P63RhoGEF couples G αq/11-mediated signaling to Ca 2+ sensitization of vascular smooth muscle contractility

Circulation Research

Volumn 109, Issue 9, 2011, Pages 993-1002

  Momotani, Ko ^a   Artamonov, Mykhaylo V ^a   Utepbergenov, Darkhan ^a   Derewenda, Urszula ^a   Derewenda, Zygmunt S ^a   Somlyo, Avril V ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Ca 2+; RhoA; RhoGEF; sensitization; signal transduction; vascular smooth muscle

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; CALCIUM ION; ENDOTHELIN 1; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE EXCHANGE FACTOR; PHENYLEPHRINE; PLECKSTRIN; PROTEIN P63; RECOMBINANT PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; THROMBOXANE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CHEMOSENSITIZATION; CONTROLLED STUDY; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; PORTAL VEIN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; RABBIT; SMOOTH MUSCLE CONTRACTILITY; SMOOTH MUSCLE TONE; VASCULAR RESISTANCE; VASCULAR SMOOTH MUSCLE; VEIN PERMEABILITY;

ANIMALS; CALCIUM; CELLS, CULTURED; ENDOTHELIN-1; GENE KNOCKDOWN TECHNIQUES; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; GUANINE NUCLEOTIDE EXCHANGE FACTORS; GUANOSINE TRIPHOSPHATE; HEK293 CELLS; HUMANS; MALE; MICE; MICE, INBRED C57BL; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; PHENYLEPHRINE; PORTAL VEIN; RABBITS; RATS; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; VASOCONSTRICTOR AGENTS;

EID: 80055009632     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.111.248898     Document Type: Article

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