메뉴 건너뛰기




Volumn 6, Issue 7, 2011, Pages

Differential inhibitory effects of CysLT1 receptor antagonists on P2Y6 Receptor-Mediated signaling and ion transport in human bronchial epithelia

Author keywords

[No Author keywords available]

Indexed keywords

8 (4 CHLOROPHENYLTHIO) 2' O METHYLADENOSINE 3',5' CYCLIC MONOPHOSPHOROTHIOATE; 8 BROMO CYCLIC AMP; CYCLIC AMP; CYSTEINYL LEUKOTRIENE 1 RECEPTOR ANTAGONIST; FORSKOLIN; MONTELUKAST; N6 PHENYLADENOSINE 3',5' CYCLIC MONOPHOSPHOROTHIOATE; PEPTIDOLEUKOTRIENE; PRANLUKAST; PURINERGIC P2 RECEPTOR ANTAGONIST; PURINERGIC P2Y6 RECEPTOR; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE; ZAFIRLUKAST;

EID: 79960662424     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0022363     Document Type: Article
Times cited : (20)

References (50)
  • 1
    • 0020669369 scopus 로고
    • Leukotrienes: a new class of mediators of immediate hypersensitivity reactions and inflammation
    • Samuelsson B, (1983) Leukotrienes: a new class of mediators of immediate hypersensitivity reactions and inflammation. Adv Prostaglandin Thromboxane Leukot Res 11: 1-13.
    • (1983) Adv Prostaglandin Thromboxane Leukot Res , vol.11 , pp. 1-13
    • Samuelsson, B.1
  • 2
    • 0037868080 scopus 로고    scopus 로고
    • Leukotrienes in asthma
    • Drazen JM, (2003) Leukotrienes in asthma. Adv Exp Med Biol 525: 1-5.
    • (2003) Adv Exp Med Biol , vol.525 , pp. 1-5
    • Drazen, J.M.1
  • 4
    • 34250852792 scopus 로고    scopus 로고
    • Cysteinyl-leukotrienes and their receptors in asthma and other inflammatory diseases: critical update and emerging trends
    • Capra V, Thompson MD, Sala A, Cole DE, Folco G, et al. (2007) Cysteinyl-leukotrienes and their receptors in asthma and other inflammatory diseases: critical update and emerging trends. Med Res Rev 27: 469-527.
    • (2007) Med Res Rev , vol.27 , pp. 469-527
    • Capra, V.1    Thompson, M.D.2    Sala, A.3    Cole, D.E.4    Folco, G.5
  • 6
    • 0034933024 scopus 로고    scopus 로고
    • Cysteinyl leukotriene receptor 1 is also a pyrimidinergic receptor and is expressed by human mast cells
    • Mellor EA, Maekawa A, Austen KF, Boyce JA, (2001) Cysteinyl leukotriene receptor 1 is also a pyrimidinergic receptor and is expressed by human mast cells. Proc Natl Acad Sci U S A 98: 7964-7969.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 7964-7969
    • Mellor, E.A.1    Maekawa, A.2    Austen, K.F.3    Boyce, J.A.4
  • 7
    • 30544447195 scopus 로고    scopus 로고
    • CysLT1 receptor is a target for extracellular nucleotide-induced heterologous desensitization: a possible feedback mechanism in inflammation
    • Capra V, Ravasi S, Accomazzo MR, Citro S, Grimoldi M, et al. (2005) CysLT1 receptor is a target for extracellular nucleotide-induced heterologous desensitization: a possible feedback mechanism in inflammation. J Cell Sci 118: 5625-5636.
    • (2005) J Cell Sci , vol.118 , pp. 5625-5636
    • Capra, V.1    Ravasi, S.2    Accomazzo, M.R.3    Citro, S.4    Grimoldi, M.5
  • 8
    • 0037370966 scopus 로고    scopus 로고
    • Control of epithelial transport via luminal P2 receptors
    • Leipziger J, (2003) Control of epithelial transport via luminal P2 receptors. Am J Physiol Renal Physiol 284: F419-F432.
    • (2003) Am J Physiol Renal Physiol , vol.284 , pp. 419-432
    • Leipziger, J.1
  • 9
    • 1642296755 scopus 로고    scopus 로고
    • Purinergic regulation of epithelial transport
    • Bucheimer RE, Linden J, (2004) Purinergic regulation of epithelial transport. J Physiol 555: 311-321.
    • (2004) J Physiol , vol.555 , pp. 311-321
    • Bucheimer, R.E.1    Linden, J.2
  • 10
    • 28244496554 scopus 로고    scopus 로고
    • CysLT1 leukotriene receptor antagonists inhibit the effects of nucleotides acting at P2Y receptors
    • Mamedova L, Capra V, Accomazzo MR, Gao ZG, Ferrario S, et al. (2005) CysLT1 leukotriene receptor antagonists inhibit the effects of nucleotides acting at P2Y receptors. Biochem Pharmacol 71: 115-125.
    • (2005) Biochem Pharmacol , vol.71 , pp. 115-125
    • Mamedova, L.1    Capra, V.2    Accomazzo, M.R.3    Gao, Z.G.4    Ferrario, S.5
  • 11
    • 66349089047 scopus 로고    scopus 로고
    • Apical versus basolateral P2Y6 receptor-mediated Cl- secretion in immortalized bronchial epithelia
    • Wong AM, Chow AW, Au SC, Wong CC, Ko WH, (2009) Apical versus basolateral P2Y6 receptor-mediated Cl- secretion in immortalized bronchial epithelia. Am J Respir Cell Mol Biol 40: 733-745.
    • (2009) Am J Respir Cell Mol Biol , vol.40 , pp. 733-745
    • Wong, A.M.1    Chow, A.W.2    Au, S.C.3    Wong, C.C.4    Ko, W.H.5
  • 13
    • 33645862308 scopus 로고    scopus 로고
    • P2 receptors activated by uracil nucleotides-an update
    • Brunschweiger A, Müller CE, (2006) P2 receptors activated by uracil nucleotides-an update. Curr Med Chem 13: 289-312.
    • (2006) Curr Med Chem , vol.13 , pp. 289-312
    • Brunschweiger, A.1    Müller, C.E.2
  • 15
    • 0037372846 scopus 로고    scopus 로고
    • International Union of Pharmacology XXXVII. Nomenclature for leukotriene and lipoxin receptors
    • Brink C, Dahlen SE, Drazen J, Evans JF, Hay DW, et al. (2003) International Union of Pharmacology XXXVII. Nomenclature for leukotriene and lipoxin receptors. Pharmacol Rev 55: 195-227.
    • (2003) Pharmacol Rev , vol.55 , pp. 195-227
    • Brink, C.1    Dahlen, S.E.2    Drazen, J.3    Evans, J.F.4    Hay, D.W.5
  • 16
    • 0025303073 scopus 로고
    • Receptor-coupled signal transduction in human polymorphonuclear neutrophils: effects of a novel inhibitor of phospholipase C-dependent processes on cell responsiveness
    • Smith RJ, Sam LM, Justen JM, Bundy GL, Bala GA, et al. (1990) Receptor-coupled signal transduction in human polymorphonuclear neutrophils: effects of a novel inhibitor of phospholipase C-dependent processes on cell responsiveness. J Pharmacol Exp Ther 253: 688-697.
    • (1990) J Pharmacol Exp Ther , vol.253 , pp. 688-697
    • Smith, R.J.1    Sam, L.M.2    Justen, J.M.3    Bundy, G.L.4    Bala, G.A.5
  • 17
    • 0033607788 scopus 로고    scopus 로고
    • [Ca2+]i oscillation frequency regulates agonist-stimulated NF-kappaB transcriptional activity
    • Hu Q, Deshpande S, Irani K, Ziegelstein RC, (1999) [Ca2+]i oscillation frequency regulates agonist-stimulated NF-kappaB transcriptional activity. J Biol Chem 274: 33995-33998.
    • (1999) J Biol Chem , vol.274 , pp. 33995-33998
    • Hu, Q.1    Deshpande, S.2    Irani, K.3    Ziegelstein, R.C.4
  • 18
    • 34548371796 scopus 로고    scopus 로고
    • Enhancement of P2Y6-induced Cl- secretion by IL-13 and modulation of SK4 channels activity in human bronchial cells
    • Dulong S, Bernard K, Ehrenfeld J, (2007) Enhancement of P2Y6-induced Cl- secretion by IL-13 and modulation of SK4 channels activity in human bronchial cells. Cell Physiol Biochem 20: 483-494.
    • (2007) Cell Physiol Biochem , vol.20 , pp. 483-494
    • Dulong, S.1    Bernard, K.2    Ehrenfeld, J.3
  • 19
    • 23944453866 scopus 로고    scopus 로고
    • Purinergic P2Y6 receptors induce Ca2+ and CFTR dependent Cl- secretion in mouse trachea
    • Schreiber R, Kunzelmann K, (2005) Purinergic P2Y6 receptors induce Ca2+ and CFTR dependent Cl- secretion in mouse trachea. Cell Physiol Biochem 16: 99-108.
    • (2005) Cell Physiol Biochem , vol.16 , pp. 99-108
    • Schreiber, R.1    Kunzelmann, K.2
  • 20
    • 0037314348 scopus 로고    scopus 로고
    • P2Y6 receptor mediates colonic NaCl secretion via differential activation of cAMP-mediated transport
    • Kottgen M, Loffler T, Jacobi C, Nitschke R, Pavenstadt H, et al. (2003) P2Y6 receptor mediates colonic NaCl secretion via differential activation of cAMP-mediated transport. J Clin Invest 111: 371-379.
    • (2003) J Clin Invest , vol.111 , pp. 371-379
    • Kottgen, M.1    Loffler, T.2    Jacobi, C.3    Nitschke, R.4    Pavenstadt, H.5
  • 21
    • 73549089880 scopus 로고    scopus 로고
    • Epac1 mediates protein kinase A-independent mechanism of forskolin-activated intestinal chloride secretion
    • Hoque KM, Woodward OM, van Rossum DB, Zachos NC, Chen L, et al. (2010) Epac1 mediates protein kinase A-independent mechanism of forskolin-activated intestinal chloride secretion. J Gen Physiol 135: 43-58.
    • (2010) J Gen Physiol , vol.135 , pp. 43-58
    • Hoque, K.M.1    Woodward, O.M.2    van Rossum, D.B.3    Zachos, N.C.4    Chen, L.5
  • 22
    • 0037424363 scopus 로고    scopus 로고
    • Epac-selective cAMP analog 8-pCPT-2′-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells
    • Kang G, Joseph JW, Chepurny OG, Monaco M, Wheeler MB, et al. (2003) Epac-selective cAMP analog 8-pCPT-2′-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells. J Biol Chem 278: 8279-8285.
    • (2003) J Biol Chem , vol.278 , pp. 8279-8285
    • Kang, G.1    Joseph, J.W.2    Chepurny, O.G.3    Monaco, M.4    Wheeler, M.B.5
  • 23
    • 33845977351 scopus 로고    scopus 로고
    • Cyclic adenosine 5′-monophosphate-stimulated neurotensin secretion is mediated through Rap1 downstream of both Epac and protein kinase A signaling pathways
    • Li J, O'Connor KL, Cheng X, Mei FC, Uchida T, et al. (2007) Cyclic adenosine 5′-monophosphate-stimulated neurotensin secretion is mediated through Rap1 downstream of both Epac and protein kinase A signaling pathways. Mol Endocrinol 21: 159-171.
    • (2007) Mol Endocrinol , vol.21 , pp. 159-171
    • Li, J.1    O'Connor, K.L.2    Cheng, X.3    Mei, F.C.4    Uchida, T.5
  • 24
    • 41549134682 scopus 로고    scopus 로고
    • Epac/Rap1 pathway regulates microvascular hyperpermeability induced by PAF in rat mesentery
    • Adamson RH, Ly JC, Sarai RK, Lenz JF, Altangerel A, et al. (2008) Epac/Rap1 pathway regulates microvascular hyperpermeability induced by PAF in rat mesentery. Am J Physiol Heart Circ Physiol 294: H1188-H1196.
    • (2008) Am J Physiol Heart Circ Physiol , vol.294 , pp. 1188-1196
    • Adamson, R.H.1    Ly, J.C.2    Sarai, R.K.3    Lenz, J.F.4    Altangerel, A.5
  • 26
    • 12144282761 scopus 로고    scopus 로고
    • Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator
    • Ponsioen B, Zhao J, Riedl J, Zwartkruis F, van der KG, et al. (2004) Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator. EMBO Rep 5: 1176-1180.
    • (2004) EMBO Rep , vol.5 , pp. 1176-1180
    • Ponsioen, B.1    Zhao, J.2    Riedl, J.3    Zwartkruis, F.4    van der, K.G.5
  • 27
    • 44849141908 scopus 로고    scopus 로고
    • A comparison of donor-acceptor pairs for genetically encoded FRET sensors: application to the Epac cAMP sensor as an example
    • van der Krogt GN, Ogink J, Ponsioen B, Jalink K, (2008) A comparison of donor-acceptor pairs for genetically encoded FRET sensors: application to the Epac cAMP sensor as an example. PLoS ONE 3: e1916.
    • (2008) PLoS ONE , vol.3
    • van der Krogt, G.N.1    Ogink, J.2    Ponsioen, B.3    Jalink, K.4
  • 28
    • 33645964965 scopus 로고    scopus 로고
    • Regulation of normal and cystic fibrosis airway surface liquid volume by phasic shear stress
    • Tarran R, Button B, Boucher RC, (2006) Regulation of normal and cystic fibrosis airway surface liquid volume by phasic shear stress. Annu Rev Physiol 68: 543-561.
    • (2006) Annu Rev Physiol , vol.68 , pp. 543-561
    • Tarran, R.1    Button, B.2    Boucher, R.C.3
  • 29
    • 60549106097 scopus 로고    scopus 로고
    • P2Y6 receptors require an intact cysteinyl leukotriene synthetic and signaling system to induce survival and activation of mast cells
    • Jiang Y, Borrelli L, Bacskai BJ, Kanaoka Y, Boyce JA, (2009) P2Y6 receptors require an intact cysteinyl leukotriene synthetic and signaling system to induce survival and activation of mast cells. J Immunol 182: 1129-1137.
    • (2009) J Immunol , vol.182 , pp. 1129-1137
    • Jiang, Y.1    Borrelli, L.2    Bacskai, B.J.3    Kanaoka, Y.4    Boyce, J.A.5
  • 30
    • 34548783949 scopus 로고    scopus 로고
    • Cysteinyl-leukotriene receptors and cellular signals
    • Rovati GE, Capra V, (2007) Cysteinyl-leukotriene receptors and cellular signals. Scientific World Journal 7: 1375-1392.
    • (2007) Scientific World Journal , vol.7 , pp. 1375-1392
    • Rovati, G.E.1    Capra, V.2
  • 31
    • 0030960773 scopus 로고    scopus 로고
    • UDP activates a mucosal-restricted receptor on human nasal epithelial cells that is distinct from the P2Y2 receptor
    • Lazarowski ER, Paradiso AM, Watt WC, Harden TK, Boucher RC, (1997) UDP activates a mucosal-restricted receptor on human nasal epithelial cells that is distinct from the P2Y2 receptor. Proc Natl Acad Sci U S A 94: 2599-2603.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 2599-2603
    • Lazarowski, E.R.1    Paradiso, A.M.2    Watt, W.C.3    Harden, T.K.4    Boucher, R.C.5
  • 32
    • 34447560054 scopus 로고    scopus 로고
    • Human bronchial epithelial cells express an active and inducible biosynthetic pathway for leukotrienes B4 and C4
    • Jame AJ, Lackie PM, Cazaly AM, Sayers I, Penrose JF, et al. (2007) Human bronchial epithelial cells express an active and inducible biosynthetic pathway for leukotrienes B4 and C4. Clin Exp Allergy 37: 880-892.
    • (2007) Clin Exp Allergy , vol.37 , pp. 880-892
    • Jame, A.J.1    Lackie, P.M.2    Cazaly, A.M.3    Sayers, I.4    Penrose, J.F.5
  • 33
    • 44249107302 scopus 로고    scopus 로고
    • Cysteinyl leukotriene-1 receptor activation in a human bronchial epithelial cell line leads to signal transducer and activator of transcription 1-mediated eosinophil adhesion
    • Profita M, Sala A, Bonanno A, Siena L, Ferraro M, et al. (2008) Cysteinyl leukotriene-1 receptor activation in a human bronchial epithelial cell line leads to signal transducer and activator of transcription 1-mediated eosinophil adhesion. J Pharmacol Exp Ther 325: 1024-1030.
    • (2008) J Pharmacol Exp Ther , vol.325 , pp. 1024-1030
    • Profita, M.1    Sala, A.2    Bonanno, A.3    Siena, L.4    Ferraro, M.5
  • 34
    • 0032817289 scopus 로고    scopus 로고
    • Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor
    • Sarau HM, Ames RS, Chambers J, Ellis C, Elshourbagy N, et al. (1999) Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor. Mol Pharmacol 56: 657-663.
    • (1999) Mol Pharmacol , vol.56 , pp. 657-663
    • Sarau, H.M.1    Ames, R.S.2    Chambers, J.3    Ellis, C.4    Elshourbagy, N.5
  • 35
    • 0032877173 scopus 로고    scopus 로고
    • New perspectives for asthma treatment: anti-leukotriene drugs
    • Garcia-Marcos L, Schuster A, (1999) New perspectives for asthma treatment: anti-leukotriene drugs. Pediatr Allergy Immunol 10: 77-88.
    • (1999) Pediatr Allergy Immunol , vol.10 , pp. 77-88
    • Garcia-Marcos, L.1    Schuster, A.2
  • 36
    • 6044234752 scopus 로고    scopus 로고
    • Architecture of P2Y nucleotide receptors: structural comparison based on sequence analysis, mutagenesis, and homology modeling
    • Costanzi S, Mamedova L, Gao ZG, Jacobson KA, (2004) Architecture of P2Y nucleotide receptors: structural comparison based on sequence analysis, mutagenesis, and homology modeling. J Med Chem 47: 5393-5404.
    • (2004) J Med Chem , vol.47 , pp. 5393-5404
    • Costanzi, S.1    Mamedova, L.2    Gao, Z.G.3    Jacobson, K.A.4
  • 37
    • 4544370584 scopus 로고    scopus 로고
    • Cellular mechanism for potentiation of Ca2+-mediated Cl--secretion by the flavonoid baicalein in intestinal epithelia
    • Yue GG, Yip TW, Huang Y, Ko WH, (2004) Cellular mechanism for potentiation of Ca2+-mediated Cl--secretion by the flavonoid baicalein in intestinal epithelia. J Biol Chem 279: 39310-39316.
    • (2004) J Biol Chem , vol.279 , pp. 39310-39316
    • Yue, G.G.1    Yip, T.W.2    Huang, Y.3    Ko, W.H.4
  • 38
    • 69249216479 scopus 로고    scopus 로고
    • EPAC proteins transduce diverse cellular actions of cAMP
    • Borland G, Smith BO, Yarwood SJ, (2009) EPAC proteins transduce diverse cellular actions of cAMP. Br J Pharmacol 158: 70-86.
    • (2009) Br J Pharmacol , vol.158 , pp. 70-86
    • Borland, G.1    Smith, B.O.2    Yarwood, S.J.3
  • 39
    • 0033858348 scopus 로고    scopus 로고
    • Chloride secretion by the intestinal epithelium: molecular basis and regulatory aspects
    • Barrett KE, Keely SJ, (2000) Chloride secretion by the intestinal epithelium: molecular basis and regulatory aspects. Annu Rev Physiol 62: 535-572.
    • (2000) Annu Rev Physiol , vol.62 , pp. 535-572
    • Barrett, K.E.1    Keely, S.J.2
  • 40
    • 0032545328 scopus 로고    scopus 로고
    • A family of cAMP-binding proteins that directly activate Rap1
    • Kawasaki H, Springett GM, Mochizuki N, Toki S, Nakaya M, et al. (1998) A family of cAMP-binding proteins that directly activate Rap1. Science 282: 2275-2279.
    • (1998) Science , vol.282 , pp. 2275-2279
    • Kawasaki, H.1    Springett, G.M.2    Mochizuki, N.3    Toki, S.4    Nakaya, M.5
  • 41
    • 33747423674 scopus 로고    scopus 로고
    • Purinergic signalling-an overview
    • Burnstock G, (2006) Purinergic signalling-an overview. Novartis Found Symp 276: 26-48.
    • (2006) Novartis Found Symp , vol.276 , pp. 26-48
    • Burnstock, G.1
  • 43
    • 34247595353 scopus 로고    scopus 로고
    • Extracellular nucleotides regulate CCL20 release from human primary airway epithelial cells, monocytes and monocyte-derived dendritic cells
    • Marcet B, Horckmans M, Libert F, Hassid S, Boeynaems JM, et al. (2007) Extracellular nucleotides regulate CCL20 release from human primary airway epithelial cells, monocytes and monocyte-derived dendritic cells. J Cell Physiol 211: 716-727.
    • (2007) J Cell Physiol , vol.211 , pp. 716-727
    • Marcet, B.1    Horckmans, M.2    Libert, F.3    Hassid, S.4    Boeynaems, J.M.5
  • 44
    • 62649105723 scopus 로고    scopus 로고
    • Extracellular nucleotides and interleukin-8 production by ARPE cells: potential role of danger signals in blood-retinal barrier activation
    • Relvas LJ, Bouffioux C, Marcet B, Communi D, Makhoul M, et al. (2009) Extracellular nucleotides and interleukin-8 production by ARPE cells: potential role of danger signals in blood-retinal barrier activation. Invest Ophthalmol Vis Sci 50: 1241-1246.
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 1241-1246
    • Relvas, L.J.1    Bouffioux, C.2    Marcet, B.3    Communi, D.4    Makhoul, M.5
  • 45
    • 20144371700 scopus 로고    scopus 로고
    • The pyrimidinergic P2Y6 receptor mediates a novel release of proinflammatory cytokines and chemokines in monocytic cells stimulated with UDP
    • Cox MA, Gomes B, Palmer K, Du K, Wiekowski M, et al. (2005) The pyrimidinergic P2Y6 receptor mediates a novel release of proinflammatory cytokines and chemokines in monocytic cells stimulated with UDP. Biochem Biophys Res Commun 330: 467-473.
    • (2005) Biochem Biophys Res Commun , vol.330 , pp. 467-473
    • Cox, M.A.1    Gomes, B.2    Palmer, K.3    du, K.4    Wiekowski, M.5
  • 46
    • 42149193728 scopus 로고    scopus 로고
    • Intestinal inflammation increases the expression of the P2Y6 receptor on epithelial cells and the release of CXC chemokine ligand 8 by UDP
    • Grbic DM, Degagne E, Langlois C, Dupuis AA, Gendron FP, (2008) Intestinal inflammation increases the expression of the P2Y6 receptor on epithelial cells and the release of CXC chemokine ligand 8 by UDP. J Immunol 180: 2659-2668.
    • (2008) J Immunol , vol.180 , pp. 2659-2668
    • Grbic, D.M.1    Degagne, E.2    Langlois, C.3    Dupuis, A.A.4    Gendron, F.P.5
  • 47
    • 0027928745 scopus 로고
    • CFTR expression and chloride secretion in polarized immortal human bronchial epithelial cells
    • Cozens AL, Yezzi MJ, Kunzelmann K, Ohrui T, Chin L, et al. (1994) CFTR expression and chloride secretion in polarized immortal human bronchial epithelial cells. Am J Respir Cell Mol Biol 10: 38-47.
    • (1994) Am J Respir Cell Mol Biol , vol.10 , pp. 38-47
    • Cozens, A.L.1    Yezzi, M.J.2    Kunzelmann, K.3    Ohrui, T.4    Chin, L.5
  • 48
    • 77957863152 scopus 로고    scopus 로고
    • Polarized Secretion of Interleukin (IL)-6 and IL-8 by Human Airway Epithelia 16HBE14o- Cells in Response to Cationic Polypeptide Challenge
    • Chow AW, Liang JF, Wong JS, Fu Y, Tang NL, et al. (2010) Polarized Secretion of Interleukin (IL)-6 and IL-8 by Human Airway Epithelia 16HBE14o- Cells in Response to Cationic Polypeptide Challenge. PLoS ONE 5: e12091.
    • (2010) PLoS ONE , vol.5
    • Chow, A.W.1    Liang, J.F.2    Wong, J.S.3    Fu, Y.4    Tang, N.L.5
  • 49
    • 0037088574 scopus 로고    scopus 로고
    • Stimulation of Cl- secretion via membrane-restricted Ca2+ signaling mediated by P2Y receptors in polarized epithelia
    • Wong CH, Ko WH, (2002) Stimulation of Cl- secretion via membrane-restricted Ca2+ signaling mediated by P2Y receptors in polarized epithelia. J Biol Chem 277: 9016-9021.
    • (2002) J Biol Chem , vol.277 , pp. 9016-9021
    • Wong, C.H.1    Ko, W.H.2
  • 50
    • 36249009070 scopus 로고    scopus 로고
    • Spatiotemporal Coupling of cAMP Transporter to CFTR Chloride Channel Function in the Gut Epithelia
    • Li C, Krishnamurthy PC, Penmatsa H, Marrs KL, Wang XQ, et al. (2007) Spatiotemporal Coupling of cAMP Transporter to CFTR Chloride Channel Function in the Gut Epithelia. Cell 131: 940-951.
    • (2007) Cell , vol.131 , pp. 940-951
    • Li, C.1    Krishnamurthy, P.C.2    Penmatsa, H.3    Marrs, K.L.4    Wang, X.Q.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.