Effect of novel A2A adenosine receptor agonist ATL 313 on Clostridium difficile toxin A-induced murine ileal enteritis

Infection and Immunity

Volumn 74, Issue 5, 2006, Pages 2606-2612

  Cavalcante, I C ^a   Castro, M V ^a   Barreto, A R F ^a   Sullivan, G W ^b   Vale, M ^a   Almeida, P R C ^a   Linden, J ^b   Rieger, J M ^c   Cunha, F Q ^d   Guerrant, R L ^b   Ribeiro, R A ^a   Brito, G A C ^a  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^b UNIVERSITY OF VIRGINIA   (United States)

^c Adenosine Therapeutics LLC   (United States)

^d UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; 4 [3 [6 AMINO 9 (5 CYCLOPROPYLCARBAMOYL 3,4 DIHYDROXYTETRAHYDROFURAN 2 YL) 9H PURIN 2 YL]PROP 2 YNYL]PIPERIDINE 1 CARBOXYLIC ACID METHYL ESTER; ADENOSINE; ADENOSINE A2A RECEPTOR; ADENOSINE A2A RECEPTOR AGONIST; ADENOSINE A2A RECEPTOR ANTAGONIST; ADENOSINE DEAMINASE; ATL 313; CLOSTRIDIUM DIFFICILE TOXIN A; CLOSTRIDIUM DIFFICILE TOXIN B; MYELOPEROXIDASE; PHOSPHATE BUFFERED SALINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VIRULENCE FACTOR; BACTERIAL TOXIN; ENTEROTOXIN; PIPERIDINE DERIVATIVE; TCDA PROTEIN, CLOSTRIDIUM DIFFICILE;

ANAEROBIC BACTERIUM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL PROTECTION; CLOSTRIDIUM DIFFICILE; DIARRHEA; EDEMA; ENTERITIS; ENZYME ACTIVITY; GRAM POSITIVE BACTERIUM; HISTOPATHOLOGY; ILEUM DISEASE; INTESTINE FLUID; MALE; MOUSE; MUCOSA INFLAMMATION; NEUTROPHIL CHEMOTAXIS; NICK END LABELING; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PSEUDOMEMBRANOUS COLITIS; SECRETION; TISSUE INJURY; ANIMAL; APOPTOSIS; BIOSYNTHESIS; DRUG POTENTIATION; ENZYMOLOGY; ILEUM; METABOLISM; PATHOLOGY;

ADENOSINE DEAMINASE; ANIMALS; APOPTOSIS; BACTERIAL TOXINS; ENTERITIS; ENTEROTOXINS; ILEAL DISEASES; ILEUM; MALE; MICE; PIPERIDINES; RECEPTOR, ADENOSINE A2A; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33646356197     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.74.5.2606-2612.2006     Document Type: Article

References (45)

1. Bartlell, J. G. 2002. Clinical practice: antibiotic-associated diarrhea. N. Engl. J. Med. 346:334-339.
2. Bayer, E. A., and M. Wilchek. 1980. The use of the avidin-biotin complex as a tool in molecular biology. Methods Biochem. Anal. 26:1-45.
3. Bouma, M. G., F. A. van den Wildenberg, and W. A. Buurman. 1996. Adenosine inhibits cytokine release and expression of adhesion molecules by activated human endothelial cells. Am. J. Physiol. 270:C522-C529.
4. Brito, G. A., B. A. Carneiro-Filho, R. B. Oriá, R. V. Destora, A. A. Lima, and R. L. Guerrant. 2005. Clostridium difficile toxin A induces intestinal epithelial cell apoptosis and damage: role of Gln and Ala-Gln in toxin A effects. Dig. Dis. Sci. 50:1271-1278.
5. Brito, G. A., J. Fajji, B. A. Carneiro-Filho, A. A. Lima, T. Obrig, and R. L. Guerrant. 2002. Mechanism of Clostridium difficile toxin A-induced apoptosis in T84 cells. J. Infect. Dis. 186:1438-1447.
6. Brito, G. A., G. W. Sullivan, W. P. Ciesla, Jr., H. T. Carper, G. L. Mandell, and R. L. Guerrant. 2002. Clostridium difficile toxin A alters in vitro-adherent neutrophil morphology and function. J. Infect. Dis. 185:1297-1306.
7. Calderou, G. M., J. Torres-Lopez, T. J. Lin, B. Chavez, M. Hernandez, O. Munoz, A. D. Befus, and J. A. Enciso. 1998. Effects of toxin A from Clostridium difficile on mast cell activation and survival. Infect. Immun. 66:2755-2761.
8. Castaglinolo, I., M. Riegler, A. Pasha, S. Nikulasson, B. La, C. Gerard, N. P. Gerard, and C. Pathoulakis. 1998. Neurokinin-1 (NK-1) receptor is required in Clostridium difficile-induced entiritis. J. Clin. Investig. 101:1547-1550.
9. Cristalli, G., S. Constanzi, C. Lambertucci, G. Lupidi, S. Vittori, R. Volpini, and K. Camaioni. 2001. Adenosine deaminase: functional implications and different classes of inhibitors. Med. Res. Rev. 21:105-128.
10. Cronstein, B. N. 1994. Adenosine, an endogenous anti-inflammatory agent. J. Appl. Physiol. 76:5-13.
11. Flegel, W. A., F. Muller, W. Daubener, H. G. Fischer, U. Hadding, and H. Northoff. 1991. Cytokine response by human monocytes to Clostridium difficile toxin A and toxin B. Infect. Immun. 59:3659-3666.
12. Fredholm, B. B., A. P. IJzerman, K. A. Jacobson, K. N. Klotz, and J. Linden. 2001. International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol. Rev. 53:527-552.
13. Frode, T. S., and Y. S. Medeiros. 2001. Myeloperoxidase and adenosine-deaminase levels in the pleural fluid leakage influenced by carrageenan in the mouse model of pleurisy. Mediators Inflamm. 10:223-227.
14. Giusti, G. 1974. Adenosine deaminase, p. 1092-1099. In H. U. Bergmeyer (ed.), Methods of enzymatic analysis, vol. 2. Academic Press, Inc., New York, N.Y.
15. 2A receptor agonist in reperfused canine myocardium. Am. J. Physiol. Heart Circ. Physiol. 288:111851-111858.
16. Haskó, G., and B. N. Cronstein. 2004. Adenosine: an endogenous regulator of innate immunity. Trends Immunol. 25:33-39.
17. Humphrey, C. D., C. W. Condon, J. R. Canley, and F. E. Pittman. 1979. Partial purification of a toxin found in hamsters with antibiotic-associated colitis: reversible binding of the toxin by cholestyramine. Gastroenterology 76:468-476.
18. Kelly, C. P., S. Becker, J. K. Linevsky, M. A. Joshi, J. C. O'Keane, B. F. Dickey, J. T. LaMont, and C. Pothoulakis. 1994. Neutrophil recruitement in Clostridium difficile toxin A enteritis in the rabbit. J. Clin. Investig. 93:1257-1265.
19. Kelly, C. P., C. Pothoulakis, and J. T. LaMont. 1994. Clostridium difficile colitis. N. Engl. J. Med. 330:257-262.
20. Klebanoff, S. J. 2005. Myeloperoxidase: friend and foe. J. Leukoc. Biol. 77:598-625.
21. Kurose, I., C. Pothoulakis, J. T. LaMont, D. C. Anderson, J. C. Paulson, M. Miyasaka, R. Wolf, and D. N. Grangner. 1994. Clostridium difficile toxin A-induced microvascular dysfunction: role of histamine. J. Clin. Investig. 94:1919-1926.
22. Kyne, L., M. Warny, A. Qamar, and C. P. Kelly. 2000. Asymptomatic carriage of Clostridium difficile and serum levels of IgG antibody against toxin A. N. Engl. J. Med. 342:390-397.
23. + T cells. J. Immunol. 174:1073-1080.
24. Lima, A. A., D. J. Innes, Jr., K. Chadec, D. M. Lyerly, T. D. Wilkins, and K. L. Guerrant. 1989. Clostridium difficile toxin A. Interactions with mucus and early sequential histopathologic effects in rabbit small intestine. Lab. Investig. 61:419-425.
25. Lima, A. A., D. M. Lyerly, T. D. Wilkins, D. J. Innes, and R. L. Guerrant. 1988. Effects of Clostridium difficile toxins A and B in rabbit small and large intestine in vivo and on cultured cells in vitro. Infect. Immun. 56:582-588.
26. Lowry, O. H., N. J. Rosenborough, A. L. Farr, and R. J. Randal. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:265-275.
27. Lyerly, D. M., H. C. Krivan, and T. D. Wilkins. 1988. Clostridium difficile: its disease and toxins. Clin. Microbiol. Rev. 1:1-18.
28. Lyerly, D. M., D. E. Lockwood, S. H. Richardson, and T. D. Wilkins. 1982. Biological activities of toxins A and B of Clostridium difficile. Infect. Immun. 35:1147-1150.
29. Mahida, Y. R., A. Galvin, S. Makh, S. Hyde, L. Sanfilippo, S. P. Borriello, and H. F. Sewell. 1998. Effect of Clostridium difficile toxin A on human colonic lamina propria cells: early loss of macrophages followed by T-cell apoptosis. Infect. Immun. 66:5462-5469.
30. Mahida, Y. R., S. Makh, S. Hyde, T. Gray, and S. P. Borriello. 1996. Effect of Clostridium difficile toxin A on human intestinal epithelial cells: induction of interleukin 8 production and apoptosis after cell detachment. Gut 38:337-347.
31. McEllistrem, M. C., R. J. Carman, D. N. Gerding, C. W. Genheimer, and L. Zheng. 2005. A hospital outbreak of Clostridium difficile disease associated with isolated carrying binary toxin genes. Clin. Infect. Dis. 40:265-272.
32. Mosmann, T. R. 1994. Properties and functions of interleukin-10. Adv. Immunol. 56:1-26.
33. Nemeth, Z. H., S. J. Leibovich, E. A. Deitch, E. S. Vizi, C. Szabo, and G. Haskó. 2003. cDNA microarray analysis reveals a nuclear factor-κB-independent regulation of macrophage function by adenosine. J. Pharmacol. Exp. Ther. 306:1042-1049.
34. Piras, M. A., C. Gakis, M. Budroni, and G. Andreoni. 1978. Adenosine deaminase activity in pleural effusions: an aid to differential diagnosis. BMJ 2:1751-1752.
35. Popoff, M. R., E. J. Rubin, D. M. Gill, and P. Boquet. 1988. Actin-specific ADP-ribosyltransferase produced by a Clostridium difficile strain. Infect. Immun. 56:2299-2306.
36. Pothoulakis, C., I. Castagliuolo, J. T. LaMont, A. Jaffer, J. C. O'Keane, R. M. Snider, and S. E. Leeman. 1994. CP-96,345, a substance P antagonist, inhibits rat intestinal responses to Clostridium difficile toxin A but not cholera toxin. Proc. Natl. Acad. Sci. USA 91:947-951.
37. Pothoulakis, C., I. Castagliuolo, and J. T. LaMont. 1998. Nerves and intestinal mast cells modulate responses to enterotoxins. News Physiol. Sci. 13:58-63.
38. 2a selective adenosine receptor antagonist. Br. J. Pharmacol. 115:1096-1102.
39. Ralevic, V., and G. Burnstock. 1998. Receptors for purines and pyrimidines. Pharmacol. Rev. 50:413-492.
40. Rehg, J. E. 1980. Cecal toxin(s) from guinea pigs with clindamycin-associated colitis, neutralized by Clostridium sordellii antitoxin. Infect. Immun. 27:387-390.
41. Rocha, M. F., M. E. Maia, L. R. Bezerra, D. M. Lyerly, R. L. Guerrant, R. A. Ribeiro, and A. A. Lima. 1997. Clostridium difficile toxin A induces the release of neutrophil chemotactic factors from rat peritoneal macrophages: role of interleukin-1β, tumor necrosis factor alpha, and leukotrienes. Infect. Immun. 65:2740-2746.
42. Sari, R. A., S. Taysi, O. Yilmaz, and N. Bakan. 2003. Correlation of serum levels of adenosine deaminase activity and its isoenzymes with disease activity in rheumatoid arthritis. Clin. Exp. Rheumatol. 21:87-90.
43. Solomon, K., J. Webb, N. Ali, R. A. Robins, and Y. R. Mahida. 2005. Monocytes are highly sensitive to Clostridium difficile toxin A-induced apoptotic and nonapoptotic cell death. Infect. Immun. 73:1625-1634.
44. Souza, M. H., L. E. Troncon, F. Q. Cunha, and R. B. Oliveira. 2003. Decreased gastric tone and delayed gastric emptying precede neutrophil infiltration and mucosal lesion formation in indomethacin-induced gastric damage in rats. Braz. J. Med. Biol. Res. 36:1383-1390.
45. 2A receptor agonists. Br. J. Pharmacol. 132:1017-1026.