Antiapoptotic proteins Bcl-2 and Bcl-XL inhibit clostridium difficile toxin A-induced cell death in human epithelial cells

Infection and Immunity

Volumn 77, Issue 12, 2009, Pages 5400-5410

  Matte, Isabelle ^a   Lane, Denis ^a   Côté, Élodie ^a   Asselin, Ann Élise ^a   Fortier, Louis Charles ^a   Asselin, Claude ^a   Piché, Alain ^a  

^a UNIVERSITY OF SHERBROOKE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITOXIN; CASPASE 3; CASPASE 3 INHIBITOR; CASPASE 8; CASPASE 8 INHIBITOR; CASPASE 9 INHIBITOR; CLOSTRIDIUM DIFFICILE TOXIN A; DEATH RECEPTOR; PROTEIN BCL 2; PROTEIN BCL X; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL ASSAY; CELL CULTURE; CELL DEATH; CLOSTRIDIUM DIFFICILE; COLON CARCINOMA; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVATION; ENZYME ACTIVITY; EPITHELIUM CELL; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MITOCHONDRIAL PERMEABILITY; MITOCHONDRION; NONHUMAN; NUCLEOTIDE SEQUENCE; OUTER MEMBRANE; OVARY CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; SIGNAL TRANSDUCTION;

BACTERIAL TOXINS; BCL-X PROTEIN; CASPASE 3; CASPASE 8; CELL DEATH; CELL LINE, TUMOR; CLOSTRIDIUM DIFFICILE; ENTEROTOXINS; EPITHELIAL CELLS; HUMANS; MITOCHONDRIAL MEMBRANES; PERMEABILITY; PROTO-ONCOGENE PROTEINS C-BCL-2; TNF-RELATED APOPTOSIS-INDUCING LIGAND;

EID: 72449195204     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00485-09     Document Type: Article

References (35)

1. Bantel, H., B. Sinha, W. Domschke, G. Peters, K. Schulze-Osthoff, and R. U. Jänicke. 2001. α-Toxin is a mediator of Staphylococcus aureus-induced cell death and activates caspases via the intrinsic death pathway independently of death receptor signalling. J. Cell Biol. 155:637-648.
2. Boise, L. H., and C. B. Thompson. 1997. Bcl-XL can inhibit apoptosis in cells that have undergone Fas-induced protease activation. Proc. Natl. Acad. Sci. USA 94:3759-3764.
3. Bodmer, J. L., N. Holler, S. Reynard, P. Vinciguerra, P. Schneider, P. Juo, J. Blenis, and J. Tschopp. 2000. TRAIL receptor-2 signals apoptosis through FADD and caspase-8. Nat. Cell Biol. 2:241-243.
4. Brito, G. A. C., J. Fujii, B. A. Carneiro-Filho, A. A. M. Lima, T. Obrig, and R. L. Guerrant. 2002. Mechanisms of Clostridium difficile toxin A-induced apoptosis in T84 cells. J. Infect. Dis. 186:1438-1447.
5. Carneiro, B. A., J. Fujii, G. A. C. Brito, C. Alcantara, R. B. Oria, A. A. M. Lima, T. Obrig, and R. L. Guerrant. 2006. Caspase and Bid involvement in Clostridium difficile toxin A-induced apoptosis and modulation of toxin A effects by glutamine and alanyl-glutamine in vivo and in vitro. Infect. Immun. 74:81-87.
6. Chae, S., L. Eckmann, Y. Miyamoto, C. Pothoulakis, M. Karin, and M. F. Kagnoff. 2006. Epithelial cell IκB-kinase has an important protective role in Clostridium difficile toxin A-induced mucosal injury. J. Immunol. 177:1214-1220.
7. Datta, S. C., A. Brunnet, and M. E. Greenberg. 2007. Cellular survival: a play in three Akts. Genes Dev. 13:2905-2927.
8. Dodier, P., and A. Piché. 2006. Bcl-XL is functionally non-equivalent for the regulation of growth and survival in human ovarian cancer cells. Gynecol. Oncol. 100:254-263.
9. Gerhard, R., S. Nottrott, J. Schoentaube, H. Tatge, A. Olling, and I. Just. 2008. Glucosylation of Rho GTPases by Clostridium difficile toxin A triggers apoptosis in intestinal epithelial cells. J. Med. Microbiol. 57:765-770.
10. Hinz, S., A. Trauzold, L. Boenicke, C. Sandberg, S. Beckmann, E. Bayer, H. Walczak, H. Kalthoff, and H. Ungefroren. 2000. Bcl-XL protects pancreatic adenocarcinoma cells against CD95- and TRAIL-receptor-mediated apoptosis. Oncogene 19:5477-5486. (Pubitemid 32000915)
11. Hippenstiel, S., B. Schmeck, P. D. N'Guessan, J. Seybold, M. Krull, K. Preissner, C. Von Eichel-Streiber, and N. Suttorp. 2002. Rho protein inactivation induced apoptosis of cultured human endothelial cells. Am. J. Physiol. 238:L830-L838.
12. Ishida, Y., T. Maegawa, T. Kondo, A. Kimura, Y. Iwakura, S. Nakamura, and N. Mukaida. 2004. Essential involvement of IFN-γ in Clostridium diffiicile toxin A-induced enteritis. J. Immunol. 172:3018-3025.
13. Kawahara, A., T. Kobayashi, and S. Nagata. 1998. Inhibition of Fas-induced apoptosis by Bcl-2. Oncogene 17:2549-2554.
14. Kelly, C. P., and J. T. LaMont. 2008. Clostridium difficile - more difficult than ever. N. Engl. J. Med. 359:1932-1940.
15. Krivan, H. C., and T. D. Wilkins. 1987. Purification of Clostridium difficile toxin A by affinity chromatography on immobilized thyroglobulin. Infect. Immun. 55:1873-1877.
16. Kischkel, F. C., S. Hellbardt, I. Behrmann, M. Germer, M. Pawlita, P. H. Krammer, and M. E. Peter. 1995. Cytotoxicity-dependent APO-1 (FAS/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. EMBO J. 14:5579-5588.
17. Kroemer, G., L. Galluzzi, P. Vandenabeele, J. Abrams, E. S. Alnemri, E. H. Baehrecke, M. V. Blagosklonny, W. S. El-Deiry, P. Golstein, D. R. Green, M. Hengartner, R. A. Knight, S. Kumar, S. A. Lipton, W. Malorni, G. Nunez, M. E. Peter, J. Tschopp, J. Yuan, M. Piacentini, B. Zhivotovsky, and G. Melino. 2009. Classification of cell death: recommendations of the nomenclature committee on cell death 2009. Cell Death Differ. 16:3-11.
18. Labbé, K., and M. Saleh. 2008. Cell death in the host response to infection. Cell Death Differ. 15:1339-1349.
19. Lane, D., A. Cartier, S. L'Espérance, M. Côté, C. Rancourt, and A. Piché. 2004. Differential induction of apoptosis by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in human ovarian carcinoma cells. Gynecol. Oncol. 93:594-604.
20. Lane, D., V. Robert, R. Grondin, C. Rancourt, and A. Piché. 2007. Malignant ascites protect against TRAIL-induced apoptosis by activating the PI3K/Akt pathway in human ovarian carcinoma cells. Int. J. Cancer 121:1227-1237. (Pubitemid 47293789)
21. Lane, D., M. Côté, R. Grondin, M. C. Couture, and A. Piché. 2006. Acquired resistance to TRAIL-induced apoptosis in human ovarian cancer cells is conferred by increased turnover of mature caspase-3. Mol. Cancer Ther. 5:509-521.
22. Lee, S.-Y., R. P. Cherla, I. Caliskan, and V. L. Tesh. 2005. Shiga toxin 1 induces apoptosis in the human myelogenous leukemia cell line THP-1 by a caspase-8-dependent, tumor necrosis factor receptor-independent mechanism. Infect. Immun. 73:5115-5126.
23. Loo, V. G., M. D. Libman, M. A. Miller, A. M. Bourgault, C. H. Frenette, M. Kelly, S. Michaud, T. Nguyen, L. Poirier, A. Vibien, R. Horn, P. J. Laflamme, and P. René. 2004. Clostridium difficile: a formidable foe. Can. Med. Assoc. J. 171:47-48.
24. Lyverly, D. M., K. E. Saum, D. K. MacDonald, and T. D. Wilkins. 1985. Effects of Clostridium difficile toxins given intragastrically to animals. Infect. Immun. 47:349-352.
25. Marriott, H. M., C. D. Bingle, R. C. Read, K. E. Braley, G. Kroemer, P. G. Hellewell, et al. 2005. Dynamic changes in Mcl-1 expression regulate macrophage viability or commitment to apoptosis during bacterial clearance. J. Clin. Investig. 115:359-368.
26. McDonald, L. C., G. E. Killgore, A. Thompson, R. C. Owen, Jr., S. V. Kazakova, S. P. Sambol, S. Johnson, and D. N. Gerding. 2005. An epidemic, toxin gene-variant strain of Clostridum difficile. N. Engl. J. Med. 353:2433-2441.
27. Muzio, M., B. R. Stockwel, H. R. Stennicke, G. S. Salvesen, and V. M. Dixit. 1998. An induced proximity model for caspase-8 activation. J. Biol. Chem. 273:2926-2930.
28. Pépin, J., L. Valiquette, M. E. Alary, P. Villemure, A. Pelletier, K. Forget, K. Pépin, and D. Chouinard. 2004. Clostridium difficile-associated diarrhea in a region of Quebec from 1991 to 2003: a changing pattern of disease severity. Can. Med. Assoc. J. 171:466-472.
29. Pépin, J., L. Valiquette, and B. Cossette. 2005. Mortality attributable to nosocomial Clostridium difficile-associated disease during an epidemic caused by a hypervirulent strain in Quebec. Can. Med. Assoc. J. 173:1037-1041.
30. Qa'Dan, M., M. Ramsey, J. Daniel, L. M. Spyres, B. Safiejko-Mroczka, W. Ortiz-Leduc, and J. D. Ballard. 2002. Clostridium difficile toxin B activates dual caspase-dependent and caspase-independent apoptosis in intoxicated cells. Cell Microbiol. 4:425-434.
31. Reed, J. C. 1998. Bcl-2 family proteins. Oncogene 17:3225-3236.
32. Tait, S. W., and D. R. Green. 2008. Caspase-independent cell death: leaving the set without the final cut. Oncogene 27:6452-6461.
33. Taylor, R. C., S. P. Cullen, and S. J. Martin. 2008. Apoptosis: controlled demolition at the cellular level. Nat. Rev. Mol. Cell Biol. 9:231-241.
34. Warny, M., and C. P. Kelly. 1999. Monocytic cell necrosis is mediated by potassium depletion and caspase-like proteases. Am. J. Physiol. 276:C717-C724.
35. Warny, M., J. Pépin, A. Fang, G. Killgore, A. Thompson, J. Brazier, E. Frost, and L. C. McDonald. 2005. Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and Europe. Lancet 366:1079-1084.