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Volumn 1841, Issue 3, 2014, Pages 422-434

Ceramide synthesis in the epidermis

Author keywords

1 O Acylceramides; Autosomal recessive congenital ichthyosis (ARCI); Ceramide synthesis; Epidermis; Omega esterified ceramides; Skin barrier function

Indexed keywords

1 O ACYLCERAMIDE; CERAMIDE; GLUCOSYLCERAMIDE; LONG CHAIN FATTY ACID; SPHINGOLIPID; UNCLASSIFIED DRUG;

EID: 84896698622     PISSN: 13881981     EISSN: 18792618     Source Type: Journal    
DOI: 10.1016/j.bbalip.2013.08.011     Document Type: Review
Times cited : (198)

References (135)
  • 1
    • 84855918312 scopus 로고    scopus 로고
    • Ceramide synthases at the centre of sphingolipid metabolism and biology
    • T.D. Mullen, Y.A. Hannun, and L.M. Obeid Ceramide synthases at the centre of sphingolipid metabolism and biology Biochem. J. 441 2012 789 802
    • (2012) Biochem. J. , vol.441 , pp. 789-802
    • Mullen, T.D.1    Hannun, Y.A.2    Obeid, L.M.3
  • 2
    • 34548329395 scopus 로고    scopus 로고
    • The metabolism and function of sphingolipids and glycosphingolipids
    • DOI 10.1007/s00018-007-7076-0
    • S. Lahiri, and A.H. Futerman The metabolism and function of sphingolipids and glycosphingolipids Cell Mol. Life Sci. 64 2007 2270 2284 (Pubitemid 47347954)
    • (2007) Cellular and Molecular Life Sciences , vol.64 , Issue.17 , pp. 2270-2284
    • Lahiri, S.1    Futerman, A.H.2
  • 3
    • 40849119996 scopus 로고    scopus 로고
    • Structure and function of glycosphingolipids and sphingolipids: Recollections and future trends
    • S.I. Hakomori Structure and function of glycosphingolipids and sphingolipids: recollections and future trends Biochim. Biophys. Acta 1780 2008 325 346
    • (2008) Biochim. Biophys. Acta , vol.1780 , pp. 325-346
    • Hakomori, S.I.1
  • 4
    • 33749049791 scopus 로고    scopus 로고
    • Epidermal sphingolipids: Metabolism, function, and roles in skin disorders
    • DOI 10.1016/j.febslet.2006.08.039, PII S0014579306010155
    • W.M. Holleran, Y. Takagi, and Y. Uchida Epidermal sphingolipids: metabolism, function, and roles in skin disorders FEBS Lett. 580 2006 5456 5466 (Pubitemid 44465907)
    • (2006) FEBS Letters , vol.580 , Issue.23 , pp. 5456-5466
    • Holleran, W.M.1    Takagi, Y.2    Uchida, Y.3
  • 5
    • 0026555825 scopus 로고
    • Lipid and protein structures in the permeability barrier of mammalian epidermis
    • D.T. Downing Lipid and protein structures in the permeability barrier of mammalian epidermis J. Lipid Res. 33 1992 301 313
    • (1992) J. Lipid Res. , vol.33 , pp. 301-313
    • Downing, D.T.1
  • 7
    • 0036036354 scopus 로고    scopus 로고
    • Decreased levels of sphingosine, a natural antimicrobial agent, may be associated with vulnerability of the stratum corneum from patients with atopic dermatitis to colonization by Staphylococcus aureus
    • DOI 10.1046/j.1523-1747.2002.01846.x
    • J. Arikawa, M. Ishibashi, M. Kawashima, Y. Takagi, Y. Ichikawa, and G. Imokawa Decreased levels of sphingosine, a natural antimicrobial agent, may be associated with vulnerability of the stratum corneum from patients with atopic dermatitis to colonization by Staphylococcus aureus J. Investig. Dermatol. 119 2002 433 439 (Pubitemid 35001954)
    • (2002) Journal of Investigative Dermatology , vol.119 , Issue.2 , pp. 433-439
    • Arikawa, J.1    Ishibashi, M.2    Kawashima, M.3    Takagi, Y.4    Ichikawa, Y.5    Imokawa, G.6
  • 11
    • 0030700338 scopus 로고    scopus 로고
    • Ceramide signalling: Regulatory role in cell proliferation, differentiation and apoptosis in human epidermis
    • DOI 10.1007/s004030050240
    • C.C. Geilen, T. Wieder, and C.E. Orfanos Ceramide signalling: regulatory role in cell proliferation, differentiation and apoptosis in human epidermis Arch. Dermatol. Res. 289 1997 559 566 (Pubitemid 27477647)
    • (1997) Archives of Dermatological Research , vol.289 , Issue.10 , pp. 559-566
    • Geilen, C.C.1    Wieder, T.2    Orfanos, C.E.3
  • 12
    • 0035742673 scopus 로고    scopus 로고
    • Sphingolipid signaling in epidermal homeostasis: Current knowledge and new therapeutic approaches in dermatology
    • DOI 10.1159/000056356
    • C.C. Geilen, S. Barz, and M. Bektas Sphingolipid signaling in epidermal homeostasis. Current knowledge and new therapeutic approaches in dermatology Skin Pharmacol. Appl. Ski. Physiol. 14 2001 261 271 (Pubitemid 34701633)
    • (2001) Skin Pharmacology and Applied Skin Physiology , vol.14 , Issue.5 , pp. 261-271
    • Geilen, C.C.1    Barz, S.2    Bektas, M.3
  • 14
    • 0037377677 scopus 로고    scopus 로고
    • De novo ceramide synthesis participates in the ultraviolet B irradiation-induced apoptosis in undifferentiated cultured human keratinocytes
    • DOI 10.1046/j.1523-1747.2003.12098.x
    • Y. Uchida, A.D. Nardo, V. Collins, P.M. Elias, and W.M. Holleran De novo ceramide synthesis participates in the ultraviolet B irradiation-induced apoptosis in undifferentiated cultured human keratinocytes J. Investig. Dermatol. 120 2003 662 669 (Pubitemid 36344011)
    • (2003) Journal of Investigative Dermatology , vol.120 , Issue.4 , pp. 662-669
    • Uchida, Y.1    Di Nardo, A.2    Collins, V.3    Elias, P.M.4    Holleran, W.M.5
  • 15
    • 0020615145 scopus 로고
    • Human stratum corneum lipids: Characterization and regional variations
    • M.A. Lampe, A.L. Burlingame, J. Whitney, M.L. Williams, B.E. Brown, E. Roitman, and P.M. Elias Human stratum corneum lipids: characterization and regional variations J. Lipid Res. 24 1983 120 130 (Pubitemid 13080345)
    • (1983) Journal of Lipid Research , vol.24 , Issue.2 , pp. 120-130
    • Lampe, M.A.1    Burlingame, A.L.2    Whitney, J.A.3
  • 17
    • 0025819102 scopus 로고
    • Decreased level of ceramides in stratum corneum of atopic dermatitis: An etiologic factor in atopic dry skin?
    • G. Imokawa, A. Abe, K. Jin, Y. Higaki, M. Kawashima, and A. Hidano Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin? J. Investig. Dermatol. 96 1991 523 526
    • (1991) J. Investig. Dermatol. , vol.96 , pp. 523-526
    • Imokawa, G.1    Abe, A.2    Jin, K.3    Higaki, Y.4    Kawashima, M.5    Hidano, A.6
  • 20
    • 0036426720 scopus 로고    scopus 로고
    • Deficiency of epidermal protein-bound ω-hydroxyceramides in atopic dermatitis
    • DOI 10.1046/j.1523-1747.2002.01833.x
    • O. Macheleidt, H.W. Kaiser, and K. Sandhoff Deficiency of epidermal protein-bound omega-hydroxyceramides in atopic dermatitis J. Investig. Dermatol. 119 2002 166 173 (Pubitemid 35304406)
    • (2002) Journal of Investigative Dermatology , vol.119 , Issue.1 , pp. 166-173
    • Macheleidt, O.1    Kaiser, H.W.2    Sandhoff, K.3
  • 23
    • 0021678861 scopus 로고
    • Stratum corneum lipids in disorders of cornification. Steroid sulfatase and cholesterol sulfate in normal desquamation and the pathogenesis of recessive X-linked ichthyosis
    • P.M. Elias, M.L. Williams, M.E. Maloney, J.A. Bonifas, B.E. Brown, S. Grayson, and E.H. Epstein Jr. Stratum corneum lipids in disorders of cornification. Steroid sulfatase and cholesterol sulfate in normal desquamation and the pathogenesis of recessive X-linked ichthyosis J. Clin. Invest. 74 1984 1414 1421 (Pubitemid 15200234)
    • (1984) Journal of Clinical Investigation , vol.74 , Issue.4 , pp. 1414-1421
    • Elias, P.M.1    Williams, M.L.2    Maloney, M.E.3
  • 28
    • 0028793605 scopus 로고
    • Free sphingosines of human skin include 6-hydroxysphingosine and unusually long-chain dihydrosphingosines
    • M.E. Stewart, and D.T. Downing Free sphingosines of human skin include 6-hydroxysphingosine and unusually long-chain dihydrosphingosines J. Investig. Dermatol. 105 1995 613 618
    • (1995) J. Investig. Dermatol. , vol.105 , pp. 613-618
    • Stewart, M.E.1    Downing, D.T.2
  • 30
    • 84855412135 scopus 로고    scopus 로고
    • Profiling and characterizing skin ceramides using reversed-phase liquid chromatography-quadrupole time-of-flight mass spectrometry
    • R. t'Kindt, L. Jorge, E. Dumont, P. Couturon, F. David, P. Sandra, and K. Sandra Profiling and characterizing skin ceramides using reversed-phase liquid chromatography-quadrupole time-of-flight mass spectrometry Anal. Chem. 84 2012 403 411
    • (2012) Anal. Chem. , vol.84 , pp. 403-411
    • T'Kindt, R.1    Jorge, L.2    Dumont, E.3    Couturon, P.4    David, F.5    Sandra, P.6    Sandra, K.7
  • 31
    • 0020770892 scopus 로고
    • Ceramides of pig epidermis: Structure determination
    • P.W. Wertz, and D.T. Downing Ceramides of pig epidermis: structure determination J. Lipid Res. 24 1983 759 765
    • (1983) J. Lipid Res. , vol.24 , pp. 759-765
    • Wertz, P.W.1    Downing, D.T.2
  • 32
    • 0032504164 scopus 로고    scopus 로고
    • Ceramides are bound to structural proteins of the human foreskin epidermal cornified cell envelope
    • DOI 10.1074/jbc.273.28.17763
    • L.N. Marekov, and P.M. Steinert Ceramides are bound to structural proteins of the human foreskin epidermal cornified cell envelope J. Biol. Chem. 273 1998 17763 17770 (Pubitemid 28355119)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.28 , pp. 17763-17770
    • Marekov, L.N.1    Steinert, P.M.2
  • 34
    • 77955481009 scopus 로고    scopus 로고
    • Current understanding of fatty acid biosynthesis and the acyl carrier protein
    • D.I. Chan, and H.J. Vogel Current understanding of fatty acid biosynthesis and the acyl carrier protein Biochem. J. 430 2010 1 19
    • (2010) Biochem. J. , vol.430 , pp. 1-19
    • Chan, D.I.1    Vogel, H.J.2
  • 35
    • 76749132709 scopus 로고    scopus 로고
    • The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice
    • H. Guillou, D. Zadravec, P.G. Martin, and A. Jacobsson The key roles of elongases and desaturases in mammalian fatty acid metabolism: insights from transgenic mice Prog. Lipid Res. 49 2010 186 199
    • (2010) Prog. Lipid Res. , vol.49 , pp. 186-199
    • Guillou, H.1    Zadravec, D.2    Martin, P.G.3    Jacobsson, A.4
  • 36
    • 33646018341 scopus 로고    scopus 로고
    • Fatty acid elongases in mammals: Their regulation and roles in metabolism
    • A. Jakobsson, R. Westerberg, and A. Jacobsson Fatty acid elongases in mammals: their regulation and roles in metabolism Prog. Lipid Res. 45 2006 237 249
    • (2006) Prog. Lipid Res. , vol.45 , pp. 237-249
    • Jakobsson, A.1    Westerberg, R.2    Jacobsson, A.3
  • 40
    • 45549086681 scopus 로고    scopus 로고
    • Characterization of four mammalian 3-hydroxyacyl-CoA dehydratases involved in very long-chain fatty acid synthesis
    • M. Ikeda, Y. Kanao, M. Yamanaka, H. Sakuraba, Y. Mizutani, Y. Igarashi, and A. Kihara Characterization of four mammalian 3-hydroxyacyl-CoA dehydratases involved in very long-chain fatty acid synthesis FEBS Lett. 582 2008 2435 2440
    • (2008) FEBS Lett. , vol.582 , pp. 2435-2440
    • Ikeda, M.1    Kanao, Y.2    Yamanaka, M.3    Sakuraba, H.4    Mizutani, Y.5    Igarashi, Y.6    Kihara, A.7
  • 41
    • 33846903325 scopus 로고    scopus 로고
    • Depletion of ceramides with very long chain fatty acids causes defective skin permeability barrier function, and neonatal lethality in ELOVL4 deficient mice
    • W. Li, R. Sandhoff, M. Kono, P. Zerfas, V. Hoffmann, B.C. Ding, R.L. Proia, and C.X. Deng Depletion of ceramides with very long chain fatty acids causes defective skin permeability barrier function, and neonatal lethality in ELOVL4 deficient mice Int. J. Biol. Sci. 3 2007 120 128 (Pubitemid 46232773)
    • (2007) International Journal of Biological Sciences , vol.3 , Issue.2 , pp. 120-128
    • Li, W.1    Sandhoff, R.2    Kono, M.3    Zerfas, P.4    Hoffmann, V.5    Ding, B.C.-H.6    Proia, R.L.7    Deng, C.-X.8
  • 46
    • 0015973328 scopus 로고
    • The fatty acid composition of sphingolipids from bovine CNS axons and myelin
    • G.H. DeVries, and W.T. Norton The fatty acid composition of sphingolipids from bovine CNS axons and myelin J. Neurochem. 22 1974 251 257
    • (1974) J. Neurochem. , vol.22 , pp. 251-257
    • Devries, G.H.1    Norton, W.T.2
  • 49
    • 0000292733 scopus 로고
    • Occurrence of 2-hydroxy fatty acids in animal tissues
    • Y. Kishimoto, and N.S. Radin Occurrence of 2-hydroxy fatty acids in animal tissues J. Lipid Res. 4 1963 139 143
    • (1963) J. Lipid Res. , vol.4 , pp. 139-143
    • Kishimoto, Y.1    Radin, N.S.2
  • 50
    • 55749103552 scopus 로고    scopus 로고
    • Absence of 2-hydroxylated sphingolipids is compatible with normal neural development but causes late-onset axon and myelin sheath degeneration
    • I. Zoller, M. Meixner, D. Hartmann, H. Bussow, R. Meyer, V. Gieselmann, and M. Eckhardt Absence of 2-hydroxylated sphingolipids is compatible with normal neural development but causes late-onset axon and myelin sheath degeneration J. Neurosci. 28 2008 9741 9754
    • (2008) J. Neurosci. , vol.28 , pp. 9741-9754
    • Zoller, I.1    Meixner, M.2    Hartmann, D.3    Bussow, H.4    Meyer, R.5    Gieselmann, V.6    Eckhardt, M.7
  • 51
    • 19544372579 scopus 로고    scopus 로고
    • A mammalian fatty acid hydroxylase responsible for the formation of α-hydroxylated galactosylceramide in myelin
    • DOI 10.1042/BJ20041451
    • M. Eckhardt, A. Yaghootfam, S.N. Fewou, I. Zoller, and V. Gieselmann A mammalian fatty acid hydroxylase responsible for the formation of alpha-hydroxylated galactosylceramide in myelin Biochem. J. 388 2005 245 254 (Pubitemid 40732952)
    • (2005) Biochemical Journal , vol.388 , Issue.1 , pp. 245-254
    • Eckhardt, M.1    Yaghootfam, A.2    Fewou, S.N.3    Zoller, I.4    Gieselmann, V.5
  • 52
    • 58149462858 scopus 로고    scopus 로고
    • Synthesis of 2-hydroxy-ceramide by ceramide synthase family members: Enzymatic basis for the preference of fatty acid chain length in cultured cell models
    • Y. Mizutani, A. Kihara, H. Chiba, H. Tojo, and Y. Igarashi Synthesis of 2-hydroxy-ceramide by ceramide synthase family members: enzymatic basis for the preference of fatty acid chain length in cultured cell models J. Lipid Res. 49 2008 2356 2364
    • (2008) J. Lipid Res. , vol.49 , pp. 2356-2364
    • Mizutani, Y.1    Kihara, A.2    Chiba, H.3    Tojo, H.4    Igarashi, Y.5
  • 53
    • 34250372937 scopus 로고    scopus 로고
    • Fatty acid 2-hydroxylase, encoded by FA2H, accounts for differentiation-associated increase in 2-OH ceramides during keratinocyte differentiation
    • DOI 10.1074/jbc.M611562200
    • Y. Uchida, H. Hama, N.L. Alderson, S. Douangpanya, Y. Wang, D.A. Crumrine, P.M. Elias, and W.M. Holleran Fatty acid 2-hydroxylase, encoded by FA2H, accounts for differentiation-associated increase in 2-OH ceramides during keratinocyte differentiation J. Biol. Chem. 282 2007 13211 13219 (Pubitemid 47100529)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.18 , pp. 13211-13219
    • Uchida, Y.1    Hama, H.2    Alderson, N.L.3    Douangpanya, S.4    Wang, Y.5    Crumrine, D.A.6    Elias, P.M.7    Holleran, W.M.8
  • 56
    • 0036015842 scopus 로고    scopus 로고
    • Utilization of sterol carrier protein-2 by phytanoyl-CoA 2-hydroxylase in the peroxisomal α oxidation of phytanic acid
    • DOI 10.1016/S1074-5521(02)00139-4, PII S1074552102001394
    • M. Mukherji, N.J. Kershaw, C.J. Schofield, A.S. Wierzbicki, and M.D. Lloyd Utilization of sterol carrier protein-2 by phytanoyl-CoA 2-hydroxylase in the peroxisomal alpha oxidation of phytanic acid Chem. Biol. 9 2002 597 605 (Pubitemid 34593040)
    • (2002) Chemistry and Biology , vol.9 , Issue.5 , pp. 597-605
    • Mukherji, M.1    Kershaw, N.J.2    Schofield, C.J.3    Wierzbicki, A.S.4    Lloyd, M.D.5
  • 57
    • 0017834896 scopus 로고
    • Epidermal metabolism in heredopathia atactica polyneuritiformis (Refsum's disease)
    • P.J. Dykes, R. Marks, M.G. Davies, and D.J. Reynolds Epidermal metabolism in heredopathia atactica polyneuritiformis (Refsum's disease) J. Investig. Dermatol. 70 1978 126 129 (Pubitemid 8305603)
    • (1978) Journal of Investigative Dermatology , vol.70 , Issue.3 , pp. 126-129
    • Dykes, P.J.1    Marks, R.2    Davies, M.G.3    Reynolds, D.J.4
  • 60
    • 34548390084 scopus 로고    scopus 로고
    • Human cytochrome P450 family 4 enzymes: Function, genetic variation and regulation
    • DOI 10.1080/03602530701468573, PII 781830503
    • M.H. Hsu, U. Savas, K.J. Griffin, and E.F. Johnson Human cytochrome p450 family 4 enzymes: function, genetic variation and regulation Drug Metab. Rev. 39 2007 515 538 (Pubitemid 47355735)
    • (2007) Drug Metabolism Reviews , vol.39 , Issue.2-3 , pp. 515-538
    • Hsu, M.-H.1    Savas, U.2    Griffin, K.J.3    Johnson, E.F.4
  • 61
    • 0034081229 scopus 로고    scopus 로고
    • Omega-hydroxyceramides are required for corneocyte lipid envelope (CLE) formation and normal epidermal permeability barrier function
    • DOI 10.1046/j.1523-1747.2000.00846.x
    • M. Behne, Y. Uchida, T. Seki, P.O. de Montellano, P.M. Elias, and W.M. Holleran Omega-hydroxyceramides are required for corneocyte lipid envelope (CLE) formation and normal epidermal permeability barrier function J. Investig. Dermatol. 114 2000 185 192 (Pubitemid 30195993)
    • (2000) Journal of Investigative Dermatology , vol.114 , Issue.1 , pp. 185-192
    • Behne, M.1    Uchida, Y.2    Seki, T.3    Ortiz De Montellano, P.4    Elias, P.M.5    Holleran, W.M.6
  • 63
    • 84856478248 scopus 로고    scopus 로고
    • CYP4F22 is highly expressed at the site and timing of onset of keratinization during skin development
    • K. Sasaki, M. Akiyama, T. Yanagi, K. Sakai, Y. Miyamura, M. Sato, and H. Shimizu CYP4F22 is highly expressed at the site and timing of onset of keratinization during skin development J. Dermatol. Sci. 65 2012 156 158
    • (2012) J. Dermatol. Sci. , vol.65 , pp. 156-158
    • Sasaki, K.1    Akiyama, M.2    Yanagi, T.3    Sakai, K.4    Miyamura, Y.5    Sato, M.6    Shimizu, H.7
  • 65
    • 84880616651 scopus 로고    scopus 로고
    • The complexity of sphingolipid biosynthesis in the endoplasmic reticulum
    • R. Tidhar, and A.H. Futerman The complexity of sphingolipid biosynthesis in the endoplasmic reticulum Biochim. Biophys. Acta 1833 2013 2511 2518
    • (2013) Biochim. Biophys. Acta , vol.1833 , pp. 2511-2518
    • Tidhar, R.1    Futerman, A.H.2
  • 69
    • 67349094025 scopus 로고    scopus 로고
    • Ceramide biosynthesis in keratinocyte and its role in skin function
    • Y. Mizutani, S. Mitsutake, K. Tsuji, A. Kihara, and Y. Igarashi Ceramide biosynthesis in keratinocyte and its role in skin function Biochimie 91 2009 784 790
    • (2009) Biochimie , vol.91 , pp. 784-790
    • Mizutani, Y.1    Mitsutake, S.2    Tsuji, K.3    Kihara, A.4    Igarashi, Y.5
  • 70
    • 0242353271 scopus 로고    scopus 로고
    • Two Mammalian Longevity Assurance Gene (LAG1) Family Members, trh1 and trh4, Regulate Dihydroceramide Synthesis Using Different Fatty Acyl-CoA Donors
    • DOI 10.1074/jbc.M307104200
    • C. Riebeling, J.C. Allegood, E. Wang, J. Merrill, and A.H. Futerman Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors J. Biol. Chem. 278 2003 43452 43459 (Pubitemid 37345968)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.44 , pp. 43452-43459
    • Riebeling, C.1    Allegood, J.C.2    Wang, E.3    Merrill Jr., A.H.4    Futerman, A.H.5
  • 71
    • 23944483995 scopus 로고    scopus 로고
    • Mammalian Lass6 and its related family members regulate synthesis of specific ceramides
    • DOI 10.1042/BJ20050291
    • Y. Mizutani, A. Kihara, and Y. Igarashi Mammalian Lass6 and its related family members regulate synthesis of specific ceramides J. Biochem. 390 2005 263 271 (Pubitemid 41192252)
    • (2005) Biochemical Journal , vol.390 , Issue.1 , pp. 263-271
    • Mizutani, Y.1    Kihara, A.2    Igarashi, Y.3
  • 72
    • 0037144554 scopus 로고    scopus 로고
    • Upstream of growth and differentiation factor 1 (uog1), a mammalian homolog of the yeast longevity assurance gene 1(LAG1), regulates N-stearoyl-sphinganine (C18-(dihydro)ceramide) synthesis in a fumonisin B1-independent manner in mammalian cells
    • K. Venkataraman, C. Riebeling, J. Bodennec, H. Riezman, J.C. Allegood, M.C. Sullards, J. Merrill, and A.H. Futerman Upstream of growth and differentiation factor 1 (uog1), a mammalian homolog of the yeast longevity assurance gene 1(LAG1), regulates N-stearoyl-sphinganine (C18-(dihydro)ceramide) synthesis in a fumonisin B1-independent manner in mammalian cells J. Biol. Chem. 277 2002 35642 35649
    • (2002) J. Biol. Chem. , vol.277 , pp. 35642-35649
    • Venkataraman, K.1    Riebeling, C.2    Bodennec, J.3    Riezman, H.4    Allegood, J.C.5    Sullards, M.C.6    Merrill, J.7    Futerman, A.H.8
  • 73
    • 41949140023 scopus 로고    scopus 로고
    • Characterization of ceramide synthase 2: Tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate
    • E.L. Laviad, L. Albee, I. Pankova-Kholmyansky, S. Epstein, H. Park, A.H. Merrill Jr., and A.H. Futerman Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate J. Biol. Chem. 283 2008 5677 5684
    • (2008) J. Biol. Chem. , vol.283 , pp. 5677-5684
    • Laviad, E.L.1    Albee, L.2    Pankova-Kholmyansky, I.3    Epstein, S.4    Park, H.5    Merrill, Jr.A.H.6    Futerman, A.H.7
  • 74
    • 33748747214 scopus 로고    scopus 로고
    • LASS3 (longevity assurance homologue 3) is a mainly testis-specific (dihydro)ceramide synthase with relatively broad substrate specificity
    • DOI 10.1042/BJ20060379
    • Y. Mizutani, A. Kihara, and Y. Igarashi LASS3 (longevity assurance homologue 3) is a mainly testis-specific (dihydro)ceramide synthase with relatively broad substrate specificity J. Biochem. 398 2006 531 538 (Pubitemid 44453398)
    • (2006) Biochemical Journal , vol.398 , Issue.3 , pp. 531-538
    • Mizutani, Y.1    Kihara, A.2    Igarashi, Y.3
  • 76
    • 0037067746 scopus 로고    scopus 로고
    • Identification and characterization of a sphingolipid Δ4-desaturase family
    • DOI 10.1074/jbc.M202947200
    • P. Ternes, S. Franke, U. Zahringer, P. Sperling, and E. Heinz Identification and characterization of a sphingolipid delta 4-desaturase family J. Biol. Chem. 277 2002 25512 25518 (Pubitemid 34951866)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.28 , pp. 25512-25518
    • Ternes, P.1    Franke, S.2    Zahringer, U.3    Sperling, P.4    Heinz, E.5
  • 79
    • 1842687415 scopus 로고    scopus 로고
    • Identification of the human sphingolipid C4-hydroxylase, hDES2, and its up-regulation during keratinocyte differentiation
    • DOI 10.1016/S0014-5793(04)00274-1, PII S0014579304002741
    • Y. Mizutani, A. Kihara, and Y. Igarashi Identification of the human sphingolipid C4-hydroxylase, hDES2, and its up-regulation during keratinocyte differentiation FEBS Lett. 563 2004 93 97 (Pubitemid 38471580)
    • (2004) FEBS Letters , vol.563 , Issue.1-3 , pp. 93-97
    • Mizutani, Y.1    Kihara, A.2    Igarashi, Y.3
  • 80
    • 2542558105 scopus 로고    scopus 로고
    • DES2 protein is responsible for phytoceramide biosynthesis in the mouse small intestine
    • DOI 10.1042/BJ20031425
    • F. Omae, M. Miyazaki, A. Enomoto, M. Suzuki, Y. Suzuki, and A. Suzuki DES2 protein is responsible for phytoceramide biosynthesis in the mouse small intestine Biochem. J. 379 2004 687 695 (Pubitemid 38703653)
    • (2004) Biochemical Journal , vol.379 , Issue.3 , pp. 687-695
    • Omae, F.1    Miyazaki, M.2    Enomoto, A.3    Suzuki, M.4    Suzuki, Y.5    Suzuki, A.6
  • 81
    • 0031915569 scopus 로고    scopus 로고
    • Ceramide and cholesterol composition of the skin of patients with atopic dermatitis
    • DOI 10.1080/00015559850135788
    • A. Di Nardo, P. Wertz, A. Giannetti, and S. Seidenari Ceramide and cholesterol composition of the skin of patients with atopic dermatitis Acta Derm. Venereol. 78 1998 27 30 (Pubitemid 28103674)
    • (1998) Acta Dermato-Venereologica , vol.78 , Issue.1 , pp. 27-30
    • Di Nardo, A.1    Wertz, P.2    Giannetti, A.3    Seidenari, S.4
  • 83
    • 0033832624 scopus 로고    scopus 로고
    • Permeability barrier disorder in Niemann-Pick disease: Sphingomyelin-ceramide processing required for normal barrier homeostasis
    • M. Schmuth, M.Q. Man, F. Weber, W. Gao, K.R. Feingold, P. Fritsch, P.M. Elias, and W.M. Holleran Permeability barrier disorder in Niemann-Pick disease: sphingomyelin-ceramide processing required for normal barrier homeostasis J. Investig. Dermatol. 115 2000 459 466
    • (2000) J. Investig. Dermatol. , vol.115 , pp. 459-466
    • Schmuth, M.1    Man, M.Q.2    Weber, F.3    Gao, W.4    Feingold, K.R.5    Fritsch, P.6    Elias, P.M.7    Holleran, W.M.8
  • 86
    • 0036038643 scopus 로고    scopus 로고
    • Human epidermal glucosylceramides are major precursors of stratum corneum ceramides
    • DOI 10.1046/j.1523-1747.2002.01836.x
    • S. Hamanaka, M. Hara, H. Nishio, F. Otsuka, A. Suzuki, and Y. Uchida Human epidermal glucosylceramides are major precursors of stratum corneum ceramides J. Investig. Dermatol. 119 2002 416 423 (Pubitemid 35001952)
    • (2002) Journal of Investigative Dermatology , vol.119 , Issue.2 , pp. 416-423
    • Hamanaka, S.1    Hara, M.2    Nishio, H.3    Otsuka, F.4    Suzuki, A.5    Uchida, Y.6
  • 89
    • 0023054480 scopus 로고
    • Linoleate content of epidermal acylglucosylceramide in newborn, growing and mature mice
    • P.W. Wertz, and D.T. Downing Linoleate content of epidermal acylglucosylceramide in newborn, growing and mature mice Biochim. Biophys. Acta 876 1986 469 473
    • (1986) Biochim. Biophys. Acta , vol.876 , pp. 469-473
    • Wertz, P.W.1    Downing, D.T.2
  • 90
    • 0025010649 scopus 로고
    • Metabolism of linoleic acid in porcine epidermis
    • P.W. Wertz, and D.T. Downing Metabolism of linoleic acid in porcine epidermis J. Lipid Res. 31 1990 1839 1844 (Pubitemid 20387352)
    • (1990) Journal of Lipid Research , vol.31 , Issue.10 , pp. 1839-1844
    • Wertz, P.W.1    Downing, D.T.2
  • 92
    • 33747332788 scopus 로고    scopus 로고
    • Barrier dysfunction and pathogenesis of neutral lipid storage disease with ichthyosis (Chanarin-Dorfman syndrome)
    • M. Demerjian, D.A. Crumrine, L.M. Milstone, M.L. Williams, and P.M. Elias Barrier dysfunction and pathogenesis of neutral lipid storage disease with ichthyosis (Chanarin-Dorfman syndrome) J. Investig. Dermatol. 126 2006 2032 2038
    • (2006) J. Investig. Dermatol. , vol.126 , pp. 2032-2038
    • Demerjian, M.1    Crumrine, D.A.2    Milstone, L.M.3    Williams, M.L.4    Elias, P.M.5
  • 95
    • 79956106129 scopus 로고    scopus 로고
    • Fat in the skin: Triacylglycerol metabolism in keratinocytes and its role in the development of neutral lipid storage disease
    • F.P. Radner, S. Grond, G. Haemmerle, A. Lass, and R. Zechner Fat in the skin: triacylglycerol metabolism in keratinocytes and its role in the development of neutral lipid storage disease Dermatoendocrinol 3 2011 77 83
    • (2011) Dermatoendocrinol , vol.3 , pp. 77-83
    • Radner, F.P.1    Grond, S.2    Haemmerle, G.3    Lass, A.4    Zechner, R.5
  • 98
    • 84866423427 scopus 로고    scopus 로고
    • A novel pathway of ceramide metabolism in Saccharomyces cerevisiae
    • N.S. Voynova, C. Vionnet, C.S. Ejsing, and A. Conzelmann A novel pathway of ceramide metabolism in Saccharomyces cerevisiae Biochem. J. 447 2012 103 114
    • (2012) Biochem. J. , vol.447 , pp. 103-114
    • Voynova, N.S.1    Vionnet, C.2    Ejsing, C.S.3    Conzelmann, A.4
  • 99
    • 79959906412 scopus 로고    scopus 로고
    • Lipoxygenases mediate the effect of essential fatty acid in skin barrier formation: A proposed role in releasing omega-hydroxyceramide for construction of the corneocyte lipid envelope
    • Y. Zheng, H. Yin, W.E. Boeglin, P.M. Elias, D. Crumrine, D.R. Beier, and A.R. Brash Lipoxygenases mediate the effect of essential fatty acid in skin barrier formation: a proposed role in releasing omega-hydroxyceramide for construction of the corneocyte lipid envelope J. Biol. Chem. 286 2011 24046 24056
    • (2011) J. Biol. Chem. , vol.286 , pp. 24046-24056
    • Zheng, Y.1    Yin, H.2    Boeglin, W.E.3    Elias, P.M.4    Crumrine, D.5    Beier, D.R.6    Brash, A.R.7
  • 102
    • 0032970258 scopus 로고    scopus 로고
    • Accumulation of protein-bound epidermal glucosylceramides in β-glucocerebrosidase deficient type 2 Gaucher mice
    • DOI 10.1016/S0014-5793(99)00274-4, PII S0014579399002744
    • T. Doering, R.L. Proia, and K. Sandhoff Accumulation of protein-bound epidermal glucosylceramides in beta-glucocerebrosidase deficient type 2 Gaucher mice FEBS Lett. 447 1999 167 170 (Pubitemid 29146079)
    • (1999) FEBS Letters , vol.447 , Issue.2-3 , pp. 167-170
    • Doering, T.1    Proia, R.L.2    Sandhoff, K.3
  • 103
    • 0028331151 scopus 로고
    • Consequences of beta-glucocerebrosidase deficiency in epidermis. Ultrastructure and permeability barrier alterations in Gaucher disease
    • W.M. Holleran, E.I. Ginns, G.K. Menon, J.U. Grundmann, M. Fartasch, C.E. McKinney, P.M. Elias, and E. Sidransky Consequences of beta-glucocerebrosidase deficiency in epidermis. Ultrastructure and permeability barrier alterations in Gaucher disease J. Clin. Invest. 93 1994 1756 1764
    • (1994) J. Clin. Invest. , vol.93 , pp. 1756-1764
    • Holleran, W.M.1    Ginns, E.I.2    Menon, G.K.3    Grundmann, J.U.4    Fartasch, M.5    McKinney, C.E.6    Elias, P.M.7    Sidransky, E.8
  • 106
    • 34547947625 scopus 로고    scopus 로고
    • A Molecular Caliper Mechanism for Determining Very Long-Chain Fatty Acid Length
    • DOI 10.1016/j.cell.2007.06.031, PII S009286740700829X
    • V. Denic, and J.S. Weissman A molecular caliper mechanism for determining very long-chain fatty acid length Cell 130 2007 663 677 (Pubitemid 47268053)
    • (2007) Cell , vol.130 , Issue.4 , pp. 663-677
    • Denic, V.1    Weissman, J.S.2
  • 107
    • 84879515141 scopus 로고    scopus 로고
    • Cooperative synthesis of ultra long-chain fatty acid and ceramide during keratinocyte differentiation
    • Y. Mizutani, H. Sun, Y. Ohno, T. Wakashima, M. Obara, K. Yuyama, A. Kihara, and Y. Igarashi Cooperative synthesis of ultra long-chain fatty acid and ceramide during keratinocyte differentiation PLoS One 8 2013 e67317
    • (2013) PLoS One , vol.8 , pp. 67317
    • Mizutani, Y.1    Sun, H.2    Ohno, Y.3    Wakashima, T.4    Obara, M.5    Yuyama, K.6    Kihara, A.7    Igarashi, Y.8
  • 109
    • 0027413499 scopus 로고
    • The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver
    • K. Hirschberg, J. Rodger, and A.H. Futerman The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver Biochem. J. 290 Pt 3 1993 751 757 (Pubitemid 23100434)
    • (1993) Biochemical Journal , vol.290 , Issue.3 , pp. 751-757
    • Hirschberg, K.1    Rodger, J.2    Futerman, A.H.3
  • 111
    • 0025993036 scopus 로고
    • Determination of the intracellular sites and topology of glucosylceramide synthesis in rat liver
    • A.H. Futerman, and R.E. Pagano Determination of the intracellular sites and topology of glucosylceramide synthesis in rat liver Biochem. J. 280 Pt 2 1991 295 302
    • (1991) Biochem. J. , vol.280 , Issue.PART 2 , pp. 295-302
    • Futerman, A.H.1    Pagano, R.E.2
  • 120
    • 57049119685 scopus 로고    scopus 로고
    • Lamellar bodies of human epidermis: Proteomics characterization by high throughput mass spectrometry and possible involvement of CLIP-170 in their trafficking/secretion
    • A.A. Raymond, A. Gonzalez de Peredo, A. Stella, A. Ishida-Yamamoto, D. Bouyssie, G. Serre, B. Monsarrat, and M. Simon Lamellar bodies of human epidermis: proteomics characterization by high throughput mass spectrometry and possible involvement of CLIP-170 in their trafficking/secretion Mol. Cell Proteomics 7 2008 2151 2175
    • (2008) Mol. Cell Proteomics , vol.7 , pp. 2151-2175
    • Raymond, A.A.1    Gonzalez De Peredo, A.2    Stella, A.3    Ishida-Yamamoto, A.4    Bouyssie, D.5    Serre, G.6    Monsarrat, B.7    Simon, M.8
  • 121
    • 20344364415 scopus 로고    scopus 로고
    • CLIPs and CLASPs and cellular dynamics
    • DOI 10.1038/nrm1664
    • N. Galjart CLIPs and CLASPs and cellular dynamics Nat. Rev. 6 2005 487 498 (Pubitemid 40780560)
    • (2005) Nature Reviews Molecular Cell Biology , vol.6 , Issue.6 , pp. 487-498
    • Galjart, N.1
  • 122
    • 0042121374 scopus 로고    scopus 로고
    • Barrier function of the skin: "La Raison d'Être" of the epidermis
    • DOI 10.1046/j.1523-1747.2003.12359.x
    • K.C. Madison Barrier function of the skin: "la raison d'etre" of the epidermis J. Investig. Dermatol. 121 2003 231 241 (Pubitemid 36969895)
    • (2003) Journal of Investigative Dermatology , vol.121 , Issue.2 , pp. 231-241
    • Madison, K.C.1
  • 125
    • 81455134359 scopus 로고    scopus 로고
    • Abca12-mediated lipid transport and Snap29-dependent trafficking of lamellar granules are crucial for epidermal morphogenesis in a zebrafish model of ichthyosis
    • Q. Li, M. Frank, M. Akiyama, H. Shimizu, S.Y. Ho, C. Thisse, B. Thisse, E. Sprecher, and J. Uitto Abca12-mediated lipid transport and Snap29-dependent trafficking of lamellar granules are crucial for epidermal morphogenesis in a zebrafish model of ichthyosis Dis. Model. Mech. 4 2011 777 785
    • (2011) Dis. Model. Mech. , vol.4 , pp. 777-785
    • Li, Q.1    Frank, M.2    Akiyama, M.3    Shimizu, H.4    Ho, S.Y.5    Thisse, C.6    Thisse, B.7    Sprecher, E.8    Uitto, J.9
  • 128
    • 33644642167 scopus 로고    scopus 로고
    • Basis for improved permeability barrier homeostasis induced by PPAR and LXR activators: Liposensors stimulate lipid synthesis, lamellar body secretion, and post-secretory lipid processing
    • DOI 10.1038/sj.jid.5700046, PII 5700046
    • M.Q. Man, E.H. Choi, M. Schmuth, D. Crumrine, Y. Uchida, P.M. Elias, W.M. Holleran, and K.R. Feingold Basis for improved permeability barrier homeostasis induced by PPAR and LXR activators: liposensors stimulate lipid synthesis, lamellar body secretion, and post-secretory lipid processing J. Investig. Dermatol. 126 2006 386 392 (Pubitemid 43323174)
    • (2006) Journal of Investigative Dermatology , vol.126 , Issue.2 , pp. 386-392
    • Man, M.-Q.1    Choi, E.-H.2    Schmuth, M.3    Crumrine, D.4    Uchida, Y.5    Elias, P.M.6    Holleran, W.M.7    Feingold, K.R.8
  • 130
    • 0035723402 scopus 로고    scopus 로고
    • Vitamin C stimulates sphingolipid production and markers of barrier formation in submerged human keratinocyte cultures
    • DOI 10.1046/j.0022-202X.2001.01555.x
    • Y. Uchida, M. Behne, D. Quiec, P.M. Elias, and W.M. Holleran Vitamin C stimulates sphingolipid production and markers of barrier formation in submerged human keratinocyte cultures J. Investig. Dermatol. 117 2001 1307 1313 (Pubitemid 34205934)
    • (2001) Journal of Investigative Dermatology , vol.117 , Issue.5 , pp. 1307-1313
    • Uchida, Y.1    Behne, M.2    Quiec, D.3    Elias, P.M.4    Holleran, W.M.5
  • 131
    • 67349174964 scopus 로고    scopus 로고
    • Vitamin D receptor and coactivators SRC2 and 3 regulate epidermis-specific sphingolipid production and permeability barrier formation
    • Y. Oda, Y. Uchida, S. Moradian, D. Crumrine, P.M. Elias, and D.D. Bikle Vitamin D receptor and coactivators SRC2 and 3 regulate epidermis-specific sphingolipid production and permeability barrier formation J. Investig. Dermatol. 129 2009 1367 1378
    • (2009) J. Investig. Dermatol. , vol.129 , pp. 1367-1378
    • Oda, Y.1    Uchida, Y.2    Moradian, S.3    Crumrine, D.4    Elias, P.M.5    Bikle, D.D.6
  • 132
    • 84880325355 scopus 로고    scopus 로고
    • Activation of TLR3 in keratinocytes increases expression of genes involved in formation of the epidermis, lipid accumulation, and epidermal organelles
    • A.W. Borkowski, K. Park, Y. Uchida, and R.L. Gallo Activation of TLR3 in keratinocytes increases expression of genes involved in formation of the epidermis, lipid accumulation, and epidermal organelles J. Investig. Dermatol. 133 2013 2031 2040
    • (2013) J. Investig. Dermatol. , vol.133 , pp. 2031-2040
    • Borkowski, A.W.1    Park, K.2    Uchida, Y.3    Gallo, R.L.4
  • 133
    • 34047097326 scopus 로고    scopus 로고
    • -/-) mouse results from disruption of the epidermal lipid barrier and adaptive thermoregulation
    • DOI 10.1515/BC.2007.046
    • E. Binczek, B. Jenke, B. Holz, R.H. Gunter, M. Thevis, and W. Stoffel Obesity resistance of the stearoyl-CoA desaturase-deficient (scd1 -/-) mouse results from disruption of the epidermal lipid barrier and adaptive thermoregulation Biol. Chem. 388 2007 405 418 (Pubitemid 46514691)
    • (2007) Biological Chemistry , vol.388 , Issue.4 , pp. 405-418
    • Binczek, E.1    Jenke, B.2    Holz, B.3    Gunter, R.H.4    Thevis, M.5    Stoffel, W.6
  • 135
    • 84873627687 scopus 로고    scopus 로고
    • Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development
    • Z. Wang, J.S. Kirkwood, A.W. Taylor, J.F. Stevens, M. Leid, G. Ganguli-Indra, and A.K. Indra Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development J. Investig. Dermatol. 133 2013 668 676
    • (2013) J. Investig. Dermatol. , vol.133 , pp. 668-676
    • Wang, Z.1    Kirkwood, J.S.2    Taylor, A.W.3    Stevens, J.F.4    Leid, M.5    Ganguli-Indra, G.6    Indra, A.K.7


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