    • Badgett, A., Bonner, J. C., and Brody, A. R. (1996) Interferon-γ modulates lung macrophage production of PDGF-BB and fibroblast growth. J. Lipid Mediat. Cell Signal. 13, 89-97
    • (1996) J. Lipid Mediat. Cell Signal. , vol.13 , pp. 89-97
    • Badgett, A.1    Bonner, J.C.2    Brody, A.R.3
  • 7
    • 0008887031 scopus 로고
    • Endothelial cell hyperplasia in human glioblastoma: Coexpression of mRNA for platelet-derived growth factor (PDGF) B chain and PDGF receptor suggests autocrine growth stimulation
    • Hermansson, M., Nistér, M., Betsholtz, C., Heldin, C. H., Westermark, B., and Funa, K. (1988) Endothelial cell hyperplasia in human glioblastoma: coexpression of mRNA for platelet-derived growth factor (PDGF) B chain and PDGF receptor suggests autocrine growth stimulation. Proc. Natl. Acad. Sci. U.S.A. 85, 7748-7752
    • (1988) Proc. Natl. Acad. Sci. U.S.A. , vol.85 , pp. 7748-7752
    • Hermansson, M.1    Nistér, M.2    Betsholtz, C.3    Heldin, C.H.4    Westermark, B.5    Funa, K.6
  • 8
    • 0028941001 scopus 로고
    • Vascular endothelial growth factor in human glioma cell lines: Induced secretion by EGF, PDGF-BB, and bFGF
    • Tsai, J. C., Goldman, C. K., and Gillespie, G. Y. (1995) Vascular endothelial growth factor in human glioma cell lines: induced secretion by EGF, PDGF-BB, and bFGF. J. Neurosurg. 82, 864-873
    • (1995) J. Neurosurg. , vol.82 , pp. 864-873
    • Tsai, J.C.1    Goldman, C.K.2    Gillespie, G.Y.3
  • 14
    • 38849146936 scopus 로고    scopus 로고
    • Targeting PDGF signaling in carcinoma-associated fibroblasts controls cervical cancer in mouse model
    • Jain, R. K., Lahdenranta, J., and Fukumura, D. (2008) Targeting PDGF signaling in carcinoma-associated fibroblasts controls cervical cancer in mouse model. PLoS Med. 5, e24
    • (2008) PLoS Med. , vol.5
    • Jain, R.K.1    Lahdenranta, J.2    Fukumura, D.3
  • 15
    • 77955271182 scopus 로고    scopus 로고
    • Breast cancer cells attract the migration of adipose tissue-derived stem cells via the PDGF-BB/PDGFR-β signaling pathway
    • Gehmert, S., Gehmert, S., Prantl, L., Vykoukal, J., Alt, E., and Song, Y. H. (2010) Breast cancer cells attract the migration of adipose tissue-derived stem cells via the PDGF-BB/PDGFR-β signaling pathway. Biochem. Biophys. Res. Commun. 398, 601-605
    • (2010) Biochem. Biophys. Res. Commun. , vol.398 , pp. 601-605
    • Gehmert, S.1    Gehmert, S.2    Prantl, L.3    Vykoukal, J.4    Alt, E.5    Song, Y.H.6
  • 16
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • DOI 10.1038/nature01322
    • Coussens, L. M., and Werb, Z. (2002) Inflammation and cancer. Nature 420, 860-867 (Pubitemid 36019639)
    • (2002) Nature , vol.420 , Issue.6917 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 17
    • 8344248747 scopus 로고    scopus 로고
    • Cancer research. Inflammation and cancer: The link grows stronger
    • Marx, J. (2004) Cancer research. Inflammation and cancer: the link grows stronger. Science 306, 966-968
    • (2004) Science , vol.306 , pp. 966-968
    • Marx, J.1
  • 18
  • 20
    • 0035901090 scopus 로고    scopus 로고
    • Inflammation and cancer: Back to Virchow?
    • DOI 10.1016/S0140-6736(00)04046-0
    • Balkwill, F., and Mantovani, A. (2001) Inflammation and cancer: back to Virchow? Lancet 357, 539-545 (Pubitemid 32173595)
    • (2001) Lancet , vol.357 , Issue.9255 , pp. 539-545
    • Balkwill, F.1    Mantovani, A.2
  • 21
    • 0038230415 scopus 로고    scopus 로고
    • The macrophage growth factor CSF-1 in mammary gland development and tumor progression
    • DOI 10.1023/A:1020399802795
    • Lin, E. Y., Gouon-Evans, V., Nguyen, A. V., and Pollard, J. W. (2002) The macrophage growth factor CSF-1 in mammary gland development and tumor progression. J. Mammary Gland. Biol. Neoplasia 7, 147-162 (Pubitemid 38420772)
    • (2002) Journal of Mammary Gland Biology and Neoplasia , vol.7 , Issue.2 , pp. 147-162
    • Lin, E.Y.1    Gouon-Evans, V.2    Nguyen, A.V.3    Pollard, J.W.4
  • 22
    • 0036839143 scopus 로고    scopus 로고
    • Macrophage polarization: Tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    • DOI 10.1016/S1471-4906(02)02302-5, PII S1471490602023025
    • Mantovani, A., Sozzani, S., Locati, M., Allavena, P., and Sica, A. (2002) Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol. 23, 549-555 (Pubitemid 35223554)
    • (2002) Trends in Immunology , vol.23 , Issue.11 , pp. 549-555
    • Mantovani, A.1    Sozzani, S.2    Locati, M.3    Allavena, P.4    Sica, A.5
  • 23
    • 0347123433 scopus 로고    scopus 로고
    • Tumour-educated macrophages promote tumour progression and metastasis
    • Pollard, J. W. (2004) Tumour-educated macrophages promote tumour progression and metastasis. Nat. Rev. Cancer 4, 71-78
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 71-78
    • Pollard, J.W.1
  • 24
    • 0034021278 scopus 로고    scopus 로고
    • Macrophage infiltration is associated with VEGF and EGFR expression in breast cancer
    • DOI 10.1002/(SICI)1096-9896(200003)190:4<430::AID
    • Leek, R. D., Hunt, N. C., Landers, R. J., Lewis, C. E., Royds, J. A., and Harris, A. L. (2000) Macrophage infiltration is associated with VEGF and EGFR expression in breast cancer. J. Pathol. 190, 430-436 (Pubitemid 30163582)
    • (2000) Journal of Pathology , vol.190 , Issue.4 , pp. 430-436
    • Leek, R.D.1    Hunt, N.C.2    Landers, R.J.3    Lewis, C.E.4    Royds, J.A.5    Harris, A.L.6
  • 25
    • 24744454660 scopus 로고    scopus 로고
    • Macrophage infiltration and its prognostic implications in breast cancer: The relationship with VEGF expression and microvessel density
    • Tsutsui, S., Yasuda, K., Suzuki, K., Tahara, K., Higashi, H., and Era, S. (2005) Macrophage infiltration and its prognostic implications in breast cancer: the relationship with VEGF expression and microvessel density. Oncol. Rep. 14, 425-431
    • (2005) Oncol. Rep. , vol.14 , pp. 425-431
    • Tsutsui, S.1    Yasuda, K.2    Suzuki, K.3    Tahara, K.4    Higashi, H.5    Era, S.6
  • 26
    • 84856463822 scopus 로고    scopus 로고
    • TGF-β-induced epithelial-mesenchymal transition of A549 lung adenocarcinoma cells is enhanced by pro-inflammatory cytokines derived from RAW 264.7 macrophage cells
    • Kawata, M., Koinuma, D., Ogami, T., Umezawa, K., Iwata, C., Watabe, T., and Miyazono, K. (2012) TGF-β-induced epithelial-mesenchymal transition of A549 lung adenocarcinoma cells is enhanced by pro-inflammatory cytokines derived from RAW 264.7 macrophage cells. J. Biochem. 151, 205-216
    • (2012) J. Biochem. , vol.151 , pp. 205-216
    • Kawata, M.1    Koinuma, D.2    Ogami, T.3    Umezawa, K.4    Iwata, C.5    Watabe, T.6    Miyazono, K.7
  • 27
    • 84871948755 scopus 로고    scopus 로고
    • TGF-β signaling and epithelial-mesenchymal transition in cancer progression
    • Katsuno, Y., Lamouille, S., and Derynck, R. (2013) TGF-β signaling and epithelial-mesenchymal transition in cancer progression. Curr. Opin. Oncol. 25, 76-84
    • (2013) Curr. Opin. Oncol. , vol.25 , pp. 76-84
    • Katsuno, Y.1    Lamouille, S.2    Derynck, R.3
  • 28
    • 42449100017 scopus 로고    scopus 로고
    • Tumoral and macrophage uPAR and MMP-9 contribute to the invasiveness of B16 murine melanoma cells
    • Marconi, C., Bianchini, F., Mannini, A., Mugnai, G., Ruggieri, S., and Calorini, L. (2008) Tumoral and macrophage uPAR and MMP-9 contribute to the invasiveness of B16 murine melanoma cells. Clin. Exp. Metastasis 25, 225-231
    • (2008) Clin. Exp. Metastasis , vol.25 , pp. 225-231
    • Marconi, C.1    Bianchini, F.2    Mannini, A.3    Mugnai, G.4    Ruggieri, S.5    Calorini, L.6
  • 29
    • 33646736321 scopus 로고    scopus 로고
    • Tumor-driven paracrine platelet-derived growth factor receptor α signaling is a key determinant of stromal cell recruitment in a model of human lung carcinoma
    • Tejada, M. L., Yu, L., Dong, J., Jung, K., Meng, G., Peale, F. V., Frantz, G. D., Hall, L., Liang, X., Gerber, H. P., and Ferrara, N. (2006) Tumor-driven paracrine platelet-derived growth factor receptor α signaling is a key determinant of stromal cell recruitment in a model of human lung carcinoma. Clin. Cancer Res. 12, 2676-2688
    • (2006) Clin. Cancer Res. , vol.12 , pp. 2676-2688
    • Tejada, M.L.1    Yu, L.2    Dong, J.3    Jung, K.4    Meng, G.5    Peale, F.V.6    Frantz, G.D.7    Hall, L.8    Liang, X.9    Gerber, H.P.10    Ferrara, N.11
  • 30
    • 0036645057 scopus 로고    scopus 로고
    • Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: Evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors
    • Lokker, N. A., Sullivan, C. M., Hollenbach, S. J., Israel, M. A., and Giese, N. A. (2002) Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors. Cancer Res. 62, 3729-3735 (Pubitemid 34728854)
    • (2002) Cancer Research , vol.62 , Issue.13 , pp. 3729-3735
    • Lokker, N.A.1    Sullivan, C.M.2    Hollenbach, S.J.3    Israel, M.A.4    Giese, N.A.5
  • 31
    • 0036385854 scopus 로고    scopus 로고
    • Platelet-derived growth factor-B and -C and active α-receptors in medulloblastoma cells
    • Andrae, J., Molander, C., Smits, A., Funa, K., and Nistér, M. (2002) Platelet-derived growth factor-B and -C and active α-receptors in medulloblastoma cells. Biochem. Biophys. Res. Commun. 296, 604-611
    • (2002) Biochem. Biophys. Res. Commun. , vol.296 , pp. 604-611
    • Andrae, J.1    Molander, C.2    Smits, A.3    Funa, K.4    Nistér, M.5
  • 32
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell- intrinsic death machinery
    • DOI 10.1016/S0092-8674(00)80405-5
    • Datta, S. R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., and Greenberg, M. E. (1997) Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91, 231-241 (Pubitemid 27456390)
    • (1997) Cell , vol.91 , Issue.2 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Xu, T.3    Masters, S.4    Haian, F.5    Gotoh, Y.6    Greenberg, M.E.7
  • 33
    • 68149107692 scopus 로고    scopus 로고
    • BAD: Undertaker by night, candyman by day
    • Danial, N. N. (2008) BAD: undertaker by night, candyman by day. Oncogene 27, S53-70
    • (2008) Oncogene , vol.27
    • Danial, N.N.1
  • 34
    • 33846106906 scopus 로고    scopus 로고
    • Larger than life: Mitochondria and the Bcl-2 family
    • DOI 10.1016/j.leukres.2006.06.027, PII S014521260600261X
    • Skommer, J., Wlodkowic, D., and Deptala, A. (2007) Larger than life: Mitochondria and the Bcl-2 family. Leuk. Res. 31, 277-286 (Pubitemid 46073182)
    • (2007) Leukemia Research , vol.31 , Issue.3 , pp. 277-286
    • Skommer, J.1    Wlodkowic, D.2    Deptala, A.3
  • 35
    • 0021972374 scopus 로고
    • Identification of minimal size requirements of DNA for activation of poly(ADP-ribose) polymerase
    • DOI 10.1021/bi00337a015
    • Berger, N. A., and Petzold, S. J. (1985) Identification of minimal size requirements of DNA for activation of poly(ADP-ribose) polymerase. Biochemistry 24, 4352-4355 (Pubitemid 15228442)
    • (1985) Biochemistry , vol.24 , Issue.16 , pp. 4352-4355
    • Berger, N.A.1    Petzold, S.J.2
  • 36
    • 0028263811 scopus 로고
    • c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines
    • Harrington, E. A., Bennett, M. R., Fanidi, A., and Evan, G. I. (1994) c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines. EMBOJ. 13, 3286-3295 (Pubitemid 24226943)
    • (1994) EMBO Journal , vol.13 , Issue.14 , pp. 3286-3295
    • Harrington, E.A.1    Bennett, M.R.2    Fanidi, A.3    Evan, G.I.4
  • 37
    • 0033517190 scopus 로고    scopus 로고
    • NF-κB is a target of AKT in anti-apoptotic PDGF signalling
    • Romashkova, J. A., and Makarov, S. S. (1999) NF-κB is a target of AKT in anti-apoptotic PDGF signalling. Nature 401, 86-90
    • (1999) Nature , vol.401 , pp. 86-90
    • Romashkova, J.A.1    Makarov, S.S.2
  • 38
    • 17144386566 scopus 로고    scopus 로고
    • Systematic evaluation of anti-apoptotic growth factor signaling in vascular smooth muscle cells: Only phosphatidylinositol 3′-kinase is important
    • DOI 10.1074/jbc.M413310200
    • Vantler, M., Caglayan, E., Zimmermann, W. H., Bäumer, A. T., and Rosenkranz, S. (2005) Systematic evaluation of anti-apoptotic growth factor signaling in vascular smooth muscle cells. Only phosphatidylinositol 3′-kinase is important. J. Biol. Chem. 280, 14168-14176 (Pubitemid 40517319)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.14 , pp. 14168-14176
    • Vantler, M.1    Caglayan, E.2    Zimmermann, W.H.3    Baumer, A.T.4    Rosenkranz, S.5
  • 39
    • 0027251256 scopus 로고
    • A structural superfamily of growth factors containing a cystine knot motif
    • DOI 10.1016/0092-8674(93)90127-C
    • McDonald, N. Q., and Hendrickson, W. A. (1993) A structural superfamily of growth factors containing a cystine knot motif. Cell 73, 421-424 (Pubitemid 23143340)
    • (1993) Cell , vol.73 , Issue.3 , pp. 421-424
    • McDonald, N.Q.1    Hendrickson, W.A.2
  • 40
    • 63049104211 scopus 로고    scopus 로고
    • Microenvironmental regulation of metastasis
    • Joyce, J. A., and Pollard, J. W. (2009) Microenvironmental regulation of metastasis. Nat. Rev. Cancer 9, 239-252
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 239-252
    • Joyce, J.A.1    Pollard, J.W.2
  • 41
    • 84879604746 scopus 로고    scopus 로고
    • The metastasis-promoting roles of tumor-associated immune cells
    • Smith, H. A., and Kang, Y. (2013) The metastasis-promoting roles of tumor-associated immune cells. J. Mol. Med. 91, 411-429
    • (2013) J. Mol. Med. , vol.91 , pp. 411-429
    • Smith, H.A.1    Kang, Y.2
  • 42
    • 76149146398 scopus 로고    scopus 로고
    • IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion
    • Gocheva, V., Wang, H. W., Gadea, B. B., Shree, T., Hunter, K. E., Garfall, A. L., Berman, T., and Joyce, J. A. (2010) IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion. Genes Dev. 24, 241-255
    • (2010) Genes Dev. , vol.24 , pp. 241-255
    • Gocheva, V.1    Wang, H.W.2    Gadea, B.B.3    Shree, T.4    Hunter, K.E.5    Garfall, A.L.6    Berman, T.7    Joyce, J.A.8
  • 43
    • 0036174325 scopus 로고    scopus 로고
    • The CC chemokine RANTES in breast carcinoma progression: Regulation of expression and potential mechanisms of promalignant activity
    • Azenshtein, E., Luboshits, G., Shina, S., Neumark, E., Shahbazian, D., Weil, M., Wigler, N., Keydar, I., and Ben-Baruch, A. (2002) The CC chemokine RANTES in breast carcinoma progression: regulation of expression and potential mechanisms of promalignant activity. Cancer Res. 62, 1093-1102 (Pubitemid 34160293)
    • (2002) Cancer Research , vol.62 , Issue.4 , pp. 1093-1102
    • Azenshtein, E.1    Luboshits, G.2    Shina, S.3    Neumark, E.4    Shahbazian, D.5    Weil, M.6    Wigler, N.7    Keydar, I.8    Ben-Baruch, A.9
  • 44
    • 0036187615 scopus 로고    scopus 로고
    • The role of tumour-associated macrophages in tumour progression: Implications for new anticancer therapies
    • DOI 10.1002/path.1027
    • Bingle, L., Brown, N. J., and Lewis, C. E. (2002) The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies. J. Pathol. 196, 254-265 (Pubitemid 34189413)
    • (2002) Journal of Pathology , vol.196 , Issue.3 , pp. 254-265
    • Bingle, L.1    Brown, N.J.2    Lewis, C.E.3
  • 45
    • 84865591281 scopus 로고    scopus 로고
    • Density of tumor associated macrophage correlates with lymph node metastasis in papillary thyroid carcinoma
    • Wei, Q., Fang, W., Ye, L., Shen, L., Zhang, X., Fei, X., Chen, X., Li, X., Xiao, J., and Ning, G. (2012) Density of tumor associated macrophage correlates with lymph node metastasis in papillary thyroid carcinoma. Thyroid. 22, 905-910
    • (2012) Thyroid. , vol.22 , pp. 905-910
    • Wei, Q.1    Fang, W.2    Ye, L.3    Shen, L.4    Zhang, X.5    Fei, X.6    Chen, X.7    Li, X.8    Xiao, J.9    Ning, G.10
  • 46
    • 84872529636 scopus 로고    scopus 로고
    • Anti-tumour strategies aiming to target tumour-associated macrophages
    • Tang, X., Mo, C., Wang, Y., Wei, D., and Xiao, H. (2013) Anti-tumour strategies aiming to target tumour-associated macrophages. Immunology 138, 93-104
    • (2013) Immunology , vol.138 , pp. 93-104
    • Tang, X.1    Mo, C.2    Wang, Y.3    Wei, D.4    Xiao, H.5
  • 47
    • 84866694009 scopus 로고    scopus 로고
    • Tumor-associated macrophages: A novel potential target for cancer treatment
    • Yue, Z. Q., Liu, Y. P., Ruan, J. S., Zhou, L., and Lu, Y. (2012) Tumor-associated macrophages: a novel potential target for cancer treatment. Chin. Med. J. 125, 3305-3311
    • (2012) Chin. Med. J. , vol.125 , pp. 3305-3311
    • Yue, Z.Q.1    Liu, Y.P.2    Ruan, J.S.3    Zhou, L.4    Lu, Y.5
  • 48
    • 67649609064 scopus 로고    scopus 로고
    • Tumor-associated macrophages as targets for tumor immunotherapy
    • Weigert, A., Sekar, D., and Brüne, B. (2009) Tumor-associated macrophages as targets for tumor immunotherapy. Immunotherapy 1, 83-95
    • (2009) Immunotherapy , vol.1 , pp. 83-95
    • Weigert, A.1    Sekar, D.2    Brüne, B.3
  • 51
    • 80052746486 scopus 로고    scopus 로고
    • Systemic delivery of neutralizing antibody targeting CCL2 for glioma therapy
    • Zhu, X., Fujita, M., Snyder, L. A., and Okada, H. (2011) Systemic delivery of neutralizing antibody targeting CCL2 for glioma therapy. J. Neurooncol. 104, 83-92
    • (2011) J. Neurooncol. , vol.104 , pp. 83-92
    • Zhu, X.1    Fujita, M.2    Snyder, L.A.3    Okada, H.4
  • 54
    • 48149105507 scopus 로고    scopus 로고
    • Zoledronic acid modulates antitumoral responses of prostate cancer-tumor associated macrophages
    • Tsagozis, P., Eriksson, F., and Pisa, P. (2008) Zoledronic acid modulates antitumoral responses of prostate cancer-tumor associated macrophages. Cancer Immunol. Immunother. 57, 1451-1459
    • (2008) Cancer Immunol. Immunother. , vol.57 , pp. 1451-1459
    • Tsagozis, P.1    Eriksson, F.2    Pisa, P.3
  • 56
    • 77952540334 scopus 로고    scopus 로고
    • Monophosphoryl lipid A (MPL) as an adjuvant for anti-cancer vaccines: Clinical results
    • Cluff, C. W. (2010) Monophosphoryl lipid A (MPL) as an adjuvant for anti-cancer vaccines: clinical results. Adv. Exp. Med. Biol. 667, 111-123
    • (2010) Adv. Exp. Med. Biol. , vol.667 , pp. 111-123
    • Cluff, C.W.1
  • 57
    • 4644299671 scopus 로고    scopus 로고
    • Topical imidazoquinoline therapy of cutaneous squamous cell carcinoma polarizes lymphoid and monocyte/macrophage populations to a Th1 and M1 cytokine pattern
    • DOI 10.1111/j.1365-2230.2004.01593.x
    • Smith, K. J., Hamza, S., and Skelton, H. (2004) Topical imidazoquinoline therapy of cutaneous squamous cell carcinoma polarizes lymphoid and monocyte/macrophage populations to a Th1 and M1 cytokine pattern. Clin. Exp. Dermatol. 29, 505-512 (Pubitemid 39278198)
    • (2004) Clinical and Experimental Dermatology , vol.29 , Issue.5 , pp. 505-512
    • Smith, K.J.1    Hamza, S.2    Skelton, H.3
  • 58
    • 77957244887 scopus 로고    scopus 로고
    • The multikinase inhibitor sorafenib reverses the suppression of IL-12 and enhancement of IL-10 by PGE(2) in murine macrophages
    • Edwards, J. P., and Emens, L. A. (2010) The multikinase inhibitor sorafenib reverses the suppression of IL-12 and enhancement of IL-10 by PGE(2) in murine macrophages. Int. Immunopharmacol. 10, 1220-1228
    • (2010) Int. Immunopharmacol. , vol.10 , pp. 1220-1228
    • Edwards, J.P.1    Emens, L.A.2
  • 60
    • 65549129226 scopus 로고    scopus 로고
    • Sunitinib inhibition of Stat3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells
    • Xin, H., Zhang, C., Herrmann, A., Du, Y., Figlin, R., and Yu, H. (2009) Sunitinib inhibition of Stat3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells. Cancer Res. 69, 2506-2513
    • (2009) Cancer Res. , vol.69 , pp. 2506-2513
    • Xin, H.1    Zhang, C.2    Herrmann, A.3    Du, Y.4    Figlin, R.5    Yu, H.6
  • 61
    • 77950944395 scopus 로고    scopus 로고
    • Macrophages, innate immunity and cancer: Balance, tolerance, and diversity
    • Mantovani, A., and Sica, A. (2010) Macrophages, innate immunity and cancer: balance, tolerance, and diversity. Curr. Opin. Immunol. 22, 231-237
    • (2010) Curr. Opin. Immunol. , vol.22 , pp. 231-237
    • Mantovani, A.1    Sica, A.2
  • 63
    • 84860130221 scopus 로고    scopus 로고
    • Anti-VEGF/VEGFR therapy for cancer: Reassessing the target
    • Sitohy, B., Nagy, J. A., and Dvorak, H. F. (2012) Anti-VEGF/VEGFR therapy for cancer: reassessing the target. Cancer Res. 72, 1909-1914
    • (2012) Cancer Res. , vol.72 , pp. 1909-1914
    • Sitohy, B.1    Nagy, J.A.2    Dvorak, H.F.3
  • 64
    • 47749097074 scopus 로고    scopus 로고
    • The inflammatory chemokines CCL2 and CCL5 in breast cancer
    • Soria, G., and Ben-Baruch, A. (2008) The inflammatory chemokines CCL2 and CCL5 in breast cancer. Cancer Lett. 267, 271-285
    • (2008) Cancer Lett. , vol.267 , pp. 271-285
    • Soria, G.1    Ben-Baruch, A.2
  • 65
    • 71749088821 scopus 로고    scopus 로고
    • CCL2 and interleukin-6 promote survival of human CD11b+ peripheral blood mononuclear cells and induce M2-type macrophage polarization
    • Roca, H., Varsos, Z. S., Sud, S., Craig, M. J., Ying, C., and Pienta, K. J. (2009) CCL2 and interleukin-6 promote survival of human CD11b+ peripheral blood mononuclear cells and induce M2-type macrophage polarization. J. Biol. Chem. 284, 34342-34354
    • (2009) J. Biol. Chem. , vol.284 , pp. 34342-34354
    • Roca, H.1    Varsos, Z.S.2    Sud, S.3    Craig, M.J.4    Ying, C.5    Pienta, K.J.6
  • 67
    • 0035010433 scopus 로고    scopus 로고
    • Evolution and classification of cystine knot-containing hormones and related extracellular signaling molecules
    • DOI 10.1210/me.15.5.681
    • Vitt, U. A., Hsu, S. Y., and Hsueh, A. J. (2001) Evolution and classification of cystine knot-containing hormones and related extracellular signaling molecules. Mol. Endocrinol. 15, 681-694 (Pubitemid 32411309)
    • (2001) Molecular Endocrinology , vol.15 , Issue.5 , pp. 681-694
    • Vitt, U.A.1    Hsu, S.Y.2    Hsueh, A.J.W.3
  • 68
    • 28044473866 scopus 로고    scopus 로고
    • Structural and functional specificities of PDGF-C and PDGF-D, the novel members of the platelet-derived growth factors family
    • DOI 10.1111/j.1742-4658.2005.04989.x
    • Reigstad, L. J., Varhaug, J. E., and Lillehaug, J. R. (2005) Structural and functional specificities of PDGF-C and PDGF-D, the novel members of the platelet-derived growth factors family. FEBS J. 272, 5723-5741 (Pubitemid 41689346)
    • (2005) FEBS Journal , vol.272 , Issue.22 , pp. 5723-5741
    • Reigstad, L.J.1    Varhaug, J.E.2    Lillehaug, J.R.3
  • 69
    • 0034706020 scopus 로고    scopus 로고
    • The mouse Pdgfc gene: Dynamic expression in embryonic tissues during organogenesis
    • Ding, H., Wu, X., Kim, I., Tam, P. P., Koh, G. Y., and Nagy, A. (2000) The mouse Pdgfc gene: dynamic expression in embryonic tissues during organogenesis. Mech. Dev. 96, 209-213
    • (2000) Mech. Dev. , vol.96 , pp. 209-213
    • Ding, H.1    Wu, X.2    Kim, I.3    Tam, P.P.4    Koh, G.Y.5    Nagy, A.6
  • 70
    • 74949105315 scopus 로고    scopus 로고
    • Platelet-derived growth factor mediates survival of leukemic large granular lymphocytes via an autocrine regulatory pathway
    • Yang, J., Liu, X., Nyland, S. B., Zhang, R., Ryland, L. K., Broeg, K., Baab, K. T., Jarbadan, N. R., Irby, R., and Loughran, T. P., Jr. (2010) Platelet-derived growth factor mediates survival of leukemic large granular lymphocytes via an autocrine regulatory pathway. Blood 115, 51-60
    • (2010) Blood , vol.115 , pp. 51-60
    • Yang, J.1    Liu, X.2    Nyland, S.B.3    Zhang, R.4    Ryland, L.K.5    Broeg, K.6    Baab, K.T.7    Jarbadan, N.R.8    Irby, R.9    Loughran Jr., T.P.10
  • 71
    • 77952701390 scopus 로고    scopus 로고
    • The PI3K/Akt pathway inhibits influenza A virus-induced Bax-mediated apoptosis by negatively regulating the JNK pathway via ASK1
    • Lu, X., Masic, A., Li, Y., Shin, Y., Liu, Q., and Zhou, Y. (2010) The PI3K/Akt pathway inhibits influenza A virus-induced Bax-mediated apoptosis by negatively regulating the JNK pathway via ASK1. J. Gen. Virol. 91, 1439-1449
    • (2010) J. Gen. Virol. , vol.91 , pp. 1439-1449
    • Lu, X.1    Masic, A.2    Li, Y.3    Shin, Y.4    Liu, Q.5    Zhou, Y.6
  • 72
    • 77952828838 scopus 로고    scopus 로고
    • Targeting fibroblast growth factor receptors blocks PI3K/AKT signaling, induces apoptosis, and impairs mammary tumor out-growth and metastasis
    • Dey, J. H., Bianchi, F., Voshol, J., Bonenfant, D., Oakeley, E. J., and Hynes, N. E. (2010) Targeting fibroblast growth factor receptors blocks PI3K/AKT signaling, induces apoptosis, and impairs mammary tumor out-growth and metastasis. Cancer Res. 70, 4151-4162
    • (2010) Cancer Res. , vol.70 , pp. 4151-4162
    • Dey, J.H.1    Bianchi, F.2    Voshol, J.3    Bonenfant, D.4    Oakeley, E.J.5    Hynes, N.E.6
  • 73
    • 36749014979 scopus 로고    scopus 로고
    • PI3K/AKT inhibition induces caspase-dependent apoptosis in HTLV-1-transformed cells
    • DOI 10.1016/j.virol.2007.09.003, PII S0042682207005867
    • Jeong, S. J., Dasgupta, A., Jung, K. J., Um, J. H., Burke, A., Park, H. U., and Brady, J. N. (2008) PI3K/AKT inhibition induces caspase-dependent apoptosis in HTLV-1-transformed cells. Virology 370, 264-272 (Pubitemid 350199679)
    • (2008) Virology , vol.370 , Issue.2 , pp. 264-272
    • Jeong, S.-J.1    Dasgupta, A.2    Jung, K.-J.3    Um, J.-H.4    Burke, A.5    Park, H.U.6    Brady, J.N.7
  • 74
    • 0032752063 scopus 로고    scopus 로고
    • Cellular survival: A play in three Akts
    • Datta, S. R., Brunet, A., and Greenberg, M. E. (1999) Cellular survival: a play in three Akts. Genes Dev. 13, 2905-2927
    • (1999) Genes Dev. , vol.13 , pp. 2905-2927
    • Datta, S.R.1    Brunet, A.2    Greenberg, M.E.3
  • 75
    • 0028918408 scopus 로고
    • Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase
    • Hu, Q., Klippel, A., Muslin, A. J., Fantl, W. J., and Williams, L. T. (1995) Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase. Science 268, 100-102
    • (1995) Science , vol.268 , pp. 100-102
    • Hu, Q.1    Klippel, A.2    Muslin, A.J.3    Fantl, W.J.4    Williams, L.T.5
  • 76
    • 0029079275 scopus 로고
    • The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
    • Franke, T. F., Yang, S. I., Chan, T. O., Datta, K., Kazlauskas, A., Morrison, D. K., Kaplan, D. R., and Tsichlis, P. N. (1995) The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 81, 727-736
    • (1995) Cell , vol.81 , pp. 727-736
    • Franke, T.F.1    Yang, S.I.2    Chan, T.O.3    Datta, K.4    Kazlauskas, A.5    Morrison, D.K.6    Kaplan, D.R.7    Tsichlis, P.N.8
  • 77
    • 58149175555 scopus 로고    scopus 로고
    • The life of a cell: Apoptosis regulation by the PI3K/PKB pathway
    • Duronio, V. (2008) The life of a cell: apoptosis regulation by the PI3K/PKB pathway. Biochem. J. 415, 333-344
    • (2008) Biochem. J. , vol.415 , pp. 333-344
    • Duronio, V.1
  • 78
    • 0033635235 scopus 로고    scopus 로고
    • 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation
    • Datta, S. R., Katsov, A., Hu, L., Petros, A., Fesik, S. W., Yaffe, M. B., and Greenberg, M. E. (2000) 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation. Mol. Cell 6, 41-51
    • (2000) Mol. Cell , vol.6 , pp. 41-51
    • Datta, S.R.1    Katsov, A.2    Hu, L.3    Petros, A.4    Fesik, S.W.5    Yaffe, M.B.6    Greenberg, M.E.7
  • 80
    • 33745950626 scopus 로고    scopus 로고
    • Mitochondrial outer membrane permeabilization during apoptosis: The innocent bystander scenario
    • DOI 10.1038/sj.cdd.4401963, PII 4401963
    • Chipuk, J. E., Bouchier-Hayes, L., and Green, D. R. (2006) Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario. Cell Death Differ. 13, 1396-1402 (Pubitemid 44057475)
    • (2006) Cell Death and Differentiation , vol.13 , Issue.8 , pp. 1396-1402
    • Chipuk, J.E.1    Bouchier-Hayes, L.2    Green, D.R.3
  • 81
    • 84874474978 scopus 로고    scopus 로고
    • Involvement of PI 3 kinase/Akt-dependent Bad phosphorylation in Toxoplasma gondii-mediated inhibition of host cell apoptosis
    • Quan, J. H., Cha, G. H., Zhou, W., Chu, J. Q., Nishikawa, Y., and Lee, Y. H. (2013) Involvement of PI 3 kinase/Akt-dependent Bad phosphorylation in Toxoplasma gondii-mediated inhibition of host cell apoptosis. Exp. Parasitol. 133, 462-471
    • (2013) Exp. Parasitol. , vol.133 , pp. 462-471
    • Quan, J.H.1    Cha, G.H.2    Zhou, W.3    Chu, J.Q.4    Nishikawa, Y.5    Lee, Y.H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.