-
1
-
-
18744391383
-
Clostridial Rho-inhibiting protein toxins
-
K Aktories I Just 2005 Clostridial Rho-inhibiting protein toxins Curr Top Microbiol Immunol 291 113 145 1:CAS:528:DC%2BD2MXnslyitbg%3D 10.1007/3-540-27511-8-7 15981462 (Pubitemid 40674913)
-
(2005)
Current Topics in Microbiology and Immunology
, vol.291
, pp. 113-145
-
-
Aktories, K.1
Just, I.2
-
3
-
-
0031813370
-
Clostridium difficile toxin B induces apoptosis in intestinal cultured cells
-
C Fiorentini A Fabbri L Falzano A Fattorossi P Matarrese R Rivabene G Donelli 1998 Clostridium difficile toxin B induces apoptosis in intestinal cultured cells Infect Immun 66 2660 2665 1:CAS:528:DyaK1cXjs1eitLk%3D 9596731 (Pubitemid 28261767)
-
(1998)
Infection and Immunity
, vol.66
, Issue.6
, pp. 2660-2665
-
-
Fiorentini, C.1
Fabbri, A.2
Falzano, L.3
Fattorossi, A.4
Matarrese, P.5
Rivabene, R.6
Donelli, G.7
-
4
-
-
67650751080
-
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes
-
1:CAS:528:DC%2BD1MXoslOitb8%3D 10.1038/cdd.2009.44 19373242
-
L Galluzzi SA Aaronson J Abrams ES Alnemri DW Andrews EH Baehrecke NG Bazan MV Blagosklonny K Blomgren C Borner DE Bredesen C Brenner M Castedo JA Cidlowski A Ciechanover GM Cohen V De Laurenzi R De Maria M Deshmukh BD Dynlacht WS El-Deiry RA Flavell S Fulda C Garrido P Golstein ML Gougeon DR Green H Gronemeyer G Hajnoczky JM Hardwick MO Hengartner H Ichijo M Jaattela O Kepp A Kimchi DJ Klionsky RA Knight S Kornbluth S Kumar B Levine SA Lipton E Lugli F Madeo W Malomi JC Marine SJ Martin JP Medema P Mehlen G Melino UM Moll E Morselli S Nagata DW Nicholson P Nicotera G Nunez M Oren J Penninger S Pervaiz ME Peter M Piacentini JH Prehn H Puthalakath GA Rabinovich R Rizzuto CM Rodrigues DC Rubinsztein T Rudel L Scorrano HU Simon H Steller J Tschopp Y Tsujimoto P Vandenabeele I Vitale KH Vousden RJ Youle J Yuan B Zhivotovsky G Kroemer 2009 Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes Cell Death Differ 16 1093 1107 1:CAS:528:DC%2BD1MXoslOitb8%3D 10.1038/cdd.2009.44 19373242
-
(2009)
Cell Death Differ
, vol.16
, pp. 1093-1107
-
-
Galluzzi, L.1
Aaronson, S.A.2
Abrams, J.3
Alnemri, E.S.4
Andrews, D.W.5
Baehrecke, E.H.6
Bazan, N.G.7
Blagosklonny, M.V.8
Blomgren, K.9
Borner, C.10
Bredesen, D.E.11
Brenner, C.12
Castedo, M.13
Cidlowski, J.A.14
Ciechanover, A.15
Cohen, G.M.16
De Laurenzi, V.17
De Maria, R.18
Deshmukh, M.19
Dynlacht, B.D.20
El-Deiry, W.S.21
Flavell, R.A.22
Fulda, S.23
Garrido, C.24
Golstein, P.25
Gougeon, M.L.26
Green, D.R.27
Gronemeyer, H.28
Hajnoczky, G.29
Hardwick, J.M.30
Hengartner, M.O.31
Ichijo, H.32
Jaattela, M.33
Kepp, O.34
Kimchi, A.35
Klionsky, D.J.36
Knight, R.A.37
Kornbluth, S.38
Kumar, S.39
Levine, B.40
Lipton, S.A.41
Lugli, E.42
Madeo, F.43
Malomi, W.44
Marine, J.C.45
Martin, S.J.46
Medema, J.P.47
Mehlen, P.48
Melino, G.49
Moll, U.M.50
Morselli, E.51
Nagata, S.52
Nicholson, D.W.53
Nicotera, P.54
Nunez, G.55
Oren, M.56
Penninger, J.57
Pervaiz, S.58
Peter, M.E.59
Piacentini, M.60
Prehn, J.H.61
Puthalakath, H.62
Rabinovich, G.A.63
Rizzuto, R.64
Rodrigues, C.M.65
Rubinsztein, D.C.66
Rudel, T.67
Scorrano, L.68
Simon, H.U.69
Steller, H.70
Tschopp, J.71
Tsujimoto, Y.72
Vandenabeele, P.73
Vitale, I.74
Vousden, K.H.75
Youle, R.J.76
Yuan, J.77
Zhivotovsky, B.78
Kroemer, G.79
more..
-
5
-
-
0032831781
-
Monoglucosylation of RhoA at threonine 37 blocks cytosol-membrane cycling
-
DOI 10.1074/jbc.274.41.29050
-
H Genth K Aktories I Just 1999 Monoglucosylation of RhoA at threonine-37 blocks cytosol-membrane cycling J Biol Chem 274 29050 29056 1:CAS:528: DyaK1MXmslWqtro%3D 10.1074/jbc.274.41.29050 10506156 (Pubitemid 29477065)
-
(1999)
Journal of Biological Chemistry
, vol.274
, Issue.41
, pp. 29050-29056
-
-
Genth, H.1
Aktories, K.2
Just, I.3
-
6
-
-
0033976505
-
New method to generate enzymatically deficient Clostridium difficile toxin B as an antigen for immunization
-
DOI 10.1128/IAI.68.3.1094-1101.2000
-
H Genth J Selzer C Busch J Dumbach F Hofmann K Aktories I Just 2000 New method to generate enzymatically deficient Clostridium difficile toxin B as an antigen for immunization Infect Immun 68 1094 1101 1:CAS:528: DC%2BD3cXhsVKktLY%3D 10.1128/IAI.68.3.1094-1101.2000 10678912 (Pubitemid 30108496)
-
(2000)
Infection and Immunity
, vol.68
, Issue.3
, pp. 1094-1101
-
-
Genth, H.1
Selzer, J.2
Busch, C.3
Dumbach, J.4
Hofmann, F.5
Aktories, K.6
Just, I.7
-
7
-
-
33646942752
-
Cellular stability of Rho-GTPases glucosylated by Clostridium difficile toxin B
-
DOI 10.1016/j.febslet.2006.04.100, PII S0014579306006314
-
H Genth J Huelsenbeck B Hartmann F Hofmann I Just R Gerhard 2006 Cellular stability of Rho-GTPases glucosylated by Clostridium difficile toxin B FEBS Lett 580 3565 3569 1:CAS:528:DC%2BD28Xltlent7w%3D 10.1016/j.febslet.2006.04.100 16730714 (Pubitemid 43795899)
-
(2006)
FEBS Letters
, vol.580
, Issue.14
, pp. 3565-3569
-
-
Genth, H.1
Huelsenbeck, J.2
Hartmann, B.3
Hofmann, F.4
Just, I.5
Gerhard, R.6
-
8
-
-
39649088950
-
Clostridium difficile toxins: More than mere inhibitors of Rho proteins
-
1:CAS:528:DC%2BD1cXivVOmtb8%3D 10.1016/j.biocel.2007.12.014 18289919
-
H Genth SC Dreger J Huelsenbeck I Just 2008 Clostridium difficile toxins: more than mere inhibitors of Rho proteins Int J Biochem Cell Biol 40 592 597 1:CAS:528:DC%2BD1cXivVOmtb8%3D 10.1016/j.biocel.2007.12.014 18289919
-
(2008)
Int J Biochem Cell Biol
, vol.40
, pp. 592-597
-
-
Genth, H.1
Dreger, S.C.2
Huelsenbeck, J.3
Just, I.4
-
9
-
-
33846018602
-
Cell death by necrosis: Towards a molecular definition
-
DOI 10.1016/j.tibs.2006.11.001, PII S0968000406003185
-
P Golstein G Kroemer 2007 Cell death by necrosis: towards a molecular definition Trends Biochem Sci 32 37 43 1:CAS:528:DC%2BD2sXisVSqsA%3D%3D 10.1016/j.tibs.2006.11.001 17141506 (Pubitemid 46043552)
-
(2007)
Trends in Biochemical Sciences
, vol.32
, Issue.1
, pp. 37-43
-
-
Golstein, P.1
Kroemer, G.2
-
10
-
-
84954358174
-
Prevention of the cytopathic effect induced by Clostridium difficile toxin B by active Rac1
-
1:CAS:528:DC%2BD1cXhtlaqtrjN 10.1016/j.febslet.2008.10.003 18848548
-
I Halabi-Cabezon J Huelsenbeck M May M Ladwein K Rottner I Just H Genth 2008 Prevention of the cytopathic effect induced by Clostridium difficile toxin B by active Rac1 FEBS Lett 582 3751 3756 1:CAS:528:DC%2BD1cXhtlaqtrjN 10.1016/j.febslet.2008.10.003 18848548
-
(2008)
FEBS Lett
, vol.582
, pp. 3751-3756
-
-
Halabi-Cabezon, I.1
Huelsenbeck, J.2
May, M.3
Ladwein, M.4
Rottner, K.5
Just, I.6
Genth, H.7
-
12
-
-
33846807241
-
Difference in the cytotoxic effects of toxin B from Clostridium difficile strain VPI 10463 and toxin B from variant Clostridium difficile strain 1470
-
DOI 10.1128/IAI.01705-06
-
J Huelsenbeck S Dreger R Gerhard H Barth I Just H Genth 2007 Difference in the cytotoxic effects of toxin B from Clostridium difficile strain VPI 10463 and toxin B from variant Clostridium difficile strain 1470 Infect Immun 75 801 809 1:CAS:528:DC%2BD2sXhs1ahs70%3D 10.1128/IAI.01705-06 17145947 (Pubitemid 46203443)
-
(2007)
Infection and Immunity
, vol.75
, Issue.2
, pp. 801-809
-
-
Huelsenbeck, J.1
Dreger, S.2
Gerhard, R.3
Barth, H.4
Just, I.5
Genth, H.6
-
13
-
-
34247493760
-
Upregulation of the immediate early gene product RhoB by exoenzyme C3 from Clostridium limosum and toxin B from Clostridium difficile
-
DOI 10.1021/bi602465z
-
J Huelsenbeck SC Dreger R Gerhard G Fritz I Just H Genth 2007 Upregulation of the immediate early gene product RhoB by exoenzyme C3 from Clostridium limosum and toxin B from Clostridium difficile Biochemistry 46 4923 4931 1:CAS:528:DC%2BD2sXjs1SktLo%3D 10.1021/bi602465z 17397186 (Pubitemid 46651213)
-
(2007)
Biochemistry
, vol.46
, Issue.16
, pp. 4923-4931
-
-
Huelsenbeck, J.1
Dreger, S.C.2
Gerhard, R.3
Fritz, G.4
Just, I.5
Genth, H.6
-
14
-
-
70350222202
-
Inhibition of cytokinesis by Clostridium difficile toxin B and cytotoxic necrotizing factors-reinforcing the critical role of RhoA in cytokinesis
-
1:CAS:528:DC%2BD1MXhsVOls77L 10.1002/cm.20390 19504561
-
SC Huelsenbeck M May G Schmidt H Genth 2009 Inhibition of cytokinesis by Clostridium difficile toxin B and cytotoxic necrotizing factors-reinforcing the critical role of RhoA in cytokinesis Cell Motil Cytoskeleton 66 967 975 1:CAS:528:DC%2BD1MXhsVOls77L 10.1002/cm.20390 19504561
-
(2009)
Cell Motil Cytoskeleton
, vol.66
, pp. 967-975
-
-
Huelsenbeck, S.C.1
May, M.2
Schmidt, G.3
Genth, H.4
-
15
-
-
44349126693
-
Colonic crypt organization and tumorigenesis
-
DOI 10.1038/nrc2392, PII NRC2392
-
A Humphries NA Wright 2008 Colonic crypt organization and tumorigenesis Nat Rev Cancer 8 415 424 1:CAS:528:DC%2BD1cXmt1Oksb4%3D 10.1038/nrc2392 18480839 (Pubitemid 351744961)
-
(2008)
Nature Reviews Cancer
, vol.8
, Issue.6
, pp. 415-424
-
-
Humphries, A.1
Wright, N.A.2
-
16
-
-
34548472378
-
2 Up-Regulation of Fas Ligand
-
DOI 10.1053/j.gastro.2007.06.063, PII S0016508507012954
-
H Kim SH Rhee C Pothoulakis JT LaMont 2007 Inflammation and apoptosis in Clostridium difficile enteritis is mediated by PGE2 up-regulation of Fas ligand Gastroenterology 133 875 886 1:CAS:528:DC%2BD2sXhtFarsrfK 10.1053/j.gastro.2007. 06.063 17854595 (Pubitemid 47374142)
-
(2007)
Gastroenterology
, vol.133
, Issue.3
, pp. 875-886
-
-
Kim, H.1
Rhee, S.H.2
Pothoulakis, C.3
LaMont, J.T.4
-
17
-
-
77957988127
-
The role of toxin A and toxin B in Clostridium difficile infection
-
1:CAS:528:DC%2BC3cXhtFGntL%2FO 10.1038/nature09397 20844489
-
SA Kuehne ST Cartman JT Heap ML Kelly A Cockayne NP Minton 2010 The role of toxin A and toxin B in Clostridium difficile infection Nature 467 711 713 1:CAS:528:DC%2BC3cXhtFGntL%2FO 10.1038/nature09397 20844489
-
(2010)
Nature
, vol.467
, pp. 711-713
-
-
Kuehne, S.A.1
Cartman, S.T.2
Heap, J.T.3
Kelly, M.L.4
Cockayne, A.5
Minton, N.P.6
-
18
-
-
9244224723
-
Intrinsic tumour suppression
-
DOI 10.1038/nature03098
-
SW Lowe E Cepero G Evan 2004 Intrinsic tumour suppression Nature 432 307 315 1:CAS:528:DC%2BD2cXpvVCjtLg%3D 10.1038/nature03098 15549092 (Pubitemid 39551658)
-
(2004)
Nature
, vol.432
, Issue.7015
, pp. 307-315
-
-
Lowe, S.W.1
Cepero, E.2
Evan, G.3
-
19
-
-
0029868433
-
Effect of Clostridium difficile toxin A on human intestinal epithelial cells: Induction of interleukin 8 production and apoptosis after cell detachment
-
YR Mahida S Makh S Hyde T Gray SP Borriello 1996 Effect of Clostridium difficile toxin A on human intestinal epithelial cells: induction of interleukin 8 production and apoptosis after cell detachment Gut 38 337 347 1:CAS:528:DyaK28XitlOjt7o%3D 10.1136/gut.38.3.337 8675084 (Pubitemid 26075533)
-
(1996)
Gut
, vol.38
, Issue.3
, pp. 337-347
-
-
Mahida, Y.R.1
Makh, S.2
Hyde, S.3
Gray, T.4
Borriello, S.P.5
-
20
-
-
34247889959
-
Clostridium difficile toxin B causes apoptosis in epithelial cells by thrilling mitochondria: Involvement of ATP-sensitive mitochondrial potassium channels
-
DOI 10.1074/jbc.M607614200
-
P Matarrese L Falzano A Fabbri L Gambardella C Frank B Geny MR Popoff W Malorni C Fiorentini 2007 Clostridium difficile toxin B causes apoptosis in epithelial cells by thrilling mitochondria. Involvement of ATP-sensitive mitochondrial potassium channels J Biol Chem 282 9029 9041 1:CAS:528: DC%2BD2sXivV2mtrY%3D 10.1074/jbc.M607614200 17220295 (Pubitemid 47093530)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.12
, pp. 9029-9041
-
-
Matarrese, P.1
Falzano, L.2
Fabbri, A.3
Gambardella, L.4
Frank, C.5
Geny, B.6
Popoff, M.R.7
Malorni, W.8
Fiorentini, C.9
-
21
-
-
0032498625
-
Apoptotic membrane blebbing is regulated by myosin light chain phosphorylation
-
DOI 10.1083/jcb.140.3.627
-
JC Mills NL Stone J Erhardt RN Pittman 1998 Apoptotic membrane blebbing is regulated by myosin light chain phosphorylation J Cell Biol 140 627 636 1:CAS:528:DyaK1cXhtVams78%3D 10.1083/jcb.140.3.627 9456322 (Pubitemid 28134065)
-
(1998)
Journal of Cell Biology
, vol.140
, Issue.3
, pp. 627-636
-
-
Mills, J.C.1
Stone, N.L.2
Erhardt, J.3
Pittman, R.N.4
-
22
-
-
34250821092
-
Clostridium difficile toxin A-induced apoptosis is p53-independent but depends on glucosylation of Rho GTPases
-
DOI 10.1007/s10495-007-0074-8
-
S Nottrott J Schoentaube H Genth I Just R Gerhard 2007 Clostridium difficile toxin A-induced apoptosis is p53-independent but depends on glucosylation of Rho GTPases Apoptosis 12 1443 1453 1:CAS:528: DC%2BD2sXmvVyqu70%3D 10.1007/s10495-007-0074-8 17437185 (Pubitemid 46988281)
-
(2007)
Apoptosis
, vol.12
, Issue.8
, pp. 1443-1453
-
-
Nottrott, S.1
Schoentaube, J.2
Genth, H.3
Just, I.4
Gerhard, R.5
-
23
-
-
0036312873
-
Clostridium difficile toxin B activates dual caspase-dependent and caspase-independent apoptosis in intoxicated cells
-
DOI 10.1046/j.1462-5822.2002.00201.x
-
M QáDan M Ramsey J Daniel LM Spyres B Safiejko-Mroczka W Ortiz-Leduc JD Ballard 2002 Clostridium difficile toxin B activates dual caspase-dependent and caspase-independent apoptosis in intoxicated cells Cell Microbiol 4 425 434 10.1046/j.1462-5822.2002.00201.x (Pubitemid 34830925)
-
(2002)
Cellular Microbiology
, vol.4
, Issue.7
, pp. 425-434
-
-
Qa'Dan, M.1
Ramsey, M.2
Daniel, J.3
Spyres, L.M.4
Safiejko-Mroczka, B.5
Ortiz-Leduc, W.6
Ballard, J.D.7
-
24
-
-
0032515914
-
Glucosylation and ADP ribosylation of Rho proteins: Effects on nucleotide binding, GTPase activity, and effector coupling
-
DOI 10.1021/bi972592c
-
P Sehr G Joseph H Genth I Just E Pick K Aktories 1998 Glucosylation and ADP-ribosylation of Rho proteins-effects on nucleotide binding, GTPase activity, and effector-coupling Biochemistry 37 5296 5304 1:CAS:528:DyaK1cXisVylur8%3D 10.1021/bi972592c 9548761 (Pubitemid 28176531)
-
(1998)
Biochemistry
, vol.37
, Issue.15
, pp. 5296-5304
-
-
Sehr, P.1
Joseph, G.2
Genth, H.3
Just, I.4
Pick, E.5
Aktories, K.6
-
25
-
-
15544364759
-
Monocytes are highly sensitive to Clostridium difficile toxin A-induced apoptotic and nonapoptotic cell death
-
DOI 10.1128/IAI.73.3.1625-1634.2005
-
K Solomon J Webb N Ali RA Robins YR Mahida 2005 Monocytes are highly sensitive to Clostridium difficile toxin A-induced apoptotic and nonapoptotic cell death Infect Immun 73 1625 1634 1:CAS:528:DC%2BD2MXit12ms7c%3D 10.1128/IAI.73.3.1625-1634.2005 15731062 (Pubitemid 40470750)
-
(2005)
Infection and Immunity
, vol.73
, Issue.3
, pp. 1625-1634
-
-
Solomon, K.1
Webb, J.2
Ali, N.3
Robins, R.A.4
Mahida, Y.R.5
-
26
-
-
33644974808
-
Clostridium difficile-associated disease: New challenges from an established pathogen
-
10.3949/ccjm.73.2.187 16478043
-
RH Sunenshine LC McDonald 2006 Clostridium difficile-associated disease: new challenges from an established pathogen Cleve Clin J Med 73 187 197 10.3949/ccjm.73.2.187 16478043
-
(2006)
Cleve Clin J Med
, vol.73
, pp. 187-197
-
-
Sunenshine, R.H.1
McDonald, L.C.2
-
27
-
-
0038052800
-
Cell cycle and apoptosis
-
DOI 10.1046/j.1365-2184.2003.00267.x
-
K Vermeulen ZN Berneman DR Van Bockstaele 2003 Cell cycle and apoptosis Cell Prolif 36 165 175 1:CAS:528:DC%2BD3sXmtVOitrw%3D 10.1046/j.1365-2184.2003. 00267.x 12814432 (Pubitemid 36808272)
-
(2003)
Cell Proliferation
, vol.36
, Issue.3
, pp. 165-175
-
-
Vermeulen, K.1
Berneman, Z.N.2
Van Bockstaele, D.R.3
-
28
-
-
17444366186
-
Clostridium difficile toxins: Mechanism of action and role in disease
-
DOI 10.1128/CMR.18.2.247-263.2005
-
DE Voth J Ballard 2005 Clostridium difficile toxins: mechanism of action and role in disease Clin Microbiol Rev 18 247 263 1:CAS:528:DC%2BD2MXksVymtLY%3D 10.1128/CMR.18.2.247-263.2005 15831824 (Pubitemid 40548293)
-
(2005)
Clinical Microbiology Reviews
, vol.18
, Issue.2
, pp. 247-263
-
-
Voth, D.E.1
Ballard, J.D.2
-
29
-
-
0034049140
-
p38 MAP kinase activation by Clostridium difficile toxin A mediates monocyte necrosis, IL-8 production, and enteritis
-
M Warny AC Keates S Keates I Castagliuolo JK Zacks S Aboudola A Qamar C Pothoulakis JT LaMont CP Kelly 2000 p38MAP kinase activation by Clostridium difficile toxin A mediates monocytes necrosis, IL-8 production, and enteritis J Clin Investig 105 1147 1156 1:CAS:528:DC%2BD3cXisFOlurY%3D 10.1172/JCI7545 10772660 (Pubitemid 30217700)
-
(2000)
Journal of Clinical Investigation
, vol.105
, Issue.8
, pp. 1147-1156
-
-
Warny, M.1
Keates, A.C.2
Keates, S.3
Castagliuolo, I.4
Zacks, J.K.5
Aboudola, S.6
Qamar, A.7
Pothoulakis, C.8
LaMont, J.T.9
Kelly, C.P.10
-
30
-
-
0042026577
-
Rho-specific Bacillus cereus ADP-Ribosyltransferase C3cer cloning and characterization
-
DOI 10.1021/bi034583b
-
C Wilde M Vogelsang K Aktories 2003 Rho-specific Bacillus cereus ADP-ribosyltransferase C3cer cloning and characterization Biochemistry 42 9694 9702 1:CAS:528:DC%2BD3sXlslegtrc%3D 10.1021/bi034583b 12911311 (Pubitemid 36993142)
-
(2003)
Biochemistry
, vol.42
, Issue.32
, pp. 9694-9702
-
-
Wilde, C.1
Vogelsgesang, M.2
Aktories, K.3
|