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Volumn 383, Issue 3, 2011, Pages 275-283

Difference in the biological effects of Clostridium difficile toxin B in proliferating and non-proliferating cells

Author keywords

Actin re organization; Apoptosis; Diarrhea; Glucosylation; Necrosis; Rho

Indexed keywords

CLOSTRIDIUM DIFFICILE TOXIN B; PHOSPHATIDYLSERINE;

EID: 79954577739     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-010-0595-5     Document Type: Article
Times cited : (18)

References (30)
  • 1
    • 18744391383 scopus 로고    scopus 로고
    • Clostridial Rho-inhibiting protein toxins
    • K Aktories I Just 2005 Clostridial Rho-inhibiting protein toxins Curr Top Microbiol Immunol 291 113 145 1:CAS:528:DC%2BD2MXnslyitbg%3D 10.1007/3-540-27511-8-7 15981462 (Pubitemid 40674913)
    • (2005) Current Topics in Microbiology and Immunology , vol.291 , pp. 113-145
    • Aktories, K.1    Just, I.2
  • 5
    • 0032831781 scopus 로고    scopus 로고
    • Monoglucosylation of RhoA at threonine 37 blocks cytosol-membrane cycling
    • DOI 10.1074/jbc.274.41.29050
    • H Genth K Aktories I Just 1999 Monoglucosylation of RhoA at threonine-37 blocks cytosol-membrane cycling J Biol Chem 274 29050 29056 1:CAS:528: DyaK1MXmslWqtro%3D 10.1074/jbc.274.41.29050 10506156 (Pubitemid 29477065)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.41 , pp. 29050-29056
    • Genth, H.1    Aktories, K.2    Just, I.3
  • 6
    • 0033976505 scopus 로고    scopus 로고
    • New method to generate enzymatically deficient Clostridium difficile toxin B as an antigen for immunization
    • DOI 10.1128/IAI.68.3.1094-1101.2000
    • H Genth J Selzer C Busch J Dumbach F Hofmann K Aktories I Just 2000 New method to generate enzymatically deficient Clostridium difficile toxin B as an antigen for immunization Infect Immun 68 1094 1101 1:CAS:528: DC%2BD3cXhsVKktLY%3D 10.1128/IAI.68.3.1094-1101.2000 10678912 (Pubitemid 30108496)
    • (2000) Infection and Immunity , vol.68 , Issue.3 , pp. 1094-1101
    • Genth, H.1    Selzer, J.2    Busch, C.3    Dumbach, J.4    Hofmann, F.5    Aktories, K.6    Just, I.7
  • 7
    • 33646942752 scopus 로고    scopus 로고
    • Cellular stability of Rho-GTPases glucosylated by Clostridium difficile toxin B
    • DOI 10.1016/j.febslet.2006.04.100, PII S0014579306006314
    • H Genth J Huelsenbeck B Hartmann F Hofmann I Just R Gerhard 2006 Cellular stability of Rho-GTPases glucosylated by Clostridium difficile toxin B FEBS Lett 580 3565 3569 1:CAS:528:DC%2BD28Xltlent7w%3D 10.1016/j.febslet.2006.04.100 16730714 (Pubitemid 43795899)
    • (2006) FEBS Letters , vol.580 , Issue.14 , pp. 3565-3569
    • Genth, H.1    Huelsenbeck, J.2    Hartmann, B.3    Hofmann, F.4    Just, I.5    Gerhard, R.6
  • 8
    • 39649088950 scopus 로고    scopus 로고
    • Clostridium difficile toxins: More than mere inhibitors of Rho proteins
    • 1:CAS:528:DC%2BD1cXivVOmtb8%3D 10.1016/j.biocel.2007.12.014 18289919
    • H Genth SC Dreger J Huelsenbeck I Just 2008 Clostridium difficile toxins: more than mere inhibitors of Rho proteins Int J Biochem Cell Biol 40 592 597 1:CAS:528:DC%2BD1cXivVOmtb8%3D 10.1016/j.biocel.2007.12.014 18289919
    • (2008) Int J Biochem Cell Biol , vol.40 , pp. 592-597
    • Genth, H.1    Dreger, S.C.2    Huelsenbeck, J.3    Just, I.4
  • 9
    • 33846018602 scopus 로고    scopus 로고
    • Cell death by necrosis: Towards a molecular definition
    • DOI 10.1016/j.tibs.2006.11.001, PII S0968000406003185
    • P Golstein G Kroemer 2007 Cell death by necrosis: towards a molecular definition Trends Biochem Sci 32 37 43 1:CAS:528:DC%2BD2sXisVSqsA%3D%3D 10.1016/j.tibs.2006.11.001 17141506 (Pubitemid 46043552)
    • (2007) Trends in Biochemical Sciences , vol.32 , Issue.1 , pp. 37-43
    • Golstein, P.1    Kroemer, G.2
  • 10
    • 84954358174 scopus 로고    scopus 로고
    • Prevention of the cytopathic effect induced by Clostridium difficile toxin B by active Rac1
    • 1:CAS:528:DC%2BD1cXhtlaqtrjN 10.1016/j.febslet.2008.10.003 18848548
    • I Halabi-Cabezon J Huelsenbeck M May M Ladwein K Rottner I Just H Genth 2008 Prevention of the cytopathic effect induced by Clostridium difficile toxin B by active Rac1 FEBS Lett 582 3751 3756 1:CAS:528:DC%2BD1cXhtlaqtrjN 10.1016/j.febslet.2008.10.003 18848548
    • (2008) FEBS Lett , vol.582 , pp. 3751-3756
    • Halabi-Cabezon, I.1    Huelsenbeck, J.2    May, M.3    Ladwein, M.4    Rottner, K.5    Just, I.6    Genth, H.7
  • 12
    • 33846807241 scopus 로고    scopus 로고
    • Difference in the cytotoxic effects of toxin B from Clostridium difficile strain VPI 10463 and toxin B from variant Clostridium difficile strain 1470
    • DOI 10.1128/IAI.01705-06
    • J Huelsenbeck S Dreger R Gerhard H Barth I Just H Genth 2007 Difference in the cytotoxic effects of toxin B from Clostridium difficile strain VPI 10463 and toxin B from variant Clostridium difficile strain 1470 Infect Immun 75 801 809 1:CAS:528:DC%2BD2sXhs1ahs70%3D 10.1128/IAI.01705-06 17145947 (Pubitemid 46203443)
    • (2007) Infection and Immunity , vol.75 , Issue.2 , pp. 801-809
    • Huelsenbeck, J.1    Dreger, S.2    Gerhard, R.3    Barth, H.4    Just, I.5    Genth, H.6
  • 13
    • 34247493760 scopus 로고    scopus 로고
    • Upregulation of the immediate early gene product RhoB by exoenzyme C3 from Clostridium limosum and toxin B from Clostridium difficile
    • DOI 10.1021/bi602465z
    • J Huelsenbeck SC Dreger R Gerhard G Fritz I Just H Genth 2007 Upregulation of the immediate early gene product RhoB by exoenzyme C3 from Clostridium limosum and toxin B from Clostridium difficile Biochemistry 46 4923 4931 1:CAS:528:DC%2BD2sXjs1SktLo%3D 10.1021/bi602465z 17397186 (Pubitemid 46651213)
    • (2007) Biochemistry , vol.46 , Issue.16 , pp. 4923-4931
    • Huelsenbeck, J.1    Dreger, S.C.2    Gerhard, R.3    Fritz, G.4    Just, I.5    Genth, H.6
  • 14
    • 70350222202 scopus 로고    scopus 로고
    • Inhibition of cytokinesis by Clostridium difficile toxin B and cytotoxic necrotizing factors-reinforcing the critical role of RhoA in cytokinesis
    • 1:CAS:528:DC%2BD1MXhsVOls77L 10.1002/cm.20390 19504561
    • SC Huelsenbeck M May G Schmidt H Genth 2009 Inhibition of cytokinesis by Clostridium difficile toxin B and cytotoxic necrotizing factors-reinforcing the critical role of RhoA in cytokinesis Cell Motil Cytoskeleton 66 967 975 1:CAS:528:DC%2BD1MXhsVOls77L 10.1002/cm.20390 19504561
    • (2009) Cell Motil Cytoskeleton , vol.66 , pp. 967-975
    • Huelsenbeck, S.C.1    May, M.2    Schmidt, G.3    Genth, H.4
  • 15
    • 44349126693 scopus 로고    scopus 로고
    • Colonic crypt organization and tumorigenesis
    • DOI 10.1038/nrc2392, PII NRC2392
    • A Humphries NA Wright 2008 Colonic crypt organization and tumorigenesis Nat Rev Cancer 8 415 424 1:CAS:528:DC%2BD1cXmt1Oksb4%3D 10.1038/nrc2392 18480839 (Pubitemid 351744961)
    • (2008) Nature Reviews Cancer , vol.8 , Issue.6 , pp. 415-424
    • Humphries, A.1    Wright, N.A.2
  • 16
    • 34548472378 scopus 로고    scopus 로고
    • 2 Up-Regulation of Fas Ligand
    • DOI 10.1053/j.gastro.2007.06.063, PII S0016508507012954
    • H Kim SH Rhee C Pothoulakis JT LaMont 2007 Inflammation and apoptosis in Clostridium difficile enteritis is mediated by PGE2 up-regulation of Fas ligand Gastroenterology 133 875 886 1:CAS:528:DC%2BD2sXhtFarsrfK 10.1053/j.gastro.2007. 06.063 17854595 (Pubitemid 47374142)
    • (2007) Gastroenterology , vol.133 , Issue.3 , pp. 875-886
    • Kim, H.1    Rhee, S.H.2    Pothoulakis, C.3    LaMont, J.T.4
  • 17
    • 77957988127 scopus 로고    scopus 로고
    • The role of toxin A and toxin B in Clostridium difficile infection
    • 1:CAS:528:DC%2BC3cXhtFGntL%2FO 10.1038/nature09397 20844489
    • SA Kuehne ST Cartman JT Heap ML Kelly A Cockayne NP Minton 2010 The role of toxin A and toxin B in Clostridium difficile infection Nature 467 711 713 1:CAS:528:DC%2BC3cXhtFGntL%2FO 10.1038/nature09397 20844489
    • (2010) Nature , vol.467 , pp. 711-713
    • Kuehne, S.A.1    Cartman, S.T.2    Heap, J.T.3    Kelly, M.L.4    Cockayne, A.5    Minton, N.P.6
  • 18
    • 9244224723 scopus 로고    scopus 로고
    • Intrinsic tumour suppression
    • DOI 10.1038/nature03098
    • SW Lowe E Cepero G Evan 2004 Intrinsic tumour suppression Nature 432 307 315 1:CAS:528:DC%2BD2cXpvVCjtLg%3D 10.1038/nature03098 15549092 (Pubitemid 39551658)
    • (2004) Nature , vol.432 , Issue.7015 , pp. 307-315
    • Lowe, S.W.1    Cepero, E.2    Evan, G.3
  • 19
    • 0029868433 scopus 로고    scopus 로고
    • Effect of Clostridium difficile toxin A on human intestinal epithelial cells: Induction of interleukin 8 production and apoptosis after cell detachment
    • YR Mahida S Makh S Hyde T Gray SP Borriello 1996 Effect of Clostridium difficile toxin A on human intestinal epithelial cells: induction of interleukin 8 production and apoptosis after cell detachment Gut 38 337 347 1:CAS:528:DyaK28XitlOjt7o%3D 10.1136/gut.38.3.337 8675084 (Pubitemid 26075533)
    • (1996) Gut , vol.38 , Issue.3 , pp. 337-347
    • Mahida, Y.R.1    Makh, S.2    Hyde, S.3    Gray, T.4    Borriello, S.P.5
  • 20
    • 34247889959 scopus 로고    scopus 로고
    • Clostridium difficile toxin B causes apoptosis in epithelial cells by thrilling mitochondria: Involvement of ATP-sensitive mitochondrial potassium channels
    • DOI 10.1074/jbc.M607614200
    • P Matarrese L Falzano A Fabbri L Gambardella C Frank B Geny MR Popoff W Malorni C Fiorentini 2007 Clostridium difficile toxin B causes apoptosis in epithelial cells by thrilling mitochondria. Involvement of ATP-sensitive mitochondrial potassium channels J Biol Chem 282 9029 9041 1:CAS:528: DC%2BD2sXivV2mtrY%3D 10.1074/jbc.M607614200 17220295 (Pubitemid 47093530)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.12 , pp. 9029-9041
    • Matarrese, P.1    Falzano, L.2    Fabbri, A.3    Gambardella, L.4    Frank, C.5    Geny, B.6    Popoff, M.R.7    Malorni, W.8    Fiorentini, C.9
  • 21
    • 0032498625 scopus 로고    scopus 로고
    • Apoptotic membrane blebbing is regulated by myosin light chain phosphorylation
    • DOI 10.1083/jcb.140.3.627
    • JC Mills NL Stone J Erhardt RN Pittman 1998 Apoptotic membrane blebbing is regulated by myosin light chain phosphorylation J Cell Biol 140 627 636 1:CAS:528:DyaK1cXhtVams78%3D 10.1083/jcb.140.3.627 9456322 (Pubitemid 28134065)
    • (1998) Journal of Cell Biology , vol.140 , Issue.3 , pp. 627-636
    • Mills, J.C.1    Stone, N.L.2    Erhardt, J.3    Pittman, R.N.4
  • 22
    • 34250821092 scopus 로고    scopus 로고
    • Clostridium difficile toxin A-induced apoptosis is p53-independent but depends on glucosylation of Rho GTPases
    • DOI 10.1007/s10495-007-0074-8
    • S Nottrott J Schoentaube H Genth I Just R Gerhard 2007 Clostridium difficile toxin A-induced apoptosis is p53-independent but depends on glucosylation of Rho GTPases Apoptosis 12 1443 1453 1:CAS:528: DC%2BD2sXmvVyqu70%3D 10.1007/s10495-007-0074-8 17437185 (Pubitemid 46988281)
    • (2007) Apoptosis , vol.12 , Issue.8 , pp. 1443-1453
    • Nottrott, S.1    Schoentaube, J.2    Genth, H.3    Just, I.4    Gerhard, R.5
  • 23
    • 0036312873 scopus 로고    scopus 로고
    • Clostridium difficile toxin B activates dual caspase-dependent and caspase-independent apoptosis in intoxicated cells
    • DOI 10.1046/j.1462-5822.2002.00201.x
    • M QáDan M Ramsey J Daniel LM Spyres B Safiejko-Mroczka W Ortiz-Leduc JD Ballard 2002 Clostridium difficile toxin B activates dual caspase-dependent and caspase-independent apoptosis in intoxicated cells Cell Microbiol 4 425 434 10.1046/j.1462-5822.2002.00201.x (Pubitemid 34830925)
    • (2002) Cellular Microbiology , vol.4 , Issue.7 , pp. 425-434
    • Qa'Dan, M.1    Ramsey, M.2    Daniel, J.3    Spyres, L.M.4    Safiejko-Mroczka, B.5    Ortiz-Leduc, W.6    Ballard, J.D.7
  • 24
    • 0032515914 scopus 로고    scopus 로고
    • Glucosylation and ADP ribosylation of Rho proteins: Effects on nucleotide binding, GTPase activity, and effector coupling
    • DOI 10.1021/bi972592c
    • P Sehr G Joseph H Genth I Just E Pick K Aktories 1998 Glucosylation and ADP-ribosylation of Rho proteins-effects on nucleotide binding, GTPase activity, and effector-coupling Biochemistry 37 5296 5304 1:CAS:528:DyaK1cXisVylur8%3D 10.1021/bi972592c 9548761 (Pubitemid 28176531)
    • (1998) Biochemistry , vol.37 , Issue.15 , pp. 5296-5304
    • Sehr, P.1    Joseph, G.2    Genth, H.3    Just, I.4    Pick, E.5    Aktories, K.6
  • 25
    • 15544364759 scopus 로고    scopus 로고
    • Monocytes are highly sensitive to Clostridium difficile toxin A-induced apoptotic and nonapoptotic cell death
    • DOI 10.1128/IAI.73.3.1625-1634.2005
    • K Solomon J Webb N Ali RA Robins YR Mahida 2005 Monocytes are highly sensitive to Clostridium difficile toxin A-induced apoptotic and nonapoptotic cell death Infect Immun 73 1625 1634 1:CAS:528:DC%2BD2MXit12ms7c%3D 10.1128/IAI.73.3.1625-1634.2005 15731062 (Pubitemid 40470750)
    • (2005) Infection and Immunity , vol.73 , Issue.3 , pp. 1625-1634
    • Solomon, K.1    Webb, J.2    Ali, N.3    Robins, R.A.4    Mahida, Y.R.5
  • 26
    • 33644974808 scopus 로고    scopus 로고
    • Clostridium difficile-associated disease: New challenges from an established pathogen
    • 10.3949/ccjm.73.2.187 16478043
    • RH Sunenshine LC McDonald 2006 Clostridium difficile-associated disease: new challenges from an established pathogen Cleve Clin J Med 73 187 197 10.3949/ccjm.73.2.187 16478043
    • (2006) Cleve Clin J Med , vol.73 , pp. 187-197
    • Sunenshine, R.H.1    McDonald, L.C.2
  • 27
    • 0038052800 scopus 로고    scopus 로고
    • Cell cycle and apoptosis
    • DOI 10.1046/j.1365-2184.2003.00267.x
    • K Vermeulen ZN Berneman DR Van Bockstaele 2003 Cell cycle and apoptosis Cell Prolif 36 165 175 1:CAS:528:DC%2BD3sXmtVOitrw%3D 10.1046/j.1365-2184.2003. 00267.x 12814432 (Pubitemid 36808272)
    • (2003) Cell Proliferation , vol.36 , Issue.3 , pp. 165-175
    • Vermeulen, K.1    Berneman, Z.N.2    Van Bockstaele, D.R.3
  • 28
    • 17444366186 scopus 로고    scopus 로고
    • Clostridium difficile toxins: Mechanism of action and role in disease
    • DOI 10.1128/CMR.18.2.247-263.2005
    • DE Voth J Ballard 2005 Clostridium difficile toxins: mechanism of action and role in disease Clin Microbiol Rev 18 247 263 1:CAS:528:DC%2BD2MXksVymtLY%3D 10.1128/CMR.18.2.247-263.2005 15831824 (Pubitemid 40548293)
    • (2005) Clinical Microbiology Reviews , vol.18 , Issue.2 , pp. 247-263
    • Voth, D.E.1    Ballard, J.D.2
  • 30
    • 0042026577 scopus 로고    scopus 로고
    • Rho-specific Bacillus cereus ADP-Ribosyltransferase C3cer cloning and characterization
    • DOI 10.1021/bi034583b
    • C Wilde M Vogelsang K Aktories 2003 Rho-specific Bacillus cereus ADP-ribosyltransferase C3cer cloning and characterization Biochemistry 42 9694 9702 1:CAS:528:DC%2BD3sXlslegtrc%3D 10.1021/bi034583b 12911311 (Pubitemid 36993142)
    • (2003) Biochemistry , vol.42 , Issue.32 , pp. 9694-9702
    • Wilde, C.1    Vogelsgesang, M.2    Aktories, K.3


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