Pharmacological profile of astemizole-derived compounds at the histamine H1 and H4 receptor - H1/H4 receptor selectivity

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 387, Issue 3, 2014, Pages 235-250

  Wagner, Eva ^a   Wittmann, Hans Joachim ^a   Elz, Sigurd ^a   Strasser, Andrea ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Astemizole; Dual H1R H4R ligands; Histamine H1 receptor; Histamine H4 receptor; JNJ7777120; Molecular dynamics

Indexed keywords

1 (5 CHLORO 2 INDOLYLCARBONYL) 4 METHYLPIPERAZINE; AMINOPYRIMIDINE DERIVATIVE; ASTEMIZOLE; BENZIMIDAZOLE; DIPHENHYDRAMINE; HISTAMINE; HISTAMINE H1 RECEPTOR; HISTAMINE H4 RECEPTOR; PIPERAZINE; PYRIMIDINE DERIVATIVE; QUINAZOLINE DERIVATIVE; THIOPERAMIDE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; MOLECULAR DYNAMICS; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; ASTEMIZOLE; FEMALE; GUINEA PIGS; HISTAMINE ANTAGONISTS; HISTAMINE H1 ANTAGONISTS; HUMANS; INDOLES; MALE; MOLECULAR DOCKING SIMULATION; MOLECULAR DYNAMICS SIMULATION; PIPERAZINES; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, HISTAMINE; RECEPTORS, HISTAMINE H1; SF9 CELLS; SPODOPTERA;

EID: 84896708869     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/s00210-013-0926-4     Document Type: Article

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