2,4-Diaminopyrimidines as histamine H4 receptor ligands-Scaffold optimization and pharmacological characterization

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 20, 2009, Pages 7186-7196

  Sander, Kerstin ^a   Kottke, Tim ^a   Tanrikulu, Yusuf ^a   Proschak, Ewgenij ^a   Weizel, Lilia ^a   Schneider, Erich H ^b   Seifert, Roland ^c   Schneider, Gisbert ^a   Stark, Holger ^a  

^a GOETHE UNIVERSITY   (Germany)

^b UNIVERSITY OF REGENSBURG   (Germany)

^c HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

GPCR; H4; Histamine; Lead optimization; Topliss scheme

Indexed keywords

2,4 DIAMINOPYRIMIDINE DERIVATIVE; HISTAMINE H4 RECEPTOR;

ARTICLE; DRUG ACTIVITY; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG TARGETING; NONHUMAN; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; PYRIMIDINES; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, HISTAMINE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 72049089060     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.08.059     Document Type: Article

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