Activation of TLR3 in keratinocytes increases expression of genes involved in formation of the epidermis, lipid accumulation, and epidermal organelles

Journal of Investigative Dermatology

Volumn 133, Issue 8, 2013, Pages 2031-2040

  Borkowski, Andrew W ^a   Park, Kyungho ^b,c   Uchida, Yoshikazu ^b,c   Gallo, Richard L ^a,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER A1; CYTOKERATIN 1; CYTOKERATIN 14; DOUBLE STRANDED RNA; FILAGGRIN; GLUCOSYLCERAMIDASE; INVOLUCRIN; KERATOHYALIN; LORICRIN; POLYINOSINIC ACID; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; SKIN LIPID; SPHINGOMYELIN; SPHINGOMYELIN PHOSPHODIESTERASE; TOLL LIKE RECEPTOR 3; TUMOR NECROSIS FACTOR;

ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; ENDOSOME; EPIDERMIS; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; KERATINOCYTE; LAMELLAR BODY; LIPID METABOLISM; LIPID STORAGE; LYSOSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; UPREGULATION;

EID: 84880325355     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2013.39     Document Type: Article

References (40)

1. Akiyama M, Sugiyama-Nakagiri Y, Sakai K et al. (2005) Mutations in lipid transporter ABCA12 in harlequin ichthyosis and functional recovery by corrective gene transfer. J Clin Invest 115:1777-84 (Pubitemid 40979716)
2. Bernard JJ, Cowing-Zitron C, Nakatsuji T et al. (2012) Ultraviolet radiation damages self non-coding RNA and is detected by TLR3. Nat Med 18:1286-90
3. Casrouge A, Zhang SY, Eidenschenk C et al. (2006) Herpes simplex virus encephalitis in human UNC-93B deficiency. Science 314:308-12 (Pubitemid 44571977)
4. Cavassani KA, Ishii M, Wen H et al. (2008) TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events. J Exp Med 205: 2609-21
5. Dunleavy F, McElvaney NG, Green CM (2010) TLR3 sensing of viral infection. Open Infect Dis J 4:1-10
6. Feingold KR (1991) The regulation and role of epidermal lipid synthesis. Adv Lipid Res 24:57-82
7. Feingold KR (2007) The role of epidermal lipids in cutaneous permeability barrier homeostasis. J Lipid Res 48:2531-46 (Pubitemid 350272838)
8. Feingold KR, Denda M (2012) Regulation of permeability barrier homeostasis. Clin Dermatol 3:263-8
9. Holleran WM, Feingold KR, Man MQ et al. (1991a) Regulation of epidermal sphingolipid synthesis by permeability barrier function. J Lipid Res 32:1151-8
10. Holleran WM, Gao WN, Feingold KR et al. (1995) Localization of epidermal sphingolipid synthesis and serine palmitoyl transferase activity: alterations imposed by permeability barrier requirements. Arch Dermatol Res 287:254-8
11. Holleran WM, Man MQ, Gao WN et al. (1991b) Sphingolipids are required for mammalian epidermal barrier function. Inhibition of sphingolipid synthesis delays barrier recovery after acute perturbation. J Clin Invest 88:1338-45
12. Holleran WM, Takagi Y, Menon GK et al. (1994) Permeability barrier requirements regulate epidermal beta-glucocerebrosidase. J Lipid Res 35:905-12 (Pubitemid 24157241)
13. Huang DW, Sherman BT, Lempicki RA (2009a) Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4:44-57
14. Huang DW, Sherman BT, Lempicki RA (2009b) Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acid Res 37:1-13
15. Ishikawa J, Narita H, Kondo N et al. (2010) Changes in the ceramide profile of atopic dermatitis patients. J Invest Dermatol 130:2511-4
16. Janssens M, van Smeden J, Gooris GS et al. (2011) Lamellar lipid organization and ceramide composition in the stratum corneum of patients with atopic eczema. J Invest Dermatol 131:2136-8
17. Jasaka I, Koster ES, Calkoen F et al. (2011) Skin barrier function in healthy subjects and patients with atopic dermatitis in relation to filaggrin loss-offunction mutations. J Invest Dermatol 131:540-2
18. Jensen JM, Schütze S, Fö rl M et al. (1999) Roles for tumor necrosis factor receptor p55 and sphingomyelinase in repairing the cutaneous permeability barrier. J Clin Invest 104:1761-70
19. Kawai T, Akira S (2008) Toll-like receptor and RIG-1-like receptor signaling. Ann NY Acad Sci 1143:1-20
20. Lai Y, Di Nardo A, Nakatsuji T et al. (2009) Commensal bacteria regulate Tolllike receptor 3-dependent inflammation after skin injury. Nat Med 15:1377-83
21. Lee SH, Elias PM, Proksch E et al. (1992) Calcium and potassium are important regulators of barrier homeostasis in murine epidermis. J Clin Invest 89:530-8
22. Lefévre C, Audebert S, Jobard F et al. (2003) Mutations in the transporter ABCA12 are associated with lamellar Ichthyosis type 2. Hum Mol Genet 12:2369-78 (Pubitemid 37160881)
23. Lin Q, Fang D, Fang J et al. (2011) Impaired wound healing with defective expression of chemokines and recruitment of myeloid cells in TLR3-deficient mice. J Immunol 186:3710-7
24. Lin Q, Wang L, Lin Y et al. (2012) Toll-like receptor 3 ligand polyinosinic:polycytidylic acid promotes wound healing in human and murine skin. J Invest Dermatol 132:2085-92
25. Matsushima H, Yamada N, Matsue H et al. (2004) TLR3-, TLR7-, and TLR9-mediated production of proinflammatory cytokines and chemokines from murine connective tissue type skin-derived mast cells but not from bone marrow-derived mast cells. J Immunol 173:531-41 (Pubitemid 38797381)
26. Mao-Qiang M, Elias PM, Feingold KR (1993) Fatty acids are required for epidermal permeability barrier function. J Clin Invest 92:791-8 (Pubitemid 23262400)
27. Melnik B, Hollmann J, Plewig G (1988) Decreased stratum corneum ceramides in atopic individuals-a pathobiochemical factor in xerosis? Br J Dermatol 119:547-8
28. Menon GK, Elias PM, Lee SH et al. (1992a) Localization of calcium in murine epidermis following disruption and repair of the permeability barrier. Cell Tissue Res 270:503-12
29. Menon GK, Feingold KR, Elias PM (1992b) Lamellar body secretory response to barrier disruption. J Invest Dermatol 98:279-89
30. Menon GK, Feingold KR, Moser AH et al. (1985a) De novo sterologenesis in the skin. II. Regulation by cutaneous barrier requirements. J Lipid Res 26:418-27 (Pubitemid 15099365)
31. Menon GK, Grayson S, Elias PM (1985b) Ionic calcium reservoirs in mammalian epidermis: ultrastructural localization by ion-capture cytochemistry. J Invest Dermatol 84:508-12 (Pubitemid 15053207)
32. Ottey KA, Wood LC, Grunfeld C et al. (1995) Cutaneous permeability barrier disruption increases fatty acid synthetic enzyme activity in the epidermis of hairless mice. J Invest Dermatol 104:401-4
33. Palmer CN, Irvine AD, Terron-Kwiatkowski A et al. (2006) Common loss-offunction variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat Genet 38:441-6
34. Sancho-Shimizu V, Pérez de Diego R, Lorenzo L et al. (2011) Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency. J Clin Invest 121:4889-902
35. Simpson CL, Kojima S, Getsios S (2010) RNA interference in keratinocytes and an organotypic model of human epidermis. Methods Mol Biol 585:127-46
36. Uchida Y, Nardo AD, Collins V et al. (2003) De novo ceramide synthesis participates in the ultraviolet B irradiation-induced apoptosis in undifferentiated cultured human keratinocytes. J Invest Dermatol 120:662-9 (Pubitemid 36344011)
37. Wang X, Schunck M, Kallen K et al. (2004) The interleukin-6 cytokine system regulates epidermal permeability barrier homeostasis. J Invest Dermatol 123:124-31 (Pubitemid 38833473)
38. Yamamoto A, Serizawa S, Ito M et al. (1991) Stratum corneum lipid abnormalities in atopic dermatitis. Arch Dermatol Res 283:219-23
39. Yu M, Levine SJ (2011) Toll-like receptor, RIG-I-like receptors and the NLRP3 inflammasome: key modulators of innate immune responses to doublestranded RNA viruses. Cytokine Growth Factor Rev 22:63-72
40. Zhang SY, Jouanguy E, Ugolini S et al. (2007) TLR3 deficiency in patients with herpes simplex encephalitis. Science 317:1522-7 (Pubitemid 47417427)