Contribution of binding enthalpy and entropy to affinity of antagonist and agonist binding at human and guinea pig histamine H1-receptor

Molecular Pharmacology

Volumn 76, Issue 1, 2009, Pages 25-37

  Wittmann, Hans Joachim ^a   Seifert, Roland ^b   Strasser, Andrea ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMITRIPTYLINE; CHLORPROMAZINE; CLOZAPINE; DIPHENHYDRAMINE; FEXOFENADINE; HISTAMINE; HISTAMINE H1 RECEPTOR; HISTAMINE H1 RECEPTOR AGONIST; HISTAMINE H1 RECEPTOR ANTAGONIST; HISTAPRODIFEN; HISTAPRODIFEN DERIVATIVE; MEPYRAMINE; MIANSERIN; PHENOPRODIFEN DERIVATIVE; PHENYLHISTAMINE DERIVATIVE; SUPRAHISTAPRODIFEN; TERFENADINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING ASSAY; DRUG RECEPTOR BINDING; ENTHALPY; ENTROPY; GUINEA PIG; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN CONFORMATION; QUANTITATIVE ANALYSIS; STRUCTURE ACTIVITY RELATION; TEMPERATURE DEPENDENCE; THERMODYNAMICS;

ANIMALS; ENTROPY; GUINEA PIGS; HISTAMINE AGONISTS; HISTAMINE H1 ANTAGONISTS; HUMANS; LIGANDS; PROTEIN CONFORMATION; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RECEPTORS, HISTAMINE H1; SPECIES SPECIFICITY; TEMPERATURE; THERMODYNAMICS;

EID: 67649840628     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.109.055384     Document Type: Article

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